FlyBase Allele Report: Dmel\Ras85D[V12.UAS]

General Information

Symbol

Dmel\Ras85D^V12.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0060587

Feature type

allele

Associated gene

Dmel\Ras85D

Associated Insertion(s)

Carried in Construct

P{UAS-Ras85D.V12}

Also Known As

UAS-Ras^V12, UAS-rasv12, UAS-Ras85D^V12, Ras^V12, UAS-Ras1^V12, RasV12, UAS Ras^V12, UAS-Dras1^V12, UAS-Ras85D.V12, UAS-Ras-V12

Key Links

Genomic Maps

JBrowse

Transgenic product class

missense_variant

(Lee et al., 1996)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Lee et al., 1996)

Mutagen

in vitro construct

(Hazelett et al., 1998, Scholz et al., 1997, Scholz et al., 1997, Szuts et al., 1997)

Progenitor genotype

Ras85D^V12

(Scholz et al., 1997, Scholz et al., 1997)

Carried in construct

P{UAS-Ras85D.V12}

Cytology

Description

A constitutively active form of Ras85D is expressed under the control of UASt regulatory sequences.

(Lee et al., 1996)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Ras85D

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:9,512,257..9,512,257 [-]

Nucleotide change:

G9512257T

Amino acid change:

G12V | Ras85D-PA

Comment:

Analogous to oncogenic mutations in one of three human RAS genes; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.

(Karim and Rubin, 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of carcinoma

CEA

(Martínez-Abarca Millán and Martín-Bermudo, 2023, Ito and Igaki, 2021, Kong et al., 2021, Rackley et al., 2021, Soler Beatty et al., 2021, Wei et al., 2021, Wu et al., 2021, Murcia et al., 2019, Zoranovic et al., 2018, Igaki et al., 2006)

CEA with dlg1^GD4689

(Santabárbara-Ruiz and Léopold, 2021)

CEA with l(2)gl⁴

(Ding et al., 2022, Singh et al., 2022, Ito and Igaki, 2021, Wu et al., 2021, Mishra-Gorur et al., 2019, Zhang et al., 2019, Srivastava et al., 2007, Igaki et al., 2006)

CEA with Lkb1^4A4-2

(Rackley et al., 2021)

CEA with scrib¹

(Kong et al., 2021, Mishra-Gorur et al., 2019, Srivastava et al., 2007, Igaki et al., 2006, Uhlirova and Bohmann, 2006)

CEA with dlg1¹⁴

(Ito and Igaki, 2021, Igaki et al., 2006)

CEA with shg^k03401

(Igaki et al., 2006)

CEA with scrib⁶⁷³

(Amcheslavsky et al., 2018)

CEA with msn³²⁰⁸

(Kong et al., 2021)

CEA with sna^UAS.cAa

(Wu et al., 2021)

CEA with scrib^KK101128

(Murcia et al., 2019)

CEC

(Karim and Rubin, 1998)

CEA with scrib^HMJ21977

(Snigdha et al., 2021)

model of cancer

CEA with fmt¹

(Ma et al., 2017)

CEA with PpV^Δ1

(Ma et al., 2017)

CEA with l(2)gl⁴

(Guo et al., 2020, Ma et al., 2017, Ma et al., 2013, Pagliarini and Xu, 2003)

CEA with PpV^GD7532

(Ma et al., 2017)

CEA

(Khalili et al., 2023, Martínez-Abarca Millán et al., 2023, Enomoto et al., 2021, Santabárbara-Ruiz and Léopold, 2021, Tamamouna et al., 2021, Ma et al., 2020, Jung et al., 2019, Rives-Quinto et al., 2017, Chabu and Xu, 2014, Hirabayashi et al., 2013, Ma et al., 2013)

CEA with scrib⁶⁷³

(Katheder et al., 2017)

CEA with scrib¹

(Kakemura and Igaki, 2024, Cong et al., 2021, Hodgson et al., 2021, Katheder et al., 2017, Figueroa-Clarevega and Bilder, 2015, Külshammer et al., 2015, Stickel and Su, 2014, Willoughby et al., 2013, Wu et al., 2010, Pagliarini and Xu, 2003)

CEA with dlg1^GD4689

(Katheder et al., 2017, Muzzopappa et al., 2017, Figueroa-Clarevega and Bilder, 2015, Willecke et al., 2011)

CEA with scrib^j7B3

(Waghmare et al., 2024, Pagliarini and Xu, 2003)

CEA with Src64B^UAS.cCa

(Enomoto et al., 2021)

CEA with dlg1¹⁴

(Kakemura and Igaki, 2024, Pagliarini and Xu, 2003)

CEA with baz⁴

(Pagliarini and Xu, 2003)

CEA with sdt^XN

(Pagliarini and Xu, 2003)

CEA with Cdc42¹

(Pagliarini and Xu, 2003)

CEA with dor^C107

(Chi et al., 2010)

CEA with dor⁸

(Chi et al., 2010)

CEA with dor^D185

(Chi et al., 2010)

CEA with car^RNAi.UAS

(Chi et al., 2010)

CEA with Vps16A^RNAi.UAS.WIZ

(Chi et al., 2010)

CEA with upd1^UAS.cUa

(Wu et al., 2010)

CEA with upd2^UAS.cUa

(Wu et al., 2010)

CEA with upd1^UAS.cUa, upd2^UAS.cUa, upd3^UAS.cUa

(Wu et al., 2010)

CEA with l(2)gl^unspecified

(Xu et al., 2023, Wu et al., 2010)

CEA with pnut^GD1512

(Gerlach et al., 2018)

CEA with Hsap\S100A4^wt.UAS

(Ismail et al., 2017)

CEA with scrib^RNAi.UAS.cUa

(Hodgson et al., 2021)

CEA with Csk^Q156Stop

(Hirabayashi et al., 2013)

CEA with scrib^KK101128

(Muzzopappa et al., 2017)

CEA with mud^JF02911

(Muzzopappa et al., 2017)

CEA with mud^HMS01458

(Muzzopappa et al., 2017)

CEA with N^RNAi.P.UAS

(Tamamouna et al., 2021)

CEA with N^DN.UAS.cUa

(Xu et al., 2023)

CEA with emei^GD3587

(Ma et al., 2020)

CEA with Rox8^GD11645

(Guo et al., 2020)

CEA with BacA\p35^UAS.cHa

(Khalili et al., 2023)

CEA with dlg1^RNAi.UAS.cUa

(Bakopoulos et al., 2023)

model of intestinal cancer

CEA

(Cabrera et al., 2023, Nászai et al., 2021)

CEA with Apc2^N175K, Apc^Q8

(Martorell et al., 2014, Martorell et al., 2014)

model of colorectal cancer

CEA

(Bangi et al., 2012)

model of leukemia

CEA

(Arefin et al., 2017)

CEA with l(2)gl^KK100777

(Arefin et al., 2017)

CEA with scrib^KK101128

(Arefin et al., 2017)

model of benign neoplasm

CEA with Alg9^c02021

(de Vreede et al., 2018)

DOES NOT model cancer

CEA with Hsap\S100A4^Δ2.UAS

(Ismail et al., 2017)

model of heart disease

CEA

(Karekar et al., 2021)

model of prostate cancer

CEA

(Rambur et al., 2020)

model of high grade glioma

CEA

(Kumar et al., 2024)

CEA with Pten^RNAi.UAS.cUa

(Cheng et al., 2016)

model of kidney cancer

CEA

(Zeng et al., 2010)

model of ovarian carcinoma

CEA with aPKC^ΔN.UAS

(Hsi et al., 2023)

model of hypertrophic cardiomyopathy

CEA

(Petersen et al., 2022)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of carcinoma

is exacerbated by mys^RNAi.UAS.cUa

(Martínez-Abarca Millán and Martín-Bermudo, 2023)

is exacerbated by dap^HMS01610

(Ito and Igaki, 2021)

is exacerbated by dap^HMS05362

(Ito and Igaki, 2021)

is ameliorated by pnt^P1.UAS

(Ito and Igaki, 2021)

is exacerbated by hep^Act.UAS

(Uhlirova and Bohmann, 2006)

is exacerbated by egr^UAS.cIa

(Igaki et al., 2006)

is exacerbated by ZnT86D^KK101698

(Wei et al., 2021)

is exacerbated by msn¹⁷²

(Kong et al., 2021)

is exacerbated by msn³²⁰⁸

(Kong et al., 2021)

is exacerbated by l(2)gl⁴

(Wu et al., 2021)

is exacerbated by sna^UAS.cAa

(Wu et al., 2021)

is ameliorated by rl^GD4697

(Murcia et al., 2019)

is ameliorated by Raf^DN.UAS

(Zoranovic et al., 2018)

is exacerbated by Tsp29Fb^GD1018

(Zoranovic et al., 2018)

is ameliorated by Tsp29Fb^UAS.Tag:HA

(Zoranovic et al., 2018)

is ameliorated by Hsap\CDKN1A^UAS.cHa

(Karim and Rubin, 1998)

is ameliorated by Raf^XS-2541

(Karim and Rubin, 1998)

is exacerbated by rl^Sem

(Karim and Rubin, 1998)

is exacerbated by Egfrap^ΔSH2

(Soler Beatty et al., 2021)

is exacerbated by Egfrap^HMJ23378

(Soler Beatty et al., 2021)

is exacerbated by Egfrap^LS

(Soler Beatty et al., 2021)

is exacerbated by Egfrap^L

(Soler Beatty et al., 2021)

is exacerbated by PVRAP^HMJ23233

(Soler Beatty et al., 2021)

is ameliorated by HAdV-C\E4orf4^UAS.cPa

(Rosen et al., 2019)

is ameliorated by HAdV-C\E4orf4^UAS.cPb

(Rosen et al., 2019)

model of cancer

is ameliorated by Sec6^GD11616

(Chabu and Xu, 2014)

is ameliorated by Sec8^KK101531

(Chabu and Xu, 2014)

is ameliorated by Sec15^KK101708

(Chabu and Xu, 2014)

is ameliorated by Sec15¹

(Chabu and Xu, 2014)

is ameliorated by Sec15^GD12109

(Chabu and Xu, 2014)

is ameliorated by Src64B^GD12263

(Ma et al., 2013)

is ameliorated by Dronc^NIG.8091R

(Waghmare et al., 2024)

is ameliorated by bsk^DN.UAS

(Waghmare et al., 2024)

is ameliorated by sgg^S9A.UAS

(Waghmare et al., 2024)

is ameliorated by yki^RNAi.N.UAS

(Waghmare et al., 2024)

is ameliorated by yki^RNAi.C.UAS

(Waghmare et al., 2024)

is ameliorated by chinmo¹

(Enomoto et al., 2021)

is exacerbated by PVRAP¹

(Martínez-Abarca Millán et al., 2023)

is exacerbated by PVRAP^HMJ23233

(Martínez-Abarca Millán et al., 2023)

is exacerbated by by^33c

(Martínez-Abarca Millán et al., 2023)

is exacerbated by by^VSH330366

(Martínez-Abarca Millán et al., 2023)

is exacerbated by Csk^Q156Stop

(Hirabayashi et al., 2013)

is exacerbated by emei¹

(Ma et al., 2020)

is exacerbated by emei²

(Ma et al., 2020)

is exacerbated by emei³

(Ma et al., 2020)

is ameliorated by Arc1^esm18

(Khalili et al., 2023)

is exacerbated by Nek2^UAS.GFP

(Das et al., 2013)

model of intestinal cancer

is ameliorated by Cortactin^HMS00658

(Cabrera et al., 2023)

is ameliorated by Cortactin^KK108594

(Cabrera et al., 2023)

is ameliorated by shg^HMS00693

(Cabrera et al., 2023)

is ameliorated by shg^JF02769

(Cabrera et al., 2023)

exacerbates alveolar rhabdomyosarcoma

modeled by Hsap\FOXO1::Hsap\PAX7^UAS.cGa

(Galindo et al., 2006)

exacerbates gastrointestinal system cancer

modeled by Apc2^g10, Apc^Q8

(Wang et al., 2013)

model of colorectal cancer

is ameliorated by bsk^DN.UAS

(Bangi et al., 2012)

is ameliorated by bsk^HMS00777

(Bangi et al., 2012)

is exacerbated by hep^Act.UAS

(Bangi et al., 2012)

is exacerbated by imd^UAS.cGa

(Bangi et al., 2012)

is ameliorated by Jra^NIG.2275R

(Bangi et al., 2012)

is ameliorated by Timp^UAS.cPa

(Bangi et al., 2012)

ameliorates cancer

modeled by dlg1^A40.2

(Parisi et al., 2014)

exacerbates carcinoma

modeled by scrib¹

(Brumby and Richardson, 2003)

modeled by arm^UAS.Exel

(Zhang et al., 2019)

model of prostate cancer

is ameliorated by Egfr^GD1654

(Rambur et al., 2020)

is ameliorated by Pi3K92E^HMC05152

(Rambur et al., 2020)

is ameliorated by mTor^GL00156

(Rambur et al., 2020)

is ameliorated by rl^HMS00173

(Rambur et al., 2020)

is ameliorated by spi^HMS01120

(Rambur et al., 2020)

exacerbates intestinal cancer

modeled by Rab11^KK108297

(Nie et al., 2019)

exacerbates cancer

modeled by Hipk^UAS.Tag:HA

(Blaquiere et al., 2018)

model of kidney cancer

is ameliorated by Pka-C1^B3

(Zeng et al., 2010)

is ameliorated by mTor^ΔP

(Zeng et al., 2010)

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Cheng et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

Ras85D^V12.UAS coexpressed with Hsap\S100A4^wt.UAS serves to model metastasis.

(Ismail et al., 2017)

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Karim and Rubin, 1998)

This somatic variant has been found associated with cancer in each of the three paralogous genes in human (KRAS, HRAS, NRAS).

HRAS:p.Gly12Val

(FlyBase curators, 2019-)

Variants Synonym(s)

Associated human disease model(s)

cancer, multiple, RAS-related

External database links

ClinVar: 12600

Comments concerning this variant

KRAS:p.Gly12Val

(FlyBase curators, 2019-)

Variants Synonym(s)

Associated human disease model(s)

External database links

ClinVar: 12583

Comments concerning this variant

NRAS:p.Gly12Val

(FlyBase curators, 2019-)

Variants Synonym(s)

Associated human disease model(s)

cancer, multiple, RAS-related

External database links

ClinVar: 40470

Comments concerning this variant

Phenotypic Data

Phenotypic Class

abnormal cell death | somatic clone, with Scer\GAL4^NP0001, Scer\GAL80^ts.αTub84B

(Buchon et al., 2010)

abnormal cell migration | adult stage | progressive, with Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

abnormal cell migration | larval stage, with Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

abnormal cell migration | larval stage, with Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

abnormal cell number | adult stage, with Scer\GAL4^NP0001

(Mundorf et al., 2019)

abnormal cell polarity, with Scer\GAL4^{E(spl)mδ-HLH.0.5}

(Gaengel and Mlodzik, 2003)

abnormal cell polarity | conditional | somatic clone, with Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL

(Zeng et al., 2010)

abnormal cell shape | larval stage, with Scer\GAL4^ap.PU

(Martínez-Abarca Millán and Martín-Bermudo, 2023)

abnormal cell shape | larval stage, with Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

abnormal cell shape | third instar larval stage, with Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

abnormal cell size, with Scer\GAL4^amn-c651

(Caldwell et al., 2005)

abnormal developmental rate | larval stage, with Scer\GAL4^amn-c651

(Caldwell et al., 2005)

abnormal developmental rate | larval stage, with Scer\GAL4^amn-X8

(Caldwell et al., 2005)

abnormal developmental rate | larval stage, with Scer\GAL4^phtm.PO

(Deng and Kerppola, 2013, Ou et al., 2011)

abnormal developmental rate | P-stage, with Scer\GAL4^GMR.PF

(Ray and Lakhotia, 2019)

abnormal DNA repair | third instar larval stage, with Scer\GAL4^ap-md544

(Murcia et al., 2019)

abnormal DNA repair | third instar larval stage, with Scer\GAL4^hh.PU

(Murcia et al., 2019)

abnormal endomitotic cell cycle | adult stage, with Scer\GAL4^NP0001

(Mundorf et al., 2019)

abnormal learning, with Scer\GAL4^c739

(Moressis et al., 2009)

abnormal learning, with Scer\GAL4^c747

(Moressis et al., 2009)

abnormal locomotor behavior | larval stage | conditional, with Scer\GAL4^Hml.Δ

(Arefin et al., 2017)

abnormal mitotic cell cycle | larval stage, with Scer\GAL4^ap.PU

(Martínez-Abarca Millán and Martín-Bermudo, 2023)

abnormal mitotic cell cycle | larval stage, with Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

abnormal mitotic cell cycle | third instar larval stage, with Scer\GAL4^Bx-MS1096

(Snee et al., 2016)

abnormal neuroanatomy, with Scer\GAL4^FRT.Act5C

(Ma et al., 2013)

abnormal neuroanatomy, with Scer\GAL4^futsch-C380

(Koh et al., 2002)

abnormal neuroanatomy | adult stage | somatic clone, with Scer\GAL4^repo.PU

(Read et al., 2009)

abnormal neuroanatomy | somatic clone | third instar larval stage, with Scer\GAL4^C855a

(Morante et al., 2013)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^C855a

(Morante et al., 2013)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^Gli-rL82

(Dahlgaard et al., 2012)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^GMR.PF

(Yogev et al., 2010)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^repo.PU

(Read et al., 2009)

abnormal size, with Scer\GAL4^NP0001

(Denton et al., 2012)

abnormal size | adult stage, with Scer\GAL4^dpp.blk1

(Karim and Rubin, 1998)

abnormal size | larval stage, with Scer\GAL4^Bx-MS1096

(Snee et al., 2016)

abnormal size | larval stage, with Scer\GAL4^dpp.PU

(Snee et al., 2016)

abnormal size | third instar larval stage, with Scer\GAL4^ap-md544

(Herranz et al., 2012)

abnormal size | third instar larval stage, with Scer\GAL4^Hml.Δ

(Baril et al., 2017)

decreased body size | adult stage, with Scer\GAL4^amn-c651

(Caldwell et al., 2005)

decreased body size | larval stage, with Scer\GAL4^amn-c651

(Caldwell et al., 2005)

decreased body size | larval stage, with Scer\GAL4^amn-X8

(Caldwell et al., 2005)

decreased body size | pupal stage, with Scer\GAL4^amn-c651

(Caldwell et al., 2005)

decreased body size | pupal stage, with Scer\GAL4^amn-X8

(Caldwell et al., 2005)

decreased body size | pupal stage, with Scer\GAL4^phtm.PO

(Deng and Kerppola, 2013, Ou et al., 2011)

decreased cell death | embryonic stage, with Scer\GAL4^en-e16E

(Parker, 2006)

decreased cell death | heat sensitive, with Scer\GAL4^hs.PB

(Cordero et al., 2004)

decreased cell death | heat sensitive, with Scer\GAL4^wg-IS650, Scer\GAL80^ts.αTub84B

(Takemura and Adachi-Yamada, 2011)

decreased cell death | somatic clone | wandering third instar larval stage, with Scer\GAL4^Act5C.PI

(Moon et al., 2005)

decreased cell death | third instar larval stage | conditional, with Scer\GAL4^hh.PU

(Murcia et al., 2019)

decreased occurrence of cell division | larval stage, with Scer\GAL4^ap.PU

(Martínez-Abarca Millán and Martín-Bermudo, 2023)

decreased occurrence of cell division | larval stage, with Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

decreased occurrence of cell division | third instar larval stage, with Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

hyperplasia, with Scer\GAL4^dpp.blk1

(Karim and Rubin, 1998)

hyperplasia | conditional, with Scer\GAL4^nub.PK

(Wu et al., 2010)

hyperplasia | conditional | somatic clone, with Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL

(Zeng et al., 2010)

hyperplasia | larval stage, with Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

hyperplasia | larval stage, with Scer\GAL4^dpp.blk1

(Karim and Rubin, 1998)

hyperplasia | somatic clone, with Scer\GAL4^Act.PU

(Jiang et al., 2011, Wu et al., 2010)

hyperplasia | somatic clone, with Scer\GAL4^FRT.Act5C

(Chi et al., 2010)

hyperplasia | third instar larval stage, with Scer\GAL4^ap-md544

(Murcia et al., 2019)

hyperplasia | third instar larval stage, with Scer\GAL4^ptc-559.1

(Soler Beatty et al., 2021)

increased cell death | cell non-autonomous | larval stage, with Scer\GAL4^ap.PU

(Martínez-Abarca Millán and Martín-Bermudo, 2023)

increased cell death | cell non-autonomous | larval stage, with Scer\GAL4^Bx-MS1096

(Brown Rackley et al., 2020)

increased cell death | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

increased cell death | larval stage, with Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

increased cell death | third instar larval stage, with Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

increased cell growth rate, with Scer\GAL4^FRT.Act5C

(Ma et al., 2013)

increased cell growth rate | larval stage, with Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

increased cell number, with Scer\GAL4^ey.PH

(Yan et al., 2009)

increased cell number, with Scer\GAL4^Hml.PG

(Ashton-Beaucage et al., 2014)

increased cell number | adult stage, with Scer\GAL4^esg.PU

(Mundorf et al., 2019)

increased cell number | adult stage | somatic clone, with Scer\GAL4^repo.PU

(Read et al., 2009)

increased cell number | adult stage | somatic clone, with Scer\GAL4^Tub.PU

(Nie et al., 2015)

increased cell number | larval stage, with Scer\GAL4^He.PZ

(Zettervall et al., 2004)

increased cell number | larval stage, with Scer\GAL4^Hml.Δ

(Arefin et al., 2017)

increased cell number | pupal stage, with Scer\GAL4^GMR.PF

(Ray and Lakhotia, 2019)

increased cell number | somatic clone, with Scer\GAL4^αTub84B.PL

(Cabernard and Affolter, 2005)

increased cell number | third instar larval stage, with Scer\GAL4^Hml.Δ

(Ramond et al., 2020)

increased cell number | third instar larval stage, with Scer\GAL4^NP7397

(Jiang and Edgar, 2009)

increased cell size | embryonic stage, with Scer\GAL4^en-e16E

(Parker, 2006)

increased cell size | somatic clone, with Scer\GAL4^Act5C.PP

(Denton et al., 2012, Prober and Edgar, 2002, Prober and Edgar, 2000)

increased cell size | third instar larval stage, with Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

increased occurrence of cell division | adult stage, with Scer\GAL4^dpp.blk1

(Karim and Rubin, 1998)

increased occurrence of cell division | adult stage, with Scer\GAL4^NP0001

(Nassari et al., 2022, Mundorf et al., 2019, Jiang et al., 2011)

increased occurrence of cell division | adult stage, with Scer\GAL4^NP5130

(Meng and Biteau, 2015)

increased occurrence of cell division | adult stage, with Scer\GAL4^NP7397

(Jiang et al., 2011)

increased occurrence of cell division | adult stage | somatic clone, with Scer\GAL4^FRT.Act5C

(Zeng et al., 2010)

increased occurrence of cell division | adult stage | somatic clone, with Scer\GAL4^NP7397

(Hudry et al., 2016)

increased occurrence of cell division | larval stage, with Scer\GAL4^ey.PU

(Gaur et al., 2013)

increased occurrence of cell division | larval stage | somatic clone, with Scer\GAL4^Act5C.PI

(Ma et al., 2020)

increased occurrence of cell division | somatic clone | third instar larval stage, with Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

increased occurrence of cell division | third instar larval stage | conditional, with Scer\GAL4^hh.PU

(Murcia et al., 2019)

increased size | larval stage, with Scer\GAL4^ap.PU

(Martínez-Abarca Millán and Martín-Bermudo, 2023)

increased size | larval stage | somatic clone - tissue specific, with Scer\GAL4^Act5C.PI

(Kong et al., 2021)

increased size | spermatogenesis, with Scer\GAL4^VP16.bam

(Azuma et al., 2021)

increased size | third instar larval stage, with Scer\GAL4^en-e16E

(Sun et al., 2020)

lethal, with Scer\GAL4^en-e16E

(Sun et al., 2020)

lethal, with Scer\GAL4^sca.PU

(Mirey et al., 2003)

lethal, with Scer\GAL4^sli.PS

(Chen and Rebay, 2000)

lethal | heat sensitive, with Scer\GAL4^dpp.blk1

(Karim and Rubin, 1998)

lethal - all die before end of larval stage | RU486 conditional, with Scer\GAL4^{Act5C.Switch.PR}

(Shen et al., 2009)

lethal - all die before end of P-stage, with Scer\GAL4^Hml.Δ

(Ramond et al., 2020, Arefin et al., 2017)

lethal - all die before end of P-stage | somatic clone, with Scer\GAL4^Act.PU

(Jiang et al., 2011)

lethal - all die before end of pupal stage

(Galindo et al., 2006)

lethal - all die before end of pupal stage, with Scer\GAL4^amn-X8

(Caldwell et al., 2005)

lethal - all die before end of pupal stage, with Scer\GAL4^ap-md544

(Pagarigan et al., 2013)

lethal - all die before end of pupal stage, with Scer\GAL4^Bx-MS1096

(Hauling et al., 2014)

lethal - all die before end of pupal stage, with Scer\GAL4^en-e16E

(Asha et al., 2003)

lethal - all die before end of pupal stage, with Scer\GAL4^GMR.PU

(Grillo-Hill et al., 2015)

lethal - all die before end of pupal stage, with Scer\GAL4^MD-638

(Terriente-Félix and de Celis, 2009)

lethal - all die before end of pupal stage | conditional, with Scer\GAL4^Cg.PA

(Asha et al., 2003)

lethal - all die before end of pupal stage | somatic clone, with Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

lethal - all die during embryonic stage, with Scer\GAL4^ptc.PU

(Kim and Choi, 2019)

lethal - all die during pupal stage, with Scer\GAL4^Bx-MS1096

(Ray and Lakhotia, 2019)

lethal - all die during pupal stage, with Scer\GAL4^GMR.PF

(Ray and Lakhotia, 2019)

majority die during larval stage, with Scer\GAL4^Hml.Δ

(Ramond et al., 2020)

majority die during pharate adult stage, with Scer\GAL4^sev.EP

(Ray and Lakhotia, 2019)

majority die during P-stage, with Scer\GAL4⁵⁰¹⁵

(Deng and Kerppola, 2013)

melanotic mass phenotype, with Scer\GAL4^Bx-MS1096

(Hauling et al., 2014)

neoplasia | adult stage, with Scer\GAL4^ey.PU

(Wei et al., 2021)

neoplasia | larval stage, with Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

neoplasia | larval stage | somatic clone, with Scer\GAL4^Act5C.PI

(Ma et al., 2020, Ismail et al., 2017, O'Farrell et al., 2017)

neoplasia | larval stage | somatic clone, with Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

neoplasia | larval stage | somatic clone - tissue specific, with Scer\GAL4^Act5C.PI

(Kong et al., 2021)

neoplasia | somatic clone, with Scer\GAL4^Act5C.PI

(Igaki et al., 2006, Uhlirova and Bohmann, 2006, Pagliarini and Xu, 2003)

neoplasia | somatic clone, with Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willecke et al., 2011)

neoplasia | somatic clone | third instar larval stage, with Scer\FLP1^ey.PU, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

neoplasia | somatic clone | third instar larval stage, with Scer\GAL4^Act.PU

(Chabu and Xu, 2014, Hirabayashi et al., 2013)

neoplasia | somatic clone | third instar larval stage, with Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

neoplasia | third instar larval stage, with Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

neoplasia | third instar larval stage, with Scer\GAL4^ey.PU

(Wei et al., 2021)

neoplasia | third instar larval stage, with Scer\GAL4^repo.PU

(Read et al., 2009)

partially lethal - majority die, with Scer\GAL4^amn-c651

(Caldwell et al., 2005)

partially lethal - majority die, with Scer\GAL4^ey.PU

(Gaur et al., 2013)

partially lethal - majority die, with Scer\GAL4^sev.EP

(Ray and Lakhotia, 2019)

short lived | RU486 conditional, with Scer\GAL4^{Act5C.Switch.PR}

(Shen et al., 2009)

some die during larval stage, with Scer\GAL4^amn-c651

(Caldwell et al., 2005)

some die during larval stage | RU486 conditional, with Scer\GAL4^{Act5C.Switch.PR}

(Shen et al., 2009)

some die during P-stage | somatic clone, with Scer\GAL4^Act.PU

(Jiang et al., 2011)

some die during pupal stage

(Galindo et al., 2006)

some die during pupal stage, with Scer\GAL4^amn-X8

(Caldwell et al., 2005)

some die during pupal stage, with Scer\GAL4^en-e16E

(Asha et al., 2003)

some die during pupal stage, with Scer\GAL4^MD-638

(Terriente-Félix and de Celis, 2009)

some die during pupal stage | conditional, with Scer\GAL4^Cg.PA

(Asha et al., 2003)

viable | somatic clone, with Scer\FLP1^ey.PU, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

viable | temperature conditional, with Scer\GAL4^Bx-MS1096, Scer\GAL80^ts.αTub84B

(Hauling et al., 2014)

visible, with Scer\GAL4^dpp.3KK

(Molnar et al., 2006)

visible, with Scer\GAL4^dpp.blk1

(Sustar and Schubiger, 2005)

visible, with Scer\GAL4^ey.PU

(Gaur et al., 2013, Jiang et al., 2011)

visible, with Scer\GAL4^hs.2sev

(Kim et al., 2006)

visible, with Scer\GAL4^sca-C253

(Culi et al., 2001)

visible | adult stage, with Scer\GAL4^ey.PH

(Lu et al., 2021)

visible | adult stage, with Scer\GAL4^ey.PU

(Wei et al., 2021)

visible | pupal stage, with Scer\GAL4^MD-638

(Terriente-Félix and de Celis, 2009)

visible | pupal stage P5, with Scer\GAL4^GMR.PF

(Ray and Lakhotia, 2019)

visible | somatic clone, with Scer\GAL4^Act5C.PP

(Prober and Edgar, 2000)

Phenotype Manifest In

abdominal dorsal adult muscle precursor cell, with Scer\GAL4^how-24B

(Figeac et al., 2010)

abdominal dorsolateral adult muscle precursor cell, with Scer\GAL4^how-24B

(Figeac et al., 2010)

abdominal lateral adult muscle precursor cell, with Scer\GAL4^how-24B

(Figeac et al., 2010)

abdominal neuron | pupal stage P6, with Scer\GAL4^GMR.PF

(Ray and Lakhotia, 2019)

adult abdomen, with Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

adult brain | somatic clone, with Scer\GAL4^repo.PU

(Read et al., 2009)

adult gut, with Scer\GAL4^NP0001

(Nassari et al., 2022)

adult hindgut, with Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

adult Malpighian tubule | conditional | somatic clone, with Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL

(Zeng et al., 2010)

adult midgut, with Scer\GAL4^NP5130

(Meng and Biteau, 2015)

adult midgut | somatic clone

(Wang et al., 2013)

adult midgut | somatic clone, with Scer\GAL4^Tub.PU

(Nie et al., 2015)

adult midgut enterocyte, with Scer\GAL4^NP0001

(Mundorf et al., 2019)

adult midgut epithelium, with Scer\GAL4^esg.PU

(Mundorf et al., 2019)

adult midgut progenitor cell | third instar larval stage, with Scer\GAL4^NP7397

(Jiang and Edgar, 2009)

adult optic lobe | adult stage | somatic clone, with Scer\GAL4^repo.PU

(Read et al., 2009)

adult posterior midgut epithelium | somatic clone | somatic clone, with Scer\GAL4^NP7397

(Hudry et al., 2016)

amnioserosa, with Scer\GAL4^{Orct2-cald-GAL4}

(Mohseni et al., 2009)

anterior-posterior compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4^ptc-559.1

(Soler Beatty et al., 2021)

arista, with Scer\GAL4^dpp.blk1

(Sustar and Schubiger, 2005)

border follicle cell, with Scer\GAL4^hs.PB

(Lee et al., 1996)

border follicle cell, with Scer\GAL4^slbo.2.6

(Duchek and Rorth, 2001)

bouton | increased number, with Scer\GAL4^futsch-C380

(Koh et al., 2002)

bract | ectopic | somatic clone, with Scer\GAL4^Act.PU

(Mou et al., 2012)

capitellum, with Scer\GAL4^dpp.blk1

(Sustar and Schubiger, 2005)

chaeta | ectopic, with Scer\GAL4^dpp.blk1

(Sustar and Schubiger, 2005)

chromosome | third instar larval stage, with Scer\GAL4^ap-md544

(Murcia et al., 2019)

coxa | proximal, with Scer\GAL4^dpp.blk1

(Sustar and Schubiger, 2005)

denticle | ectopic, with Scer\GAL4^en-e16E

(O'Keefe et al., 1997)

denticle row 5, with Scer\GAL4^arm.PS

(Szuts et al., 1997)

denticle row 6, with Scer\GAL4^arm.PS

(Szuts et al., 1997)

dorsal air sac primordium | somatic clone, with Scer\GAL4^αTub84B.PL

(Cabernard and Affolter, 2005)

dorsal mesothoracic disc & peripodial epithelium | somatic clone, with Scer\GAL4^αTub84B.PL

(Baena-Lopez et al., 2003)

embryo | dorsal closure stage, with Scer\GAL4^en.PU

(Pickering et al., 2013)

embryonic/first instar larval cuticle, with Scer\GAL4^en-e16E

(O'Keefe et al., 1997)

embryonic/larval hemocyte | increased number, with Scer\GAL4^stop.Hml

(Sinenko and Mathey-Prevot, 2004)

embryonic/larval hemocyte | increased number | heat sensitive, with Scer\GAL4^Cg.PA

(Asha et al., 2003)

embryonic/larval hemocyte | increased number | third instar larval stage, with Scer\GAL4^Hml.Δ

(Ramond et al., 2020)

embryonic/larval hemocyte | larval stage | increased number, with Scer\GAL4^Hml.Δ

(Arefin et al., 2017)

embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4^Hml.Δ

(Baril et al., 2017)

embryonic/larval midgut, with Scer\GAL4^NP0001

(Denton et al., 2012)

embryonic/larval oenocyte | increased number, with Scer\GAL4^en-e16E

(Brodu et al., 2004)

embryonic/larval salivary gland, with Scer\GAL4^Bx-MS1096

(Hauling et al., 2014)

embryonic/larval salivary gland, with Scer\GAL4^fkh.PH

(Berry and Baehrecke, 2007)

embryonic/larval tracheal section, with Scer\GAL4^btl.PS

(Mortimer and Moberg, 2009)

embryonic cardioblast, with Scer\GAL4^Mef2.PR

(Grigorian et al., 2011)

embryonic epidermis, with Scer\GAL4^69B

(Payre et al., 1999)

embryonic epidermis, with Scer\GAL4^e22c

(Payre et al., 1999)

embryonic leading edge cell, with Scer\GAL4^en.PU

(Pickering et al., 2013)

embryonic midgut constriction 1, with Scer\GAL4^how-24B

(Szuts et al., 1998)

embryonic segment, with Scer\GAL4^en-e16E

(Parker, 2006)

enterocyte, with Scer\GAL4^NP0001, Scer\GAL80^ts.αTub84B

(Jiang et al., 2011)

enterocyte, with Scer\GAL4^NP7397

(Jiang et al., 2011)

enterocyte | somatic clone, with Scer\GAL4^unspecified

(Buchon et al., 2010)

epithelial cell of wing disc | third instar larval stage, with Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

eye, with Scer\GAL4^dpp.blk1

(Karim and Rubin, 1998)

eye, with Scer\GAL4^ey.PH

(Lu et al., 2021, Yan et al., 2009)

eye, with Scer\GAL4^ey.PU

(Wei et al., 2021, Gaur et al., 2013, Jiang et al., 2011)

eye, with Scer\GAL4^sev.EP

(Ray and Lakhotia, 2019)

eye | somatic clone, with Scer\FLP1^ey.PU, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

eye-antennal disc, with Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

eye-antennal disc | larval stage, with Scer\GAL4^dpp.PU

(Snee et al., 2016)

eye-antennal disc | larval stage | somatic clone, with Scer\GAL4^Act5C.PI

(O'Farrell et al., 2017)

eye-antennal disc | somatic clone, with Scer\GAL4^Act5C.PI

(Ismail et al., 2017, Uhlirova and Bohmann, 2006)

eye-antennal disc | somatic clone, with Scer\GAL4^Act.PU

(Jiang et al., 2011)

eye-antennal disc | somatic clone | third instar larval stage, with Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

eye disc, with Scer\GAL4^Act5C.PP

(Hazelett et al., 1998)

eye disc, with Scer\GAL4^GMR.PF

(Ishimaru et al., 1999)

eye disc & photoreceptor cell, with Scer\GAL4^Act5C.PP

(Hazelett et al., 1998)

eye disc | heat sensitive, with Scer\GAL4^hs.PB

(Cordero et al., 2004)

eye disc | larval stage, with Scer\GAL4^ey.PU

(Gaur et al., 2013)

eye disc | larval stage, with Scer\GAL4^GMR.PF

(Baker and Yu, 2001)

eye disc | somatic clone, with Scer\FLP1^ey.PU, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

eye disc | somatic clone, with Scer\GAL4^Act5C.PI

(Ma et al., 2020)

eye disc | somatic clone, with Scer\GAL4^Act.PU

(Chabu and Xu, 2014, Wu et al., 2010)

eye disc | somatic clone | third instar larval stage, with Scer\GAL4^Act.PU

(Hirabayashi et al., 2013)

eye disc | somatic clone - tissue specific, with Scer\GAL4^Act5C.PI

(Kong et al., 2021)

eye disc | third instar larval stage, with Scer\GAL4^ey.PU

(Wei et al., 2021)

eye disc morphogenetic furrow | ectopic, with Scer\GAL4^dpp.blk1

(Kumar and Moses, 2001)

eye disc morphogenetic furrow | somatic clone, with Scer\GAL4^GMR.PF

(Brown et al., 2006)

eye photoreceptor cell | ectopic, with Scer\GAL4^da.G32

(Roignant et al., 2006)

fusion competent cell, with Scer\GAL4^twi.PB

(Beckett and Baylies, 2006)

gastric caecum, with Scer\GAL4^NP0001

(Denton et al., 2012)

gastric caecum | somatic clone, with Scer\GAL4^Act5C.PP

(Denton et al., 2012)

glial cell | adult stage | somatic clone | increased number, with Scer\GAL4^repo.PU

