Allele Dmel\Klp64Dⁿ¹²³

General Information
Symbol	Dmel\Klp64Dⁿ¹²³	Species	D. melanogaster
Name		FlyBase ID	FBal0060615
Feature type	allele	Associated gene	Dmel\Klp64D

Allele class
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity (Perez and Steller, 1996)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{PZ}A8 (Perez and Steller, 1996)
Nature of the lesion	Statement Reference Imprecise excision of the P-element insertion resulting in a deletion. (Perez and Steller, 1996)
Cytology
Phenotypic Data
Phenotypic Class
	lethal (Perez and Steller, 1996) lethal \| recessive (Ray et al., 1999)
Phenotype Manifest In
	Johnston's organ & scolopidial cilium (with Klp64D^k1) (Sarpal et al., 2003) scolopidial cilium (with Klp64D^k1) (Han et al., 2003)
Detailed Description
	Statement Reference Klp64D^k1/Klp64Dⁿ¹²³ mutants lack cilia in the chordotonal organs. (Han et al., 2003) In Klp64D^k1/Klp64Dⁿ¹²³ mutant animals, the sensory cilia from Johnston's organ are absent, but inner-dendritic segment and desmosomal junctions appear normal. (Sarpal et al., 2003)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Klp64D^k1/Klp64Dⁿ¹²³ has lethal phenotype, suppressible by Mmus\Kif3a^Scer\UAS.cRa/Scer\GAL4^elav.PLu (Ray et al., 1999)
Other
Statement Reference Klp64D^k1/Klp64Dⁿ¹²³, Mmus\Kif3a^Scer\UAS.cRa, Scer\GAL4^elav.PLu has viable phenotype (Ray et al., 1999)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference The lethality of Klp64D^k1/Klp64Dⁿ¹²³ flies is completely rescued by Mmus\Kif3a^Scer\UAS.cRa expressed under the control of Scer\GAL4^elav.PLu. (Ray et al., 1999)
Complementation & Rescue Data
Fails to complement	Klp64D^k1 (Ray et al., 1999) Klp64D^k5 (Ray et al., 1999) Klp64D^k33 (Ray et al., 1999)
Rescued by	Klp64D^k1/Klp64Dⁿ¹²³ is rescued by Scer\GAL4[-]/Klp64D^Scer\UAS.cRa (Ray et al., 1999) Klp64D^k5/Klp64Dⁿ¹²³ is rescued by Scer\GAL4[-]/Klp64D^Scer\UAS.cRa (Ray et al., 1999)
Comments	Klp64D^Scer\UAS.cRa rescues the lethality and uncoordinated behaviour of Klp64D^k1 and Klp64D^k5, in transheterozygous combination with Klp64Dⁿ¹²³, in the absence of a Scer\GAL4 driver. (Ray et al., 1999)
Stocks ( 2 )
Bloomington	5674 y¹ w¹; Klp64Dⁿ¹²³/TM3, y⁺ Ser¹
Kyoto	108354 y¹ w¹; Klp64Dⁿ¹²³/TM3, y⁺ Ser¹
Notes on Origin
Discoverer

Comments
	Complements: sinu⁰⁶⁵²⁴. (Beitel and Krasnow, 2000)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Df(3L)Klp64D^A8.n123 (Ray et al., 1999) Klp64D^A8.n123 (Sarpal et al., 2003) KLP64D^A8N123 (Beitel and Krasnow, 2000) Klp64Dⁿ¹²³ (Lee et al., 2008) unnamed (Perez and Steller, 1996)
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Han et al., 2003, Curr. Biol. 13(19): 1679--1686 Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm. [FBrf0167401] Sarpal et al., 2003, Curr. Biol. 13(19): 1687--1696 Drosophila KAP interacts with the kinesin II motor subunit KLP64D to assemble chordotonal sensory cilia, but not sperm tails. [FBrf0167402] Beitel and Krasnow, 2000