(Read et al., 2009)

glial cell | increased number | third instar larval stage, with Scer\GAL4^repo.PU

(Read et al., 2009)

haltere pedicel, with Scer\GAL4^dpp.blk1

(Sustar and Schubiger, 2005)

hemocyte, with Scer\GAL4^He.PZ

(Zettervall et al., 2004)

hemocyte, with Scer\GAL4^Hml.PG

(Ashton-Beaucage et al., 2014)

hypogynial tooth | ectopic, with Scer\GAL4^dpp.blk1

(Sustar and Schubiger, 2005)

imaginal disc | somatic clone, with Scer\GAL4^Act5C.PP

(Prober and Edgar, 2000)

interommatidial bristle, with Scer\GAL4^hs.2sev

(Kim et al., 2006)

intestinal stem cell, with Scer\GAL4^NP0001

(Mundorf et al., 2019)

intestinal stem cell, with Scer\GAL4^NP0001, Scer\GAL80^ts.αTub84B

(Jiang et al., 2011)

intestinal stem cell, with Scer\GAL4^NP7397

(Jiang et al., 2011)

intestinal stem cell | somatic clone

(Wang et al., 2013)

lamellocyte | increased number, with Scer\GAL4^Bx-MS1096

(Hauling et al., 2014)

lamina | third instar larval stage

(Yogev et al., 2010)

larval brain | somatic clone | third instar larval stage, with Scer\GAL4^C855a

(Morante et al., 2013)

larval brain | third instar larval stage, with Scer\GAL4^C855a

(Morante et al., 2013)

larval brain | third instar larval stage, with Scer\GAL4^repo.PU

(Read et al., 2009)

larval neuroblast | ectopic | somatic clone | third instar larval stage, with Scer\GAL4^C855a

(Morante et al., 2013)

larval neuroblast | ectopic | third instar larval stage, with Scer\GAL4^C855a

(Morante et al., 2013)

larval peripheral nervous system | third instar larval stage, with Scer\GAL4^Gli-rL82

(Dahlgaard et al., 2012)

larval tracheal system, with Scer\GAL4^btl.PS

(Imam et al., 1999)

larval ventral nerve cord, with Scer\GAL4^FRT.Act5C

(Ma et al., 2013)

larval ventral nerve cord | larval stage | somatic clone, with Scer\GAL4^Act5C.PI

(Ismail et al., 2017)

lipid droplet | larval stage, with Scer\GAL4^Hml.Δ

(Ramond et al., 2020)

male terminalia

(Macias et al., 2004)

male terminalia, with Scer\GAL4^Pvf1-LP23

(Macias et al., 2004)

Malpighian tubule | pupal stage P5, with Scer\GAL4^GMR.PF

(Ray and Lakhotia, 2019)

Malpighian tubule | pupal stage P6, with Scer\GAL4^GMR.PF

(Ray and Lakhotia, 2019)

melanotic mass, with Scer\GAL4^He.PZ

(Zettervall et al., 2004)

mesonotum | ectopic | larval stage | somatic clone, with Scer\GAL4^αTub84B.PL

(Baena-Lopez et al., 2003)

mesothoracic tergum & macrochaeta | ectopic, with Scer\GAL4^sca-C253

(Hasson et al., 2005)

mesothoracic tergum & macrochaeta | supernumerary, with Scer\GAL4^sca-C253

(Culi et al., 2001)

midline glial cell | ectopic, with Scer\GAL4^sli.PS

(Scholz et al., 1997, Scholz et al., 1997)

mitotic cell cycle | somatic clone, with Scer\GAL4^Act5C.PP

(Prober and Edgar, 2002, Prober and Edgar, 2000)

muscle founder cell & visceral muscle primordium | ectopic, with Scer\GAL4^twi.2PE

(Lee et al., 2003)

ommatidial precursor cluster | somatic clone, with Scer\GAL4^GMR.PF

(Brown et al., 2006)

ommatidium, with Scer\GAL4^{E(spl)mδ-HLH.0.5}

(Gaengel and Mlodzik, 2003)

ommatidium, with Scer\GAL4^hs.2sev

(Kim et al., 2006)

optic cartridge | third instar larval stage, with Scer\GAL4^GMR.PF

(Yogev et al., 2010)

photoreceptor neuron | ectopic, with Scer\GAL4^Act5C.PP

(Hazelett et al., 1998)

photoreceptor neuron | ectopic, with Scer\GAL4^GMR.PF

(Yang and Baker, 2003)

photoreceptor neuron | increased number, with Scer\GAL4^GMR.PF

(Baker and Yu, 2001)

primary lobe of embryonic/larval lymph gland | third instar larval stage, with Scer\GAL4^Hml.Δ

(Baril et al., 2017)

prothoracic gland, with Scer\GAL4^amn-c651

(Caldwell et al., 2005)

prothoracic gland, with Scer\GAL4^phtm.PO

(Ou et al., 2011)

pupa | pupal stage P5, with Scer\GAL4^GMR.PF

(Ray and Lakhotia, 2019)

rhabdomere | increased number, with Scer\GAL4^hs.2sev

(Kim et al., 2006)

salivary gland | pupal stage P6, with Scer\GAL4^GMR.PF

(Ray and Lakhotia, 2019)

sensory mother cell, with Scer\GAL4^sca-C253

(Culi et al., 2001)

spermatocyte, with Scer\GAL4^VP16.bam

(Azuma et al., 2021)

tarsal segment, with Scer\GAL4^dpp.blk1

(Karim and Rubin, 1998)

third segment of antenna, with Scer\GAL4^dpp.blk1

(Sustar and Schubiger, 2005)

trichoid sensillum | increased number, with Scer\GAL4^dpp.blk1

(Sustar and Schubiger, 2005)

ventral denticle belt, with Scer\GAL4^69B

(Payre et al., 1999)

ventral denticle belt, with Scer\GAL4^arm.PS

(Szuts et al., 1997)

ventral denticle belt, with Scer\GAL4^e22c

(Payre et al., 1999)

wing, with Scer\GAL4^dpp.blk1

(Karim and Rubin, 1998)

wing disc, with Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

wing disc, with Scer\GAL4^Bx-MS1096

(Hauling et al., 2014)

wing disc, with Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

wing disc | conditional, with Scer\GAL4^nub.PK

(Wu et al., 2010)

wing disc | larval stage, with Scer\GAL4^ap.PU

(Martínez-Abarca Millán and Martín-Bermudo, 2023)

wing disc | larval stage, with Scer\GAL4^Bx-MS1096

(Snee et al., 2016)

wing disc | larval stage, with Scer\GAL4^dpp.blk1

(Karim and Rubin, 1998)

wing disc | larval stage, with Scer\GAL4^dpp.PU

(Snee et al., 2016)

wing disc | third instar larval stage, with Scer\GAL4^ap-md544

(Murcia et al., 2019)

wing disc | third instar larval stage, with Scer\GAL4^Bx-MS1096

(Snee et al., 2016)

wing disc | third instar larval stage, with Scer\GAL4^hh.PU

(Murcia et al., 2019)

wing disc | third instar larval stage | conditional, with Scer\GAL4^hh.PU

(Murcia et al., 2019)

wing disc | wandering third instar larval stage, with Scer\GAL4^Act5C.PI

(Moon et al., 2005)

wing disc anterior compartment | larval stage, with Scer\GAL4^dpp.blk1

(Karim and Rubin, 1998)

wing disc dorsal compartment | third instar larval stage, with Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

wing disc dorsal compartment | third instar larval stage, with Scer\GAL4^ap-md544

(Herranz et al., 2012)

wing disc posterior compartment | third instar larval stage, with Scer\GAL4^en-e16E

(Sun et al., 2020)

wing disc ventral compartment | third instar larval stage, with Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

wing hair | heat sensitive, with Scer\GAL4^wg-IS650, Scer\GAL80^ts.αTub84B

(Takemura and Adachi-Yamada, 2011)

wing margin, with Scer\GAL4^vg.PU

(Lyulcheva et al., 2008)

wing margin | heat sensitive, with Scer\GAL4^wg-IS650, Scer\GAL80^ts.αTub84B

(Takemura and Adachi-Yamada, 2011)

wing vein, with Scer\GAL4^dpp.3KK

(Molnar et al., 2006)

wing vein | ectopic, with Scer\GAL4^MD-638

(Terriente-Félix and de Celis, 2009)

wing vein | ectopic | increased number, with Scer\GAL4^Bx-MS1096

(Maeng et al., 2012)

wing vein | ectopic | somatic clone, with Scer\GAL4^Act5C.PP

(Prober and Edgar, 2000)

wing vein L3, with Scer\GAL4^dpp.blk1

(Karim and Rubin, 1998)

Detailed Description

Statement

Reference

Eye-antennal disc-specific clones that both express Ras85D^V12.UAS under the control of Scer\GAL4^Act5C.PI and are homozygous for l(2)gl⁴ form tumors that invade the neighboring ventral nerve cord.

(Ding et al., 2022)

Clonal expression of Ras85D^V12.UAS under the control of Scer\GAL4^Act.PU leads to bigger, tumorigenic clones as compared to controls.

(Ito and Igaki, 2021)

Eye disc-specific clones expressing Ras85D^V12.UAS under the control of Scer\GAL4^Act5C.PI undergo mild tumor growth.

(Kong et al., 2021)

Third instar larvae expressing Ras85D^V12.UAS under the control of Scer\GAL4^ap.PU exhibit overgrowth of the wing disc dorsal compartment, with ectopic folds; cells show decreased mitotic index; some cells are invasive, and are always found basally; cells are shorter, more cuboidal and with increased volume; cells close to wild-type cells show increased apoptosis; and cells in the wild-type ventral region are more compressed.

Third instar larvae expressing Ras85D^V12.UAS under the control of Scer\GAL4^ptc-559.1 exhibit overgrowth along the third wing disc anterior-posterior boundary, with ectopic folds.

(Soler Beatty et al., 2021)

The expression of Ras85D^V12.UAS under the control of Scer\GAL4^ey.PU leads to third instar larval eye disc and adult eye overgrowth.

(Wei et al., 2021)

Eye-antennal disc clones that both express Ras85D^V12.UAS under the control of Scer\GAL4^Act.PU and are l(2)gl⁴-homozygous form tumors.

(Guo et al., 2020)

Clonal expression of Ras85D^V12.UAS under the control of Scer\GAL4^Act5C.PI results in eye disc tumors/overgrowths; clones show increased mitotic index.

(Ma et al., 2020)

Expression of Ras85D^V12.UAS under the control of Scer\GAL4^Hml.Δ leads to lethality in animals raised on poor diet.

Expression of Ras85D^V12.UAS under the control of Scer\GAL4^Hml.Δ leads to smaller lipid droplets with reduced intensity in fat body of larvae.

(Ramond et al., 2020)

Expression of Ras85D^V12.UAS under the control of Scer\GAL4^en-e16E (in combination with Gal80[ts] to control the timing of expression) leads to an increase in the size of posterior compartment of third instar wing discs.

(Sun et al., 2020)

Expression of Ras85D^V12.UAS under the control of Scer\GAL4^esg.PU, in combination with a Gal80[ts] transgene to restrict expression to the adult stage, results in gut dysplasia, compared to controls; adult-stage expression under the control of Scer\GAL4^NP0001 results in loss of enterocytes, excessive enterocyte endoreplication and increased intestinal stem cell proliferation, compared to controls.

(Mundorf et al., 2019)

The expression of Ras85D^V12.UAS for 3 days during larval development under the combined control of Scer\GAL4^ap-md544 and Gal80[ts] induces hyperplastic third instar larval wing discs, with an increased number of cells in G2/M, a decreased number of cells in G1 or S-phase (Fly-Fuccy/flow cytometry), and increased DNA damage (comet assay), including some abnormal mitotic figures with chromosomal bridges.

The expression of Ras85D^V12.UAS for 3 days during larval development under the combined control of Scer\GAL4^hh.PU and Gal80[ts] leads to third instar larval wing discs exhibiting a decrease in DNA damage response (phospho-H2Av) either in control conditions or upon irradiation, and abolishes the irradiation-induced cell cycle arrest (phospho-Histone3) and apoptosis (Dcp1 immunostaining) normally observed in controls.

(Murcia et al., 2019)

Escapers expressing Ras85D^V12.UAS under the control of Scer\GAL4^sev.EP exhibit rough eyes.

Expression of Ras85D^V12.UAS under the control of Scer\GAL4^GMR.PF, but not of Scer\GAL4^sev.EP, leads to severe pupal defects: absence of proper demarcation of head, thorax, and abdomen; Malpighian tubule do not retract but persists in the anterior part, wiht cells not compacting; lack of salivary gland histolysis; and persistence of the posterior seven pairs of abdominal segmental dorsomedian (Scer\GAL4^sev.EP-positive) neurons.

(Ray and Lakhotia, 2019)

Expressing Ras85D^V12.UAS under the control of Scer\GAL4^dpp.blk1 leads to wing disc overgrowths, with the widening of the Dpp expression domain and its cells showing an invasive phenotype.

(Blaquiere et al., 2018)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Hml.Δ leads to a substantial increase in hemocyte count per larva, but pupae with this genotype exhibit similar eclosion rates at 25[o]C as compared to controls. None of these flies eclose when reared at 29[o]C, and pupae exhibit dessication and an absence of precursors of adult structures, in contrast to controls.

Larvae expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Hml.Δ exhibit no significant difference in wound healing; larvae wounded and infected with the bacteria Staphylococcus aureus, Erwinia carotovora, or E.coli survive equally well as controls; and hemocytes isolated from larvae exhibit normal phagocytosis levels upon exposure to to heat killed E. coli, as compared to controls.

Larvae expressing both Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Bx-MS1096 or Scer\GAL4^Hml.Δ infected with the nematode Heterorhabditis bacteriophora and its associated bacterium Photorhabdus luminescens, do not show a significant difference in survival as compared to controls; however, when under the control of Scer\GAL4^Hml.Δ, infected (but not uninfected) larvae show a significant decrease in motility, as compared to controls.

(Arefin et al., 2017)

Larvae expressing Ras85D^V12.UAS under the control of Scer\GAL4^Hml.Δ present extremely severe increase in circulating hemocytes and disrupted lymph gland primary lobes, but do not present defects in posterior signaling center size or morphology.

(Baril et al., 2017)

Whole eye-antennal disc clones that express Ras85D^V12.UAS under the control of Scer\GAL4^Act5C.PI form tumors that mostly stay in the CNS and rarely extend into the VNC.

(Ismail et al., 2017)

Clones expressing Ras85D^V12.Scer\UAS in third instar larval eye-antennal imaginal discs (under the control of Scer\GAL4^Act.PU) or wing imaginal discs (under the control of Scer\GAL4^tub.PU) do not lead to invasive tumors and do not lead to an increase in autophagosomes (assessed by a Atg8a fluorescence reporter) in either clone or neighboring disc tissue, as compared to controls; the eye-antennal imaginal disc clones do no exhibit an obvious increase in the proportion of cells entering cell cycle, and do not lead to an increase in autophagosomes in distant tissues - i.e. somatic muscles, midgut and fat body -, as compared to controls.

(Katheder et al., 2017)

Expression of Ras85D^V12.Scer\UAS driven by Scer\GAL4^{Scer\FRT.Act5C} in clones induced in the eye-antennal discs leads to mild benign tumors in third instar larvae.

(Ma et al., 2017)

The expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI leads to a moderate overgrowth of the eye-antennal discs, without delaying pupal formation, as compared to controls.

(O'Farrell et al., 2017)

Under control conditions, the clonal expression of Ras85D^V12.UAS under the control of Scer\GAL4^esg-NP7397 leads to a significant increase in the adult posterior midgut mitotic index in females and males, as compared to controls.

(Hudry et al., 2016)

Expression of Ras85D^V12.Scer\UAS driven by Scer\GAL4^dpp.PU leads to tissue overgrowth in eye-antennal imaginal or wing discs; expression driven by Scer\GAL4^Bx-MS1096 leads to tissue overgrowth in wing discs.

Expression of Ras85D^V12.Scer\UAS driven by Scer\GAL4^Bx-MS1096 leads to changes in the mitotic cell cycle, with fewer cells in G1 or S phases and an increased fraction in the G2/M transition phase in third instar larval wing discs compared to wild type.

(Snee et al., 2016)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^esg-NP5130 dramatically increases the number of mitotic cells in the adult gut.

(Meng and Biteau, 2015)

Adult midgut somatic clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^tub.PU have a significantly increased cell number as compared to control clones.

(Nie et al., 2015)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU does not affect the formation of cytoophidia (CTPsyn filaments) in follicle cells somatic clones in the egg chamber.

(Wang et al., 2015)

Animals expressing Ras85D^V12.Scer\UAS via Scer\GAL4^Hml.PG increases hemocyte count by approximately 100-fold.

(Ashton-Beaucage et al., 2014)

Larval eye-antenna disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU overgrow to develop tumors. Cell death is detected in the wild type cells surrounding the clones.

Eye disc clone cells expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU are able to undergo endocytosis, showing an increased level of dye internalisation compared with controls. The cells also show more efficient secretion: the rate of dye clearance is increased compared to controls.

Generating clones expressing Ras85D^V12.Scer\UAS in the whole eye disc (using the ey-FLP method) results in moderate overgrowth, compared to that seen in in mosaic eyes. The animals do not exhibit lethality.

(Chabu and Xu, 2014)

Overexpression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Bx-MS1096 leads to an increase in the size of both wing imaginal discs and also the salivary glands in larvae and to pupal lethality. Dead pupae show signs of melanization focused around two areas in the dorsal part. Inhibition of Scer\GAL4 through the addition of Scer\GAL80^ts.αTub84B rescues pupal lethality in a temperature-dependent manner. Larvae raised at 18[o]C pupate and eclose with wild-type wings while crosses shifted to 25[o]C give rise to flies with strongly melanized wings. Raising crosses at 29[o]C, where Scer\GAL80^ts.αTub84B is inactive, re-establishes pupal lethality and the appearance of two melanotic spots in the anterior part of the wing.

Overexpression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Bx-MS1096 induces Mmp1 expression and damage-associated signals (nuclear fragmentation, caspase activity). The integrity of the basement membrane in Ras85D^V12.Scer\UAS expressing salivary glands are more severely affected than in imaginal discs from the same animal.

Ras85D^V12.Scer\UAS-expressing salivary glands exhibit an infiltration of haemocytes. However, the overall haemocyte count is not different from controls. Despite the presence of crystal cells attaching to the larval salivary glands, they do not exhibit any signs of melanization although this is subsequently observed in pupae.

Ras85D^V12.Scer\UAS-expressing salivary glands exhibit an increase in lamellocytes.

(Hauling et al., 2014)

The expression of Ras85D^V12.UAS under the control of Scer\GAL4^Hml.Δ does not have an obvious effect on the growth, patterning and apoptosis levels (cleaved caspase 3 immunostaining) in the wing disc, which is in agreement with a normal adult wing, as compared to controls

(Parisi et al., 2014)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^phm.PO results in earlier pupation compared to controls.

Most animals expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4⁵⁰¹⁵ arrest at early pupal stages (P1-P9) with no detectable eye pigmentation or wings.

(Deng and Kerppola, 2013)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^ey.PU at 21-22[o]C results in only approximately 40% of flies surviving to adulthood. Approximately 10% of the surviving adults have normal to nearly normal eye morphology, with the remaining adults having either hyperplastic or deformed eyes, or lacking one or both eyes.

The number of mitotic cells per eye imaginal disc is increased compared to wild type in third instar larvae expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^ey.PU.

(Gaur et al., 2013)

Somatic clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU induced specifically in the eye disc show tumor overgrowth phenotype but the animals do not show any significant delay in pupariation.

(Hirabayashi et al., 2013)

Scer\GAL4^C855a-mediated expression of Ras85D^V12.Scer\UAS results in overgrown larval L3 neuroepithelium and ectopic neuroblasts.

Scer\GAL4^C855a-mediated expression of Ras85D^V12.Scer\UAS in clones (via MARCM) produces cell-autonomous outgrowths and ectopic neuroblasts in the larval neuroepithelium.

(Morante et al., 2013)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^ap-md544 results in pupal lethality. More than 90% of mutants reach the prepupal stage.

(Pagarigan et al., 2013)

Cells expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^en.PU show a significant increase in zippering speed during dorsal closure compared to neighbouring control cells. The number of filopodia at the leading edge is significantly increased in the mutant cells.

(Pickering et al., 2013)

Fewer intestinal stem cell clones expressing Ras85D^V12.Scer\UAS are seen per midgut over time. Clone cell polarity appears normal.

(Wang et al., 2013)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^byn-Gal4 (in combination with a Gal80[ts] transgene to restrict expression to the adult stage) for at least 7 days results in delamination of hindgut cells through the basal side of the epithelium, and evidence of basement membrane degradation, in contrast to controls. The delaminated hindgut cells progressively disseminate away from the hindgut to distant sites in the body, including the body wall, trachea, fat body and nephrocytes, increasing in penetrance and severity over time. This dissemination is not seen in the midgut when Ras85D^V12.Scer\UAS is expressed under the control of Scer\GAL4^esg-NP5130.

(Bangi et al., 2012)

Expression of Ras85D^V12.Scer\UAS in subperineurial glia under the control of Scer\GAL4^Gli-rL82 increases the diameter of the peripheral nerves as compared with wild-type. Similarly to wild-type, plasmatocytes are not seen attached to peripheral nerves.

(Dahlgaard et al., 2012)

Mosaic clones overexpressing Ras85D^V12.Scer\UAS in the gastric caeca of the midgut are enlarged and show reduced autophagy compared to surrounding wild type cells.

Scer\GAL4^{Myo31DF-NP0001}-mediated expression of Ras85D^V12.Scer\UAS results in a large midgut with delayed degradation - gastric caeca still persist at +4 h relative puparium formation (RPF), and a less condensed midgut is observed at +12 h RPF compared to controls.

(Denton et al., 2012)

Expressing Ras85D^V12.UAS under the control of Scer\GAL4^ap-md544 results in a larger wing disc dorsal compartment in third instar larvae compared to wild-type controls.

(Herranz et al., 2012)

Expression of Ras85D^V12.Scer\UAS using Scer\GAL4^Bx-MS1096 generates extra and ectopic veins in various wing regions.

(Maeng et al., 2012)

Homozygous clones in the leg which express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU show autonomous activation of bract fate.

(Mou et al., 2012)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Mef2.PR results in an increase in cardioblast number in embryos compared to controls. Both blood progenitors and pericardial nephrocytes are also increased in number.

(Grigorian et al., 2011)

Expression of Ras85D^V12.Scer\UAS in the midgut, under the control of Scer\GAL4^esg-NP7397 results in the generation of many new midgut cells, including enterocyte-like cells.

Expression of Ras85D^V12.Scer\UAS in the midgut, under the control of Scer\GAL4^{Myo31DF-NP0001} and Scer\GAL80^ts.αTub84B results in the generation of many new midgut cells, including enterocyte-like cells.

(Jiang et al., 2011)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU in clones in the eye-antennal disc results in benign overgrowth of the clones in third instar larvae at 7 days after egg laying (AEL), but cells never invade into the nearby ventral nerve cord or other tissues. These animals can grow as larvae for up to 9 days AEL and then die as early pupae.

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^ey.PU results in overgrowth of the eye.

(Jiang et al., 2011)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^phm.PO results in severe larval growth defects, with shortened larval stages and small pupae. Scer\GAL4^phm.PO->Ras85D^V12.Scer\UAS prepupae preceed the appearance of control prepupae by up to 20 hours. These larvae also exhibit large and malformed prothoracic glands.

(Ou et al., 2011)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^wg-IS650 and Scer\GAL80^ts.αTub84B activates EGFR signalling and blocks apoptosis in wing margin cells.

(Takemura and Adachi-Yamada, 2011)

Expression of Ras85D^V12.Scer\UAS in a MARCM third instar imaginal disc clone results in small tumours.

(Willecke et al., 2011)

Clones of enterocytes overexpressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^{Myo31DF-NP0001} and Scer\GAL80^ts.αTub84B rapidly disappear from the epithelium compared with wild-type clones suggesting an increased rate of delamination. The detached cells in these guts differ from those in wild-type flies in that they do not undergo cell death, have normal nuclei and do not contain enlarged vacuoles.

(Buchon et al., 2010)

Clones of cells in the developing eye expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^{Scer\FRT.Act5C} exhibit moderate benign overgrowth and never invade into the nearby ventral nerve cord or other tissues.

Clones of cells in the developing eye expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^{Scer\FRT.Act5C} in larvae bred on chloroquine or monensin exhibit invasive tumours. On day 18 AEL, 16.1% of chloroquine-treated tumours have prominently invaded into the ventral nerve cord, although the overgrowth is not notably enhanced. This invasive behavior is never observed in control tumours fed with solvent only medium. 11.8% of monensin-treated mutant animals develop ventral nerve cord invasion.

Clones of cells expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^{Scer\FRT.Act5C} display efficient lysosomal degradation.

(Chi et al., 2010)

Embryos expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^how-24B show an increase in the number of dorsal, dorsolateral and lateral adult muscle precursor cells compared to wild type. The number of ventral adult muscle precursor cells is unaffected in these embryos.

(Figeac et al., 2010)

Eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU moderately overgrow. Marked overgrowth or invasion does not occur when the entire eye-antennal disc is composed of Ras85D^V12.Scer\UAS-expressing cells.

Inhibition of apoptosis in the overgrown eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU does not induce tumors.

In contrast to wild type, where wounded wing discs are reduced in size compared to unwounded controls, wounded wing discs expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^nub.PK show a marked increase in overgrowth compared to the uninjured discs. No metastasis is detected.

(Wu et al., 2010)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^GMR.PF results in third instar larval eye discs with an enlarged lamina containing extra lamina cartridge neurons.

(Yogev et al., 2010)

Expression of Ras85D^V12.Scer\UAS in adult Malpighian tubule clones (using the MARCM system, under the control of Scer\GAL80^αTub84B.PL and Scer\GAL4^{Scer\FRT.Act5C}) results in renal and nephric stem cell over proliferation, and results in tumorous growth. The mitotic index of mutant clones is much greater than in wild-type clones. No cell death is detected the mutant clones. Mutant cells display disrupted polarity.

(Zeng et al., 2010)

Ectopic expression of Ras85D^V12.Scer\UAS driven by Scer\GAL4^esg-NP7397 in adult midgut progenitor cells results in their overproliferation compared with control third instar larval midguts.

(Jiang and Edgar, 2009)

Scer\GAL4^{Orct2-cald-GAL4}-mediated expression of Ras85D^V12.Scer\UAS results in downregulation of autophagy and a strong persistent amnioserosa phenotype.

(Mohseni et al., 2009)

Expression of Ras85D^V12.Scer\UAS within adult mushroom bodies (under the control of either Scer\GAL4^c747 or Scer\GAL4^c739) results in severe learning deficits.

(Moressis et al., 2009)

Scer\GAL4^btl.PS-mediated expression of Ras85D^V12.Scer\UAS disrupts tracheal branching in the embryo.

(Mortimer and Moberg, 2009)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^repo.PU induces 5-10 fold excess glia in the larval brain, and these glial are smaller than in wild type.

Glial clones in adult brains expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^repo.PU contain two-fold more cells than wild type.

Optic lobe clones expressing Ras85D^V12.Scer\UAS generated using eyFLP under the control of Scer\GAL4^repo.PU contain a modest number of excess and abnormal glia relative to wild type controls.

(Read et al., 2009)

Expression of Ras85D^V12.Scer\UAS in the larvae under the control of Scer\GAL4^{Act5C.Switch.PR} results in lethality. Both male and female life-span are reduced by 80% when Ras85D^V12.Scer\UAS is expressed in adult flies.

(Shen et al., 2009)

Expression of Ras85D^V12.Scer\UAS in the wing blade using Scer\GAL4^MD-638 causes pupal lethality, and the wings dissected from pharate adults are severely malformed and display excess vein differentiation.

(Terriente-Félix and de Celis, 2009)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^ey.PH early in the entire eye results in dramatic overgrowth and an increase in organ size.

(Yan et al., 2009)

Expression of Ras85D^V12.Scer\UAS along the wing margin using Scer\GAL4^vg.PU results in wing notching.

(Lyulcheva et al., 2008)

Primary cell cultures derived from embryos, and in which clones of cells that are expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PP (and expressing an Avic\GFP marker) have been induced, show large clones of Avic\GFP-positive cells 10 days after clone induction (in contrast to control cultures where cells are induced to express the Avic\GFP marker alone). Most of the clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PP are comprised of spindle-shaped cells and in 3-4 weeks, the cultures are confluent with Avic\GFP-positive cells expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PP. The fraction of cells in S-phase is elevated and fewer cells die by apoptosis in primary cell cultures expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PP compared to control cell cultures.

Cells derived from embryos expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C give rise to a cell culture population that can be passaged for prolonged periods and appear immortalised and transformed.

(Simcox et al., 2008)

The salivary glands of animals expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^fkh.PH are greatly increased in area compared to controls at 13.5 hours after puparium formation. At 24 hours APF, animals expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^fkh.PH still contain salivary gland tissue, in contrast to wild-type animals, where the salivary glands have completely degraded by this stage. Degradation is almost completely blocked in the mutant animals as intact salivary glands are still seen at 24 hours APF. The induction of autophagy that is seen in wild-type salivary glands at 13.5 hours APF is not seen in animals expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^fkh.PH.

DNA fragmentation is detected by TUNEL in salivary glands of animals expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^fkh.PH at 13.5 hours after puparium formation, as occurs in control salivary glands at this stage.

(Berry and Baehrecke, 2007)

Glia are normal in animals expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^GMR.PF. These animals have more plasmatocytes on the developing retina than wild type.

(Firth and Baker, 2007)

Clones in the eye antennal disc expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C do not show invasive behaviour.

(Srivastava et al., 2007)

The number of fusion competent myoblasts is decreased in stage 11 embryos that express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^twi.PB.

(Beckett and Baylies, 2006)

Clones that express Ras85D^V12.Scer\UAS behind the morphogenetic furrow of the eye disc, driven by Scer\GAL4^GMR.PF, leads to disorganised clusters with many cells having upregulated adherens junction components.

(Brown et al., 2006)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Mhc.PW results in a microscopically normal larval muscle pattern, although these animals die as pupae.

(Galindo et al., 2006)

Expression of Ras85D^V12.Scer\UAS in somatic clones under the control of Scer\GAL4^Act5C.PI results in activation of the JNK pathway and induction of benign tumours.

(Igaki et al., 2006)

Expression of Ras85D^V12.Scer\UAS, under the control of Scer\GAL4^hs.2sev, causes a roughened eye phenotype with extra rhabdomeres in some ommatidia.

(Kim et al., 2006)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^dpp.3KK results in wing vein thickening.

(Molnar et al., 2006)

Expression of Ras85D^V12.Scer\UAS, under the control of Scer\GAL4^en-e16E, in the posterior compartment cells of embryos leads to a reduction in the level of apoptosis of these cells, but has no effect on mitosis. Cells are of an increased size leading to an increase in compartment size of 29%.

(Parker, 2006)

Expression of Ras85D^V12.Scer\UAS, under the control of Scer\GAL4^da.G32, causes ectopic eye photoreceptor cell differentiation.

(Roignant et al., 2006)

Clones of eye/antennal imaginal disc cells that express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI give rise to a mild tumor phenotype with no detectable invasiveness.

(Uhlirova and Bohmann, 2006)

Ras85D^V12.Scer\UAS Scer\GAL4^αTub84B.PL somatic clones in the dorsal air sac primordium are larger than wild-type clones, forming bulging outgrowths. However, these clones never contribute to the primordium tip. (clones generated by Scer\GAL80 MARCM technique.)

(Cabernard and Affolter, 2005)

Adults that express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^amn-c651 are morphologically normal but are significantly reduced in size. A count of wing hair-cell number and wing hair-cell density shows that the reduced size phenotype is accompanied by a reduction in both cell number and cell size. Mutants that express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^amn-X8 are very small but morphologically normal as third-instar larvae and pupae. However, such mutants fail to eclose. Larvae of this genotype develop more rapidly than normal and begin pupariation about 18 hours before wild-type larvae. Scer\GAL4^amn-c651-driven Ras85D^V12.Scer\UAS larvae begin wandering and pupariate about 24 hours before controls, although the pupariation time of these larvae is much more variable than in wild-type controls. Until about 84 hr AEL, these larvae are similar in size to wild-type larvae. At this time, about one-third of the Ras85D^V12.Scer\UAS-expressing larvae appear to stop growing, begin pupariation, but fail to develop and ultimately die. The other two-thirds of these larvae grow, although more slowly than wild-type larvae, and form small pupae, which progress to become viable adults. Expression of Ras85D^V12.Scer\UAS, under the control of Scer\GAL4^amn-c651, increases prothoracic gland cell size, with no effect on cell number.

(Caldwell et al., 2005)

Expression of Ras85D^V12.Scer\UAS, driven by Scer\GAL4^sca-C253, leads to expression of ectopic bristles on the notum.

(Hasson et al., 2005)

Cells in regions of the late third instar wing disc which are normally sensitive to irradiation induced apoptosis become resistant to it if they are part of Ras85D^V12.Scer\UAS; Scer\GAL4^Act5C.PI somatic clones. (40Gy of γ rays; assayed after 4hrs)

(Moon et al., 2005)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^dpp.blk1 results in ectopic bristles and an excess of sensilla trichodea in the most proximal part of the coxa, ectopic bristles in the arista and third antennal segment, ectopic bristles in the capitellum and occasionally in the pedicellum of the haltere and ectopic thorn bristles in the female genitalia.

(Sustar and Schubiger, 2005)

Stage 16 Ras85D^V12.Scer\UAS; Scer\GAL4^en-e16E embryos have more oenocytes per cluster than wild-type. Unlike rho^{Scer\UAS.cdCa}; Scer\GAL4^en-e16E the oenocyte clusters in these embryos do not show a multi-modal distribution of cell numbers with peaks corresponding to multiples of 3, suggesting that normal delamination cycles in groups of 3 are not occurring. In the resulting oenocyte clusters, terminal differentiation of some oenocytes is blocked or delayed.

(Brodu et al., 2004)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^hs.PB using two 1 hour 37^oC heat shocks at 14 hours after puparium formation (APF) and at 18 hours APF almost completely blocks the "late-stage" cell death which is normally seen in pupal retinas between 26-36 hours APF. However, "early-stage" cell death (which occurs between 18-24 hours APF) seems to be unaffected in these retinas.

(Cordero et al., 2004)

4% of P{UAS-Ras85D.V12} males show rotated terminalia, rising to 55% when expression is driven by Scer\GAL4^Pvf1-LP23.

(Macias et al., 2004)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^stop.Hml results in an elevation in the number of circulating larval hemocytes compared to wild type.

(Sinenko and Mathey-Prevot, 2004)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^sim.P3.7 in embryos does not result in a reduction in the number of midline glia.

(Sonnenfeld et al., 2004)

When expression is driven by Scer\GAL4^He.PZ, hemocyte proliferation is increased and lamellocyte and crystal cell numbers are unaffected. Melanotic masses form.

(Zettervall et al., 2004)

Late third instar larvae expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Cg.PA show a 40-fold increase in the number of hemocytes compared to wild type. These cells resemble plasmatocytes morphologically, but do not stain with a plasmatocyte-specific antigen. Cells that morphologically resemble lamellocytes are also seen in these larvae, and parasitisation of the larvae with L.boulardi results in induction of lamellocytes. Embryos carrying both Ras85D^V12.Scer\UAS and Scer\GAL4^Cg.PA do not have an increased number of hemocytes. 99% of animals expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Cg.PA die as early pupae under normal culture conditions at 25^oC. However, 33% of these animals can survive to adulthood if cultured at very low densities. Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^en-e16E has no effect on the number and morphology of circulating hemocytes. When hemocytes expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Cg.PA are injected into the abdomens of wild-type females, the abdomens become enlarged and 64% of the injected flies die within 3 days. Hemocytes expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Cg.PA are capable of phagocytosing bacteria in an in vitro assay, although they are slightly less proficient than wild-type hemocytes.

(Asha et al., 2003)

Cells in Ras85D^V12.Scer\UAS; Scer\GAL4^αTub84B.PL somatic clones in the peripodial epithelium of the wing disc are transformed from squamous to columnar morphology. Gene expression in the clones indicate a transformation towards notum fate, rather than wing hinge or wing pouch.

(Baena-Lopez et al., 2003)

When Ras85D^V12.Scer\UAS is driven by Scer\GAL4^HLHmδ ommatidial misrotations are seen in the eye.

(Gaengel and Mlodzik, 2003)

Ras85D^V12.Scer\UAS; Scer\GAL4^twi.2PE embryos have increased numbers of visceral muscle founder cells.

(Lee et al., 2003)

Marked clones in the eye disc expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI are increased in size compared to control marked clones but are always located in the same areas as the control clones; mutant cells are not seen outside of the eye-antennal disc/optic lobe region, suggesting that tissue integrity is not compromised. The basement membrane is smooth and continuous on the outer surface of eye discs containing clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI.

(Pagliarini and Xu, 2003)

Caspase activation in cells posterior to the furrow in eye discs is completely suppressed by Ras85D^V12.Scer\UAS; Scer\GAL4^GMR.PF. These discs also exhibit extensive ectopic photoreceptor differentiation posterior to the furrow.

(Yang and Baker, 2003)

Overexpression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^C380 causes a large increase in the number of synaptic boutons compared to overexpression of wild-type Ras85D^Scer\UAS.cKa.

(Koh et al., 2002)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PP in wing disc cells results in an increase in cell size compared to controls. The proportion of cells in G₁ is decreased compared to controls. Clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PP are significantly more round than control clones.

(Prober and Edgar, 2002)

Clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^αTub84B.PC in the wing disc (induced during the first larval instar) do not appear to stimulate growth or patterning of surrounding cells.

(Zecca and Struhl, 2002)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^GMR.PF in the eye disc results in all second mitotic wave cells dividing between columns 3-6 before a massive increase in photoreceptor differentiation.

(Baker and Yu, 2001)

When expression is driven by Scer\GAL4^sca-C253, extra SMCs appear in proneural clusters and several extra macrochaetae are generated near extant ones.

(Culi et al., 2001)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^slbo.2.6 moderately affects posterior and dorsal border cell migration.

(Duchek and Rorth, 2001)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^dpp.blk1 results in ectopic furrow formation in the eye disc.

(Kumar and Moses, 2001)

Imaginal disc cells expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PP are larger than wild-type cells. The clones are round with smooth borders, mixing poorly with neighbouring wild-type cells. Elevated levels of cell death are not seen. The apparent cell doubling time is not affected. The proportion of cells in G1 is decreased and the proportion of cells in G2 and S phase is increased. 36 hours after induction, clones in imaginal discs expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PP are 21% larger than control clones. Clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PP (and control clones) induced during larval development are evenly distributed throughout developing vein and intervein regions of the wing approximately 24 hours after pupal formation. However, the nuclei of cells in the centre of some intervein clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PP drop basally or disappear completely. Later in development (36 hours after puparium formation) most clones become concentrated in developing vein regions. When large clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PP are induced in the wing, many intervein clones survive and form ectopic vein-like cuticle in adult wings.

(Prober and Edgar, 2000)

When expression is driven by Scer\GAL4^btl.PS in wild-type embryos, the primary branching pattern is not disrupted, however ectopic induction of downstream genes and extra terminal branching is seen.

(Imam et al., 1999)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^GMR.PF results in excessive neural determination of precursor cells in the eye disc.

(Ishimaru et al., 1999)

Ubiquitously expressed Ras85D^V12.Scer\UAS driven by Scer\GAL4^e22c or Scer\GAL4^69B leads to the formation of extra denticles.

(Payre et al., 1999)

Clones expressing Ras85D^V12.Scer\UAS in the eye disc under the control of Scer\GAL4^Act5C.PP show ectopic photoreceptor formation anterior or posterior to the morphogenetic furrow.

(Hazelett et al., 1998)

Scer\GAL4^dpp.blk1-mediated expression at 25^oC causes lethality as early pupae, expression at 18^oC causes lethality as young adults that exhibit severe developmental defects: mild rough eyes, severely malformed legs with missing or fused tarsal segments and smaller wings with broad L3 wing vein. Expression induces ectopic cell proliferation which leads to hyperplastic growth in imaginal discs that disrupts both the normal folding in the anterior compartment. Scer\GAL4^dpp.blk1-mediated expression causes non-autonomous cell death.

(Karim and Rubin, 1998)

When expressed under the influence of Scer\GAL4^how-24B, midgut constriction 1 development is delayed or suppressed.

(Szuts et al., 1998)

Embryos expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^en-e16E have ectopic denticles anterior to the denticle belts.

(O'Keefe et al., 1997)

Scer\GAL4^sli.PS-mediated expression causes ectopic midline glial cells.

(Scholz et al., 1997, Scholz et al., 1997)

Produces larvae with an excessive number of denticles, when expressed ubiquitously in embryos using Scer\GAL4^arm.PS. Denticle rows 1-4 are normal, while small additional hooked denticles form anteriorly, and also posteriorly at the expense of denticles rows 5 and 6.

(Szuts et al., 1997)

Lethal in combination with Scer\GAL4 lines expressed in the border cells. When expressed under the influence of Scer\GAL4^hs.PB, delayed border cell migration is observed in 80% of stage 10B egg chambers. The time period for this effect is in stage 8 egg chambers. Little delay is seen when Ras85D^V12.Scer\UAS is expressed in stage 9 egg chambers: border cells in the process of migrating are unaffected.

(Lee et al., 1996)

External Data

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Phenotypic Class

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Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^ap.PU has increased size | larval stage phenotype, enhanceable by mys^RNAi.UAS.cUa, Scer\GAL4^ap.PU

(Martínez-Abarca Millán and Martín-Bermudo, 2023)

Ras85D^V12.UAS, Scer\GAL4^ap.PU has abnormal cell shape | larval stage phenotype, enhanceable by mys^RNAi.UAS.cUa, Scer\GAL4^ap.PU

(Martínez-Abarca Millán and Martín-Bermudo, 2023)

Ras85D^V12.UAS, Scer\GAL4^ap.PU has abnormal mitotic cell cycle | larval stage phenotype, enhanceable by mys^RNAi.UAS.cUa, Scer\GAL4^ap.PU

(Martínez-Abarca Millán and Martín-Bermudo, 2023)

Ras85D^V12.UAS, Scer\GAL4^ap.PU has increased cell death | larval stage | cell non-autonomous phenotype, enhanceable by mys^RNAi.UAS.cUa, Scer\GAL4^ap.PU

(Martínez-Abarca Millán and Martín-Bermudo, 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has hyperplasia | larval stage phenotype, enhanceable by by^VSH330366, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has hyperplasia | larval stage phenotype, enhanceable by PVRAP^HMJ23233, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has hyperplasia | larval stage phenotype, enhanceable by by^33c

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has hyperplasia | larval stage phenotype, enhanceable by PVRAP¹

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has hyperplasia | larval stage phenotype, enhanceable by PVRAP²

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has abnormal cell shape | larval stage phenotype, enhanceable by by^33c

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has increased cell growth rate | larval stage phenotype, enhanceable by by^33c

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has abnormal cell shape | larval stage phenotype, enhanceable by PVRAP¹

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has increased cell growth rate | larval stage phenotype, enhanceable by PVRAP¹

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has increased cell death | larval stage phenotype, enhanceable by PVRAP¹

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has increased cell death | larval stage phenotype, enhanceable by by^33c

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | larval stage | somatic clone phenotype, enhanceable by +/Df(3R)Exel9012

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | larval stage | somatic clone phenotype, enhanceable by pnt[+]/pnt^Δ88

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | larval stage | somatic clone phenotype, enhanceable by pnt^HMS01452, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | larval stage | somatic clone phenotype, enhanceable by pnt^KK100473, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | larval stage | somatic clone phenotype, enhanceable by dap^HMS01610, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | larval stage | somatic clone phenotype, enhanceable by dap^HMS05362, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | larval stage | somatic clone phenotype, enhanceable by l(2)gl⁴/l(2)gl⁴

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | larval stage | somatic clone phenotype, enhanceable by dlg1¹⁴/dlg1¹⁴

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | larval stage | somatic clone - tissue specific phenotype, enhanceable by msn³²⁰⁸/msn³²⁰⁸

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | larval stage | somatic clone - tissue specific phenotype, enhanceable by msn¹⁷²/msn¹⁷²

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ap.PU has neoplasia | third instar larval stage phenotype, enhanceable by Egfrap^HMJ23378, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ptc-559.1 has hyperplasia | third instar larval stage phenotype, enhanceable by Egfrap^HMJ23378, Scer\GAL4^ptc-559.1

(Soler Beatty et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ap.PU has increased cell size | third instar larval stage phenotype, enhanceable by Egfrap^HMJ23378, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ap.PU has increased cell death | third instar larval stage phenotype, enhanceable by Egfrap^HMJ23378, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ap.PU has neoplasia | third instar larval stage phenotype, enhanceable by PVRAP^HMJ23233, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ap.PU has neoplasia | third instar larval stage phenotype, enhanceable by Egfrap^LS/Egfrap^LS

(Soler Beatty et al., 2021)

Egfrap^LS, Ras85D^V12.UAS, Scer\GAL4^ap.PU has neoplasia | third instar larval stage phenotype, enhanceable by PVRAP^HMJ23233, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

PVRAP^HMJ23233, Ras85D^V12.UAS, Scer\GAL4^ap.PU has neoplasia | third instar larval stage phenotype, enhanceable by Egfrap^LS/Egfrap^LS

(Soler Beatty et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PU has neoplasia | third instar larval stage phenotype, enhanceable by ZnT86D^HMS02884, Scer\GAL4^ey.PU

(Wei et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PU has neoplasia | adult stage phenotype, enhanceable by ZnT86D^HMS02884, Scer\GAL4^ey.PU

(Wei et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PU has visible | adult stage phenotype, enhanceable by ZnT86D^HMS02884, Scer\GAL4^ey.PU

(Wei et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | larval stage | somatic clone phenotype, enhanceable by POSH^UAS.cSa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | larval stage | somatic clone phenotype, enhanceable by Alg-2^UAS.cTa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | larval stage | somatic clone phenotype, enhanceable by emei¹/emei¹

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | larval stage | somatic clone phenotype, enhanceable by emei²/emei²

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | larval stage | somatic clone phenotype, enhanceable by emei³/emei³

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has increased occurrence of cell division | larval stage | somatic clone phenotype, enhanceable by emei¹/emei¹

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | larval stage | somatic clone phenotype, enhanceable by emei^GD3587, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | larval stage | somatic clone phenotype, enhanceable by SERCA^JF01948, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | larval stage | somatic clone phenotype, enhanceable by Stim^UAS.cEa/Orai^UAS.cZa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^sev.EP has increased mortality during development phenotype, enhanceable by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^sev.EP

(Ray and Lakhotia, 2019)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ has increased cell number | larval stage phenotype, enhanceable by l(2)gl^KK100777, Scer\GAL4^Hml.Δ

(Arefin et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ has increased cell number | larval stage phenotype, enhanceable by scrib^KK101128, Scer\GAL4^Hml.Δ

(Arefin et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | larval stage | somatic clone phenotype, enhanceable by Hsap\S100A4^wt.UAS, Scer\GAL4^Act5C.PI

(Ismail et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | larval stage | somatic clone phenotype, enhanceable by Hsap\S100A4^Δ2.UAS, Scer\GAL4^Act5C.PI

(Ismail et al., 2017)

PpV^GD7532, Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has neoplasia | third instar larval stage | somatic clone phenotype, enhanceable by fmt[+]/fmt¹

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has neoplasia | third instar larval stage | somatic clone phenotype, enhanceable by fmt¹/fmt¹

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has increased occurrence of cell division | third instar larval stage | somatic clone phenotype, enhanceable by fmt¹/fmt¹

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has neoplasia | third instar larval stage | somatic clone phenotype, enhanceable by PpV^Δ1/PpV^Δ1

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has increased occurrence of cell division | third instar larval stage | somatic clone phenotype, enhanceable by PpV^Δ1/PpV^Δ1

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has neoplasia | third instar larval stage | somatic clone phenotype, enhanceable by l(2)gl⁴/l(2)gl⁴

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, dlg1^GD4689 has neoplasia | larval stage phenotype, enhanceable by stg^UAS.cNa, Scer\GAL4^ap-md544

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | larval stage | somatic clone phenotype, enhanceable by Vps15⁵

(O'Farrell et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096 has increased cell growth rate | larval stage phenotype, enhanceable by Dis3^KK101473, Scer\GAL4^Bx-MS1096

(Snee et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^dpp.PU has increased cell growth rate | larval stage phenotype, enhanceable by Dis3^KK101473, Scer\GAL4^dpp.PU

(Snee et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096 has melanotic mass phenotype phenotype, enhanceable by santa-maria^hs.PW

(Hauling et al., 2014)

Ras85D^V12.UAS, Scer\GAL4^ey.PU has visible phenotype, enhanceable by Df(3L)Exel6111/+

(Gaur et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^ey.PU has partially lethal - majority die phenotype, enhanceable by Rpt4^UAS.cGa, Scer\GAL4^ey.PU

(Gaur et al., 2013)

Csk^Q156Stop, Ras85D^V12.UAS, Scer\GAL4^Act.PU has abnormal developmental rate | somatic clone phenotype, enhanceable by InR^A1325D.UAS, Scer\GAL4^Act.PU

(Hirabayashi et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^salm.EPv has visible | adult stage phenotype, enhanceable by tay^RNAi.UAS, Scer\GAL4^salm.EPv

(Molnar and de Celis, 2013)

Ras85D^V12.UAS, Scer\GAL4^byn-Gal4 has abnormal cell migration | adult stage | progressive phenotype, enhanceable by hep^Act.UAS, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^byn-Gal4 has abnormal cell migration | adult stage | progressive phenotype, enhanceable by imd^UAS.cGa, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has abnormal size | third instar larval stage phenotype, enhanceable by Socs36E^GD8929, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C} has neoplasia | somatic clone phenotype, enhanceable by dlg1^GD4689, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C} has neoplasia | somatic clone phenotype, enhanceable by yki^UAS.cHa, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C} has neoplasia | somatic clone phenotype, enhanceable by upd1^UAS.cZa, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, dlg1^GD4689 has neoplasia phenotype, enhanceable by yki^UAS.cHa, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has hyperplasia phenotype, enhanceable by dor^C107

(Chi et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has hyperplasia | somatic clone phenotype, enhanceable by car^RNAi.UAS, Scer\GAL4^FRT.Act5C

(Chi et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has hyperplasia | somatic clone phenotype, enhanceable by Vps16A^RNAi.UAS.WIZ, Scer\GAL4^FRT.Act5C

(Chi et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd1^UAS.cUa has neoplasia | somatic clone phenotype, enhanceable by upd2^UAS.cUa

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd2^UAS.cUa has neoplasia | somatic clone phenotype, enhanceable by upd2^UAS.cUa

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^repo.PU has neoplasia | adult stage | somatic clone phenotype, enhanceable by Pten¹¹⁷

(Read et al., 2009)

Ras85D^V12.UAS, Scer\GAL4^repo.PU has neoplasia | adult stage | somatic clone phenotype, enhanceable by Egfr^2.A887T.UAS, Scer\GAL4^repo.PU

(Read et al., 2009)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, shg^k03401 has neoplasia | somatic clone phenotype, enhanceable by egr^UAS.cIa, Scer\GAL4^Act5C.PI

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^hs.2sev has visible phenotype, enhanceable by S6kII^D1/S6kII[+]

(Kim et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype, enhanceable by Timp^UAS.cPa, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | somatic clone phenotype, enhanceable by scrib¹

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | somatic clone phenotype, enhanceable by hep^Act.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | somatic clone phenotype, enhanceable by hep^UAS.cBa, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | somatic clone phenotype, enhanceable by Cdc42¹/Cdc42¹

(Pagliarini and Xu, 2003)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | somatic clone phenotype, enhanceable by baz⁴/baz⁴

(Pagliarini and Xu, 2003)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | somatic clone phenotype, enhanceable by sdt^XN/sdt^XN

(Pagliarini and Xu, 2003)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | somatic clone phenotype, enhanceable by scrib^unspecified/scrib^unspecified

(Pagliarini and Xu, 2003)

Ras85D^V12.UAS, Scer\GAL4^dpp.blk1 has hyperplasia | larval stage phenotype, enhanceable by rl^Sem

(Karim and Rubin, 1998)

NOT Enhanced by

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^ap.PU has decreased occurrence of cell division | larval stage phenotype, non-enhanceable by mys^RNAi.UAS.cUa, Scer\GAL4^ap.PU

(Martínez-Abarca Millán and Martín-Bermudo, 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has abnormal mitotic cell cycle | larval stage phenotype, non-enhanceable by PVRAP¹

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has abnormal cell migration | larval stage phenotype, non-enhanceable by by^33c

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has abnormal cell migration | larval stage phenotype, non-enhanceable by PVRAP¹

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | larval stage | somatic clone - tissue specific phenotype, non-enhanceable by msn^UAS.cSa, Scer\GAL4^Act5C.PI/msn³²⁰⁸/msn³²⁰⁸

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ap.PU has decreased occurrence of cell division | third instar larval stage phenotype, non-enhanceable by Egfrap^HMJ23378, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has increased occurrence of cell division | larval stage | somatic clone phenotype, non-enhanceable by emei^UAS.cMa, emei¹/emei¹/Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ has abnormal locomotor behavior | larval stage | conditional phenotype, non-enhanceable by scrib^KK101128, Scer\GAL4^Hml.Δ

(Arefin et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ has abnormal locomotor behavior | larval stage | conditional phenotype, non-enhanceable by l(2)gl^KK100777, Scer\GAL4^Hml.Δ

(Arefin et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^NP7397 has increased occurrence of cell division | adult stage | somatic clone phenotype, non-enhanceable by Apc2^N175K/Apc2^N175K/Apc^Q8/Apc^Q8

(Hudry et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^NP7397 has increased occurrence of cell division | adult stage | somatic clone phenotype, non-enhanceable by Sxl^KK116156, Apc2^N175K/Apc2^N175K/Apc^Q8/Apc^Q8, Scer\GAL4^NP7397

(Hudry et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^dpp.PU has increased cell growth rate | larval stage phenotype, non-enhanceable by sbr^HMS02414, Scer\GAL4^dpp.PU

(Snee et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^dpp.PU has increased cell growth rate | larval stage phenotype, non-enhanceable by CG10803^KK104790, Scer\GAL4^dpp.PU

(Snee et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^ey.PU has partially lethal - majority die phenotype, non-enhanceable by BHD^UAS.Tag:HA, Scer\GAL4^ey.PU

(Gaur et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^NP7397 has increased cell number | third instar larval stage phenotype, non-enhanceable by Raf^K497M.UAS, Scer\GAL4^NP7397

(Jiang and Edgar, 2009)

Suppressed by

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has decreased occurrence of cell division | larval stage phenotype, suppressible by by^33c

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has decreased occurrence of cell division | larval stage phenotype, suppressible by PVRAP¹

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has neoplasia | larval stage | somatic clone - tissue specific phenotype, suppressible by Toll-7^GD14417, Scer\GAL4^Act5C.PI

(Ding et al., 2022)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has neoplasia | larval stage | somatic clone - tissue specific phenotype, suppressible by Toll-7^HM05230, Scer\GAL4^Act5C.PI

(Ding et al., 2022)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has neoplasia | larval stage | somatic clone - tissue specific phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^Act5C.PI

(Ding et al., 2022)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, dlg1¹⁴ has neoplasia | somatic clone | larval stage phenotype, suppressible by Rheb^HMS00923, Scer\GAL4^Act5C.PI

(Cong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone | larval stage phenotype, suppressible by JhI-21^HMS02271, Scer\GAL4^Act5C.PI

(Cong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone | larval stage phenotype, suppressible by JhI-21^KK112996, Scer\GAL4^Act5C.PI

(Cong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has lethal | somatic clone phenotype, suppressible by JhI-21^HMS02271, Scer\GAL4^Act5C.PI

(Cong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has neoplasia | somatic clone | larval stage phenotype, suppressible | partially by pnt^P1.UAS, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, dlg1¹⁴ has neoplasia | somatic clone | larval stage phenotype, suppressible | partially by pnt^P1.UAS, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has neoplasia | somatic clone | larval stage phenotype, suppressible | partially by mir-ban^{sponge.UAS.DsRed(Unk)}, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has neoplasia | somatic clone | larval stage phenotype, suppressible | partially by mir-9c^{sponge.V2.UAS.mCherry}, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has neoplasia | somatic clone | larval stage phenotype, suppressible | partially by mir-79^{sponge.V2.UAS.mCherry}, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | somatic clone | larval stage phenotype, suppressible by pnt^P1.UAS, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, bsk^DN.UAS.cUa, msn³²⁰⁸ has neoplasia | larval stage | somatic clone - tissue specific phenotype, suppressible by wts^UAS.cUa, Scer\GAL4^Act5C.PI

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, msn³²⁰⁸ has neoplasia | larval stage | somatic clone - tissue specific phenotype, suppressible | partially by bsk^DN.UAS.cUa, Scer\GAL4^Act5C.PI

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, msn³²⁰⁸ has neoplasia | larval stage | somatic clone - tissue specific phenotype, suppressible by wts^UAS.cUa, Scer\GAL4^Act5C.PI

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has increased size | larval stage | somatic clone - tissue specific phenotype, suppressible by msn^UAS.cSa, Scer\GAL4^Act5C.PI

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has increased size | larval stage | somatic clone - tissue specific phenotype, suppressible by msn^UAS.cSa, Scer\GAL4^Act5C.PI

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, suppressible by dlg1^{Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, suppressible by dlg1^{Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has decreased size | adult stage phenotype, suppressible by dlg1^{Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has increased mortality during development phenotype, suppressible by dlg1^{Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has increased mortality during development phenotype, suppressible by dlg1^{ΔPDZ.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has increased mortality during development phenotype, suppressible by dlg1^{KR6Q.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has increased mortality during development phenotype, suppressible | partially by dlg1^{m30.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, suppressible | partially by dlg1^{ΔGUK.m30.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, suppressible | partially by dlg1^{ΔGUK.m30.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has increased mortality during development phenotype, suppressible | partially by dlg1^{ΔPDZ.m30.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has increased mortality during development phenotype, suppressible | partially by dlg1^{ΔGUK.m30.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, suppressible by dlg1^{ΔPDZ.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, suppressible by dlg1^{ΔPDZ.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, suppressible by dlg1^{S4A.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, suppressible by dlg1^{S4A.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, suppressible by dlg1^{ΔGUK.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, suppressible by dlg1^{ΔGUK.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, suppressible by dlg1^{ΔPDZ.S4A.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, suppressible by dlg1^{ΔPDZ.S4A.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ap.PU has neoplasia | third instar larval stage phenotype, suppressible | partially by Diap1^UAS.cHa, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096 has increased cell death | cell non-autonomous | larval stage phenotype, suppressible by Lkb1^HMS01351, Scer\GAL4^Bx-MS1096

(Brown Rackley et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has neoplasia | somatic clone | larval stage phenotype, suppressible by Rox8^EY02351, Scer\GAL4^Act.PU

(Guo et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has neoplasia | somatic clone | larval stage phenotype, suppressible by wts^G4808, Scer\GAL4^Act.PU

(Guo et al., 2020)

Ras85D^V12.UAS, Rox8^GD11645, Scer\GAL4^Act.PU has neoplasia | somatic clone | larval stage phenotype, suppressible by yki[+]/yki^B5

(Guo et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has some die during larval stage | somatic clone phenotype, suppressible by emei^UAS.cMa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has some die during larval stage | somatic clone phenotype, suppressible by wts^UAS.cYa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has neoplasia | somatic clone | larval stage phenotype, suppressible by wts^UAS.cYa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has some die during larval stage | somatic clone phenotype, suppressible by bsk^DN.UAS.cUa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has increased occurrence of cell division | somatic clone | larval stage phenotype, suppressible by bsk^DN.UAS.cUa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has increased occurrence of cell division | somatic clone | larval stage phenotype, suppressible by Stim^RNAi.cEa.UAS, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has neoplasia | somatic clone | larval stage phenotype, suppressible | partially by POSH^GD11467, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has neoplasia | somatic clone | larval stage phenotype, suppressible | partially by SERCA^UAS.cFa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei^GD3587 has neoplasia | somatic clone | larval stage phenotype, suppressible by yki^B5/yki^B5

(Ma et al., 2020)

POSH^UAS.cSa, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | somatic clone | larval stage phenotype, suppressible by wts^UAS.cYa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Orai^UAS.cZa, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, Stim^UAS.cEa has neoplasia | somatic clone | larval stage phenotype, suppressible by bsk^DN.UAS.cUa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^en-e16E has increased size | third instar larval stage phenotype, suppressible by Ciz1^JF02716, Scer\GAL4^en-e16E

(Sun et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^ptc.PU has lethal - all die during embryonic stage phenotype, suppressible by CCT4^KK108551, Scer\GAL4^ptc.PU

(Kim and Choi, 2019)

Ras85D^V12.UAS, Scer\GAL4^hh.PU has abnormal DNA repair | third instar larval stage phenotype, suppressible | conditional | partially by His2Av^UAS.mKO, Scer\GAL4^hh.PU

(Murcia et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^hh.PU has decreased cell death | third instar larval stage | conditional phenotype, suppressible by rl^GD4697, Scer\GAL4^hh.PU

(Murcia et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, rl^GD4697 has increased cell death | third instar larval stage phenotype, suppressible | partially by Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^hh.PU

(Murcia et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^sev.EP, lncRNA:Hsrω^RNAi.Sym.UAS has increased mortality during development phenotype, suppressible by Raf^{RBD+CRD.UAS.Tag:FLAG}, Scer\GAL4^sev.EP

(Ray and Lakhotia, 2019)

Ras85D^V12.UAS, Scer\GAL4^sev.EP has increased mortality during development phenotype, suppressible by Raf^{RBD+CRD.UAS.Tag:FLAG}, Scer\GAL4^sev.EP

(Ray and Lakhotia, 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has neoplasia | somatic clone | larval stage phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^Act.PU

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has abnormal cell migration | somatic clone | larval stage phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^Act.PU

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has increased mortality during development | somatic clone phenotype, suppressible | partially by puc^UAS.cMa, Scer\GAL4^Act.PU

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has neoplasia | somatic clone | larval stage phenotype, suppressible | partially by wg^GD5007, Scer\GAL4^Act.PU

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has neoplasia | somatic clone | larval stage phenotype, suppressible | partially by arm^GD1372, Scer\GAL4^Act.PU

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has abnormal cell migration | somatic clone | larval stage phenotype, suppressible | partially by wg^GD5007, Scer\GAL4^Act.PU

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has abnormal cell migration | somatic clone | larval stage phenotype, suppressible | partially by arm^GD1372, Scer\GAL4^Act.PU

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has increased mortality during development | somatic clone phenotype, suppressible | partially by wg^GD5007, Scer\GAL4^Act.PU

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has increased mortality during development | somatic clone phenotype, suppressible | partially by arm^GD1372, Scer\GAL4^Act.PU

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has increased mortality during development | somatic clone phenotype, suppressible | partially by pan^GD1506, Scer\GAL4^Act.PU

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has neoplasia | somatic clone | larval stage phenotype, suppressible | partially by pan^GD1506, Scer\GAL4^Act.PU

(Zhang et al., 2019)

Hsap\S100A4^wt.UAS, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | somatic clone | larval stage phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act5C.PI

(Ismail et al., 2017)

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has neoplasia | somatic clone | third instar larval stage phenotype, suppressible by Atg13^{+tCH322-168O18}, Atg13^Δ81/Atg13^Δ81

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | cell non-autonomous | partially by Atg14^Δ5.2/Atg14^Δ5.2

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | partially | somatic clone by Atg13^Δ81/Atg13^Δ81/Atg14^Δ5.2/Atg14^Δ5.2

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | partially by Atg13^ey.3.5, Atg13^Δ81/Atg13^Δ81

(Katheder et al., 2017)

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has abnormal size | somatic clone | third instar larval stage phenotype, suppressible by Atg13^{+tCH322-168O18}, Atg13^Δ81/Atg13^Δ81

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has abnormal size | somatic clone | third instar larval stage phenotype, suppressible | cell non-autonomous | partially by Atg14^Δ5.2/Atg14^Δ5.2

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has abnormal size | somatic clone | third instar larval stage phenotype, suppressible | partially | somatic clone by Atg13^Δ81/Atg13^Δ81/Atg14^Δ5.2/Atg14^Δ5.2

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has abnormal size | somatic clone | third instar larval stage phenotype, suppressible | partially by Atg13^ey.3.5, Atg13^Δ81/Atg13^Δ81

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has increased cell number | somatic clone | third instar larval stage phenotype, suppressible | cell non-autonomous by Atg13^Δ81/Atg13^Δ81

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689 has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by sd^JF02514, Scer\GAL4^{Act5C.CoinFLP-FRT}

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689 has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by yki^HMS00041, Scer\GAL4^{Act5C.CoinFLP-FRT}

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689 has neoplasia | somatic clone | cell non-autonomous | third instar larval stage phenotype, suppressible | partially | somatic clone by Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^{Act5C.CoinFLP-FRT}

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689 has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by slif^UY681, Scer\GAL4^{Act5C.CoinFLP-FRT}

(Katheder et al., 2017)

Atg13^Δ81, Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has neoplasia | somatic clone | third instar larval stage phenotype, suppressible by Atg14^EY14568/Atg14^Δ5.2

(Katheder et al., 2017)

Atg13^Δ81, Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has neoplasia | somatic clone | third instar larval stage phenotype, suppressible by Atg8a^d4/Atg8a^d4

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689 has abnormal size | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by sd^JF02514, Scer\GAL4^{Act5C.CoinFLP-FRT}

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689 has abnormal size | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by yki^HMS00041, Scer\GAL4^{Act5C.CoinFLP-FRT}

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689 has abnormal size | somatic clone | cell non-autonomous | third instar larval stage phenotype, suppressible | partially | somatic clone by Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^{Act5C.CoinFLP-FRT}

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689 has abnormal size | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by slif^UY681, Scer\GAL4^{Act5C.CoinFLP-FRT}

(Katheder et al., 2017)

Atg13^Δ81, Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has abnormal size | somatic clone | third instar larval stage phenotype, suppressible by Atg14^EY14568/Atg14^Δ5.2

(Katheder et al., 2017)

Atg13^Δ81, Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has abnormal size | somatic clone | third instar larval stage phenotype, suppressible by Atg8a^d4/Atg8a^d4

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, fmt¹ has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by bsk^DN.UAS, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, fmt¹ has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Tak1^K46R.UAS, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

PpV^Δ1, Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by bsk^DN.UAS, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

PpV^Δ1, Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has increased occurrence of cell division | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by bsk^DN.UAS, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

PpV^Δ1, Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Tak1^K46R.UAS, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by fmt^UAS.cMa, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by PpV^UASp.N.EGFP, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by fmt^UAS.cMa/PpV^UASp.N.EGFP, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, dlg1^GD4689 has neoplasia | larval stage phenotype, suppressible | partially by trbl^UAS.cMa, Scer\GAL4^ap-md544

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, mud^HMS01458 has neoplasia | larval stage phenotype, suppressible by wg^GD5007, Scer\GAL4^hh.PU

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, scrib^KK101128 has increased cell number | larval stage phenotype, suppressible by rpr^UAS.C/Scer\GAL4^He.PZ

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, Vps15⁵ has neoplasia | somatic clone | larval stage phenotype, suppressible | somatic clone by Lkb1^X5

(O'Farrell et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, Vps15⁵ has abnormal developmental rate phenotype, suppressible | somatic clone by Lkb1^X5

(O'Farrell et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | somatic clone | larval stage phenotype, suppressible by Lkb1^X5

(O'Farrell et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096 has abnormal mitotic cell cycle | third instar larval stage phenotype, suppressible by Dis3^KK101473, Scer\GAL4^Bx-MS1096

(Snee et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^GD4689 has neoplasia phenotype, suppressible by grnd^KK109939, Scer\GAL4^Act5C.PP

(Andersen et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, scrib¹ has neoplasia phenotype, suppressible by grnd^KK109939, Scer\GAL4^Act5C.PP

(Andersen et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, scrib¹ has neoplasia phenotype, suppressible by egr¹/egr³

(Andersen et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^ey.PU, dlg1^GD4689 has neoplasia | somatic clone phenotype, suppressible | partially by ImpL2^GD6004, Scer\GAL4^ey.PU

(Figueroa-Clarevega and Bilder, 2015)

Ets21C^KK103211, Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | somatic clone phenotype, suppressible | partially | somatic clone by bsk^DN.UAS.cUa, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has majority die during third instar larval stage | somatic clone phenotype, suppressible | partially | somatic clone by Ets21C^KK103211, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has abnormal developmental rate | somatic clone phenotype, suppressible | partially | somatic clone by Ets21C^KK103211, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has majority die during third instar larval stage | somatic clone phenotype, suppressible | partially | somatic clone by kay^N-Ala.UAS, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has abnormal developmental rate | somatic clone phenotype, suppressible | partially | somatic clone by kay^N-Ala.UAS, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has majority die during third instar larval stage | somatic clone phenotype, suppressible | partially | somatic clone by ftz-f1^JF02738, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has abnormal developmental rate | somatic clone phenotype, suppressible | partially | somatic clone by ftz-f1^JF02738, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has majority die during third instar larval stage | somatic clone phenotype, suppressible | partially | somatic clone by kay³

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has abnormal developmental rate | somatic clone phenotype, suppressible | partially | somatic clone by kay³

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^JF02738, scrib¹ has abnormal developmental rate | somatic clone phenotype, suppressible | partially | somatic clone by Ets21C^KK103211, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ets21C^KK103211, Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has abnormal developmental rate | somatic clone phenotype, suppressible | partially | somatic clone by ftz-f1^JF02738, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone phenotype, suppressible | partially | somatic clone by kay^N-Ala.UAS, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone phenotype, suppressible | partially | somatic clone by ftz-f1^JF02738, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone phenotype, suppressible | partially | somatic clone by kay³

(Külshammer et al., 2015)

Ets21C^KK103211, Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has majority die during third instar larval stage | somatic clone phenotype, suppressible | somatic clone by kay³

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, kay³, scrib¹ has majority die during third instar larval stage | somatic clone phenotype, suppressible | somatic clone by Ets21C^KK103211, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Tub.PU has increased cell number | somatic clone | adult stage phenotype, suppressible | somatic clone by bun^200B/bun^200B

(Nie et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib^unspecified has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | partially by Sec15^KK101708, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib^unspecified has lethal - all die before end of pupal stage | somatic clone phenotype, suppressible | partially by Sec15^KK101708, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib^unspecified has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | partially by Sec15^GD12109, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib^unspecified has lethal - all die before end of pupal stage | somatic clone phenotype, suppressible | partially by Sec15^GD12109, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, Sec15¹ has increased cell death | somatic clone | cell autonomous | third instar larval stage phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, Tak1^UAS.cTa has neoplasia | somatic clone | cell autonomous | third instar larval stage phenotype, suppressible | cell non-autonomous by Tak1¹

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has lethal - all die before end of pupal stage | somatic clone phenotype, suppressible by Sec15¹

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | somatic clone | third instar larval stage phenotype, suppressible by Sec15¹

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has increased cell death | somatic clone | cell non-autonomous | third instar larval stage phenotype, suppressible by Sec15¹

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | somatic clone | third instar larval stage phenotype, suppressible by Sec6^GD11616, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has lethal - all die before end of pupal stage | somatic clone phenotype, suppressible by Sec6^GD11616, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | somatic clone | third instar larval stage phenotype, suppressible by Sec8^KK101531, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has lethal - all die before end of pupal stage | somatic clone phenotype, suppressible by Sec8^KK101531, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | somatic clone | third instar larval stage phenotype, suppressible by egr^RNAi.UAS, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | somatic clone | third instar larval stage phenotype, suppressible by egr¹

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | somatic clone | third instar larval stage phenotype, suppressible by Tace^GD572, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | somatic clone | third instar larval stage phenotype, suppressible by Tace^RNAi.UAS.cSa, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | somatic clone | third instar larval stage phenotype, suppressible by dome^JF01682, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | somatic clone | third instar larval stage phenotype, suppressible by Scer\FLP1^ey.PU/dome^JF01682, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096 has lethal - all die before end of pupal stage phenotype, suppressible by santa-maria¹

(Hauling et al., 2014)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has neoplasia | somatic clone phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^FRT.Act5C

(Ma et al., 2014)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has neoplasia | somatic clone phenotype, suppressible by ben^GD1387, Scer\GAL4^FRT.Act5C

(Ma et al., 2014)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has neoplasia | somatic clone phenotype, suppressible by ben[+]/ben¹

(Ma et al., 2014)

Ras85D^V12.UAS, Scer\GAL4⁵⁰¹⁵ has lethal phenotype, suppressible | partially by cnc^RNAi.C.UAS, Scer\GAL4⁵⁰¹⁵

(Deng and Kerppola, 2013)

Ras85D^V12.UAS, Scer\GAL4^phtm.PO has decreased body size | pupal stage phenotype, suppressible by cnc^RNAi.C.UAS, Scer\GAL4^phtm.PO

(Deng and Kerppola, 2013)

Ras85D^V12.UAS, Scer\GAL4^ey.PU has visible phenotype, suppressible by BHD^UAS.Tag:HA, Scer\GAL4^ey.PU

(Gaur et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^ey.PU has partially lethal - majority die phenotype, suppressible by Rpt4[+]/Rpt4^G0345

(Gaur et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^ey.PU has partially lethal - majority die phenotype, suppressible by RpI135[+]/Polr1B^k16513

(Gaur et al., 2013)

Csk^Q156Stop, Ras85D^V12.UAS, Scer\GAL4^Act.PU has increased cell death | somatic clone | third instar larval stage phenotype, suppressible by InR^A1325D.UAS

(Hirabayashi et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | somatic clone | third instar larval stage phenotype, suppressible by Csk^Q156Stop/Csk^Q156Stop

(Hirabayashi et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has abnormal cell migration | somatic clone phenotype, suppressible by cher^KK107518, Scer\GAL4^T80

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has abnormal cell migration | somatic clone phenotype, suppressible by cher¹

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has abnormal cell migration | somatic clone phenotype, suppressible by zip^GD1566, Scer\GAL4^T80

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has neoplasia | somatic clone phenotype, suppressible by zip^GD1566, Scer\GAL4^T80

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has lethal - all die during third instar larval stage phenotype, suppressible | partially by cher¹

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has increased cell growth rate phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^FRT.Act5C

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has abnormal neuroanatomy phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^FRT.Act5C

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has neoplasia phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^FRT.Act5C

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has increased cell growth rate phenotype, suppressible by Src42A^NIG.7873R, Scer\GAL4^FRT.Act5C

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has abnormal neuroanatomy phenotype, suppressible by Src42A^NIG.7873R, Scer\GAL4^FRT.Act5C

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has neoplasia phenotype, suppressible by Src42A^NIG.7873R, Scer\GAL4^FRT.Act5C

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has increased cell growth rate phenotype, suppressible by Src64B^GD12263, Scer\GAL4^FRT.Act5C

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has abnormal neuroanatomy phenotype, suppressible by Src64B^GD12263, Scer\GAL4^FRT.Act5C

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has neoplasia phenotype, suppressible by Src64B^GD12263, Scer\GAL4^FRT.Act5C

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has lethal - all die during larval stage phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^FRT.Act5C

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has lethal - all die during larval stage phenotype, suppressible by Src42A^NIG.7873R, Scer\GAL4^FRT.Act5C

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has lethal - all die during larval stage phenotype, suppressible by Src64B^GD12263, Scer\GAL4^FRT.Act5C

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has increased cell growth rate phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^GMR.PF

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has abnormal neuroanatomy phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^GMR.PF

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has increased body size phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^GMR.PF

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has neoplasia phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^GMR.PF

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has increased cell growth rate phenotype, suppressible by Uev1A^GD6650, Scer\GAL4^GMR.PF

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has abnormal neuroanatomy phenotype, suppressible by Uev1A^GD6650, Scer\GAL4^GMR.PF

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has increased body size phenotype, suppressible by Uev1A^GD6650, Scer\GAL4^GMR.PF

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has neoplasia phenotype, suppressible by Uev1A^GD6650, Scer\GAL4^GMR.PF

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has increased cell growth rate phenotype, suppressible by Uev1A[+]/Uev1A^DG14805

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has abnormal neuroanatomy phenotype, suppressible by Uev1A[+]/Uev1A^DG14805

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has increased body size phenotype, suppressible by Uev1A[+]/Uev1A^DG14805

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has neoplasia phenotype, suppressible by Uev1A[+]/Uev1A^DG14805

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^salm.EPv has visible | adult stage phenotype, suppressible by tay^EP-866, Scer\GAL4^salm.EPv

(Molnar and de Celis, 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype, suppressible by Ctps^GD4740, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype, suppressible by CG9674^GD14285, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype, suppressible by bur^GD13797, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype, suppressible by r^GD9607, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype, suppressible by Pfas^GD1356, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype, suppressible by Gfat1^GD7732, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype, suppressible by Prat^GD9838, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype, suppressible by Prat2^GD16167, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype, suppressible by Nadsyn^GD14730, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^byn-Gal4 has abnormal cell migration | adult stage | progressive phenotype, suppressible | partially by bsk^DN.UAS, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^byn-Gal4 has abnormal cell migration | adult stage | progressive phenotype, suppressible | partially by bsk^HMS00777, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^byn-Gal4 has abnormal cell migration | adult stage | progressive phenotype, suppressible | partially by Jra^NIG.2275R, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^byn-Gal4 has abnormal cell migration | adult stage | progressive phenotype, suppressible | partially by Timp^UAS.cPa, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^NP7397 has increased occurrence of cell division | adult stage phenotype, suppressible by Mkp3^UAS.cUa, Scer\GAL4^NP7397

(Jiang et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has neoplasia | somatic clone phenotype, suppressible | somatic clone by sds22^UAS.cJa, Scer\GAL4^Act.PU

(Jiang et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^phtm.PO has abnormal developmental rate | larval stage phenotype, suppressible by Scer\GAL4^P0206/Hr4^UAS.cQa

(Ou et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^phtm.PO has decreased body size | pupal stage phenotype, suppressible by Scer\GAL4^P0206/Hr4^UAS.cQa

(Ou et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C} has neoplasia | somatic clone phenotype, suppressible by Pi3K92E^GD11228, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, dlg1^GD4689 has neoplasia | somatic clone phenotype, suppressible by Pi3K92E^GD11228, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, Scer\GAL80^ts.αTub84B, dlg1^GD4689 has neoplasia phenotype, suppressible by Pi3K92E^GD11228, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, Scer\GAL80^ts.αTub84B

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, Scer\GAL80^ts.αTub84B, dlg1^GD4689 has neoplasia phenotype, suppressible by Akt^GD1361, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, Scer\GAL80^ts.αTub84B

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, dlg1^GD4689 has neoplasia phenotype, suppressible by Pi3K92E^1C1

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, dlg1^GD4689 has neoplasia phenotype, suppressible by InR^GD104, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, dlg1^GD4689 has neoplasia phenotype, suppressible by S6k^GD6646, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, dlg1^GD4689 has neoplasia phenotype, suppressible by Rheb^NIG.1081R, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, dlg1^GD4689 has neoplasia phenotype, suppressible by mTor^NIG.5092R, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, dlg1^GD4689 has neoplasia phenotype, suppressible by Pten^KK109278, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^en.PU, dlg1^GD4689 has neoplasia phenotype, suppressible by Pi3K92E^GD11228, Scer\GAL4^en.PU

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^en.PU, dlg1^GD4689 has increased cell growth rate phenotype, suppressible by stg^hs.PE2/CycE^UAS.cRa, Scer\GAL4^en.PU

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, dor^C107 has hyperplasia phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^FRT.Act5C

(Chi et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl^unspecified has neoplasia | somatic clone | cell autonomous phenotype, suppressible | partially by upd1^RNAi.UAS.cUa, Scer\GAL4^Act.PU

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl^unspecified, upd1^RNAi.UAS.cUa has neoplasia | somatic clone | cell autonomous phenotype, suppressible by upd2^Δ3-62

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone phenotype, suppressible by dome^ΔCYT.UAS, Scer\GAL4^Act.PU

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone phenotype, suppressible by Stat92E⁰⁶³⁴⁶, Scer\GAL4^Act.PU

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd1^UAS.cUa has neoplasia | somatic clone phenotype, suppressible by dome^ΔCYT.UAS, Scer\GAL4^Act.PU

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act.PU

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by Rab11^S25N.UAS, Scer\GAL4^GMR.PF

(Yogev et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL has hyperplasia | conditional | somatic clone phenotype, suppressible by Rho1^N19.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL

(Zeng et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL has hyperplasia | conditional | somatic clone phenotype, suppressible by Raf^K497M.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL

(Zeng et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL has hyperplasia | conditional | somatic clone phenotype, suppressible by Dsor1^VDRC.cUa, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL

(Zeng et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL has hyperplasia | conditional | somatic clone phenotype, suppressible by Pka-C1^B3

(Zeng et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL has hyperplasia | conditional | somatic clone phenotype, suppressible by mTor^ΔP

(Zeng et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^NP7397 has increased cell number | third instar larval stage phenotype, suppressible by Mkp3^UAS.cUa, Scer\GAL4^NP7397

(Jiang and Edgar, 2009)

Ras85D^V12.UAS, Scer\GAL4^MD-638 has lethal | pupal stage phenotype, suppressible by osa[+]/osa³⁰⁸

(Terriente-Félix and de Celis, 2009)

Ras85D^V12.UAS, Scer\GAL4^MD-638 has visible | pupal stage phenotype, suppressible | partially by osa[+]/osa³⁰⁸

(Terriente-Félix and de Celis, 2009)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has neoplasia | somatic clone phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act5C.PU

(Srivastava et al., 2007)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has neoplasia | somatic clone phenotype, suppressible | partially by Mmp1^Q273/Mmp1^Q273

(Srivastava et al., 2007)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has neoplasia | somatic clone phenotype, suppressible by Timp^UAS.cSa/Reck^UAS.cSa, Scer\GAL4^Act5C.PU

(Srivastava et al., 2007)

Ras85D^V12.UAS, scrib¹ has neoplasia | somatic clone phenotype, suppressible by bsk^DN.UAS/Scer\GAL4^Act5C.PI

(Igaki et al., 2006)

Ras85D^V12.UAS, scrib¹ has neoplasia | somatic clone phenotype, suppressible by Akt¹

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has neoplasia | somatic clone phenotype, suppressible by Traf6^RNAi.UAS, Scer\GAL4^Act5C.PI

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has neoplasia | somatic clone phenotype, suppressible by Tak1^NIG.1388R, Scer\GAL4^Act5C.PI

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has neoplasia | somatic clone phenotype, suppressible by hep^NIG.4353R, Scer\GAL4^Act5C.PI

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has neoplasia | somatic clone phenotype, suppressible | partially by wgn^RNAi.UAS, Scer\GAL4^Act5C.PI

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, shg^k03401 has neoplasia | somatic clone phenotype, suppressible by hep^CA.UAS, Scer\GAL4^Act5C.PI

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act5C.PI

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype, suppressible by Akt¹

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^hs.2sev has visible phenotype, suppressible by S6kII^UAS.Tag:MYC, Scer\GAL4^hs.2sev

(Kim et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^hs.2sev has visible phenotype, suppressible by S6kII^{K231R.UAS.Tag:MYC}, Scer\GAL4^hs.2sev

(Kim et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype, suppressible | partially by bsk^DN.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype, suppressible | partially by puc^UAS.cMa, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has lethal | somatic clone | third instar larval stage phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has lethal | somatic clone | third instar larval stage phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS has lethal | pupal stage phenotype, suppressible by scrib¹/Scer\GAL4^Act5C.PI/puc^UAS.cMa

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has neoplasia | somatic clone phenotype, suppressible by dap^UAS.cdNa

(Brumby and Richardson, 2003)

Ras85D^V12.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has neoplasia | somatic clone | larval stage phenotype, suppressible by dap^UAS.cdNa, Scer\GAL4^αTub84B.PL

(Brumby and Richardson, 2003)

Ras85D^V12.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has neoplasia | somatic clone phenotype, suppressible by E2f1⁹¹

(Brumby and Richardson, 2003)

Ras85D^V12.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has neoplasia | somatic clone | larval stage phenotype, suppressible by E2f1⁹¹

(Brumby and Richardson, 2003)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype, suppressible by shg^UAS.cOa, Scer\GAL4^Act5C.PI

(Pagliarini and Xu, 2003)

Ras85D^V12.UAS, Scer\GAL4^sli.PS has lethal phenotype, suppressible by spen^ΔC.UAS, Scer\GAL4^sli.PS

(Chen and Rebay, 2000)

Ras85D^V12.UAS, Scer\GAL4^dpp.blk1 has increased occurrence of cell division phenotype, suppressible by Hsap\CDKN1A^UAS.cHa

(Karim and Rubin, 1998)

Ras85D^V12.UAS, Scer\GAL4^dpp.blk1 has hyperplasia | larval stage phenotype, suppressible by Hsap\CDKN1A^UAS.cHa

(Karim and Rubin, 1998)

NOT suppressed by

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^ap.PU has decreased occurrence of cell division | larval stage phenotype, non-suppressible by mys^RNAi.UAS.cUa, Scer\GAL4^ap.PU

(Martínez-Abarca Millán and Martín-Bermudo, 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has abnormal mitotic cell cycle | larval stage phenotype, non-suppressible by PVRAP¹

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has abnormal cell migration | larval stage phenotype, non-suppressible by by^33c

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has abnormal cell migration | larval stage phenotype, non-suppressible by PVRAP¹

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has partially lethal - majority die phenotype, non-suppressible by dlg1^{ΔPDZ.KR6Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, non-suppressible by dlg1^{ΔPDZ.KR6Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, non-suppressible by dlg1^{ΔPDZ.KR6Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has decreased size | adult stage phenotype, non-suppressible by dlg1^{ΔPDZ.KR6Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, non-suppressible by dlg1^{KR6Q.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, non-suppressible by dlg1^{KR6Q.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, non-suppressible by dlg1^{m30.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, non-suppressible by dlg1^{m30.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, non-suppressible by dlg1^{ΔPDZ.m30.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, non-suppressible by dlg1^{ΔPDZ.m30.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, non-suppressible by dlg1^{KR15Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, non-suppressible by dlg1^{KR15Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, non-suppressible by dlg1^{ΔPDZ.KR15Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, non-suppressible by dlg1^{ΔPDZ.KR15Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype, non-suppressible by dlg1^{S4A.ΔGUK.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype, non-suppressible by dlg1^{S4A.ΔGUK.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has increased occurrence of cell division | somatic clone | larval stage phenotype, non-suppressible by emei^UAS.cMa, emei¹/emei¹/Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | somatic clone | larval stage phenotype, non-suppressible by Stim^RNAi.cEa.UAS, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, SERCA^JF01948, Scer\GAL4^Act5C.PI has neoplasia | somatic clone | larval stage phenotype, non-suppressible by BacA\p35^UAS.cHa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Orai^UAS.cZa, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, Stim^UAS.cEa has neoplasia | somatic clone | larval stage phenotype, non-suppressible by BacA\p35^UAS.cHa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^NP0001 has abnormal cell number | adult stage phenotype, non-suppressible by Ets21C^KK103211, Scer\GAL4^NP0001

(Mundorf et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^NP0001 has increased occurrence of cell division | adult stage phenotype, non-suppressible by Ets21C^KK103211, Scer\GAL4^NP0001

(Mundorf et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^NP0001 has abnormal endomitotic cell cycle | adult stage phenotype, non-suppressible by Ets21C^KK103211, Scer\GAL4^NP0001

(Mundorf et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^esg.PU has increased cell number | adult stage phenotype, non-suppressible by Ets21C^KK103211, Scer\GAL4^esg.PU

(Mundorf et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^hh.PU has abnormal DNA repair | third instar larval stage phenotype, non-suppressible by His2Av^mRFP1

(Murcia et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^hh.PU has decreased cell death | third instar larval stage | conditional phenotype, non-suppressible by p53^GD4483/rl^GD4697, Scer\GAL4^hh.PU

(Murcia et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ has abnormal locomotor behavior | larval stage | conditional phenotype, non-suppressible by scrib^KK101128, Scer\GAL4^Hml.Δ

(Arefin et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ has abnormal locomotor behavior | larval stage | conditional phenotype, non-suppressible by l(2)gl^KK100777, Scer\GAL4^Hml.Δ

(Arefin et al., 2017)

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has neoplasia | somatic clone | third instar larval stage phenotype, non-suppressible by Atg13^{+tCH322-168O18}, Atg13^Δ81/Atg13^Δ81

(Katheder et al., 2017)

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has abnormal size | somatic clone | third instar larval stage phenotype, non-suppressible by Atg13^{+tCH322-168O18}, Atg13^Δ81/Atg13^Δ81

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has increased cell death | somatic clone | third instar larval stage phenotype, non-suppressible | cell autonomous | cell non-autonomous by Atg13^Δ81/Atg13^Δ81

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, dlg1^GD4689 has neoplasia | larval stage phenotype, non-suppressible by egr^RNAi.UAS, Scer\GAL4^ap-md544

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, dlg1^GD4689 has neoplasia | larval stage phenotype, non-suppressible by egr¹/egr¹

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, dlg1^GD4689 has neoplasia | larval stage phenotype, non-suppressible by grnd^KK109939, Scer\GAL4^hh.PU

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, dlg1^GD4689 has neoplasia | larval stage phenotype, non-suppressible by grnd^MI05292/grnd^MI05292

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, dlg1^GD4689 has neoplasia | larval stage phenotype, non-suppressible by rpr^lexAop.cSa/Ecol\lexA^GMR15B03

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, dlg1^GD4689 has increased cell number | larval stage phenotype, non-suppressible by rpr^lexAop.cSa/Ecol\lexA^GMR15B03

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, dlg1^GD4689 has neoplasia | larval stage phenotype, non-suppressible by rpr^lexAop.cSa/Ecol\lexA^GMR15B03

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, dlg1^GD4689 has neoplasia | larval stage phenotype, non-suppressible by rpr^UAS.C/rpr^lexAop.cSa/Ecol\lexA^GMR15B03/Scer\GAL4^He.PZ

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, scrib^KK101128 has neoplasia | larval stage phenotype, non-suppressible by rpr^UAS.C/Scer\GAL4^He.PZ

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^GD4689 has neoplasia phenotype, non-suppressible by wgn^RNAi.UAS, Scer\GAL4^Act5C.PP

(Andersen et al., 2015)

Ets21C^KK103211, Ras85D^V12.UAS, Scer\GAL4^Act.PU has abnormal developmental rate | somatic clone phenotype, non-suppressible | somatic clone by bsk^DN.UAS.cUa, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has majority die during third instar larval stage | somatic clone phenotype, non-suppressible | somatic clone by Jra^RNAi.UAS, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone phenotype, non-suppressible | somatic clone by Ets21C^KK103211, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone phenotype, non-suppressible | somatic clone by Jra^RNAi.UAS, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^ey.PU has partially lethal - majority die phenotype, non-suppressible by BHD^UAS.Tag:HA, Scer\GAL4^ey.PU

(Gaur et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has neoplasia | somatic clone phenotype, non-suppressible by cher^KK107518, Scer\GAL4^T80

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has abnormal mitotic cell cycle | somatic clone phenotype, non-suppressible by cher^KK107518, Scer\GAL4^T80

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^salm.EPv, rl^{Sem.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by tay^{FL.UAS.Tag:FLAG}, Scer\GAL4^salm.EPv

(Molnar and de Celis, 2013)

Ras85D^V12.UAS, Scer\GAL4^ey.PU has visible phenotype, non-suppressible by sds22^UAS.cJa, Scer\GAL4^ey.PU

(Jiang et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl^unspecified has neoplasia | somatic clone | cell autonomous phenotype, non-suppressible by upd2^Δ3-62, Scer\GAL4^Act.PU

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd1^UAS.cUa has neoplasia | somatic clone phenotype, non-suppressible by bsk^DN.UAS, Scer\GAL4^Act.PU

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL has hyperplasia | conditional | somatic clone phenotype, non-suppressible by aPKC^k06403

(Zeng et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL has hyperplasia | conditional | somatic clone phenotype, non-suppressible by Pi3K92E^A2860C.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL

(Zeng et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL has hyperplasia | conditional | somatic clone phenotype, non-suppressible by Stat92E^j6C8

(Zeng et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^NP7397 has increased cell number | third instar larval stage phenotype, non-suppressible by Raf^K497M.UAS, Scer\GAL4^NP7397

(Jiang and Edgar, 2009)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has neoplasia | somatic clone phenotype, non-suppressible by Traf4^RNAi.UAS, Scer\GAL4^Act5C.PI

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has neoplasia | somatic clone phenotype, non-suppressible by Pvr^RNAi.UAS, Scer\GAL4^Act5C.PI

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has neoplasia | somatic clone phenotype, non-suppressible by Traf6^RNAi.UAS, Scer\GAL4^Act5C.PI

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype, non-suppressible by Mmp1^RNAi.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype, non-suppressible by Mmp2^RNAi.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^sca.PU has lethal phenotype, non-suppressible by Rala^S25N.cMa.UAS, Scer\GAL4^sca.PU

(Mirey et al., 2003)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype, non-suppressible by shg^{i.UAS.Tag:SS(aos),Tag:MYC}, Scer\GAL4^Act5C.PI

(Pagliarini and Xu, 2003)

Enhancer of

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^ap.PU is an enhancer of abnormal cell shape | larval stage phenotype of Scer\GAL4^ap.PU, mys^RNAi.UAS.cUa

(Martínez-Abarca Millán and Martín-Bermudo, 2023)

Ras85D^V12.UAS, Scer\GAL4^hh.PU is an enhancer of increased cell death | third instar larval stage phenotype of Scer\GAL4^hh.PU, rl^GD4697

(Murcia et al., 2019)

Ras85D^V12.UAS/scrib^KK101128, Scer\GAL4^hh.PU is an enhancer of increased cell death | third instar larval stage phenotype of Scer\GAL4^hh.PU, rl^GD4697

(Murcia et al., 2019)

Ras85D^V12.UAS/Scer\GAL4^Hml.Δ is an enhancer of increased cell number | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

Ras85D^V12.UAS/Scer\GAL4^Gli-rL82 is an enhancer of abnormal neuroanatomy | third instar larval stage phenotype of egh^62d18

(Dahlgaard et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^repo.PU is an enhancer of abnormal neuroanatomy | adult stage | somatic clone phenotype of Pten¹¹⁷, Scer\GAL4^repo.PU

(Read et al., 2009)

Ras85D^V12.UAS, Scer\GAL4^repo.PU is an enhancer of neoplasia | adult stage | somatic clone phenotype of Pten¹¹⁷, Scer\GAL4^repo.PU

(Read et al., 2009)

Ras85D^V12.UAS/Scer\GAL4^Act5C.PI is an enhancer of neoplasia | somatic clone phenotype of scrib¹

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS/Scer\GAL4^GMR.PF is an enhancer of abnormal mitotic cell cycle | somatic clone phenotype of pnt^Δ88

(Yang and Baker, 2003)

NOT Enhancer of

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^ptc.PU is a non-enhancer of abnormal size | adult stage phenotype of CCT4^KK108551, Scer\GAL4^ptc.PU

(Kim and Choi, 2019)

Ras85D^V12.UAS, Scer\GAL4^ptc.PU is a non-enhancer of abnormal size | adult stage phenotype of CCT4^NIG.5525R, Scer\GAL4^ptc.PU

(Kim and Choi, 2019)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ, egr^KK103432 is a non-enhancer of neoplasia | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

Suppressor of

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^phtm.PO is a suppressor of abnormal developmental rate phenotype of Scer\GAL4^phtm.PO, salr^JF03226

(Ostalé et al., 2024)

Ras85D^V12.UAS, Scer\GAL4^VP16.bam is a suppressor | partially of decreased size | spermatogenesis phenotype of InR^K1409A.UAS, Scer\GAL4^VP16.bam

(Azuma et al., 2021)

Ras85D^V12.UAS/Scer\GAL4^Act.PU is a suppressor | partially of increased cell death | somatic clone | larval stage phenotype of Rbf^15aΔ, psidin^55D4

(Sheng and Du, 2020)

Ras85D^V12.UAS, Scer\GAL4^hh.PU is a suppressor | partially of increased cell death | third instar larval stage phenotype of Scer\GAL4^hh.PU, p53^GD4483

(Murcia et al., 2019)

Ras85D^V12.UAS/scrib^KK101128, Scer\GAL4^hh.PU is a suppressor | conditional of increased cell death | third instar larval stage phenotype of Scer\GAL4^hh.PU, rl^GD4697

(Murcia et al., 2019)

Ras85D^V12.UAS/Scer\GAL4^Act.PU is a suppressor of increased cell death | somatic clone | third instar larval stage phenotype of Rbf^15aΔ, Stam¹⁹

(Sheng et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096 is a suppressor of abnormal mitotic cell cycle | third instar larval stage phenotype of Dis3^KK101473, Scer\GAL4^Bx-MS1096

(Snee et al., 2016)

Ras85D^V12.UAS/Scer\GAL4^Tub.PU is a suppressor of increased cell death | somatic clone | third instar larval stage phenotype of Vps4^3B1

(Legent et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^en.PU is a suppressor of visible phenotype of Ptpmeg^UAS.cLa, Scer\GAL4^en.PU

(Li et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^phtm.PO is a suppressor | partially of abnormal developmental rate | larval stage phenotype of Itpr^GD1676, Scer\GAL4^phtm.PO

(Yamanaka et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^phtm.PO is a suppressor | partially of some die during larval stage phenotype of Itpr^GD1676, Scer\GAL4^phtm.PO

(Yamanaka et al., 2015)

Ras85D^V12.UAS/Scer\GAL4^Act5C.PI is a suppressor | partially of cell lethal | recessive | somatic clone phenotype of ecd^l(3)23

(Claudius et al., 2014)

Ras85D^V12.UAS/Scer\GAL4^Hml.Δ is a suppressor | partially of neoplasia | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

Ras85D^V12.UAS, Scer\GAL4^phtm.PO is a suppressor of increased body size | pupal stage phenotype of Scer\GAL4^phtm.PO, cnc^RNAi.C.UAS

(Deng and Kerppola, 2013)

Ras85D^V12.UAS, Scer\GAL4^P0206 is a suppressor of abnormal developmental rate | second instar larval stage phenotype of Hr4^UAS.cQa, Scer\GAL4^P0206

(Ou et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^phtm.PO is a suppressor of increased body size phenotype of Scer\GAL4^phtm.PO, tor^GD14396

(Rewitz et al., 2009)

Ras85D^V12.UAS, Scer\GAL4^phtm.PO is a suppressor of abnormal developmental rate phenotype of Scer\GAL4^phtm.PO, tor^GD14396

(Rewitz et al., 2009)

Ras85D^V12.UAS, Scer\GAL4^en-e16E is a suppressor of increased cell death | embryonic stage phenotype of CycE^UAS.cLa, Scer\GAL4^en-e16E

(Parker, 2006)

Ras85D^V12.UAS/Scer\GAL4^sim.P3.7 is a suppressor of abnormal neuroanatomy phenotype of jing³

(Sonnenfeld et al., 2004)

Ras85D^V12.UAS/Scer\GAL4^αTub84B.PZ is a suppressor | cell autonomous | somatic clone of decreased occurrence of cell division | larval stage phenotype of vn^L6/vn^ddd-4

(Zecca and Struhl, 2002)

Ras85D^V12.UAS, Scer\GAL4^sli.PS is a suppressor of lethal phenotype of Scer\GAL4^sli.PS, spen^ΔC.UAS

(Chen and Rebay, 2000)

NOT Suppressor of

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^ptc.PU is a non-suppressor of abnormal size | adult stage phenotype of CCT4^KK108551, Scer\GAL4^ptc.PU

(Kim and Choi, 2019)

Ras85D^V12.UAS, Scer\GAL4^ptc.PU is a non-suppressor of abnormal size | adult stage phenotype of CCT4^NIG.5525R, Scer\GAL4^ptc.PU

(Kim and Choi, 2019)

Ras85D^V12.UAS, Scer\GAL4^hh.PU is a non-suppressor | somatic clone of increased cell death | somatic clone | larval stage phenotype of Rab5^GD10492, Scer\GAL4^hh.PU

(Ballesteros-Arias et al., 2014)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ, egr^KK103432 is a non-suppressor of neoplasia | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

Ras85D^V12.UAS/Scer\GAL4^Act.PU is a non-suppressor of decreased cell number | somatic clone | adult stage phenotype of mys¹¹

(Lin et al., 2013)

Ras85D^V12.UAS/Scer\GAL4^Act.PU is a non-suppressor | somatic clone of decreased cell number | somatic clone | adult stage phenotype of mys^M2

(Lin et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^NP5130 is a non-suppressor of decreased cell number | adult stage phenotype of Scer\GAL4^NP5130, mys^GD15002

(Lin et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^NP5130 is a non-suppressor of decreased cell number | adult stage phenotype of Scer\GAL4^NP5130, mys^JF02819

(Lin et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^elav.PU is a non-suppressor of abnormal neuroanatomy phenotype of PlexA^UAS.Tag:HA, Scer\GAL4^elav.PU

(Yang and Terman, 2012)

Ras85D^V12.UAS/Scer\GAL4^αTub84B.PBb is a non-suppressor of increased cell death | somatic clone | cell non-autonomous phenotype of Myc^αTub84B.PBb

(Moreno and Basler, 2004)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP is a non-suppressor of decreased occurrence of cell division | somatic clone | cell autonomous | larval stage phenotype of Rbf^UAS.cDa, Scer\GAL4^Act5C.PP

(Prober and Edgar, 2000)

Other

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has neoplasia | larval stage | somatic clone - tissue specific phenotype

(Ding et al., 2022)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, dlg1¹⁴ has neoplasia | somatic clone | larval stage phenotype

(Cong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has lethal | somatic clone phenotype

(Cong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone | larval stage phenotype

(Cong et al., 2021)

JhI-21^HMS02271, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has visible | adult stage phenotype

(Cong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, msn³²⁰⁸ has some die during larval stage phenotype

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, msn³²⁰⁸ has increased occurrence of cell division | larval stage | somatic clone - tissue specific phenotype

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, msn¹⁷² has some die during larval stage phenotype

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has partially lethal - majority die phenotype

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has visible | adult stage phenotype

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has melanotic mass phenotype | adult stage phenotype

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has some die during P-stage phenotype

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has some die during larval stage phenotype

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has decreased size | adult stage phenotype

(Lu et al., 2021)

Lkb1^HMS01351, Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096 has increased occurrence of cell division | larval stage phenotype

(Brown Rackley et al., 2020)

Lkb1^HMS01351, Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096 has increased size | larval stage phenotype

(Brown Rackley et al., 2020)

Ras85D^V12.UAS, Rox8^KO, Scer\GAL4^Act.PU has neoplasia | somatic clone | larval stage phenotype

(Guo et al., 2020)

Ras85D^V12.UAS, Rox8^GD11645, Scer\GAL4^Act.PU has neoplasia | somatic clone | larval stage phenotype

(Guo et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has neoplasia | somatic clone | larval stage phenotype

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has some die during larval stage | somatic clone phenotype

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has neoplasia | somatic clone | larval stage phenotype

(Guo et al., 2020, Zhang et al., 2019)

CCT4^KK108551, Ras85D^V12.UAS, Scer\GAL4^ptc.PU has viable phenotype

(Kim and Choi, 2019)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, scrib^KK101128 has abnormal DNA repair | third instar larval stage phenotype

(Murcia et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^sev.EP, lncRNA:Hsrω^RNAi.Sym.UAS has abnormal developmental rate | P-stage phenotype

(Ray and Lakhotia, 2019)

Ras85D^V12.UAS, Scer\GAL4^sev.EP, lncRNA:Hsrω^RNAi.Sym.UAS has increased cell number | pupal stage phenotype

(Ray and Lakhotia, 2019)

Ras85D^V12.UAS, Scer\GAL4^sev.EP, lncRNA:Hsrω^RNAi.Sym.UAS has lethal - all die during pupal stage phenotype

(Ray and Lakhotia, 2019)

Ras85D^V12.UAS, Scer\GAL4^sev.EP, lncRNA:Hsrω^RNAi.Sym.UAS has visible | pupal stage P5 phenotype

(Ray and Lakhotia, 2019)

Raf^{RBD+CRD.UAS.Tag:FLAG}, Ras85D^V12.UAS, Scer\GAL4^sev.EP, lncRNA:Hsrω^RNAi.Sym.UAS has viable phenotype

(Ray and Lakhotia, 2019)

Raf^{RBD+CRD.UAS.Tag:FLAG}, Ras85D^V12.UAS, Scer\GAL4^sev.EP has viable phenotype

(Ray and Lakhotia, 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, arm^GD1372, l(2)gl⁴ has lethal - all die before end of P-stage | somatic clone phenotype

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, arm^GD1372, l(2)gl⁴ has some die during P-stage | somatic clone phenotype

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, arm^GD1372, l(2)gl⁴ has majority die during larval stage | somatic clone phenotype

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴, pan^GD1506 has lethal - all die before end of P-stage | somatic clone phenotype

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴, pan^GD1506 has some die during P-stage | somatic clone phenotype

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴, pan^GD1506 has majority die during larval stage | somatic clone phenotype

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has abnormal developmental rate | somatic clone | larval stage phenotype

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has abnormal cell migration | somatic clone | larval stage phenotype

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has lethal - all die during larval stage | somatic clone phenotype

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, arm^UAS.Exel has neoplasia | somatic clone | larval stage phenotype

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, arm^UAS.Exel has abnormal cell migration | somatic clone | larval stage phenotype

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, arm^UAS.Exel has lethal - all die during larval stage | somatic clone phenotype

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, pnut^GD1512 has neoplasia | third instar larval stage phenotype

(Gerlach et al., 2018)

Alg3^tid2, Ras85D^V12.UAS, Scer\GAL4^unspecified has neoplasia | somatic clone | larval stage phenotype

(de Vreede et al., 2018)

Alg9^c02021, Ras85D^V12.UAS, Scer\GAL4^unspecified has neoplasia | somatic clone | larval stage phenotype

(de Vreede et al., 2018)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ, l(2)gl^KK100777 has abnormal immune response | larval stage phenotype

(Arefin et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ, l(2)gl^KK100777 has lethal - all die before end of P-stage phenotype

(Arefin et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ, scrib^KK101128 has abnormal immune response | larval stage phenotype

(Arefin et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ, scrib^KK101128 has lethal - all die before end of P-stage phenotype

(Arefin et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has abnormal size | somatic clone | cell autonomous phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has increased cell number | somatic clone | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has abnormal size | somatic clone | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has increased cell death | somatic clone | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has neoplasia | somatic clone | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has abnormal size | somatic clone | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone | third instar larval stage phenotype

(Katheder et al., 2017)

Atg13^Δ81, Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has abnormal size | somatic clone | third instar larval stage phenotype

(Katheder et al., 2017)

Atg13^Δ81, Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has decreased cell number | somatic clone | third instar larval stage phenotype

(Katheder et al., 2017)

Atg13^Δ81, Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has neoplasia | somatic clone | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689 has abnormal size | somatic clone | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689 has neoplasia | somatic clone | third instar larval stage phenotype

(Katheder et al., 2017)

PpV^GD7532, Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has neoplasia | somatic clone | third instar larval stage phenotype

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, dlg1^GD4689 has increased cell number | larval stage phenotype

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, dlg1^GD4689 has neoplasia | larval stage phenotype

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, dlg1^GD4689 has neoplasia | larval stage phenotype

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, dlg1^GD4689 has increased occurrence of cell division | larval stage phenotype

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, scrib^KK101128 has increased cell number | larval stage phenotype

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, scrib^KK101128 has neoplasia | larval stage phenotype

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, mud^HMS01458 has neoplasia | larval stage phenotype

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, mud^JF02911 has neoplasia | larval stage phenotype

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, Vps15⁵ has abnormal developmental rate phenotype

(O'Farrell et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Dll-md23, scrib¹ has neoplasia | somatic clone | third instar larval stage phenotype

(Rives-Quinto et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Dll-md23, scrib¹ has abnormal neuroanatomy | somatic clone | third instar larval stage phenotype

(Rives-Quinto et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^GD4689 has neoplasia phenotype

(Andersen et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, scrib¹ has neoplasia phenotype

(Andersen et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^ey.PU, dlg1^GD4689 has neoplasia | somatic clone phenotype

(Figueroa-Clarevega and Bilder, 2015)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has neoplasia | somatic clone phenotype

(Figueroa-Clarevega and Bilder, 2015, Igaki et al., 2006)

Ets21C^KK103211, Ras85D^V12.UAS, Scer\GAL4^Act.PU has abnormal developmental rate | somatic clone phenotype

(Külshammer et al., 2015)

Ets21C^KK103211, Ras85D^V12.UAS, Scer\GAL4^Act.PU has neoplasia | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^{UAS.α.Tag:FLAG} has hyperplasia | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^{UAS.α.Tag:FLAG} has lethal - all die during P-stage | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^{UAS.β.Tag:FLAG} has hyperplasia | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^{UAS.β.Tag:FLAG} has lethal - all die during P-stage | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, kay^UAS.cEa has hyperplasia | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, kay^UAS.cEa has lethal - all die during P-stage | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has abnormal developmental rate | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has majority die during third instar larval stage | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^JF02738, scrib¹ has visible | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^JF02738, scrib¹ has abnormal size | somatic clone phenotype

(Külshammer et al., 2015)

Ets21C^KK103211, Ras85D^V12.UAS, Scer\GAL4^Act.PU, kay³, scrib¹ has lethal - all die during P-stage | somatic clone phenotype

(Külshammer et al., 2015)

Rab5^GD10492, Ras85D^V12.UAS, Scer\GAL4^hh.PU has neoplasia | somatic clone | larval stage phenotype

(Ballesteros-Arias et al., 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, Sec15¹ has increased cell death | somatic clone | cell autonomous | third instar larval stage phenotype

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib^unspecified has lethal - all die before end of pupal stage | somatic clone phenotype

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib^unspecified has neoplasia | somatic clone | third instar larval stage phenotype

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\FLP1^ey.PU, Scer\GAL4^Act.PU, dome^JF01682 has viable phenotype

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\FLP1^ey.PU, Scer\GAL4^Act.PU, dome^JF01682 has visible phenotype

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has neoplasia | somatic clone phenotype

(Ma et al., 2014)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ, dlg1^A40.2, egr^KK103432 has decreased cell death | larval stage phenotype

(Parisi et al., 2014)

Csk^Q156Stop, Ras85D^V12.UAS, Scer\GAL4^Act.PU has abnormal developmental rate | somatic clone phenotype

(Hirabayashi et al., 2013)

Csk^Q156Stop, Ras85D^V12.UAS, Scer\GAL4^Act.PU has increased cell death | somatic clone | third instar larval stage phenotype

(Hirabayashi et al., 2013)

Csk^Q156Stop, InR^A1325D.UAS, Ras85D^V12.UAS, Scer\GAL4^Act.PU has majority die during third instar larval stage | somatic clone phenotype

(Hirabayashi et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^Tub.PU, l(2)gl⁴ has neoplasia | somatic clone phenotype

(Khan et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has abnormal mitotic cell cycle | somatic clone phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has neoplasia | somatic clone phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has lethal - all die during third instar larval stage phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has abnormal cell migration | somatic clone phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, cher¹, scrib¹ has abnormal developmental rate phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, cher¹, scrib¹ has abnormal mitotic cell cycle | somatic clone phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has abnormal neuroanatomy phenotype

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has increased cell growth rate phenotype

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has neoplasia phenotype

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has lethal - all die during larval stage phenotype

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has abnormal neuroanatomy phenotype

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has increased body size phenotype

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has increased cell growth rate phenotype

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has neoplasia phenotype

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^salm.EPv, rl^{Sem.UAS.Tag:HA} has visible | adult stage phenotype

(Molnar and de Celis, 2013)

PRL-1^UAS.cPa, Ras85D^V12.UAS, Scer\GAL4^ap-md544 has decreased rate of movement | larval stage phenotype

(Pagarigan et al., 2013)

PRL-1^UAS.cPa, Ras85D^V12.UAS, Scer\GAL4^ap-md544 has lethal - all die before end of prepupal stage phenotype

(Pagarigan et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, scrib¹ has neoplasia phenotype

(Willoughby et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, sds22^Δ2.8 has neoplasia | somatic clone phenotype

(Jiang et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has lethal | somatic clone | larval stage phenotype

(Jiang et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has neoplasia | somatic clone phenotype

(Jiang et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³, sds22^UAS.cJa has lethal | somatic clone | P-stage phenotype

(Jiang et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, Scer\GAL80^ts.αTub84B, dlg1^GD4689 has neoplasia phenotype

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^en.PU, dlg1^GD4689 has neoplasia phenotype

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl^unspecified has neoplasia | somatic clone | cell autonomous phenotype

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd1^UAS.cUa has neoplasia | somatic clone phenotype

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd2^UAS.cUa has neoplasia | somatic clone phenotype

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd3^UAS.cUa has neoplasia | somatic clone phenotype

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has neoplasia | somatic clone | cell autonomous phenotype

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has neoplasia | somatic clone phenotype

(Srivastava et al., 2007)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, shg^k03401 has neoplasia | somatic clone phenotype

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, bsk^DN.UAS, egr^UAS.cIa, shg^k03401 has neoplasia | somatic clone phenotype

(Igaki et al., 2006)

Ras85D^V12.UAS, dlg1¹⁴ has neoplasia | somatic clone phenotype

(Igaki et al., 2006)

Ras85D^V12.UAS, scrib¹ has neoplasia | somatic clone phenotype

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, egr^UAS.cIa has neoplasia | somatic clone phenotype

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, dlg1¹⁴ has neoplasia phenotype

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has neoplasia | somatic clone phenotype

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has lethal | somatic clone | third instar larval stage phenotype

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, bsk^DN.UAS, scrib¹ has lethal | somatic clone | pharate adult stage phenotype

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has lethal | somatic clone | pupal stage phenotype

(Brumby and Richardson, 2003)

Ras85D^V12.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has neoplasia | somatic clone phenotype

(Brumby and Richardson, 2003)

Ras85D^V12.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has neoplasia | somatic clone | larval stage phenotype

(Brumby and Richardson, 2003)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, stg^UAS.cNa has decreased occurrence of cell division | somatic clone | cell autonomous | larval stage phenotype

(Prober and Edgar, 2000)

BacA\p35^UAS.cHa, Ras85D^V12.UAS, Scer\GAL4^dpp.blk1 has lethal | adult stage phenotype

(Karim and Rubin, 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^ap.PU has wing disc | larval stage phenotype, enhanceable by mys^RNAi.UAS.cUa, Scer\GAL4^ap.PU

(Martínez-Abarca Millán and Martín-Bermudo, 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has wing disc phenotype, enhanceable by by^VSH330366, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has wing disc phenotype, enhanceable by PVRAP^HMJ23233, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has wing disc phenotype, enhanceable by by^33c

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has wing disc phenotype, enhanceable by PVRAP¹

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has wing disc phenotype, enhanceable by PVRAP²

(Martínez-Abarca Millán et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye-antennal disc | somatic clone phenotype, enhanceable by +/Df(3R)Exel9012

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye-antennal disc | somatic clone phenotype, enhanceable by pnt[+]/pnt^Δ88

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye-antennal disc | somatic clone phenotype, enhanceable by pnt^HMS01452, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye-antennal disc | somatic clone phenotype, enhanceable by pnt^KK100473, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye-antennal disc | somatic clone phenotype, enhanceable by dap^HMS05362, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye-antennal disc | somatic clone phenotype, enhanceable by dap^HMS01610, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye-antennal disc | somatic clone phenotype, enhanceable by l(2)gl⁴/l(2)gl⁴

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye-antennal disc | somatic clone phenotype, enhanceable by dlg1¹⁴/dlg1¹⁴

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye disc | somatic clone - tissue specific phenotype, enhanceable by msn³²⁰⁸/msn³²⁰⁸

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye disc | somatic clone - tissue specific phenotype, enhanceable by msn¹⁷²/msn¹⁷²

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ap.PU has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by Egfrap^HMJ23378, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ptc-559.1 has anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype, enhanceable by Egfrap^HMJ23378, Scer\GAL4^ptc-559.1

(Soler Beatty et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ap.PU has epithelial cell of wing disc | third instar larval stage phenotype, enhanceable by Egfrap^HMJ23378, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ap.PU has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by Egfrap^LS/Egfrap^LS

(Soler Beatty et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ap.PU has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by Egfrap^L/Egfrap^L

(Soler Beatty et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ap.PU has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by Egfrap^ΔSH2/Egfrap^ΔSH2

(Soler Beatty et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ap.PU has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by PVRAP^HMJ23233, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

Egfrap^LS, Ras85D^V12.UAS, Scer\GAL4^ap.PU has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by PVRAP^HMJ23233, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

PVRAP^HMJ23233, Ras85D^V12.UAS, Scer\GAL4^ap.PU has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by Egfrap^ΔSH2/Egfrap^ΔSH2

(Soler Beatty et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PU has eye disc | third instar larval stage phenotype, enhanceable by ZnT86D^HMS02884, Scer\GAL4^ey.PU

(Wei et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PU has eye phenotype, enhanceable by ZnT86D^HMS02884, Scer\GAL4^ey.PU

(Wei et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye disc | somatic clone phenotype, enhanceable by emei¹/emei¹

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye disc | somatic clone phenotype, enhanceable by emei³/emei³

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye disc | somatic clone phenotype, enhanceable by emei²/emei²

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye disc | somatic clone phenotype, enhanceable by SERCA^JF01948, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye disc | somatic clone phenotype, enhanceable by Stim^UAS.cEa/Orai^UAS.cZa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye disc | somatic clone phenotype, enhanceable by POSH^UAS.cSa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye disc | somatic clone phenotype, enhanceable by Alg-2^UAS.cTa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | larval stage | increased number phenotype, enhanceable by l(2)gl^KK100777, Scer\GAL4^Hml.Δ

(Arefin et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | larval stage | increased number phenotype, enhanceable by scrib^KK101128, Scer\GAL4^Hml.Δ

(Arefin et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye-antennal disc | somatic clone phenotype, enhanceable by Hsap\S100A4^wt.UAS, Scer\GAL4^Act5C.PI

(Ismail et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has larval ventral nerve cord | larval stage | somatic clone phenotype, enhanceable by Hsap\S100A4^wt.UAS, Scer\GAL4^Act5C.PI

(Ismail et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye-antennal disc | somatic clone phenotype, enhanceable by Hsap\S100A4^Δ2.UAS, Scer\GAL4^Act5C.PI

(Ismail et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has larval ventral nerve cord | larval stage | somatic clone phenotype, enhanceable by Hsap\S100A4^Δ2.UAS, Scer\GAL4^Act5C.PI

(Ismail et al., 2017)

PpV^GD7532, Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has eye-antennal disc | third instar larval stage | somatic clone phenotype, enhanceable by fmt[+]/fmt¹

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has eye-antennal disc | third instar larval stage | somatic clone phenotype, enhanceable by fmt¹/fmt¹

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has eye-antennal disc | third instar larval stage | somatic clone phenotype, enhanceable by PpV^Δ1/PpV^Δ1

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has eye-antennal disc | third instar larval stage | somatic clone phenotype, enhanceable by l(2)gl⁴/l(2)gl⁴

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, dlg1^GD4689 has wing disc phenotype, enhanceable by stg^UAS.cNa, Scer\GAL4^ap-md544

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye-antennal disc | larval stage | somatic clone phenotype, enhanceable by Vps15⁵

(O'Farrell et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^dpp.PU has eye-antennal disc | larval stage phenotype, enhanceable by Dis3^KK101473, Scer\GAL4^dpp.PU

(Snee et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^dpp.PU has wing disc | larval stage phenotype, enhanceable by Dis3^KK101473, Scer\GAL4^dpp.PU

(Snee et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096 has embryonic/larval salivary gland phenotype, enhanceable by santa-maria^hs.PW

(Hauling et al., 2014)

Csk^unspecified, Ras85D^V12.UAS has eye disc | larval stage | somatic clone phenotype, enhanceable by Nek2^UAS.GFP

(Das et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^ey.PU has eye phenotype, enhanceable by Df(3L)Exel6111/+

(Gaur et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^salm.EPv has wing vein | ectopic phenotype, enhanceable by tay^RNAi.UAS, Scer\GAL4^salm.EPv

(Molnar and de Celis, 2013)

Ras85D^V12.UAS, Scer\GAL4^byn-Gal4 has adult hindgut phenotype, enhanceable by hep^Act.UAS, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^byn-Gal4 has adult abdomen phenotype, enhanceable by hep^Act.UAS, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^byn-Gal4 has adult hindgut phenotype, enhanceable by imd^UAS.cGa, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^byn-Gal4 has adult abdomen phenotype, enhanceable by imd^UAS.cGa, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^ap-md544 has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by Socs36E^GD8929, Scer\GAL4^ap-md544

(Herranz et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096 has wing vein | ectopic | increased number phenotype, enhanceable by Plzf^UAS.cMa, Scer\GAL4^Bx-MS1096

(Maeng et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye-antennal disc | somatic clone phenotype, enhanceable by sds22^Δ2.8/sds22^Δ2.8

(Jiang et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd1^UAS.cUa has eye disc | somatic clone phenotype, enhanceable by upd2^UAS.cUa

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd2^UAS.cUa has eye disc | somatic clone phenotype, enhanceable by upd2^UAS.cUa

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^repo.PU has glial cell | adult stage | increased number | somatic clone phenotype, enhanceable by Pten¹¹⁷

(Read et al., 2009)

Ras85D^V12.UAS, Scer\GAL4^repo.PU has adult brain | somatic clone phenotype, enhanceable by Pten¹¹⁷

(Read et al., 2009)

Ras85D^V12.UAS, Scer\GAL4^repo.PU has adult optic lobe | adult stage | somatic clone phenotype, enhanceable by Pten¹¹⁷

(Read et al., 2009)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, shg^k03401 has larval ventral nerve cord | somatic clone phenotype, enhanceable by egr^UAS.cIa, Scer\GAL4^Act5C.PI

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^hs.2sev has ommatidium phenotype, enhanceable by S6kII^D1/S6kII[+]

(Kim et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^hs.2sev has interommatidial bristle phenotype, enhanceable by S6kII^D1/S6kII[+]

(Kim et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^hs.2sev has rhabdomere phenotype, enhanceable by S6kII^D1/S6kII[+]

(Kim et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye-antennal disc | somatic clone phenotype, enhanceable by scrib¹

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^dpp.blk1 has wing disc | larval stage phenotype, enhanceable by rl^Sem

(Karim and Rubin, 1998)

NOT Enhanced by

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye disc | somatic clone - tissue specific phenotype, non-enhanceable by msn^UAS.cSa, Scer\GAL4^Act5C.PI/msn³²⁰⁸/msn³²⁰⁸

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye disc | somatic clone phenotype, non-enhanceable by emei^UAS.cMa, emei¹/emei¹/Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^NP7397 has adult posterior midgut epithelium | somatic clone phenotype, non-enhanceable by Apc2^N175K/Apc2^N175K/Apc^Q8/Apc^Q8

(Hudry et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^NP7397 has adult posterior midgut epithelium | somatic clone phenotype, non-enhanceable by Sxl^KK116156, Apc2^N175K/Apc2^N175K/Apc^Q8/Apc^Q8, Scer\GAL4^NP7397

(Hudry et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096 has wing disc | larval stage phenotype, non-enhanceable by Dis3^KK101473, Scer\GAL4^Bx-MS1096

(Snee et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^dpp.PU has eye-antennal disc | larval stage phenotype, non-enhanceable by sbr^HMS02414, Scer\GAL4^dpp.PU

(Snee et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^dpp.PU has wing disc | larval stage phenotype, non-enhanceable by sbr^HMS02414, Scer\GAL4^dpp.PU

(Snee et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^dpp.PU has eye-antennal disc | larval stage phenotype, non-enhanceable by CG10803^KK104790, Scer\GAL4^dpp.PU

(Snee et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^dpp.PU has wing disc | larval stage phenotype, non-enhanceable by CG10803^KK104790, Scer\GAL4^dpp.PU

(Snee et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^NP7397 has adult midgut progenitor cell | third instar larval stage phenotype, non-enhanceable by Raf^K497M.UAS, Scer\GAL4^NP7397

(Jiang and Edgar, 2009)

Suppressed by

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^RNAi.UAS.cUa has larval muscle system | larval stage phenotype, suppressible | partially by gbb^VSH330684, Scer\GAL4^Act5C.PP

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^RNAi.UAS.cUa has larval muscle system | larval stage phenotype, suppressible | partially by ImpL2^GD6004, Scer\GAL4^Act5C.PP

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^RNAi.UAS.cUa has larval muscle system | larval stage phenotype, suppressible by ImpL2^GD6004/gbb^VSH330684, Scer\GAL4^Act5C.PP

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^RNAi.UAS.cUa has embryonic/larval fat body | larval stage phenotype, suppressible | partially by gbb^VSH330684, Scer\GAL4^Act5C.PP

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^RNAi.UAS.cUa has embryonic/larval fat body | larval stage phenotype, suppressible | partially by ImpL2^GD6004/gbb^VSH330684, Scer\GAL4^Act5C.PP

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^RNAi.UAS.cUa has embryonic/larval fat body | larval stage phenotype, suppressible | partially by ImpL2^GD6004, Scer\GAL4^Act5C.PP

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^RNAi.UAS.cUa has extracellular matrix | larval stage phenotype, suppressible | partially by gbb^VSH330684, Scer\GAL4^Act5C.PP

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^RNAi.UAS.cUa has extracellular matrix | larval stage phenotype, suppressible | partially by ImpL2^GD6004/gbb^VSH330684, Scer\GAL4^Act5C.PP

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^RNAi.UAS.cUa has muscle attachment site | larval stage phenotype, suppressible | partially by gbb^VSH330684, Scer\GAL4^Act5C.PP

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^RNAi.UAS.cUa has muscle attachment site | larval stage phenotype, suppressible | partially by ImpL2^GD6004, Scer\GAL4^Act5C.PP

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^RNAi.UAS.cUa has muscle attachment site | larval stage phenotype, suppressible by ImpL2^GD6004/gbb^VSH330684, Scer\GAL4^Act5C.PP

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^RNAi.UAS.cUa has larval muscle system | larval stage phenotype, suppressible | partially by sog^UAS.Tag:HA, Scer\GAL4^Act5C.PP

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^RNAi.UAS.cUa has muscle attachment site | larval stage phenotype, suppressible | partially by sog^UAS.Tag:HA, Scer\GAL4^Act5C.PP

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has larval ventral nerve cord | somatic clone - tissue specific phenotype, suppressible by Toll-7^GD14417, Scer\GAL4^Act5C.PI

(Ding et al., 2022)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has eye-antennal disc | somatic clone - tissue specific phenotype, suppressible by Toll-7^HM05230, Scer\GAL4^Act5C.PI

(Ding et al., 2022)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has eye-antennal disc | somatic clone - tissue specific phenotype, suppressible by Toll-7^GD14417, Scer\GAL4^Act5C.PI

(Ding et al., 2022)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has larval ventral nerve cord | somatic clone - tissue specific phenotype, suppressible by Toll-7^HM05230, Scer\GAL4^Act5C.PI

(Ding et al., 2022)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has larval ventral nerve cord | somatic clone - tissue specific phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^Act5C.PI

(Ding et al., 2022)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has eye-antennal disc | somatic clone - tissue specific phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^Act5C.PI

(Ding et al., 2022)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, dlg1¹⁴ has eye-antennal disc | somatic clone | larval stage phenotype, suppressible by Rheb^HMS00923, Scer\GAL4^Act5C.PI

(Cong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has eye-antennal disc | somatic clone | larval stage phenotype, suppressible by JhI-21^HMS02271, Scer\GAL4^Act5C.PI

(Cong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has eye-antennal disc | somatic clone | larval stage phenotype, suppressible by JhI-21^KK112996, Scer\GAL4^Act5C.PI

(Cong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has eye-antennal disc | somatic clone phenotype, suppressible | partially by pnt^P1.UAS, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, dlg1¹⁴ has eye-antennal disc | somatic clone phenotype, suppressible | partially by pnt^P1.UAS, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has eye-antennal disc | somatic clone phenotype, suppressible | partially by mir-79^{sponge.V2.UAS.mCherry}, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has eye-antennal disc | somatic clone phenotype, suppressible | partially by mir-9c^{sponge.V2.UAS.mCherry}, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has eye-antennal disc | somatic clone phenotype, suppressible | partially by mir-ban^{sponge.UAS.DsRed(Unk)}, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye-antennal disc | somatic clone phenotype, suppressible by pnt^P1.UAS, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, bsk^DN.UAS.cUa, msn³²⁰⁸ has eye disc | somatic clone - tissue specific phenotype, suppressible by wts^UAS.cUa, Scer\GAL4^Act5C.PI

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, msn³²⁰⁸ has eye disc | somatic clone - tissue specific phenotype, suppressible | partially by bsk^DN.UAS.cUa, Scer\GAL4^Act5C.PI

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, msn³²⁰⁸ has eye disc | somatic clone - tissue specific phenotype, suppressible by wts^UAS.cUa, Scer\GAL4^Act5C.PI

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye disc | somatic clone - tissue specific phenotype, suppressible by msn^UAS.cSa, Scer\GAL4^Act5C.PI

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, suppressible by dlg1^{Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, suppressible | partially by dlg1^{ΔGUK.m30.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, suppressible by dlg1^{ΔPDZ.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, suppressible by dlg1^{S4A.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, suppressible by dlg1^{ΔGUK.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, suppressible by dlg1^{ΔPDZ.S4A.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ap.PU has epithelial cell of wing disc | third instar larval stage phenotype, suppressible | partially by Diap1^UAS.cHa, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has eye-antennal disc | somatic clone | larval stage phenotype, suppressible by Rox8^EY02351, Scer\GAL4^Act.PU

(Guo et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has eye-antennal disc | somatic clone | larval stage phenotype, suppressible by wts^G4808, Scer\GAL4^Act.PU

(Guo et al., 2020)

Ras85D^V12.UAS, Rox8^GD11645, Scer\GAL4^Act.PU has eye-antennal disc | somatic clone | larval stage phenotype, suppressible by yki[+]/yki^B5

(Guo et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has eye disc | somatic clone phenotype, suppressible by wts^UAS.cYa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has eye disc | somatic clone phenotype, suppressible by bsk^DN.UAS.cUa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has eye disc | somatic clone phenotype, suppressible by Stim^RNAi.cEa.UAS, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has eye disc | somatic clone phenotype, suppressible | partially by POSH^GD11467, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has eye disc | somatic clone phenotype, suppressible | partially by SERCA^UAS.cFa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei^GD3587 has eye disc | somatic clone phenotype, suppressible by yki^B5/yki^B5

(Ma et al., 2020)

POSH^UAS.cSa, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye disc | somatic clone phenotype, suppressible by wts^UAS.cYa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Orai^UAS.cZa, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, Stim^UAS.cEa has eye disc | somatic clone phenotype, suppressible by bsk^DN.UAS.cUa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^hh.PU has wing disc | third instar larval stage phenotype, suppressible | conditional | partially by His2Av^UAS.mKO, Scer\GAL4^hh.PU

(Murcia et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^hh.PU has wing disc | third instar larval stage | conditional phenotype, suppressible by rl^GD4697, Scer\GAL4^hh.PU

(Murcia et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, rl^GD4697 has wing disc | third instar larval stage phenotype, suppressible | partially by Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^hh.PU

(Murcia et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has larval ventral nerve cord | somatic clone | larval stage phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^Act.PU

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has eye-antennal disc | somatic clone phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^Act.PU

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has larval ventral nerve cord | somatic clone | larval stage phenotype, suppressible | partially by wg^GD5007, Scer\GAL4^Act.PU

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has larval ventral nerve cord | somatic clone | larval stage phenotype, suppressible | partially by arm^GD1372, Scer\GAL4^Act.PU

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has eye-antennal disc | somatic clone phenotype, suppressible | partially by wg^GD5007, Scer\GAL4^Act.PU

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has eye-antennal disc | somatic clone phenotype, suppressible | partially by arm^GD1372, Scer\GAL4^Act.PU

(Zhang et al., 2019)

Hsap\S100A4^wt.UAS, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye-antennal disc | somatic clone phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act5C.PI

(Ismail et al., 2017)

Hsap\S100A4^wt.UAS, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has larval ventral nerve cord | somatic clone | larval stage phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act5C.PI

(Ismail et al., 2017)

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible by Atg13^{+tCH322-168O18}, Atg13^Δ81/Atg13^Δ81

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible | cell non-autonomous | partially by Atg14^Δ5.2/Atg14^Δ5.2

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible | partially | somatic clone by Atg13^Δ81/Atg13^Δ81/Atg14^Δ5.2/Atg14^Δ5.2

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible | partially by Atg13^ey.3.5, Atg13^Δ81/Atg13^Δ81

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has eye-antennal disc | somatic clone | cell non-autonomous | third instar larval stage phenotype, suppressible | partially by Atg13^Δ81/Atg13^Δ81

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has autophagosome | somatic clone | cell non-autonomous | third instar larval stage phenotype, suppressible by Atg13^Δ81/Atg13^Δ81

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has larval somatic muscle cell | somatic clone | cell non-autonomous | third instar larval stage phenotype, suppressible by Atg13^Δ81/Atg13^Δ81

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has embryonic/larval midgut | somatic clone | cell non-autonomous | third instar larval stage phenotype, suppressible by Atg13^Δ81/Atg13^Δ81

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has embryonic/larval fat body | somatic clone | cell non-autonomous | third instar larval stage phenotype, suppressible by Atg13^Δ81/Atg13^Δ81

(Katheder et al., 2017)

(Katheder et al., 2017)

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has autophagosome | somatic clone | cell non-autonomous | third instar larval stage phenotype, suppressible | somatic clone by dome^ΔCYT.UAS, Scer\GAL4^Act.PU

(Katheder et al., 2017)

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689 has autophagosome | somatic clone | cell non-autonomous | third instar larval stage phenotype, suppressible | cell non-autonomous | somatic clone by sd^JF02514, Scer\GAL4^{Act5C.CoinFLP-FRT}

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689 has eye-antennal disc | somatic clone | cell non-autonomous | third instar larval stage phenotype, suppressible | cell non-autonomous | somatic clone by sd^JF02514, Scer\GAL4^{Act5C.CoinFLP-FRT}

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689 has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by slif^UY681, Scer\GAL4^{Act5C.CoinFLP-FRT}

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has autophagosome | somatic clone | third instar larval stage phenotype, suppressible by Ets21C^KK103211/kay^RNAi.UAS.cUa, Scer\GAL4^Act.PU

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible by Ets21C^KK103211/kay^RNAi.UAS.cUa, Scer\GAL4^Act.PU

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible by egr¹/egr³

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has autophagosome | somatic clone | third instar larval stage phenotype, suppressible by bsk^DN.UAS.cUa, Scer\GAL4^Act.PU

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible by bsk^DN.UAS.cUa, Scer\GAL4^Act.PU

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has autophagosome | somatic clone | third instar larval stage phenotype, suppressible by kay³/kay³

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible by kay³/kay³

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, fmt¹ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by bsk^DN.UAS, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, fmt¹ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Tak1^K46R.UAS, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

PpV^Δ1, Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by bsk^DN.UAS, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

PpV^Δ1, Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Tak1^K46R.UAS, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by fmt^UAS.cMa, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by PpV^UASp.N.EGFP, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by fmt^UAS.cMa/PpV^UASp.N.EGFP, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, dlg1^GD4689 has wing disc phenotype, suppressible | partially by trbl^UAS.cMa, Scer\GAL4^ap-md544

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, mud^HMS01458 has wing disc phenotype, suppressible by wg^GD5007, Scer\GAL4^hh.PU

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, scrib^KK101128 has embryonic/larval hemocyte | increased number | larval stage phenotype, suppressible by rpr^UAS.C/Scer\GAL4^He.PZ

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, Vps15⁵ has eye-antennal disc | somatic clone | larval stage phenotype, suppressible | somatic clone by Lkb1^X5

(O'Farrell et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye-antennal disc | somatic clone | larval stage phenotype, suppressible by Lkb1^X5

(O'Farrell et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096 has wing disc | larval stage phenotype, suppressible by Dis3^KK101473, Scer\GAL4^Bx-MS1096

(Snee et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible | partially | somatic clone by kay^N-Ala.UAS, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible | partially | somatic clone by ftz-f1^JF02738, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible | partially | somatic clone by kay³

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has photoreceptor neuron | somatic clone phenotype, suppressible | partially | somatic clone by kay^N-Ala.UAS, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has photoreceptor neuron | somatic clone phenotype, suppressible | partially | somatic clone by kay³

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Tub.PU has adult midgut | somatic clone phenotype, suppressible | somatic clone by bun^200B/bun^200B

(Nie et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib^unspecified has eye disc | somatic clone phenotype, suppressible | partially by Sec15^KK101708, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib^unspecified has eye disc | somatic clone phenotype, suppressible | partially by Sec15^GD12109, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, Tak1^UAS.cTa has eye disc | somatic clone | cell autonomous | third instar larval stage phenotype, suppressible | cell non-autonomous by Tak1¹

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye disc | somatic clone phenotype, suppressible by Sec15¹

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye disc | somatic clone phenotype, suppressible by Sec6^GD11616, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye disc | somatic clone phenotype, suppressible by Sec8^KK101531, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye disc | somatic clone | third instar larval stage phenotype, suppressible by egr^RNAi.UAS, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye disc | somatic clone | third instar larval stage phenotype, suppressible by egr¹

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye disc | somatic clone | third instar larval stage phenotype, suppressible by Tace^GD572, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye disc | somatic clone | third instar larval stage phenotype, suppressible by Tace^RNAi.UAS.cSa, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye disc | somatic clone | third instar larval stage phenotype, suppressible by Scer\FLP1^ey.PU/dome^JF01682, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096 has embryonic/larval salivary gland phenotype, suppressible by santa-maria¹

(Hauling et al., 2014)

Ras85D^V12.UAS, Scer\GAL4^ey.PU has eye phenotype, suppressible by BHD^UAS.Tag:HA, Scer\GAL4^ey.PU

(Gaur et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye disc | third instar larval stage phenotype, suppressible by Csk^Q156Stop/Csk^Q156Stop

(Hirabayashi et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has ommatidium | somatic clone phenotype, suppressible by cher¹

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has photoreceptor neuron | somatic clone phenotype, suppressible by cher¹

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has larval ventral nerve cord phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^FRT.Act5C

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has larval ventral nerve cord phenotype, suppressible by Src42A^NIG.7873R, Scer\GAL4^FRT.Act5C

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has larval ventral nerve cord phenotype, suppressible by Src64B^GD12263, Scer\GAL4^FRT.Act5C

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has larval ventral nerve cord phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^GMR.PF

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has larva phenotype, suppressible by Uev1A^GD6650, Scer\GAL4^GMR.PF

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has larval ventral nerve cord phenotype, suppressible by Uev1A^GD6650, Scer\GAL4^GMR.PF

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has larva phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^GMR.PF

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has larval ventral nerve cord phenotype, suppressible by Uev1A[+]/Uev1A^DG14805

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has larva phenotype, suppressible by Uev1A[+]/Uev1A^DG14805

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^salm.EPv has wing vein | ectopic phenotype, suppressible by tay^EP-866, Scer\GAL4^salm.EPv

(Molnar and de Celis, 2013)

Ras85D^V12.UAS, Scer\GAL4^byn-Gal4 has adult hindgut phenotype, suppressible | partially by bsk^DN.UAS, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^byn-Gal4 has adult abdomen phenotype, suppressible | partially by bsk^DN.UAS, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^byn-Gal4 has adult hindgut phenotype, suppressible | partially by bsk^HMS00777, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^byn-Gal4 has adult abdomen phenotype, suppressible | partially by bsk^HMS00777, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^byn-Gal4 has adult hindgut phenotype, suppressible | partially by Jra^NIG.2275R, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^byn-Gal4 has adult abdomen phenotype, suppressible | partially by Jra^NIG.2275R, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^byn-Gal4 has adult hindgut phenotype, suppressible | partially by Timp^UAS.cPa, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^byn-Gal4 has adult abdomen phenotype, suppressible | partially by Timp^UAS.cPa, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096 has wing vein | ectopic | increased number phenotype, suppressible by Plzf^Δ145/Plzf[+]

(Maeng et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096 has wing vein | ectopic | increased number phenotype, suppressible by Plzf^Δ11/Plzf[+]

(Maeng et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has eye-antennal disc | somatic clone phenotype, suppressible | somatic clone by sds22^UAS.cJa, Scer\GAL4^Act.PU

(Jiang et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^phtm.PO has prothoracic gland phenotype, suppressible by Scer\GAL4^P0206/Hr4^UAS.cQa

(Ou et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, Scer\GAL80^ts.αTub84B, dlg1^GD4689 has eye phenotype, suppressible by Akt^GD1361, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, Scer\GAL80^ts.αTub84B

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, Scer\GAL80^ts.αTub84B, dlg1^GD4689 has eye phenotype, suppressible by Pi3K92E^GD11228, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, Scer\GAL80^ts.αTub84B

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^en.PU, dlg1^GD4689 has wing disc phenotype, suppressible by Pi3K92E^GD11228, Scer\GAL4^en.PU

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^en.PU, dlg1^GD4689 has wing disc phenotype, suppressible by stg^hs.PE2/CycE^UAS.cRa, Scer\GAL4^en.PU

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl^unspecified has eye disc | somatic clone | cell autonomous phenotype, suppressible | partially by upd1^RNAi.UAS.cUa, Scer\GAL4^Act.PU

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl^unspecified, upd1^RNAi.UAS.cUa has eye disc | somatic clone | cell autonomous phenotype, suppressible by upd2^Δ3-62

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye disc | somatic clone phenotype, suppressible by dome^ΔCYT.UAS, Scer\GAL4^Act.PU

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye disc | somatic clone phenotype, suppressible by Stat92E⁰⁶³⁴⁶, Scer\GAL4^Act.PU

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd1^UAS.cUa has eye disc | somatic clone phenotype, suppressible by dome^ΔCYT.UAS, Scer\GAL4^Act.PU

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye disc | somatic clone phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act.PU

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF has optic cartridge | third instar larval stage phenotype, suppressible by Rab11^S25N.UAS, Scer\GAL4^GMR.PF

(Yogev et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL has adult Malpighian tubule | conditional | somatic clone phenotype, suppressible by Rho1^N19.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL

(Zeng et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL has adult Malpighian tubule | conditional | somatic clone phenotype, suppressible by Raf^K497M.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL

(Zeng et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL has adult Malpighian tubule | conditional | somatic clone phenotype, suppressible by Dsor1^VDRC.cUa, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL

(Zeng et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL has adult Malpighian tubule | conditional | somatic clone phenotype, suppressible by Pka-C1^B3

(Zeng et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL has adult Malpighian tubule | conditional | somatic clone phenotype, suppressible by mTor^ΔP

(Zeng et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^NP7397 has adult midgut progenitor cell | third instar larval stage phenotype, suppressible by Mkp3^UAS.cUa, Scer\GAL4^NP7397

(Jiang and Edgar, 2009)

Ras85D^V12.UAS, Scer\GAL4^vg.PU has wing margin phenotype, suppressible by pico^RNAi.UAS, Scer\GAL4^vg.PU

(Lyulcheva et al., 2008)

Ras85D^V12.UAS, Scer\GAL4^fkh.PH has embryonic/larval salivary gland phenotype, suppressible | partially by mTor^TED.UAS, Scer\GAL4^fkh.PH

(Berry and Baehrecke, 2007)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act5C.PU

(Srivastava et al., 2007)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible | partially by Mmp1^Q273/Mmp1^Q273

(Srivastava et al., 2007)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, suppressible by Timp^UAS.cSa/Reck^UAS.cSa, Scer\GAL4^Act5C.PU

(Srivastava et al., 2007)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has basement membrane | somatic clone phenotype, suppressible by Timp^UAS.cSa/Reck^UAS.cSa, Scer\GAL4^Act5C.PU

(Srivastava et al., 2007)

Ras85D^V12.UAS, Scer\GAL4^hs.2sev has ommatidium phenotype, suppressible by S6kII^UAS.Tag:MYC, Scer\GAL4^hs.2sev

(Kim et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^hs.2sev has interommatidial bristle phenotype, suppressible by S6kII^{K231R.UAS.Tag:MYC}, Scer\GAL4^hs.2sev

(Kim et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^hs.2sev has rhabdomere phenotype, suppressible by S6kII^{K231R.UAS.Tag:MYC}, Scer\GAL4^hs.2sev

(Kim et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^hs.2sev has ommatidium phenotype, suppressible by S6kII^{K231R.UAS.Tag:MYC}, Scer\GAL4^hs.2sev

(Kim et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^hs.2sev has interommatidial bristle phenotype, suppressible by S6kII^UAS.Tag:MYC, Scer\GAL4^hs.2sev

(Kim et al., 2006)

Ras85D^V12.UAS has rhabdomere phenotype, suppressible by Scer\GAL4^hs.2sev/S6kII^UAS.Tag:MYC

(Kim et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^da.G32 has eye photoreceptor cell | ectopic phenotype, suppressible by ave^108V

(Roignant et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval ventral nerve cord | somatic clone phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act5C.PI

(Igaki et al., 2006, Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval brain | somatic clone phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval ventral nerve cord | somatic clone phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval brain | somatic clone phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval ventral nerve cord | somatic clone phenotype, suppressible by Timp^UAS.cPa, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval brain | somatic clone phenotype, suppressible by Timp^UAS.cPa, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval ventral nerve cord | somatic clone phenotype, suppressible | partially by Mmp1^RNAi.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval brain | somatic clone phenotype, suppressible | partially by Mmp1^RNAi.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval ventral nerve cord | somatic clone phenotype, suppressible | partially by Mmp2^RNAi.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval brain | somatic clone phenotype, suppressible | partially by Mmp2^RNAi.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval brain | somatic clone phenotype, suppressible by Mmp1^RNAi.UAS/Mmp2^RNAi.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval ventral nerve cord | somatic clone phenotype, suppressible by Mmp1^RNAi.UAS/Mmp2^RNAi.UAS, Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS has eye-antennal disc | somatic clone phenotype, suppressible by bsk^DN.UAS/Scer\GAL4^Act5C.PI

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS has eye-antennal disc | somatic clone phenotype, suppressible by Scer\GAL4^Act5C.PI/puc^UAS.cMa

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Cg.PA has embryonic/larval hemocyte | increased number phenotype, suppressible | partially by rl[+]/rl^R26

(Asha et al., 2003)

Ras85D^V12.UAS, Scer\GAL4^Cg.PA has embryonic/larval hemocyte | increased number phenotype, suppressible by Hsap\CDKN1A^UAS.cHa, Scer\GAL4^Cg.PA

(Asha et al., 2003)

Ras85D^V12.UAS, Scer\GAL4^e22c has embryonic epidermis phenotype, suppressible by ovo^D1.UAS, Scer\GAL4^e22c

(Payre et al., 1999)

Ras85D^V12.UAS, Scer\GAL4^e22c has denticle | ectopic phenotype, suppressible by ovo^D1.UAS, Scer\GAL4^e22c

(Payre et al., 1999)

Ras85D^V12.UAS, Scer\GAL4^69B has denticle | ectopic phenotype, suppressible by ovo^D1.UAS, Scer\GAL4^69B

(Payre et al., 1999)

Ras85D^V12.UAS, Scer\GAL4^69B has embryonic epidermis phenotype, suppressible by ovo^D1.UAS, Scer\GAL4^69B

(Payre et al., 1999)

NOT suppressed by

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^RNAi.UAS.cUa has extracellular matrix | larval stage phenotype, non-suppressible by ImpL2^GD6004, Scer\GAL4^Act5C.PP

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye-antennal disc | somatic clone phenotype, non-suppressible by BacA\p35^UAS.cUa, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, non-suppressible by dlg1^{ΔPDZ.KR15Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, non-suppressible by dlg1^{S4A.ΔGUK.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, non-suppressible by dlg1^{KR6Q.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, non-suppressible by dlg1^{ΔPDZ.KR6Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, non-suppressible by dlg1^{ΔPDZ.m30.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, non-suppressible by dlg1^{m30.Ubi-p63E.RR.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype, non-suppressible by dlg1^{KR15Q.Ubi-p63E.GFP}

(Lu et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye disc | somatic clone phenotype, non-suppressible by emei^UAS.cMa, emei¹/emei¹/Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye disc | somatic clone phenotype, non-suppressible by Stim^RNAi.cEa.UAS, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, SERCA^JF01948, Scer\GAL4^Act5C.PI has eye disc | somatic clone phenotype, non-suppressible by BacA\p35^UAS.cHa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Orai^UAS.cZa, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, Stim^UAS.cEa has eye disc | somatic clone phenotype, non-suppressible by BacA\p35^UAS.cHa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^NP0001 has adult midgut enterocyte phenotype, non-suppressible by Ets21C^KK103211, Scer\GAL4^NP0001

(Mundorf et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^NP0001 has intestinal stem cell phenotype, non-suppressible by Ets21C^KK103211, Scer\GAL4^NP0001

(Mundorf et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^esg.PU has adult midgut epithelium phenotype, non-suppressible by Ets21C^KK103211, Scer\GAL4^esg.PU

(Mundorf et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^hh.PU has wing disc | third instar larval stage phenotype, non-suppressible by His2Av^mRFP1

(Murcia et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^hh.PU has wing disc | third instar larval stage | conditional phenotype, non-suppressible by p53^GD4483/rl^GD4697, Scer\GAL4^hh.PU

(Murcia et al., 2019)

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has eye-antennal disc | somatic clone | third instar larval stage phenotype, non-suppressible by Atg13^{+tCH322-168O18}, Atg13^Δ81/Atg13^Δ81

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has eye-antennal disc | somatic clone | cell non-autonomous | third instar larval stage phenotype, non-suppressible by Atg13^{+tCH322-168O18}, Atg13^Δ81/Atg13^Δ81

(Katheder et al., 2017)

(Katheder et al., 2017)

(Katheder et al., 2017)

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has autophagosome | somatic clone | cell non-autonomous | third instar larval stage phenotype, non-suppressible | cell autonomous by Stat92E^85C9/Stat92E^85C9

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has eye-antennal disc | somatic clone | cell non-autonomous | third instar larval stage phenotype, non-suppressible | cell autonomous by Stat92E^85C9/Stat92E^85C9

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689 has autophagosome | somatic clone | cell non-autonomous | third instar larval stage phenotype, non-suppressible | cell non-autonomous | somatic clone by ImpL2^RNAi.UAS.cUa, Scer\GAL4^{Act5C.CoinFLP-FRT}

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689 has eye-antennal disc | somatic clone | cell non-autonomous | third instar larval stage phenotype, non-suppressible | cell non-autonomous | somatic clone by ImpL2^RNAi.UAS.cUa, Scer\GAL4^{Act5C.CoinFLP-FRT}

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, dlg1^GD4689 has wing disc phenotype, non-suppressible by egr^RNAi.UAS, Scer\GAL4^ap-md544

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, dlg1^GD4689 has wing disc phenotype, non-suppressible by egr¹/egr¹

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, dlg1^GD4689 has wing disc phenotype, non-suppressible by grnd^KK109939, Scer\GAL4^hh.PU

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, dlg1^GD4689 has wing disc phenotype, non-suppressible by grnd^MI05292/grnd^MI05292

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, dlg1^GD4689 has wing disc phenotype, non-suppressible by rpr^lexAop.cSa/Ecol\lexA^GMR15B03

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, dlg1^GD4689 has myoblast | increased number | larval stage phenotype, non-suppressible by rpr^lexAop.cSa/Ecol\lexA^GMR15B03

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, dlg1^GD4689 has wing disc phenotype, non-suppressible by rpr^lexAop.cSa/Ecol\lexA^GMR15B03

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, dlg1^GD4689 has wing disc phenotype, non-suppressible by rpr^UAS.C/rpr^lexAop.cSa/Ecol\lexA^GMR15B03/Scer\GAL4^He.PZ

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, scrib^KK101128 has wing disc phenotype, non-suppressible by rpr^UAS.C/Scer\GAL4^He.PZ

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, non-suppressible | somatic clone by Ets21C^KK103211, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone phenotype, non-suppressible | somatic clone by Jra^RNAi.UAS, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has photoreceptor neuron | somatic clone phenotype, non-suppressible | somatic clone by Jra^RNAi.UAS, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has photoreceptor neuron | somatic clone phenotype, non-suppressible | somatic clone by Ets21C^KK103211, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has eye-antennal disc | somatic clone phenotype, non-suppressible by cher^KK107518, Scer\GAL4^T80

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^salm.EPv, rl^{Sem.UAS.Tag:HA} has wing vein | ectopic phenotype, non-suppressible by tay^{FL.UAS.Tag:FLAG}, Scer\GAL4^salm.EPv

(Molnar and de Celis, 2013)

Ras85D^V12.UAS, Scer\GAL4^ey.PU has eye phenotype, non-suppressible by sds22^UAS.cJa, Scer\GAL4^ey.PU

(Jiang et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl^unspecified has eye disc | somatic clone | cell autonomous phenotype, non-suppressible by upd2^Δ3-62, Scer\GAL4^Act.PU

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd1^UAS.cUa has eye disc | somatic clone phenotype, non-suppressible by bsk^DN.UAS, Scer\GAL4^Act.PU

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL has adult Malpighian tubule | conditional | somatic clone phenotype, non-suppressible by aPKC^k06403

(Zeng et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL has adult Malpighian tubule | conditional | somatic clone phenotype, non-suppressible by Pi3K92E^A2860C.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL

(Zeng et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL has adult Malpighian tubule | conditional | somatic clone phenotype, non-suppressible by Stat92E^j6C8

(Zeng et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^NP7397 has adult midgut progenitor cell | third instar larval stage phenotype, non-suppressible by Raf^K497M.UAS, Scer\GAL4^NP7397

(Jiang and Edgar, 2009)

Ras85D^V12.UAS, Scer\GAL4^MD-638 has wing vein | ectopic phenotype, non-suppressible by osa[+]/osa³⁰⁸

(Terriente-Félix and de Celis, 2009)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP has photoreceptor neuron | ectopic | somatic clone phenotype, non-suppressible by arm^{ΔN.UAS.Tag:HA,Tag:Myr(Unk)}, Scer\GAL4^Act5C.PP

(Hazelett et al., 1998)

Enhancer of

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^hh.PU is an enhancer of wing disc | third instar larval stage phenotype of Scer\GAL4^hh.PU, rl^GD4697

(Murcia et al., 2019)

Ras85D^V12.UAS/scrib^KK101128, Scer\GAL4^hh.PU is an enhancer of wing disc | third instar larval stage phenotype of Scer\GAL4^hh.PU, rl^GD4697

(Murcia et al., 2019)

Ras85D^V12.UAS/Scer\GAL4^Dll-md23 is an enhancer of antennal disc | third instar larval stage | somatic clone phenotype of scrib¹

(Rives-Quinto et al., 2017)

Ras85D^V12.UAS/Scer\GAL4^Hml.Δ is an enhancer of embryonic/larval hemocyte | larval stage phenotype of dlg1^A40.2

(Parisi et al., 2014)

Ras85D^V12.UAS/Scer\GAL4^Gli-rL82 is an enhancer of larval peripheral nervous system | third instar larval stage phenotype of egh^62d18

(Dahlgaard et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096 is an enhancer of wing vein | ectopic | increased number phenotype of Plzf^UAS.cMa, Scer\GAL4^Bx-MS1096

(Maeng et al., 2012)

Ras85D^V12.UAS, Scer\GAL4^repo.PU is an enhancer of glial cell | adult stage | increased number | somatic clone phenotype of Pten¹¹⁷, Scer\GAL4^repo.PU

(Read et al., 2009)

Ras85D^V12.UAS, Scer\GAL4^repo.PU is an enhancer of adult brain | somatic clone phenotype of Pten¹¹⁷, Scer\GAL4^repo.PU

(Read et al., 2009)

Ras85D^V12.UAS, Scer\GAL4^repo.PU is an enhancer of adult optic lobe | adult stage | somatic clone phenotype of Pten¹¹⁷, Scer\GAL4^repo.PU

(Read et al., 2009)

Ras85D^V12.UAS, Scer\GAL4^Mhc.PW is an enhancer of larval somatic muscle cell phenotype of Hsap\FOXO1::Hsap\PAX7^UAS.cGa, Scer\GAL4^Mhc.PW

(Galindo et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Mhc.PW is an enhancer of larval muscle system phenotype of Hsap\FOXO1::Hsap\PAX7^UAS.cGa, Scer\GAL4^Mhc.PW

(Galindo et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Mhc.PW is an enhancer of larval somatic muscle & cell phenotype of Hsap\FOXO1::Hsap\PAX7^UAS.cGa, Scer\GAL4^Mhc.PW

(Galindo et al., 2006)

Ras85D^V12.UAS/Scer\GAL4^Act5C.PI is an enhancer of eye-antennal disc | somatic clone phenotype of scrib¹

(Uhlirova and Bohmann, 2006)

NOT Enhancer of

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^phtm.PO is a non-enhancer of nucleolus | larval stage phenotype of Scer\GAL4^phtm.PO, salr^JF03226

(Ostalé et al., 2024)

Ras85D^V12.UAS, Scer\GAL4^phtm.PO is a non-enhancer of prothoracic gland | larval stage phenotype of Scer\GAL4^phtm.PO, salr^JF03226

(Ostalé et al., 2024)

Ras85D^V12.UAS/Scer\GAL4^phtm.PU is a non-enhancer of muscle attachment site | larval stage phenotype of Ncra\QF^QF2.Act5C.PL, Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

Ras85D^V12.UAS/Scer\GAL4^phtm.PU is a non-enhancer of embryonic/larval fat body | larval stage phenotype of Ncra\QF^QF2.Act5C.PL, Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ptc.PU is a non-enhancer of wing blade phenotype of CCT4^KK108551, Scer\GAL4^ptc.PU

(Kim and Choi, 2019)

Ras85D^V12.UAS, Scer\GAL4^ptc.PU is a non-enhancer of wing blade phenotype of CCT4^NIG.5525R, Scer\GAL4^ptc.PU

(Kim and Choi, 2019)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ, egr^KK103432 is a non-enhancer of wing disc phenotype of dlg1^A40.2

(Parisi et al., 2014)

Suppressor of

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^VP16.bam is a suppressor | partially of spermatocyte phenotype of InR^K1409A.UAS, Scer\GAL4^VP16.bam

(Azuma et al., 2021)

Ras85D^V12.UAS/Scer\GAL4^Act.PU is a suppressor | partially of eye disc | somatic clone | larval stage phenotype of Rbf^15aΔ, psidin^55D4

(Sheng and Du, 2020)

Ras85D^V12.UAS, Scer\GAL4^hh.PU is a suppressor | partially of wing disc | third instar larval stage phenotype of Scer\GAL4^hh.PU, p53^GD4483

(Murcia et al., 2019)

Ras85D^V12.UAS/scrib^KK101128, Scer\GAL4^hh.PU is a suppressor | conditional of wing disc | third instar larval stage phenotype of Scer\GAL4^hh.PU, rl^GD4697

(Murcia et al., 2019)

Ras85D^V12.UAS/Scer\GAL4^Act.PU is a suppressor | somatic clone of eye disc | somatic clone | third instar larval stage phenotype of Rbf^15aΔ, Stam¹⁹

(Sheng et al., 2016)

Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096 is a suppressor of wing disc | larval stage phenotype of Dis3^KK101473, Scer\GAL4^Bx-MS1096

(Snee et al., 2016)

Ras85D^V12.UAS/Scer\GAL4^Tub.PU is a suppressor of eye disc | somatic clone | third instar larval stage phenotype of Vps4^3B1

(Legent et al., 2015)

Ras85D^V12.UAS/Scer\GAL4^Tub.PU is a suppressor of photoreceptor | somatic clone | third instar larval stage phenotype of Vps4^3B1

(Legent et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^en.PU is a suppressor of wing vein phenotype of Ptpmeg^UAS.cLa, Scer\GAL4^en.PU

(Li et al., 2015)

Ras85D^V12.UAS/Scer\GAL4^Hml.Δ is a suppressor | partially of wing disc phenotype of dlg1^A40.2

(Parisi et al., 2014)

Ras85D^V12.UAS/Scer\GAL4^Act.PU is a suppressor of adult midgut | somatic clone phenotype of Apc2^g10, Apc^Q8

(Wang et al., 2013)

Ras85D^V12.UAS/Scer\GAL4^Act.PU is a suppressor of intestinal stem cell | somatic clone phenotype of Apc2^g10, Apc^Q8

(Wang et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^P0206 is a suppressor of ring gland phenotype of Hr4^UAS.cQa, Scer\GAL4^P0206

(Ou et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^en-e16E is a suppressor of embryonic segment posterior compartment phenotype of CycE^UAS.cLa, Scer\GAL4^en-e16E

(Parker, 2006)

Ras85D^V12.UAS/Scer\GAL4^srp.Hemo is a suppressor | partially of embryonic/larval plasmatocyte | embryonic stage phenotype of Pvr¹

(Bruckner et al., 2004)

Ras85D^V12.UAS/Scer\GAL4^sim.P3.7 is a suppressor of larval ventral midline glial cell phenotype of jing³

(Sonnenfeld et al., 2004)

Ras85D^V12.UAS/Scer\GAL4^twi.2PE is a suppressor of visceral trunk mesoderm phenotype of jeb^-c1

(Lee et al., 2003)

Ras85D^V12.UAS/Scer\GAL4^hs.PB is a suppressor of larval tracheal system phenotype of stumps^09904b

(Imam et al., 1999)

Ras85D^V12.UAS/Scer\GAL4^twi.PG is a suppressor of mesoderm phenotype of stumps^09904b

(Imam et al., 1999)

Ras85D^V12.UAS/Scer\GAL4^btl.PS is a suppressor of larval tracheal system phenotype of stumps^09904b

(Imam et al., 1999, Vincent et al., 1998)

Ras85D^V12.UAS/Scer\GAL4^dpp.PH is a suppressor of eye disc phenotype of eyg¹/Df(3L)iro-2

(Hazelett et al., 1998)

Ras85D^V12.UAS/Scer\GAL4^dpp.PH is a suppressor of photoreceptor neuron phenotype of eyg¹/Df(3L)iro-2

(Hazelett et al., 1998)

Ras85D^V12.UAS, Scer\GAL4^ey.PH is a suppressor of photoreceptor neuron phenotype of Scer\GAL4^ey.PH, wg^UAS.cAa

(Hazelett et al., 1998)

Ras85D^V12.UAS, Scer\GAL4^ey.PH is a suppressor of eye disc | posterior phenotype of Scer\GAL4^ey.PH, wg^UAS.cAa

(Hazelett et al., 1998)

Ras85D^V12.UAS/Scer\GAL4^btl.PS is a suppressor of larval tracheal system phenotype of btl^LG19

(Vincent et al., 1998)

NOT Suppressor of

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^phtm.PO is a non-suppressor of nucleolus | larval stage phenotype of Scer\GAL4^phtm.PO, salr^JF03226

(Ostalé et al., 2024)

Ras85D^V12.UAS, Scer\GAL4^phtm.PO is a non-suppressor of prothoracic gland | larval stage phenotype of Scer\GAL4^phtm.PO, salr^JF03226

(Ostalé et al., 2024)

Ras85D^V12.UAS/Scer\GAL4^phtm.PU is a non-suppressor of muscle attachment site | larval stage phenotype of Ncra\QF^QF2.Act5C.PL, Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

Ras85D^V12.UAS/Scer\GAL4^phtm.PU is a non-suppressor of embryonic/larval fat body | larval stage phenotype of Ncra\QF^QF2.Act5C.PL, Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^ptc.PU is a non-suppressor of wing blade phenotype of CCT4^KK108551, Scer\GAL4^ptc.PU

(Kim and Choi, 2019)

Ras85D^V12.UAS, Scer\GAL4^ptc.PU is a non-suppressor of wing blade phenotype of CCT4^NIG.5525R, Scer\GAL4^ptc.PU

(Kim and Choi, 2019)

Ras85D^V12.UAS, Scer\GAL4^hh.PU is a non-suppressor | somatic clone of wing disc posterior compartment | somatic clone | larval stage phenotype of Rab5^GD10492, Scer\GAL4^hh.PU

(Ballesteros-Arias et al., 2014)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ, egr^KK103432 is a non-suppressor of wing disc phenotype of dlg1^A40.2

(Parisi et al., 2014)

Ras85D^V12.UAS/Scer\GAL4^Act.PU is a non-suppressor of adult posterior midgut epithelium | somatic clone phenotype of mys¹¹

(Lin et al., 2013)

Ras85D^V12.UAS/Scer\GAL4^Act.PU is a non-suppressor | somatic clone of adult posterior midgut epithelium | somatic clone phenotype of mys^M2

(Lin et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^NP5130 is a non-suppressor of adult posterior midgut epithelium phenotype of Scer\GAL4^NP5130, mys^GD15002

(Lin et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^NP5130 is a non-suppressor of adult posterior midgut epithelium phenotype of Scer\GAL4^NP5130, mys^JF02819

(Lin et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^elav.PU is a non-suppressor of larval central nervous system phenotype of PlexA^UAS.Tag:HA, Scer\GAL4^elav.PU

(Yang and Terman, 2012)

Ras85D^V12.UAS/Scer\GAL4^da.G32 is a non-suppressor of photoreceptor cell R1 | somatic clone phenotype of ave^108V

(Roignant et al., 2006)

Ras85D^V12.UAS/Scer\GAL4^da.G32 is a non-suppressor of photoreceptor cell R6 | somatic clone phenotype of ave^108V

(Roignant et al., 2006)

Ras85D^V12.UAS/Scer\GAL4^da.G32 is a non-suppressor of photoreceptor cell R4 | somatic clone phenotype of ave^108V

(Roignant et al., 2006)

Ras85D^V12.UAS/Scer\GAL4^da.G32 is a non-suppressor of photoreceptor cell R3 | somatic clone phenotype of ave^108V

(Roignant et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP is a non-suppressor | somatic clone of mitotic cell cycle | somatic clone phenotype of Rbf^UAS.cDa, Scer\GAL4^Act5C.PP

(Prober and Edgar, 2000)

Other

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^RNAi.UAS.cUa has larval muscle system | larval stage phenotype

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^RNAi.UAS.cUa has embryonic/larval fat body | larval stage phenotype

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^RNAi.UAS.cUa has muscle attachment site | larval stage phenotype

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^RNAi.UAS.cUa has extracellular matrix | larval stage phenotype

(Bakopoulos et al., 2023)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has eye-antennal disc | somatic clone - tissue specific phenotype

(Ding et al., 2022)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, l(2)gl⁴ has larval ventral nerve cord | somatic clone - tissue specific phenotype

(Ding et al., 2022)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, dlg1¹⁴ has eye-antennal disc | somatic clone | larval stage phenotype

(Cong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval brain | somatic clone | larval stage phenotype

(Cong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has eye-antennal disc | somatic clone | larval stage phenotype

(Cong et al., 2021)

JhI-21^HMS02271, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has eye phenotype

(Cong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval ventral nerve cord | somatic clone phenotype

(Cong et al., 2021, Igaki et al., 2006, Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, msn³²⁰⁸ has larval ventral nerve cord | larval stage | somatic clone - tissue specific phenotype

(Kong et al., 2021)

Ras85D^V12.UAS, Scer\GAL4^ey.PH, dlg1^HMS00172 has eye phenotype

(Lu et al., 2021)

Lkb1^HMS01351, Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096 has wing disc phenotype

(Brown Rackley et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has eye-antennal disc | somatic clone | larval stage phenotype

(Guo et al., 2020)

Ras85D^V12.UAS, Rox8^KO, Scer\GAL4^Act.PU has eye-antennal disc | somatic clone | larval stage phenotype

(Guo et al., 2020)

Ras85D^V12.UAS, Rox8^GD11645, Scer\GAL4^Act.PU has eye-antennal disc | somatic clone | larval stage phenotype

(Guo et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has wing disc phenotype

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has larval ventral nerve cord | larval stage phenotype

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, scrib^KK101128 has wing disc | third instar larval stage phenotype

(Murcia et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^sev.EP, lncRNA:Hsrω^RNAi.Sym.UAS has pupa | pupal stage P5 phenotype

(Ray and Lakhotia, 2019)

Ras85D^V12.UAS, Scer\GAL4^sev.EP, lncRNA:Hsrω^RNAi.Sym.UAS has abdominal neuron | pupal stage P6 phenotype

(Ray and Lakhotia, 2019)

Ras85D^V12.UAS, Scer\GAL4^sev.EP, lncRNA:Hsrω^RNAi.Sym.UAS has Malpighian tubule | pupal stage P6 phenotype

(Ray and Lakhotia, 2019)

Ras85D^V12.UAS, Scer\GAL4^sev.EP, lncRNA:Hsrω^RNAi.Sym.UAS has Malpighian tubule | pupal stage P5 phenotype

(Ray and Lakhotia, 2019)

Ras85D^V12.UAS, Scer\GAL4^sev.EP, lncRNA:Hsrω^RNAi.Sym.UAS has salivary gland | pupal stage P6 phenotype

(Ray and Lakhotia, 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has eye-antennal disc | somatic clone | third instar larval stage phenotype

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl⁴ has larval ventral nerve cord | somatic clone | larval stage phenotype

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, arm^UAS.Exel has eye-antennal disc | somatic clone | third instar larval stage phenotype

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, arm^UAS.Exel has larval ventral nerve cord | somatic clone | larval stage phenotype

(Zhang et al., 2019)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, pnut^GD1512 has wing disc | third instar larval stage phenotype

(Gerlach et al., 2018)

Alg3^tid2, Ras85D^V12.UAS, Scer\GAL4^unspecified has eye disc | somatic clone phenotype

(de Vreede et al., 2018)

Alg9^c02021, Ras85D^V12.UAS, Scer\GAL4^unspecified has eye disc | somatic clone phenotype

(de Vreede et al., 2018)

Hsap\S100A4^wt.UAS, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has embryonic/larval gut | somatic clone | larval stage phenotype

(Ismail et al., 2017)

Hsap\S100A4^wt.UAS, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has gonad | somatic clone | larval stage phenotype

(Ismail et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has eye-antennal disc | somatic clone | cell non-autonomous | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has eye-antennal disc | somatic clone | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has autophagosome | somatic clone | cell non-autonomous | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has larval somatic muscle cell | somatic clone | cell non-autonomous | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has embryonic/larval midgut | somatic clone | cell non-autonomous | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has embryonic/larval fat body | somatic clone | cell non-autonomous | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has mitochondrion | somatic clone | cell autonomous phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd1^UAS.cUa has eye-antennal disc | somatic clone | cell non-autonomous | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd1^UAS.cUa has autophagosome | somatic clone | cell non-autonomous | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd3^d04951 has eye-antennal disc | somatic clone | cell non-autonomous | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd3^d04951 has autophagosome | somatic clone | cell non-autonomous | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone | cell non-autonomous | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has autophagosome | somatic clone | cell non-autonomous | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Tub.PU, scrib⁶⁷³ has wing disc | somatic clone | cell non-autonomous | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Tub.PU, scrib⁶⁷³ has autophagosome | somatic clone | cell non-autonomous | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689 has eye-antennal disc | somatic clone | cell non-autonomous | third instar larval stage phenotype

(Katheder et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^{Act5C.CoinFLP-FRT}, dlg1^GD4689 has autophagosome | somatic clone | cell non-autonomous | third instar larval stage phenotype

(Katheder et al., 2017)

PpV^GD7532, Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has eye-antennal disc | somatic clone | third instar larval stage phenotype

(Ma et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, dlg1^GD4689 has wing disc phenotype

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, dlg1^GD4689 has embryonic/larval hemocyte | increased number | larval stage phenotype

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, dlg1^GD4689 has myoblast | increased number | larval stage phenotype

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, dlg1^GD4689 has wing disc phenotype

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, scrib^KK101128 has wing disc phenotype

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^ap-md544, scrib^KK101128 has myoblast | increased number | larval stage phenotype

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, mud^HMS01458 has wing disc phenotype

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, mud^JF02911 has wing disc phenotype

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Dll-md23, scrib¹ has type II neuroblast | increased number | somatic clone | third instar larval stage phenotype

(Rives-Quinto et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^Tub.PU, l(2)gl⁴ has tracheal section | ectopic | somatic clone phenotype

(Grifoni et al., 2015)

Nhe2^UAS.cGa, Ras85D^V12.UAS, Scer\GAL4^ptc.PU has wing disc phenotype

(Grillo-Hill et al., 2015)

Ets21C^KK103211, Ras85D^V12.UAS, Scer\GAL4^Act.PU has photoreceptor neuron | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^{UAS.α.Tag:FLAG} has eye-antennal disc | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^{UAS.β.Tag:FLAG} has eye-antennal disc | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, kay^UAS.cEa has eye-antennal disc | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has photoreceptor neuron | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye-antennal disc | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^JF02738, scrib¹ has ommatidium | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^JF02738, scrib¹ has eye | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib^unspecified has eye disc | somatic clone phenotype

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\FLP1^ey.PU, Scer\GAL4^Act.PU, dome^JF01682 has eye phenotype

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ, dlg1^A40.2, egr^KK103432 has wing disc phenotype

(Parisi et al., 2014)

Csk^unspecified, Ras85D^V12.UAS has eye disc | somatic clone | larval stage phenotype

(Das et al., 2013)

Csk^Q156Stop, Ras85D^V12.UAS, Scer\GAL4^Act.PU has eye disc | third instar larval stage phenotype

(Hirabayashi et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^Tub.PU, l(2)gl⁴ has wing disc | distal | somatic clone phenotype

(Khan et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^Tub.PU, l(2)gl⁴ has wing disc | proximal | somatic clone phenotype

(Khan et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has ommatidium | somatic clone phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has photoreceptor neuron | somatic clone phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, scrib¹ has eye-antennal disc | somatic clone phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, cher¹, scrib¹ has eye phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^T80, cher¹, scrib¹ has ommatidium phenotype

(Külshammer and Uhlirova, 2013)

Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, l(2)gl⁴ has larval ventral nerve cord phenotype

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has larva phenotype

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^GMR.PF, l(2)gl⁴ has larval ventral nerve cord phenotype

(Ma et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^salm.EPv, rl^{Sem.UAS.Tag:HA} has wing vein | ectopic phenotype

(Molnar and de Celis, 2013)

Apc2^g10, Apc^Q8, Ras85D^V12.UAS, Scer\GAL4^Act.PU has enterocyte | somatic clone phenotype

(Wang et al., 2013)

Apc2^g10, Apc^Q8, Ras85D^V12.UAS, Scer\GAL4^Act.PU has enteroendocrine cell | somatic clone phenotype

(Wang et al., 2013)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³ has eye-antennal disc | somatic clone phenotype

(Jiang et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^en.PU, dlg1^GD4689 has wing disc phenotype

(Willecke et al., 2011)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl^unspecified has eye disc | somatic clone | cell autonomous phenotype

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd1^UAS.cUa has eye disc | somatic clone phenotype

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd2^UAS.cUa has eye disc | somatic clone phenotype

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd3^UAS.cUa has eye disc | somatic clone phenotype

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹ has eye disc | somatic clone | cell autonomous phenotype

(Wu et al., 2010)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has eye-antennal disc | somatic clone phenotype

(Srivastava et al., 2007)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PU, scrib¹ has basement membrane | somatic clone phenotype

(Srivastava et al., 2007)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, shg^k03401 has larval ventral nerve cord | somatic clone phenotype

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, bsk^DN.UAS, egr^UAS.cIa, shg^k03401 has larval ventral nerve cord | somatic clone phenotype

(Igaki et al., 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has larval brain | somatic clone phenotype

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, hep^Act.UAS has larval brain | somatic clone phenotype

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, hep^UAS.cBa has larval brain | somatic clone phenotype

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, hep^UAS.cBa has larval ventral nerve cord | somatic clone phenotype

(Uhlirova and Bohmann, 2006)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has basal lamina & eye disc | somatic clone phenotype

(Pagliarini and Xu, 2003)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib^unspecified has basal lamina & eye disc | somatic clone phenotype

(Pagliarini and Xu, 2003)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, stg^UAS.cNa has imaginal disc | somatic clone | cell autonomous | larval stage phenotype

(Prober and Edgar, 2000)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, stg^UAS.cNa has mitotic cell cycle | somatic clone phenotype

(Prober and Edgar, 2000)

BacA\p35^UAS.cHa, Ras85D^V12.UAS, Scer\GAL4^dpp.blk1 has adult phenotype

(Karim and Rubin, 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Clones both expressing Ras85D^V12.UAS under the control of Scer\GAL4^Act5C.PI and homozygous for scrib¹ form tumors in the larval brain (which metastasize to the ventral nerve cord). Larval eye/antennal disc clones also form tumors and their induction leads to lethality. Co-expression of JhI-21^HMS02271 suppresses tumorigenesis and lethality, but adults exhibit an eye phenotype.

Eye/antennal disc clones both expressing Ras85D^V12.UAS under the control of Scer\GAL4^Act5C.PI and homozygous for dlg1¹⁴ also form tumors.

(Cong et al., 2021)

Larvae with eye disc-specific clones that both express Ras85D^V12.UAS under the control of Scer\GAL4^Act5C.PI and are homozygous for msn³²⁰⁸ form tumors that invade the neighboring ventral nerve cord; eye discs exhibit increased mitotic index, as compared to controls or clones either only expressing Ras85D^V12.UAS under the control of Scer\GAL4^Act5C.PI or only homozygous for msn³²⁰⁸.

(Kong et al., 2021)

Eye-antennal disc clones that express both Ras85D^V12.UAS and Rox8^GD11645 under the control of Scer\GAL4^Act.PU form tumors.

(Guo et al., 2020)

Expression of Ras85D^V12.UAS under the control of Scer\GAL4^Act5C.PI and emei¹ homozygosity synergize to induce tumor formation in wing disc clones.

Tumors derived from clones that both express Ras85D^V12.UAS under the control of Scer\GAL4^Act5C.PI and are emei¹ homozygous display invasive behavior into the ventral nerve cord.

(Ma et al., 2020)

Co-expression of Ciz1^JF02716 and Ras85D^V12.UAS under the control of Scer\GAL4^en-e16E (in combination with Gal80[ts] to control the timing of expression) leads to increased cell death in third instar larval wing discs.

(Sun et al., 2020)

The double expression of Ras85D^V12.UAS and scrib^KK101128 for 3 days during larval development under the combined control of Scer\GAL4^hh.PU and Gal80[ts] results in increased DNA damage (comet assay) and decreased DNA damage response (phospho-H2Av) in third instar larval wing discs.

(Murcia et al., 2019)

Co-expression of Ras85D^V12.UAS with lncRNA:Hsrω^{dsRNA.Sym.UAS} under the control of Scer\GAL4^GMR.PF leads to following changes during pupal development: complete absence of proper demarcation of head, thorax, and abdomen; and absence of retraction of Malpighian tubules (MT) to become abdominal.

In the early dying 24- to 25-hour-old lncRNA:Hsrω^{dsRNA.Sym.UAS} and Ras85D^V12.UAS co-expressing pupae under the control of Scer\GAL4^sev.EP the metamorphic changes causing compaction of cells in MT, the histolysis of salivary gland, or the disappearance of the posterior seven pairs of abdominal segmental dorsomedian UAS-GFP expressing neurons under the control of Scer\GAL4^sev.EP do not occur. These pupae continue to show those structures as in 8- to 9-hour-old pupae even at 24 to 25 hours APF.

(Ray and Lakhotia, 2019)

Whole eye-antennal disc clones that both express Ras85D^V12.UAS under the control of Scer\GAL4^Act.PU and are homozygous for l(2)gl⁴ form large tumors that invade the adjacent ventral nerve cord by day 7 after egg laying; individuals have an extended larval stage and die as bloated 3rd instar larvae.

Whole eye-antennal disc clones that co-express Ras85D^V12.UAS and arm^UAS.Exel under the control of Scer\GAL4^Act.PU form tumors that invade the adjacent ventral nerve cord by day 7 after egg laying.

(Zhang et al., 2019)

The co-expression of pnut^GD1512 and Ras85D^V12.UAS from the second instar larval stage under the combined control of Scer\GAL4^ap-md544 and Gal80[ts] leads to the formation of tumors in the third instar larval wing disc.

(Gerlach et al., 2018)

Eye disc clones expressing Ras85D^V12.UAS under the control of Scer\GAL4^unspecified and are simultaneously homozygous for either Alg3^tid2 or Alg9^c02021 show non-invasive overgrowths, as compared to either single mutant clones.

(de Vreede et al., 2018)

Co-expression of l(2)gl^KK100777 or scrib^KK101128 exacerbates the increased hemocyte count observed in larvae expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Hml.Δ; these larvae are viable up to pupal stage and prepare for pupation, but only a subset of these pupae successfully eclose at 25[o]C, as compared to controls. None of these flies eclose when reared at 29[o]C, and pupae exhibit dessication and an absence of precursors of adult structures, in contrast to controls.

Larvae expressing both Ras85D^V12.Scer\UAS and l(2)gl^KK100777 or both Ras85D^V12.Scer\UAS and scrib^KK101128 under the control of Scer\GAL4^Hml.Δ exhibit no significant difference in wound healing; larvae wounded and infected with the bacteria Staphylococcus aureus, Erwinia carotovora, or E.coli survive equally well as controls; and hemocytes isolated from larvae exhibit normal phagocytosis levels upon exposure to to heat killed E. coli, as compared to controls.

Larvae expressing both Ras85D^V12.Scer\UAS and l(2)gl^KK100777 or both Ras85D^V12.Scer\UAS and scrib^KK101128 under the control of Scer\GAL4^Bx-MS1096 infected with the nematode Heterorhabditis bacteriophora and its associated bacterium Photorhabdus luminescens, do not show a significant difference in survival as compared to controls; but when these constructs are driven under the control of Scer\GAL4^Hml.Δ, infected larvae show a significant increase in mortality as compared to controls, and also show a similar decrease in motility upon nematode infection as seen in those expressing only Ras85D^V12.Scer\UAS.

(Arefin et al., 2017)

Clones homozygous for scrib⁶⁷³ and expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU in third instar larval eye-antennal imaginal discs form invasive tumors, which display increased proportions of clone cells entering the cell cycle (but not undergoing mitosis), undergoing apoptosis and presenting mitochondrial defects - i.e., significant increases in the average mass and number of mitochondria per cell, a strong increase in the proportion of burst mitochondria, and a significant increase in the levels of reactive oxygen species, as compared to controls; the presence of these tumor clones also leads to a cell non-autonomous increase in autophagosomes (assessed by a Atg8a fluorescence reporter) in both neighboring disc tissue and distant tissues - i.e. somatic muscles, midgut and fat body - and in significant decreases in the respiratory capacity in both tumor and neighboring disc tissue, as compared to controls.

scrib⁶⁷³-homozygous, Ras85D^V12.Scer\UAS-expressing eye-antennal imaginal disc clone tumors are significantly suppressed by Atg13^Δ81 homozygosity in clone cells (leading to reductions in the proportions of clone cells entering the cell cycle, but not undergoing mitosis or apoptosis, and leading to a reduction in the tumor size, but not invasiveness), in neighboring disc cells (leading to reductions in the tumor size and in the proportion of cell entering the cell cycle, but not undergoing mitosis or apoptosis), in the full organism except the clone cells (leading to reductions in the tumor size and invasiveness), or in the full organism (leading to reductions in the proportions of cells entering the cell cycle and undergoing mitosis, but not undergoing apoptosis, and leading to reductions in the tumor size and invasiveness); these tumors are also significantly suppressed by Atg14^Δ5.2 homozygosity in the neighboring disc cells (leading to a reduction in the tumor size) or by the combination of Atg13^Δ81 homozygosity in the tumor cells and Atg14^Δ5.2 homozygosity in the neighboring disc cells. One copy of Atg13^{+tCH322-168O18} in the full organism suppresses the decrease in tumor size, but not invasiveness, resulting from Atg13^Δ81 homozygosity in the full organism or in the full organism apart from the clone cells; one copy of Atg13^ey.3.5 in the full organism also partially suppresses the decrease in tumor size resulting from Atg13^Δ81 homozygosity. These tumors grow to significantly smaller sizes when grafted into the abdomen of either Atg14^Δ5.2/Atg14^EY14568 transheterozygous adult hosts (but not if the hosts possess one copy of Atg14^{+tCH322-175F03}) or Atg8a^d4 homozygous adult hosts, as compared to control hosts.

The cell non-autonomous increase in autophagosomes resulting from the presence of clones homozygous for scrib⁶⁷³ and expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU in third instar larval eye-antennal imaginal discs is suppressed by Atg13^Δ81 homozygosity in either the full organism (leading to suppression in distant tissues - somatic muscles, midgut and fat body) or in the full organism apart from the clone cells (leading to suppression in neighboring disc tissue), and suppressed by the clonal co-expression of either dome^{ΔCYT.Scer\UAS} (leading to suppression in neighboring disc tissue) or bsk^{DN.Scer\UAS.cUa} (leading to suppression in the midgut, but not in the somatic muscles or the fat body), but not suppressed by Stat92E^85C9 homozygosity in the full organism apart from the clone cells.

Clones homozygous for scrib⁶⁷³ and expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^tub.PU in third instar larval wing imaginal discs lead to a cell non-autonomous increase in autophagosomes (assessed by a Atg8a fluorescence reporter) in neighboring disc tissue, as compared to controls.

Third instar larval eye-antennal imaginal disc clones homozygous for scrib¹ and expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU form invasive tumors; the presence of these clones in egr¹/egr³ transheterozygotes, or additional clonal homozygosity for kay³, or additional clonal co-expression of Ets21C^KK103211 in combination with kay^{dsRNA.Scer\UAS.cUa} do not lead to significant cell non-autonomous induction of autophagosomes (assessed by a Atg8a fluorescence reporter) in neighboring disc cells.

Third instar larval eye-antennal imaginal disc clones co-expressing Ras85D^V12.Scer\UAS and dlg1^GD4689 under the control of Scer\GAL4^{Act5C.CoinFLP-FRT}, in combination with Dicer-2 for efficient RNAi, form invasive tumors and induce autophagosomes in a cell non-autonomous manner in neighboring disc tissue (assessed by a Atg8a fluorescence reporter), as compared to controls; both the tumor formation and the cell non-autonomous autophagosome induction are suppressed by the additional clonal co-expression of either sd^JF02514 or yki^HMS00041; the volume of these tumors is also significantly reduced by the clonal co-expression of either slif^UY681 or Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^{Act5C.CoinFLP-FRT}; the cell non-autonomous increase in autophagosomes is also suppressed by the clonal co-expression of bsk^{DN.Scer\UAS.cUa}, but not of ImpL2^{dsRNA.Scer\UAS.cUa} or Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}.

The presence of third instar larval eye-antennal imaginal disc clones co-expressing Ras85D^V12.Scer\UAS with either upd1[Scer\UAS.cUa] or upd3[d04951], but not ImpL2[s.Scer\UAS], under the control of Scer\GAL4^Act.PU lead to a cell non-autonomous increase in autophagosomes (assessed by a Atg8a fluorescence reporter) in neighboring disc tissue, as compared to controls.

(Katheder et al., 2017)

The comparatively weak tumor induction observed in clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^{Scer\FRT.Act5C} induced in eye-antennal discs in third instar larvae is strongly enhanced when the clones are also homozygous mutant for fmt¹. With continuous tumor progression almost half of the larvae show invasion of the tumor tissue into the ventral nerve cord at 11 days after egg laying (AEL). Number of mitotic cells is also highly increased compared to either of the single mutant clones, but no increase in the level of apoptosis is observed. The strong tumorigenic activity of Scer\GAL4^{Scer\FRT.Act5C}>Ras85D^V12.Scer\UAS;fmt¹/fmt¹ MARCM clones in third instar larval eye-antennal discs is strongly impeded and their invasive capacity abolished by co-expression of either bsk^DN.Scer\UAS or Tak1^{K46R.Scer\UAS} in the clones.

Similarly, the tumorigenicity of Ras85D^V12.Scer\UAS-expressing clones is also enhanced if the clones are mutant for PpV^Δ1, they display invasive behavior and increased mitotic activity; these characteristics are suppressed by co-expression of bsk^DN.Scer\UAS or Tak1^{K46R.Scer\UAS}. Scer\GAL4^{Scer\FRT.Act5C}>Ras85D^V12.Scer\UAS;l(2)gl⁴/l(2)gl⁴ are also highly tumorigenic and have invasive capability and their overgrowth as well as invasiveness is significantly suppressed by co-expression of either fmt^Scer\UAS.cMa or PpV^{Scer\UAS.P\T.N.T:Avic\GFP-EGFP} and to even greater extent when both transgenes are expressed simultaneously in the mutant clones (however this effect is not due to increase in cell death).

Co-expression of Ras85D^V12.Scer\UAS and PpV^GD7532 in somatic clones in the eye-antennal disc under the control of Scer\GAL4^Act5C.PI results in mild tumorous overgrowth which is further enhanced by fmt¹ heterozygosity.

(Ma et al., 2017)

The co-expression of Ras85D^V12.UAS and scrib^KK101128 under the control of Scer\GAL4^ap-md544 induces wing disc neoplasia which, when transplanted, can form solid tumors in the host; in both wing discs and allografts, there is amplification of the resident myoblast population, as well as accumulation of circulating hemocytes. The same tumor induction and hemocyte recruitment occurs if expression is only induced in wing disc transplants (expression induction is controlled by Gal80[ts] and temperature-shift); hemocyte ablation on the host (by expressing rpr^UAS.C under the control of Scer\GAL4^He.PZ) alone does not suppress the tumor-like growth.

The co-expression of Ras85D^V12.UAS and dlg1^GD4689 under the control of Scer\GAL4^ap-md544 induces wing disc neoplasia which, when transplanted, can form solid tumors in the host; there is amplification of the resident myoblast population, as well as accumulation of circulating hemocytes on the wing disc. Myoblast ablation (by expressing rpr^lexAop.cSa under the control of Ecol\lexA^GMR15B03) does not suppress the tumor-like growth.

The co-expression of Ras85D^V12.UAS and dlg1^GD4689 under the control of Scer\GAL4^hh.PU induces wing disc tumor-like growth, with increased mitotic index; myoblast ablation (by expressing rpr^lexAop.cSa under the control of Ecol\lexA^GMR15B03) does not suppress the tumor-like growth. Similar tumor induction occurs if expression is induced in wing disc transplants (expression induction is controlled by Gal80[ts] and temperature-shift); hemocyte ablation on the host (by expressing rpr^UAS.C under the control of Scer\GAL4^He.PZ) together with myoblast ablation on the implant (by expressing rpr^UAS.C under the control of Ecol\lexA^GMR15B03) does not suppress the tumor-like growth.

The co-expression of Ras85D^V12.UAS with either mud^HMS01458 or mud^JF02911 under the control of Scer\GAL4^hh.PU induces wing disc tumor-like growths.

(Muzzopappa et al., 2017)

The moderate overgrowth of eye-antennal discs bearing clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI is suppressed by Lkb1^X5 homozygosity in the clones.

The induction of larval eye-antennal disc clones both homozygous for Vps15⁵ and expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI leads to an enhanced eye-antennal disc tumor phenotype, as compared to clones only expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI, and leads to delayed pupation, as compared to controls. Both these phenotypes are suppressed by additional Lkb1^X5 homozygosity in the clones.

(O'Farrell et al., 2017)

scrib¹ in type II neuroblast lineage MARCM clones expressing Ras85D^V12.Scer\UAS can be recovered at a similar rate as wild-type ones and instead of a single neuroblast they frequently contain 2 or 3 but the clones do not show significant overgrowth.

scrib¹ mutant clones in larval antennal discs clones expressing Ras85D^V12.Scer\UAS (under the control of Scer\GAL4^Dll-md23) all display tumor-like overgrowth.

(Rives-Quinto et al., 2017)

The increased mitotic index in the adult posterior midgut induced by the clonal expression of Ras85D^V12.UAS under the control of Scer\GAL4^esg-NP7397 is not enhanced by clonal Apc2^N175K, Apc^Q8 double homozygosity alone or by clonal Apc2^N175K, Apc^Q8 double homozygosity in combination with clonal Sxl^KK116156 co-expression.

(Hudry et al., 2016)

The high levels of apoptosis (detected by Caspase-3 staining) observed in Rbf^15aΔ;Stam¹⁹ double homozygous somatic MARCM clones in third instar larval eye disc is strongly suppressed by expression of Ras85D^V12.Scer\UAS under the control of the Scer\GAL4^Act.PU driver in the mutant clones.

(Sheng et al., 2016)

Co-expression of Dis3^KK101473 significantly enhances tissue overgrowth in eye-antennal imaginal or wing discs with expression of Ras85D^V12.Scer\UAS driven by Scer\GAL4^dpp.PU or Scer\GAL4^Bx-MS1096.

Co-expression of sbr^HMS02414 or CG10803^KK104790 does not enhance tissue overgrowth in eye-antennal imaginal or wing discs with expression of Ras85D^V12.Scer\UAS driven by Scer\GAL4^dpp.PU or Scer\GAL4^Bx-MS1096.

Co-expression of Dis3^KK101473 and Ras85D^V12.Scer\UAS driven by Scer\GAL4^Bx-MS1096 leads to mutual suppression of mitotic cell cycle changes in third instar larval wing discs with expression of either construct alone.

(Snee et al., 2016)

scrib¹ eye discs expressing Ras85D^V12.Scer\UAS in clones show a dramatic tumour-like overgrowth and metastasis.

Eye discs co-expressing dlg1^GD4689 and Ras85D^V12.Scer\UAS in clones show tumour-like overgrowth and metastasis.

(Andersen et al., 2015)

Transplanted scrib¹ mutant eye disc fragments expressing MARCM closes of Ras85D^V12.Scer\UAS grow continuously and induce distinctive bloating of the abdomen before killing the host. Wild-type discs grow only a limited amount before ceasing, and the transplanted host survives for weeks. Metastasis-like events are rare for the tumors. However, all the tumor-bearing hosts show robust wasting phenotypes in tissues distant from the transplant. Transplanted wild-type disc fragments do not induce these phenotypes. Cachexia-like wasting is observed in adipose tissue (fat body), muscle, and ovaries. Comparison of food consumption in wild-type and tumor-bearing hosts show that he tumor-induced wasting is not due to decreased food consumption (anorexia).

Transplanted tissue fragments of Ras85D^V12.Scer\UAS donors also expressing dlg1^GD4689 under the control of Scer\GAL4^ey.PU cause non-autonomous wasting.

Expression of ImpL2^GD6004 within the tumors of Scer\GAL4^ey.PU>Ras85D^V12.Scer\UAS,dlg1^GD4689 origin significantly ameliorates the peripheral tissue wasting phenotypes. Hosts bearing dlg1^GD4689, Ras85D^V12.Scer\UAS, ImpL2^GD6004 tumors show increased abdominal fat body mass. Muscle function assays further reveal improvements in both climbing ability and speed. There is a significant rescue of ovariole health, leading to restoration of egg production. The rescue is only observed when ImpL2^GD6004 is expressed in the tumor. Transplanting dlg1^GD4689, Ras85D^V12.Scer\UAS tumors into ImpL2^Def20 hosts does not ameliorate wasting.

(Figueroa-Clarevega and Bilder, 2015)

l(2)gl⁴ mutant wing disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^tub.PU show increased levels of hypoxia compared to controls or either mutant alone. Ectopic tracheal structures are seen at the basal side of the disc, and in some cases several branches depart from a central mass and enclose a rudimentary lumen. l(2)gl⁴ Ras85D^V12.Scer\UAS cells form mosaic tracheal branches with resident tracheal cells. Clone cells at the apical side of the disc are frequently interconnected with clone cells at the basal side by a bridge of tumour cells.

When l(2)gl⁴ mutant clones expressing Ras85D^V12.Scer\UAS are generated at 48 hours after egg laying (AEL) using a tracheal specific driver (Scer\GAL4^btl.PU) no wing disc clones are observed. Tracheal clones are generated when clones are induced at 0-4 hours AEL but no overgrowth is observed.

(Grifoni et al., 2015)

Co-expression of Nhe2^Scer\UAS.cGa and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^ptc.PU results in a significant increase in the overall size of the wing disc compared with either transgene alone or wild type. There is also an increase in the number of invasive cells seen.

(Grillo-Hill et al., 2015)

Larvae with eye-antennal disc clones co-expressing Ets21C^KK103211 and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU exhibit developmental delay, a noticeable enlargement of clonal tissue that eventually outcompetes the non-clonal tissue, defective photoreceptor differentiation, and clonal tissue exhibits invasive behavior and infiltrates the brain lobes and the ventral nerve cord, as compared to controls.

Clonal co-expression of bsk^{DN.Scer\UAS.cUa} suppresses the invasiveness of clonal cells, but does not suppress tumor formation or developmental delay seen with eye-antennal disc clones co-expressing Ets21C^KK103211 and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

Larval eye-antennal disc clones co-expressing kay^Scer\UAS.cEa and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU exhibit hyperplasia but no invasive growth, as compared to controls, and pupae containing these clones die during the P4 or P5 stage.

The majority of larvae with scrib¹ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU exhibit defective photoreceptor differentiation, and developmental arrest as third instar giant larvae and die; only a few individuals form pseudopuparia and are developmentally delayed, starting on day 8 after egg laying. The cells of scrib¹ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU are highly invasive, penetrating the ventral nerve cord of a majority of developmentally arrested larvae.

Clonal co-expression of Ets21C^KK103211 partially suppresses the lethality and developmental delay seen in larvae with scrib¹ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, but fails to suppress the invasive infiltration of the ventral nerve cord exhibited by cells of these clones.

Clonal co-expression of ftz-f1^JF02738 or kay^{N-Ala.Scer\UAS}, or addition of a clonal kay³ mutation, but not co-expression of Jra^{dsRNA.Scer\UAS}, partially suppresses the lethality and developmental delay seen in larvae with scrib¹ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, and suppresses the invasive infiltration of the ventral nerve cord exhibited by cells of these clones, although the tumor mass is not significantly decreased.

Larvae with scrib¹ mutant eye-antennal disc clones expressing ftz-f1^JF02738, Ets21C^KK103211, and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU reach pupation faster than larvae with scrib¹ mutant eye-antennal disc clones expressing ftz-f1^JF02738 and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, or those with scrib¹ mutant eye-antennal disc clones expressing Ets21C^KK103211 and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

Clonal co-expression of kay^{N-Ala.Scer\UAS}, or addition of a clonal kay³ mutation, but not co-expression of Jra^{dsRNA.Scer\UAS} or ftz-f1^JF02738, partially suppresses the defective photoreceptor differentiation seen in scrib¹ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

Larvae with scrib¹, kay³ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS and Ets21C^KK103211 under the control of Scer\GAL4^Act.PU exhibit suppression of larval lethality as compared to either larvae with scrib¹, kay³ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, or those with scrib¹ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS and Ets21C^KK103211 under the control of Scer\GAL4^Act.PU; but these larvae still exhibit pupal lethality.

Adults with scrib¹ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS and ftz-f1^JF02738 under the control of Scer\GAL4^Act.PU exhibit a rough eye that is increased in size, and contains fewer clonally-derived ommatidia, as compared to controls.

Larval eye-antennal disc clones co-expressing ftz-f1^{Scer\UAS.β.T:Zzzz\FLAG} and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU exhibit hyperplasia but no invasive growth, as compared to controls, and pupae containing these clones die during the P4 or P5 stage.

Larval eye-antennal disc clones co-expressing ftz-f1^{Scer\UAS.α.T:Zzzz\FLAG} and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU exhibit hyperplasia but no invasive growth, as compared to controls, and pupae containing these clones die during the P4 or P5 stage.

(Külshammer et al., 2015)

Expression of Ras85D^V12.Scer\UAS suppresses the photoreceptor differentiation defects seen in Vps4^3B1 mutant clones. The increase in cell death seen in Vps4^3B1 mutant clones is also suppressed by Ras85D^V12.Scer\UAS.

(Legent et al., 2015)

Expression of Ras85D^V12.Scer\UAS suppresses the wing vein loss seen when Ptpmeg^Scer\UAS.cLa is expressed under the control of Scer\GAL4^en.PU.

(Li et al., 2015)

The increased cell proliferation observed upon expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^esg-NP5130 in the adult gut is suppressed by co-expression of either Sox21a^JF02191 or kay^{dsRNA.Scer\UAS}.

(Meng and Biteau, 2015)

The presence of bun^200B/bun^200B suppresses the increased cell number seen in midgut clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^tub.PU.

(Nie et al., 2015)

Co-expression of Ras85D^V12.Scer\UAS partially suppresses the pupariation delay and developmental arrest at the larval stage seen in Scer\GAL4^phm.PO>Itp-r83A^GD1676 (along with UAS-Dcr-2).

(Yamanaka et al., 2015)

Co-expression of rl^GD4697, gfzf^GD10273, Prp19^KK101335, Prp19^GD11681, CG11266^NIG.11266R or CG1603^GD9160 reduces hemocyte proliferation induced by expression of Ras85D^V12.Scer\UAS via Scer\GAL4^Hml.PG.

(Ashton-Beaucage et al., 2014)

Co-expression of Ras85D^V12.Scer\UAS fails to rescue the increased apoptosis observed in clones expressing Rab5^GD10492 under the control of Scer\GAL4^hh.PU in the posterior compartment of the wing disc, however if there are many of these clones in the wing disc, they are able to form invasive tumors despite containing many cells in apoptosis.

(Ballesteros-Arias et al., 2014)

Sec15¹ dramatically suppresses the overgrowth phenotype and pupal lethality seen in eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU. The increased secretion (dye clearance) seen in cells expressing Ras85D^V12.Scer\UAS is also suppressed by Sec15¹. Cell death is no longer detected in the wild type cells surrounding the clones.

Larval eye-antenna disc clones expressing Ras85D^V12.Scer\UAS in a scrib^unspecified mutant background overgrow and invade the ventral nerve cord, killing the animal during the larval stages.

Expression of Sec15^KK101708 suppresses the overgrowth and ventral nerve cord invasion seen in eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU in a scrib^unspecified mutant background.

Expression of Sec15^GD12109 suppresses the overgrowth and ventral nerve cord invasion seen in eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU in a scrib^unspecified mutant background.

Expression of Sec8^KK101531 suppresses the overgrowth phenotype and pupal lethality seen in eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

Expression of Sec6^GD11616 suppresses the overgrowth phenotype and pupal lethality seen in eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

Expression of bsk^DN.Scer\UAS suppresses the increased cell death seen in eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU in a Sec15¹ mutant background. Tumor growth is not restored to that seen in clones expressing Ras85D^V12.Scer\UAS alone.

Expression of egr^{dsRNA.Scer\UAS} suppresses the overgrowth seen in eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

A egr¹ mutant background suppresses the overgrowth seen in eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

Expression of Tace^GD572 suppresses the overgrowth seen in eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU. The phenotype is further suppressed when the adjacent cells are homozygous mutant for Tak1¹.

Expression of Tace^{dsRNA.Scer\UAS} suppresses the overgrowth seen in eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU. The phenotype is further suppressed when the adjacent cells are homozygous mutant for Tak1¹.

Expression of dome^JF01682 suppresses the overgrowth seen in eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU. The Ras85D^V12.Scer\UAS, dome^JF01682 clones have reduced mitotic potential compared to Ras85D^V12.Scer\UAS alone. The phenotype is less severe when the clones are generated in the entire eye disc than when the clones are surrounded by wild type cells in mosaic clones, and yields viable adults. The adult flies co-expressing dome^JF01682 have a smaller eye size than those expressing Ras85D^V12.Scer\UAS alone.

(Chabu and Xu, 2014)

Rare and extremely small homozygous ecd^l(3)23 clones can be recovered if cell growth is enhanced in the clones by expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI.

(Claudius et al., 2014)

A santa-maria¹ homozygous mutant background partially suppresses the Ras85D^V12.Scer\UAS-induced overgrowth, including the aberrant histology of the salivary glands and the mortality.

Heat-shock expression of santa-maria^hs.PW in flies expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Bx-MS1096 at 29[o]C results in melanization of the salivary glands in approximately 4% of cases, in contrast to larvae that express Ras85D^V12.Scer\UAS alone at the same temperature and which do not show any signs of melanization.

(Hauling et al., 2014)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^{Scer\FRT.Act5C} in l(2)gl⁴ mutant cells in eye-antennal discs using the ey-FLP/MARCM system results in tumor-like growth with invasive migration into the ventral nerve cord of the CNS. The growth and invasion of these tumors is dramatically suppressed upon co-expression of puc^Scer\UAS.cMa.

Expression of ben^GD1387 significantly suppresses the growth and invasion of the tumors seen when Ras85D^V12.Scer\UAS is expressed in l(2)gl⁴ mutant cells in eye-antennal discs using the ey-FLP/MARCM system.

One copy of ben¹ partially suppresses the growth and invasion of the tumors seen when Ras85D^V12.Scer\UAS is expressed in l(2)gl⁴ mutant cells in eye-antennal discs using the ey-FLP/MARCM system.

(Ma et al., 2014)

The apoptosis observed in dlg1^A40.2 mutant wing disc tumors is virtually abrogated by the co-expression of egr^KK103432 and Ras85D^V12.UAS, but not by the expression of Ras85D^V12.UAS alone, under the control of Scer\GAL4^Hml.Δ.

(Parisi et al., 2014)

Clones generated in the larval eye discs expressing Csk^unspecified and Ras85D^V12.Scer\UAS show limited tissue overgrowth.

Expression of Nek2^{Scer\UAS.T:Avic\GFP} enhances the tissue overgrowth seen in larval eye disc clones expressing Csk^unspecified and Ras85D^V12.Scer\UAS, and leads to the production of secondary tumours in the body of the larvae. This phenotype can be suppressed by feeding flies with the Akt1 inhibitor MZ2206; significantly smaller primary tumours are seen and there is a complete absence of secondary tumours.

Injection of dissociated cells from Nek2^{Scer\UAS.T:Avic\GFP} Csk^unspecified Ras85D^V12.Scer\UAS mutant eye discs (generated using ey-FLP MARCM) into the dorsal notum region of wild type adult flies results in detection of T:Avic\GFP positive cells in various parts of the adult body. Dispersed Avic\GFP-positive cells are not seen when flies are injected with eye disc cells that express Nek2^{Scer\UAS.T:Avic\GFP} alone.

(Das et al., 2013)

Co-expression of cnc^{dsRNA.C.Scer\UAS} in animals expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4⁵⁰¹⁵ allows the majority of animals to develop to late pupal stages, and some eclose as adults.

Co-expression of cnc^{dsRNA.C.Scer\UAS} suppresses the small body size of pupae expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^phm.PO.

(Deng and Kerppola, 2013)

Co-expression of BHD^{Scer\UAS.T:Ivir\HA1} has no effect on the semi-lethality caused by expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^ey.PU at 21-22[o]C. However, the eye overgrowth and deformation phenotypes seen in adult survivors is partially suppressed.

Co-expression of BHD^{Scer\UAS.T:Ivir\HA1} almost completely suppresses the increase in the number of mitotic cells per eye imaginal disc seen in larvae expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^ey.PU.

Co-expression of either BHD^{dsRNA.Sym.Scer\UAS} or BHD^GD6590 enhances the semi-lethality caused by expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^ey.PU at 21-22[o]C, such that few adult escapers emerge. The eye defects of adult escapers are enhanced.

Co-expression of either BHD^{dsRNA.Sym.Scer\UAS} or BHD^GD6590 exacerbates the increase in the number of mitotic cells per eye imaginal disc seen in larvae expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^ey.PU.

Rpt4^G0345/+ partially suppresses the semi-lethality caused by expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^ey.PU at 21-22[o]C.

Co-expression of Rpt4^Scer\UAS.cGa enhances the semi-lethality caused by expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^ey.PU at 21-22[o]C.

RpI135^k16513/+ partially suppresses the semi-lethality caused by expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^ey.PU at 21-22[o]C.

(Gaur et al., 2013)

The tumor overgrowth of somatic clones (induced specifically in the eye disc) expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU is suppressed when the clones are also homozygous for either Csk^Q156Stop or Csk^j1D8. Ras85D^V12.Scer\UAS expressing Csk^Q156Stop mutant clones show highly increased levels of apoptosis, have an intact basement membrane and only very rarely form secondary tumors distant from the eye field in third instar larvae. The larvae display a delay in pupariation.

The increased cell-death phenotype of Csk^Q156Stop/Csk^Q156Stop somatic clones (induced specifically in the eye disc) expressing Ras85D^V12.Scer\UAS under Scer\GAL4^Act.PU is fully suppressed by co-expression of InR^{A1325D.Scer\UAS}, resulting in tumor overgrowth of the eye disc in nearly all larvae. Majority of the larvae fail to pupariate, the ones that manage do so with a significant delay.

Somatic clones (induced specifically in the eye disc) expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU and homozygous mutant for scrib¹ show substantial tumorigenic overgrowth but do not form secondary tumors although floating clone cells are frequently observed in the hemolymph.

(Hirabayashi et al., 2013)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^tub.PU in l(2)gl⁴ mutant wing disc mutant clones results in overproliferation and neoplastic transformation in both the proximal and distal domains.

(Khan et al., 2013)

Ras85D^V12.Scer\UAS scrib¹ tumour cells fail to differentiate into neurons.

Loss of cher markedly interferes with the growth of Ras85D^V12.Scer\UAS scrib¹ tumours. The loss of cher does not affect the level of apoptosis in either the clonal nor the surrounding eye-antennal imaginal disc, indicating that loss of cher does not affect tumour cell viability.

Eye-antennal imaginal discs carrying Ras85D^V12.Scer\UAS scrib¹ cher¹ clones display extra cell divisions, mainly occurring in the surrounding non-clonal tissue. Despite sizeable Ras85D^V12.Scer\UAS scrib¹ cher¹ clones clones located posterior to the morphogenetic furrow, the number of elav-positive differentiating photoreceptors increases and their organization is better than in Ras85D^V12.Scer\UAS scrib¹ clones. Consequently, well-ordered arrays of ommatidia appear in Ras85D^V12.Scer\UAS scrib¹ cher¹ eye-antennal imaginal discs compared with the indiscernible pattern in Ras85D^V12.Scer\UAS scrib¹ discs.

Many apically localised Ras85D^V12.Scer\UAS scrib¹ cells are elongated.

Cross-sections of Ras85D^V12.Scer\UAS scrib¹ cher¹ eye-antennal discs reveals that large tumours only reside within the basal compartment of the columnar epithelium. Smaller Ras85D^V12.Scer\UAS scrib¹ cher¹ clones are confined between the squamous peripodial epithelium and the columnar epithelium.

In contrast to highly invasive Ras85D^V12.Scer\UAS scrib¹ clonal tumours, fewer Ras85D^V12.Scer\UAS scrib¹ cher¹ clones invaded the brain and the ventral nerve cord. Expression of cher^KK107518 suppresses the tumour invasiveness found in Ras85D^V12.Scer\UAS scrib¹ clones.

Larvae bearing Ras85D^V12.Scer\UAS scrib¹ tumours all die in the third instar and never pupate. In contrast, on day 8-9 after egg laying, 30% of Ras85D^V12.Scer\UAS scrib¹ cher¹ larvae begin to wander and pupate, albeit 2-3 days later than control animals. Thirty percent of Ras85D^V12.Scer\UAS scrib¹ cher¹ pupape emerge as adults. These adult flies exhibit abnormally enlarged eyes with a folded surface, accommodating surplus ommatidia.

Expression of zip^GD1566 lessens the invasiveness of Ras85D^V12.Scer\UAS scrib¹ tumours and improves pupation rate.

(Külshammer and Uhlirova, 2013)

Expression of Ras85D^V12.Scer\UAS in l(2)gl⁴ mutant cells in eye-antenna discs using the ey-FLP/MARCM system induces strong tumour-like growths, with invasive migration into the VNC 8 days after egg laying. Such animals keep growing as oversized larvae carrying huge tumours in their heads and die before pupation.

Blocking JNK signaling by expression of puc^Scer\UAS.cMa dramatically suppresses the growth and invasion behaviours of Ras85D^V12.Scer\UAS/l(2)gl⁴ tumours.

Loss of Src42A, through expression of Src42A^NIG.7873R, dramatically suppresses tumour cell invasion into the ventral nerve cord found in Ras85D^V12.Scer\UAS/l(2)gl⁴ mutants and enables the animals to survive to the pupal stage, whereas the tumour size remains largely unaffected.

Loss of Src64B, through expression of Src64B^GD12263, dramatically suppresses tumour cell invasion into the ventral nerve cord in Ras85D^V12.Scer\UAS/l(2)gl⁴ mutants and enables the animals to survive to the pupal stage, whereas the tumour size remains largely unaffected.

(Ma et al., 2013)

Expression of Ras85D^V12.Scer\UAS in l(2)gl⁴ mutant developing eye-antennal discs, under the control of Scer\GAL4^GMR.PF, results in tumour-like overgrowths, with invasive migration into the ventral nerve cord of the central nervous system. The mutant animals keep growing as oversized larvae with huge tumours in the head region and die before pupation.

Inactivation of JNK signaling, through the expression of puc^Scer\UAS.cMa, dramatically suppresses the Ras85D^V12.Scer\UAS/l(2)gl⁴ mutant tumour growth and invasion, and rescues animals to pupal stage.

Expression of Uev1A^GD6650 mutant background dramatically suppresses the Ras85D^V12.Scer\UAS/l(2)gl⁴ mutant tumour growth and invasion, and rescues animals to pupal stage.

A Uev1A^DG14805 heterozygous mutant background dramatically suppresses the Ras85D^V12.Scer\UAS/l(2)gl⁴ mutant tumour growth and invasion, and rescues animals to pupal stage.

(Ma et al., 2013)

Expression of tay^{dsRNA.Scer\UAS} enhances the ectopic wing vein phenotype seen when Ras85D^V12.Scer\UAS is expressed under the control of Scer\GAL4^salm.EPv.

Expression of tay^EP-866 suppresses the ectopic wing vein phenotype seen when Ras85D^V12.Scer\UAS is expressed under the control of Scer\GAL4^salm.EPv.

Co-expression of Ras85D^V12.Scer\UAS and rl^{Sem.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^salm.EPv results in a strong ectopic wing vein phenotype.

Expression of tay^{FL.Scer\UAS.T:Zzzz\FLAG} does not suppress the ectopic wing vein phenotype seen when Ras85D^V12.Scer\UAS and rl^{Sem.Scer\UAS.T:Ivir\HA1} are co-expressed under the control of Scer\GAL4^salm.EPv.

(Molnar and de Celis, 2013)

Expression of PRL-1^Scer\UAS.cPa enhances the lethality seen when Ras85D^V12.Scer\UAS is expressed in the dorsal compartment of the wing disc under the control of Scer\GAL4^ap-md544. Fewer than 10% of mutants reach the prepupal stage, compared to 90% when Ras85D^V12.Scer\UAS is expressed alone. The larvae appear lethargic.

(Pagarigan et al., 2013)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^crq.PO partially rescues the embryonic lethality of Df(2L)Pvf2-3/Df(2L)Pvf2-3 mutants.

(Parsons and Foley, 2013)

Flies co-expressing Ras85D^V12.Scer\UAS produce fewer intestinal stem cell (ISC) clones per midgut over time compared with Apc2^g10 Apc^Q8 mutants alone, similar to what is seen when Ras85D^V12.Scer\UAS is expressed alone. Approximately 35% of the clones that remain undergo rapid proliferation and develop into large spherical-tumor cell masses (termed 'transformed clones'). There is no obvious increase in apoptosis in these transformed clones and the majority are found in the anterior or posterior midgut rather than the middle midgut. Few enterocytes (ECs) or enteroendocrine cells (ees) are seen, indicating that differentiation is blocked. The remaining 65% of clones are smaller than their wild type counterparts, but the ratio of ISCs to differentiated EC and ee cells is comparable to wild type.

Approximately 10% of Apc2^g10 Apc^Q8, Ras85D^V12.Scer\UAS mutant ISC clones extrude basally toward the surrounding muscle layer, although the underlying base layer remains unbroken. Expression of Ras85D^V12.Scer\UAS induces polarity changes in Apc2^g10 Apc^Q8 mutant clones.

(Wang et al., 2013)

Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones exhibit tissue overgrowth. Exposure to acivicin restrains Ras85D^V12.Scer\UAS-scrib¹ tumor overgrowth.

Knockdown of CTPsyn, through expression of CTPsyn^GD4740, induces a strong, significant reduction in tumor growth in Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones.

Knockdown of CG9674, through expression of CG9674^GD14285, induces a strong, significant reduction in tumor growth in Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones.

Knockdown of bur, through expression of bur^GD13797, induces a reduction in tumor growth in Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones.

Knockdown of r, through expression of r^GD9607, induces a reduction in tumor growth in Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones.

Knockdown of ade2, through expression of ade2^GD1356, induces a reduction in tumor growth in Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones.

Knockdown of Gfat1, through expression of Gfat1^GD7732, induces a reduction in tumor growth in Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones.

Knockdown of Prat, through expression of Prat^GD9838, induces a reduction in tumor growth in Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones.

Knockdown of Prat2, through expression of Prat2^GD16167, induces a reduction in tumor growth in Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones.

Knockdown of CG9940, through expression of CG9940^GD14730, induces a reduction in tumor growth in Ras85D^V12.Scer\UAS-scrib¹ mutant larval MARCM clones.

(Willoughby et al., 2013)

Co-expression of bsk^DN.Scer\UAS, bsk^HMS00777, Timp^Scer\UAS.cPa or Jra^NIG.2275R partially suppresses the dissemination of hindgut cells seen in flies expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^byn-Gal4.

Co-expression of hep^Act.Scer\UAS or imd^Scer\UAS.cGa enhances the dissemination of hindgut cells seen in flies expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^byn-Gal4.

(Bangi et al., 2012)

Larvae expressing Scer\GAL4^Gli-rL82>Ras85D^V12.Scer\UAS display nerves that are significantly wider than either Scer\GAL4^Gli-rL82>Ras85D^V12.Scer\UAS or egh^62d18 single mutants.

(Dahlgaard et al., 2012)

Scer\GAL4^Bx-MS1096-mediated expression of both Ras85D^V12.Scer\UAS and Plzf^Scer\UAS.cMa generates significantly enhanced extra and ectopic veins as compared to expression of either transgene alone. This effect is more dramatic at 18[o]C than 25[o]C.

The Scer\GAL4^Bx-MS1096, Ras85D^V12.Scer\UAS extra wing vein phenotype is partially suppressed in Plzf^Δ145/+ or Plzf^Δ11/+ heterozygotes.

(Maeng et al., 2012)

Co-expression of Ras85D^V12.UAS and Mkp3^UAS.cUa in the midgut, under the control of Scer\GAL4^NP7397 fails to induce midgut cell proliferation.

Induction of activated Ras85D in Ras85D^V12.UAS Stat92E³⁹⁷ MARCM clones drives the growth of large intestinal stem cells, regardless of the Stat92E mutant background.

(Jiang et al., 2011)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU in clones in the eye-antennal disc (where the clones are also homozygous for sds22^Δ2.8) results in extensive hyperproliferation of the clones in the eye-antennal disc at 7 days after egg laying (AEL), but in addition, clonal cells are also seen in the ventral nerve cord at low frequency. At 15 days AEL, significant numbers of clonal cells are seen spreading from a primary tumour in the brain into the ventral nerve cord. In addition, as the tumours grow, the two eye-antennal discs appear to fuse into one large mass. These animals can grow as larvae for up to 15 days AEL and die before pupation or as early pupae.

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU in clones in the eye-antennal disc (where the clones are also homozygous for scrib⁶⁷³) results in strong tumour growth at 7 days AEL. These animals grow as larvae until 13 days AEL and die before pupation. Co-expression of sds22^Scer\UAS.cJa in these clones strongly suppresses the tumour growth phenotype in all clones observed at 7 days AEL and most of these animals can pupate, but die as early pupae.

Eye overgrowth caused by expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^ey.PU is not suppressed by co-expression of sds22^Scer\UAS.cJa.

(Jiang et al., 2011)

Co-expression of Ras85D^V12.Scer\UAS and Hr4^Scer\UAS.cQa under the control of Scer\GAL4^P0206 results in wild-type timing of pupariation, and a partial suppression of the Hr4^Scer\UAS.cQa-mediated lethality. Hr4^Scer\UAS.cQa co-expression with Ras85D^V12.Scer\UAS represses the hyper-proliferation of the ring gland seen in Ras85D overexpression flies.

(Ou et al., 2011)

Co-expression of Pi3K92E^GD11228 suppresses tumour growth in Ras85D^V12.Scer\UAS MARCM third instar imaginal disc clones, although this suppression is weaker than that seen upon expression of Pi3K92E^GD11228 in Ras85D^V12.Scer\UAS-dlg1^GD4689 MARCM third instar imaginal disc clones.

Overexpression of yki^Scer\UAS.cHa in Ras85D^V12.Scer\UAS MARCM clones generates larger tumorigenic overgrowths than in either single mutant clone.

Overexpression of upd1^Scer\UAS.cZa in Ras85D^V12.Scer\UAS MARCM clones generates larger tumorigenic overgrowths than in either single mutant clone.

Expression of Ras85D^V12.Scer\UAS and dlg1^GD4689 in MARCM third instar imaginal disc clones results in a neoplastic phenotype.

Co-expression of Pi3K92E^GD11228 suppresses tumour growth in dlg1^GD4689 MARCM third instar imaginal disc clones, although this suppression is weaker than that seen upon expression of Pi3K92E^GD11228 in Ras85D^V12.Scer\UAS-dlg1^GD4689 MARCM third instar imaginal disc clones.

Knockdown of either Pi3K92E or Akt1 in Ras85D^V12.Scer\UAS-dlg1^GD4689 cells, through expression of either Pi3K92E^GD11228 or Akt1^GD1361, causes a complete suppression of neoplastic growth and even causes a near-complete absence of mutant eye cells. Only small structures, which contain few cells, remain.

MARCM Ras85D^V12.Scer\UAS-dlg1^GD4689 expressing clones are dramatically smaller in a Pi3K92E^1C1 homozygous mutant than in a wild-type background, indicating that a loss of Pi3K92E signaling interferes with Ras85D^V12.Scer\UAS-dlg1^GD4689 tumour growth.

Depletion of InR, through expression of InR^GD104, slightly reduces tumour size in Ras85D^V12.Scer\UAS-dlg1^GD4689 MARCM clones.

Depletion of S6k, through expression of S6k^GD6646, slightly reduces tumour size in Ras85D^V12.Scer\UAS-dlg1^GD4689 MARCM clones.

Depletion of Rheb, through expression of Rheb^NIG.1081R, strongly reduces tumour size in Ras85D^V12.Scer\UAS-dlg1^GD4689 MARCM clones.

Depletion of Tor, through expression of Tor^NIG.5092R, strongly reduces tumour size in Ras85D^V12.Scer\UAS-dlg1^GD4689 MARCM clones.

Depletion of Pten, through expression of Pten^KK109278, increases tumour size in Ras85D^V12.Scer\UAS-dlg1^GD4689 MARCM clones.

Overexpression of yki^Scer\UAS.cHa in dlg1^GD4689 MARCM clones generates larger tumorigenic overgrowths than in either single mutant clone.

Expression of Ras85D^V12.Scer\UAS and dlg1^GD4689 in the posterior compartment of wing discs, under the control of Scer\GAL4^en.PU results in an enlarged posterior wing disc compartment. These wing discs exhibit high levels of cell proliferation.

Co-expression of Pi3K92E^GD11228 together with Ras85D^V12.Scer\UAS and dlg1^GD4689, under the control of Scer\GAL4^en.PU, strongly reduces the size of the Ras85D^V12.Scer\UAS-dlg1^GD4689 tumours in the posterior wing disc compartment. There is an almost complete absence of cellular proliferation in this compartment.

Wing disc compartments expressing Ras85D^V12.Scer\UAS, dlg1^GD4689, Pi3K92E^GD11228, together with CycE^Scer\UAS.cRa and stg^hs.PE2 show a rescue in compartment size and high levels of His3-positive cells.

(Willecke et al., 2011)

Starting on day 8 after egg laying (AEL), Ras85D^V12.Scer\UAS, Scer\GAL4^{Scer\FRT.Act5C} tumours with a homozygous dor^C107 background exhibit enhanced outgrowth when compared with Ras85D^V12.Scer\UAS, Scer\GAL4^{Scer\FRT.Act5C} controls. On day 14 AEL, these double mutant tumour cells clearly invade into the ventral nerve cord with a high frequency. On day 18 AEL, the dramatically overgrown double mutant tumours occupy about one-quarter volume of the larvae body and completely enveloped ventral nerve cord. Occasionally, tumour cells are also found in the gut and the trachea of the double mutant larvae, indicating secondary tumour formation in distal organs. All double mutant larvae die prior to pupation.

Knockdown of car through expression of car^{dsRNA.Scer\UAS} under the control of Scer\GAL4^{Scer\FRT.Act5C} moderately enhances the overgrowth seen in Ras85D^V12.Scer\UAS, Scer\GAL4^{Scer\FRT.Act5C} tumour cells.

Knockdown of Vps16A through expression of Vps16A^{dsRNA.Scer\UAS.WIZ} under the control of Scer\GAL4^{Scer\FRT.Act5C} moderately enhances the overgrowth seen in Ras85D^V12.Scer\UAS, Scer\GAL4^{Scer\FRT.Act5C} tumour cells and leads to tumour invasion towards the ventral nerve cord.

Ras85D^V12.Scer\UAS, Scer\GAL4^{Scer\FRT.Act5C} tumours in a homozygous dor^C107 background exhibit a massive accumulation of Hsap\LAMP1^{Scer\UAS.T:Avic\GFP-EGFP} proteins in the leading edge of invading tumour cells indicating impaired lysosomal degradation.

Expression of bsk^DN.Scer\UAS in Ras85D^V12.Scer\UAS, Scer\GAL4^{Scer\FRT.Act5C} /dor^C107 clones suppresses the enhanced tumour overgrowth and metastasis.

(Chi et al., 2010)

scrib¹ mutant eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU grow into large metastatic tumors. Wild type cells are almost completely absent from late Ras85D^V12.Scer\UAS scrib¹ tumors.

Eye-antennal disc clones that express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, and in which adjacent cells are mutant for scrib¹, develop into large tumors capable of invading the ventral nerve cord. In the late stages of tumor development most cells in the tumor mass are Ras85D^V12.Scer\UAS cells and scrib¹ cells and wild type cells are almost completely absent.

Eye-antennal disc clones that express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, and in which adjacent cells are mutant for l(2)gl^unspecified, develop into large tumors capable of invading the ventral nerve cord.

l(2)gl^unspecified mutant eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU grow into large metastatic tumors.

Expression of upd1^{dsRNA.Scer\UAS.cUa} partially suppresses the overgrowth and invasion of the nerve cord seen in l(2)gl^unspecified mutant eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU. The phenotype is further suppressed when the clones are generated in a upd2^Δ3-62 mutant background.

upd2^Δ3-62 does not suppress the overgrowth and invasion of the nerve cord seen in l(2)gl^unspecified mutant eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

Expression of dome^{ΔCYT.Scer\UAS} suppresses the overgrowth and invasion of the nerve cord seen in scrib¹ mutant eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

Expression of dome^{ΔCYT.Scer\UAS} in eye-antennal disc clones that express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, and in which adjacent cells are mutant for scrib¹, suppresses the overgrowth and invasion of the nerve cord.

Stat92E⁰⁶³⁴⁶ partially suppresses the overgrowth and invasion of the nerve cord seen in scrib¹ mutant eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

Stat92E⁰⁶³⁴⁶ in eye-antennal disc clones that express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, and in which adjacent cells are mutant for scrib¹, partially suppresses the overgrowth and completely abrogates the invasion of the nerve cord.

Eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS and upd1^Scer\UAS.cUa under the control of Scer\GAL4^Act.PU grow into large invasive tumors.

Eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS and upd2^Scer\UAS.cUa under the control of Scer\GAL4^Act.PU grow into large invasive tumors.

Eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS and upd3^Scer\UAS.cUa under the control of Scer\GAL4^Act.PU result in small non-invasive tumors.

Eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS, upd1^Scer\UAS.cUa and upd2^Scer\UAS.cUa under the control of Scer\GAL4^Act.PU grow into large invasive tumors that are larger than those seen when Ras85D^V12.Scer\UAS is co-expressed with either upd1^Scer\UAS.cUa or upd2^Scer\UAS.cUa alone.

Expression of dome^{ΔCYT.Scer\UAS} in eye-antennal disc clones that express Ras85D^V12.Scer\UAS and upd1^Scer\UAS.cUa under the control of Scer\GAL4^Act.PU suppresses the overgrowth and invasion of the nerve cord.

Expression of bsk^DN.Scer\UAS suppresses the tumors seen in scrib¹ mutant eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

Expression of bsk^DN.Scer\UAS does not suppress the tumors seen in eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS and upd1^Scer\UAS.cUa under the control of Scer\GAL4^Act.PU.

Expression of bsk^DN.Scer\UAS in eye-antennal disc clones that express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, and in which adjacent cells are mutant for scrib¹, partially suppresses the tumor phenotype. Few scrib¹ cells remain in the tissue at late stages.

(Wu et al., 2010)

Expression of Rab11^{S25N.Scer\UAS} suppresses the enlarged lamina seen in third instar larval eye discs when Ras85D^V12.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF.

(Yogev et al., 2010)

Hyperplasia in adult Malpighian tubule clones expressing Ras85D^V12.Scer\UAS (using the MARCM system, under the control of Scer\GAL80^αTub84B.PL and Scer\GAL4^{Scer\FRT.Act5C}) is not suppressed by making them also mutant for aPKC^k06403.

Hyperplasia in adult Malpighian tubule clones expressing Ras85D^V12.Scer\UAS (using the MARCM system, under the control of Scer\GAL80^αTub84B.PL and Scer\GAL4^{Scer\FRT.Act5C}) is suppressed by co-expression of phl^{K497M.Scer\UAS}.

Hyperplasia in adult Malpighian tubule clones expressing Ras85D^V12.Scer\UAS (using the MARCM system, under the control of Scer\GAL80^αTub84B.PL and Scer\GAL4^{Scer\FRT.Act5C}) is suppressed by making them also mutant for Pka-C1^B3.

(Zeng et al., 2010)

Co-expression of Raf^K497M.UAS with Ras85D^V12.UAS via Scer\GAL4^NP7397 results in a phenotype similar to that of Ras85D^V12.UAS overexpression alone.

Mkp3^UAS.cUa overexpression via Scer\GAL4^NP7397 significantly suppresses the adult progenitor cell overproliferation phenotype induced by Ras85D^V12.UAS in third instar larval midguts.

(Jiang and Edgar, 2009)

Expression of Ras85D^V12.Scer\UAS within drk^ΔP24/+ adult mushroom bodies (under the control of either Scer\GAL4^c747 or Scer\GAL4^c739) results in severe learning deficits.

(Moressis et al., 2009)

Ras85D^V12.Scer\UAS Pten¹¹⁷ double mutant clones generated under the control of Scer\GAL4^repo.PU are overgrown and invasive. Cells from mutant clones appear to invade the brain, typically following fibre tracts, and sometimes inducing the formation of trachea. Mutant cells often penetrate deep into the brain. Smaller clones are commonly seen that are composed of relatively differentiated, enlarged glia with diffusely invasive projections.

Ras85D^V12.Scer\UAS Pten¹¹⁷ double mutant optic lobe clones generated using eyFLP under the control of Scer\GAL4^repo.PU contain more excess glial cells than in either mutant alone. The clones are composed of 10s of glial cells in third instar larvae, becoming large invasive tumors composed of hundreds to thousands of cells in adults.

(Read et al., 2009)

The effects on wing shape and size in animals expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^MD-638 are partially rescued in a osa³⁰⁸/+ background, although these wings still show ectopic vein differentiation.

(Terriente-Félix and de Celis, 2009)

The wing notching that results from expressing Ras85D^V12.Scer\UAS along the wing margin using Scer\GAL4^vg.PU is partially suppressed by co-expression of pico^IR.Scer\UAS.

(Lyulcheva et al., 2008)

Excessive photoreceptor differentiation can occur in mop^T612 clones in the eye disc which are also expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^unspecified.

(Miura et al., 2008)

Co-expression of Tor^TED.Scer\UAS partially suppresses the salivary gland overgrowth phenotype that is seen in animals expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^fkh.PH and at 24 hours after puparium formation the salivary glands are predominantly degraded in the double mutant animals.

(Berry and Baehrecke, 2007)

Clones in the eye antennal disc which are expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C and are also homozygous for scrib¹ show invasive behaviour, invading the ventral nerve cord. These clones show degradation of the basement membrane.

Co-expression of bsk^DN.Scer\UAS suppresses the invasive behaviour of clones in the eye antennal disc which are expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C and are also homozygous for scrib¹.

The invasive behaviour of clones in the eye antennal disc which are expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C and are also homozygous for scrib¹ is partially suppressed in a Mmp1^Q273 homozygous background.

The invasive behaviour and degradation of the basement membrane of clones in the eye antennal disc which are expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C and are also homozygous for scrib¹ is suppressed if the clones are also co-expressing both Reck^Scer\UAS.cSa and Timp^Scer\UAS.cSa simultaneously.

(Srivastava et al., 2007)

dlg1¹⁴ mutant clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI exhibit invasive tumours.

Expression of Ras85D^V12.Scer\UAS in scrib¹ mutant clones results in massive and metastatic tumours. After 6 days the cells exhibit moderate tumour growth and ventral nerve cord invasion phenotypes. Co-expression of bsk^DN.Scer\UAS and Ras85D^V12.Scer\UAS in scrib¹ mutant clones completely blocks the invasion of the ventral nerve cord as well as secondary tumour foci formation.

The presence of an Akt1¹ mutant background considerably reduces the tumour load in scrib¹ mutant clones expressing Ras85D^V12.Scer\UAS (under the control of Scer\GAL4^Act5C.PI) using the FLP/FRT system but does not impair metastatic behaviour.

Overexpression of egr^Scer\UAS.cIa in Ras85D^V12.Scer\UAS mutants (both under the control of Scer\GAL4^Act5C.PI) using the FLP/FRT system in brain somatic clones results in accelerated tumour growth, despite nether expression of Ras85D^V12.Scer\UAS or egr^Scer\UAS.cIa alone causing dramatic overgrowth. These tumorigenic regions do not invade into the ventral nerve cord.

Expression of Traf4^{dsRNA.Scer\UAS} (under the control of Scer\GAL4^Act5C.PI) using the FLP/FRT system fails to suppress metastatic behaviour in l(2)gl⁴ mutants expressing Ras85D^V12.Scer\UAS.

Expression of Traf6^{dsRNA.Scer\UAS} (under the control of Scer\GAL4^Act5C.PI) using the FLP/FRT system strongly suppresses metastatic behaviour in l(2)gl⁴ mutants expressing Ras85D^V12.Scer\UAS.

Expression of Tak1^{dsRNA.Scer\UAS} (under the control of Scer\GAL4^Act5C.PI) using the FLP/FRT system strongly suppresses metastatic behaviour in l(2)gl⁴ mutants expressing Ras85D^V12.Scer\UAS.

Expression of hep^{dsRNA.Scer\UAS} (under the control of Scer\GAL4^Act5C.PI) using the FLP/FRT system strongly suppresses metastatic behaviour in l(2)gl⁴ mutants expressing Ras85D^V12.Scer\UAS.

Expression of wgn^{dsRNA.Scer\UAS} (under the control of Scer\GAL4^Act5C.PI) using the FLP/FRT system partially suppresses metastatic behaviour in l(2)gl⁴ mutants expressing Ras85D^V12.Scer\UAS.

Expression of Pvr^{dsRNA.Scer\UAS} (under the control of Scer\GAL4^Act5C.PI) using the FLP/FRT system does not suppress metastatic behaviour in l(2)gl⁴ mutants expressing Ras85D^V12.Scer\UAS.

shg^k03401 mutant larval brain cells expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI exhibit a weak invasive phenotype and can invade the ventral nerve cord (this phenotype occurs with 20% penetrance).

shg^k03401 mutant larval brain cells expressing both Ras85D^V12.Scer\UAS and egr^Scer\UAS.cIa under the control of Scer\GAL4^Act5C.PI generate into invasive tumours that can invade the ventral nerve cord (this phenotype occurs with 88% penetrance).

Expression of Ras85D^V12.Scer\UAS, egr^Scer\UAS.cIa and bsk^DN.Scer\UAS, under the control of Scer\GAL4^Act5C.PI in shg^k03401 mutant larval cephalic complexes (brain, eye and antennal discs) induces tumor invasion of the ventral nerve cord.

Overexpression of hep^CA.Scer\UAS in shg^k03401 mutant cephalic cells (i.e. cells in the larval brain and eye-antennal discs) expressing Ras85D^V12.Scer\UAS results in neither enhanced tumour growth nor metastatic behaviour.

(Igaki et al., 2006)

The roughened eye and increased rhabdomere phenotype seen when Ras85D^V12.Scer\UAS is expressed under the control of Scer\GAL4^hs.2sev is enhanced in a S6kII^D1/+ or S6kII^D1/Y background. These eye phenotypes are suppressed when either S6kII^{Scer\UAS.T:Hsap\MYC} or S6kII^{K231R.Scer\UAS.T:Hsap\MYC} is coexpressed with Ras85D^V12.Scer\UAS (all under the control of Scer\GAL4^hs.2sev).

(Kim et al., 2006)

Coexpression of CycE^Scer\UAS.cLa and Ras85D^V12.Scer\UAS, under the control of Scer\GAL4^en-e16E, in the posterior compartment cells of embryos, leads to a reduction in compartment size, similar to that seen when only Ras85D^V12.Scer\UAS is expressed, and cells are of a size similar to that seen when only CycE^Scer\UAS.cLa is expressed.

(Parker, 2006)

Mutant clones that express Ras85D^V12.Scer\UAS, under the control of Scer\GAL4^da.G32, in an ave^108V background show the ave^108V photoreceptor differentiation phenotype. The Scer\GAL4^da.G32>Ras85D^V12.Scer\UAS ectopic photoreceptor phenotype is therefore suppressed.

(Roignant et al., 2006)

Clones of eye/antennal imaginal disc cells that express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI and are also homozygous for scrib¹ show an enhancement of the tumorigenic phenotype seen in clones that are mutant for either scrib¹ or express Ras85D^V12.Scer\UAS. The Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ cells become invasive; at 6 days after egg laying, imaginal disc cells appear in the ventral nerve cord (VNC). At day 9, the invading cells obscure the eye/antennal discs, brain lobes, and the VNC so these anatomical structures are no longer distinguishable. The invading tumor cells are morphologically distinct and have a prominent actin cytoskeleton network typical of cells undergoing movement or shape change.

Animals bearing Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ clones progress normally through larval development but fail to pupate and die as third instar larvae and around day 13 AEL.

Expression of bsk^DN.Scer\UAS clones blocks the cell invasive phenotype of Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ eye/antennal imaginal disc clones. These clones still overgrow in the discs but never leave this structure. bsk^DN.Scer\UAS expression also rescues the larval lethality of Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ clone-bearing animals, with rescued animals progressing through most of metamorphosis and dying as pharate adults.

Expression of puc^Scer\UAS.cMa in Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ eye/antennal imaginal disc clones prevents the invasion cell phenotype but does not rescue the overgrowth of the eye/antennal imaginal disc clones. puc^Scer\UAS.cMa expression rescues the larval lethality of Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ clone-bearing animals and partially restores pupariation.

Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, Timp^Scer\UAS.cPa, scrib¹ eye/antennal disc clones produce a tumor mass larger than that seen in Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ disc clones. However, the tumor cell invasiveness observed in Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ clones is suppressed by expression of Timp^Scer\UAS.cPa.

Expression of either Mmp1^{dsRNA.Scer\UAS} or Mmp2^{dsRNA.Scer\UAS} in Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ eye/antennal imaginal disc clones significantly suppresses the cell invasiveness phenotype but does not suppress the formation of tumors within the disc. Coexpression of Mmp1^{dsRNA.Scer\UAS} and Mmp2^{dsRNA.Scer\UAS} further reduces the invasiveness of Scer\GAL4^Act5C.PI>Ras85D^V12.Scer\UAS, scrib¹ cells.

Coexpression of hep^Act.Scer\UAS and Ras85D^V12.Scer\UAS, under the control of Scer\GAL4^Act5C.PI, in eye/antennal imaginal disc clones results in migration of some disc cells to ectopic regions of the brain, although cell invasion is not efficient in this genotype. Coexpression of hep^Scer\UAS.cBa and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI results in these discs results in the invasion of the disc cells into the ventral nerve cord and regions of the brain.

(Uhlirova and Bohmann, 2006)

Ras85D^V12.Scer\UAS; Scer\GAL4^srp.Hemo suppresses the macrophage aggregation phenotype of stage 16 Pvr¹ homozygous embryos. However, these embryos have a mild deficiency of hemocytes in the ventral-posterior region and in the posterior end of the elongated germ band.

(Bruckner et al., 2004)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^sim.P3.7 reduces the penetrance of the loss of midline glia phenotype seen in homozygous jing³ embryos, so that only 11.3% of double mutant embryos have a reduced number of midline glial cells.

(Sonnenfeld et al., 2004)

Denticle belt fusions in the cuticles of rho^7M43; ru¹ double homozygous embryos are suppressed Ras85D^V12.Scer\UAS; Scer\GAL4^prd.RG1.

(Urban et al., 2004)

Scer\GAL4^αTub84B.PL-driven expression of Ras85D^V12.Scer\UAS in scrib¹ clones leads to massive overproliferation of the scrib¹ tissue, larval/pupal lethality.

The addition of E2f1⁹¹ or dap^{Scer\UAS.cdNa} suppresses the overproliferation phenotype seen in scrib¹, Ras85D^V12.Scer\UAS, Scer\GAL4^αTub84B.PL clones.

(Brumby and Richardson, 2003)

Ras85D^V12.Scer\UAS; Scer\GAL4^twi.2PE substantially suppresses the visceral mesoderm phenotype seen in stage 12 jeb^-c1 homozygous embryos.

(Lee et al., 2003)

Marked clones in the eye disc expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI and which are also homozygous

for scrib^unspecified show metastatic behaviour; third instar larvae

carrying these marked clones have large primary tumours in the head

and also have small groups of cells floating in the hemolymph and other

distant sites. The majority of ectopic tumour cells spread from the

primary tumour onto the ventral nerve cord (VNC), eventually enveloping

it and also spread into the first and second leg discs and tracheal

vasculature at a lower frequency. The mutant cells can invade the

inside of the VNC and the leading edge of the cells has a morphology

common to actively migrating cells.

The basement membrane has many points of discontinuity in eye discs

containing clones which are homozygous for scrib^unspecified and

which are expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI,

and mutant cells spread from these areas.

The basement membrane has many points of discontinuity in eye discs

containing clones which are homozygous for scrib¹ and which are

expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI,

and mutant cells spread from these areas.

The metastatic behaviour seen in marked clones in the eye disc which

are homozygous for scrib^unspecified and are also expressing Ras85D^V12.Scer\UAS

under the control of Scer\GAL4^Act5C.PI is suppressed if they are

co-expressing scrib^Scer\UAS.cBa.

Marked clones in the eye disc expressing Ras85D^V12.Scer\UAS under

the control of Scer\GAL4^Act5C.PI and which are also homozygous

for wts^unspecified result in immensely overgrown tumours in the

eye-antennal discs, but marked cells are never seen on the ventral

nerve cord or other locations in third instar larvae (indicating that

the mutant tumour cells do not show metastatic behaviour).

Marked clones in the eye disc expressing Ras85D^V12.Scer\UAS under

the control of Scer\GAL4^Act5C.PI and which are also homozygous

for scrib¹ show metastatic behaviour.

The metastatic behaviour seen in clones in the eye disc which are homozygous

for scrib¹ and are also expressing Ras85D^V12.Scer\UAS under

the control of Scer\GAL4^Act5C.PI is suppressed if they are co-expressing

shg^Scer\UAS.cOa but is not suppressed if they are co-expressing

argos::shg^{i.Scer\UAS.T:Hsap\MYC}.

Marked clones in the eye disc expressing Ras85D^V12.Scer\UAS under

the control of Scer\GAL4^Act5C.PI and which are also homozygous

for shg^unspecified do not show metastatic behaviour, although the

cells cause disc eversion defects during metamorphosis.

Marked clones in the eye disc expressing Ras85D^V12.Scer\UAS under

the control of Scer\GAL4^Act5C.PI and which are also homozygous

for one of baz⁴, sdt^N5, Cdc42¹, l(2)gl⁴ or dlg1¹⁴

show metastatic behaviour.

The metastatic behaviour seen in clones in the eye disc which are homozygous

for scrib¹ and are also expressing Ras85D^V12.Scer\UAS under

the control of Scer\GAL4^Act5C.PI is not suppressed if they are

co-expressing Hsap\CDKN1A^Scer\UAS.cHa; although the tumour size

is decreased, mutant cells can still spread into the ventral nerve

cord.

(Pagliarini and Xu, 2003)

Clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^αTub84B.PC usually do not stimulate the growth of vn^L6/vn^ddd-4 wing discs. A few discs do show a modest increase in size, but this rescue appears to be due to a cell-autonomous rescue of proliferation within the Ras85D^V12.Scer\UAS expressing clone.

(Zecca and Struhl, 2002)

Over 50% of flies expressing both Ras85D^V12.Scer\UAS and spen^ΔC.Scer\UAS under the control of Scer\GAL4^sli.PS are viable and appear to be normally patterned.

(Chen and Rebay, 2000)

Expression of stg^Scer\UAS.cNa under the control of Scer\GAL4^Act5C.PP in clones in the imaginal discs results in cells that have only slightly shorter doubling times than normal. Co-expression of both stg^Scer\UAS.cNa and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PP results in shorter doubling times and cells of normal size. Large G1 and small G2 cell populations are seen (as is seen when stg^Scer\UAS.cNa is expressed under the control of Scer\GAL4^Act5C.PP). The areas of clones co-expressing both stg^Scer\UAS.cNa and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PP are increased compared to controls (as is seen when Ras85D^V12.Scer\UAS is expressed under the control of Scer\GAL4^Act5C.PP). The inhibitory effect on cell cycle rates of Rbf^Scer\UAS.cDa expressed under the control of Scer\GAL4^Act5C.PP in clones in the imaginal discs is not suppressed by co-expression of Ras85D^V12.Scer\UAS. Co-expression of Rbf^Scer\UAS.cDa and Ras85D^V12.Scer\UAS has an additive effect on cell size.

(Prober and Edgar, 2000)

When expression is driven in stumps^09904b mutants by Scer\GAL4^btl.PS or by Scer\GAL4^hs.PB, many or all tracheal cells show erratic outgrowth of primary branches. These features are not normally seen in stumps^09904b mutants. When expression is driven by Scer\GAL4^twi.PG in stumps^09904b embryos, some random mesodermal migrations are restored.

(Imam et al., 1999)

Co-expression of Ras85D^V12.Scer\UAS and ovo^D1.Scer\UAS driven by Scer\GAL4^e22c or Scer\GAL4^69B suppresses the extra denticle phenotype seen by ubiquitous expression of Ras85D^V12.Scer\UAS alone.

(Payre et al., 1999)

Photoreceptor differentiation and growth is strongly rescued in flies expressing wg^Scer\UAS.cAa under the control of Scer\GAL4^ey.PH if they are also co-expressing Ras85D^V12.Scer\UAS. The ectopic photoreceptor formation seen in clones expressing Ras85D^V12.Scer\UAS in the eye disc under the control of Scer\GAL4^Act5C.PP is not prevented by coexpression of arm^{Δ.Scer\UAS.T:Ivir\HA1}. eyg¹/Df(3L)iro-2 hemizygous eye discs completely lack photoreceptors. Photoreceptor development in these discs is rescued by Ras85D^V12.Scer\UAS expressed under the control of Scer\GAL4^dpp.PH. The lack of photoreceptor phenotype of eya¹ eye discs is not rescued by Ras85D^V12.Scer\UAS expressed under the control of Scer\GAL4^ey.PH.

(Hazelett et al., 1998)

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^btl.PS in btl^LG19 or stumps^09904b mutant embryos partially rescues tracheal morphogenesis.

(Vincent et al., 1998)

Xenogenetic Interactions

Statement

Reference

Hsap\S100A4^wt.UAS enhances the tumorigenesis of whole eye-antennal disc clones expressing Ras85D^V12.UAS under the control of Scer\GAL4^Act5C.PI, leading to extensive metastasis to the VNC and other organs, particularly to the gut and gonads. In contrast, Hsap\S100A4^Δ2.UAS only results in a modest enhancement.

(Ismail et al., 2017)

Co-expression of Hsap\FOXO1A::Hsap\PAX7^Scer\UAS.cGa and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Mhc.PW results in disorganized larval musculature: the contours of many myofibres are vague and ill-defined. Collections of mononuclear cells are present (at the expense of syncitial myofiber tissue) at a significantly higher frequency than in larvae expressing Hsap\FOXO1A::Hsap\PAX7^Scer\UAS.cGa alone.

(Galindo et al., 2006)

Coexpression with BacA\p35^Scer\UAS.cHa greatly reduces cell death but animals still die as young adults with deletion of structures, presumably as a consequence of non-autonomous cell death. Scer\GAL4^dpp.blk1-mediated expression of one copy of Hsap\CDKN1A^Scer\UAS.cHa suppresses most, but not all, of Ras85D^V12.Scer\UAS-induced cell proliferation and hyperplastic growth seen in wing discs. The lethal phase is delayed but not suppressed. Coexpression with two copies of Hsap\CDKN1A^Scer\UAS.cHa results in the complete suppression of lethality associated with Ras85D expression. Morphologically, the wing is restored to its normal shape and size, although Hsap\CDKN1A^Scer\UAS.cHa only partially suppresses the extra wing vein material along L3. Larger wing cell size is completely suppressed.

(Karim and Rubin, 1998)

Complementation and Rescue Data

Rescues

Ras85D^V12.UAS, Scer\GAL80^ts.αTub84B, Scer\GAL4^αTub84B.PL rescues Ras85D^ΔC40B

(Sung et al., 2010)

Comments

Expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^αTub84B.PL in combination with Scer\GAL80^ts.αTub84B in eye disc clones rescues the ommatidial development defects of Ras85D^ΔC40B homozygous cells. Clones show hyper-recruitment of photoreceptors.

(Sung et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (8)

Bloomington

64196

w^*; P{UAS-Ras85D.V12}2

64195

w^*; P{UAS-Ras85D.V12}TL1

4847

w¹¹¹⁸; P{UAS-Ras85D.V12}TL1

64197

w^*; P{UAS-Ras85D.V12}TL1, P{attP.w⁺.attP}JB89B

82147

w^*; P{UAS-Ras85D.V12}2; M6^NC P{FRT.TX}79E/TM6B, Tb¹

82146

w^*; P{UAS-Ras85D.V12}2; M6^G152E P{FRT.TX}79E/TM6B, Tb¹

82148

w^*; P{UAS-Ras85D.V12}2; M6^W186stop P{FRT.TX}79E/TM6B, Tb¹

Kyoto

107906

w¹¹¹⁸; P{UAS-Ras85D.V12}TL1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

Ras1^V12

(Yang and Terman, 2012, Boettner et al., 2003, Ishimaru et al., 1999)

Ras85D^V12.Scer\UAS

Ras85D^V12.UAS

Ras85D^V12

(Azuma et al., 2021, Gaengel and Mlodzik, 2003)

Ras^V12

(Amcheslavsky et al., 2018, Arefin et al., 2017, Figueroa-Clarevega and Bilder, 2015, Wang et al., 2015, Jiang et al., 2011, Srivastava et al., 2007, Tseng et al., 2007, Brown et al., 2006)

Ras^V12(1)

(Nászai et al., 2021)

Ras^V12(2)

(Nászai et al., 2021)

UAS.Dras^V12

(Szuts et al., 1998)

ras1^val12

(Frankfort and Mardon, 2004)

ras^V12

(Külshammer et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (283)

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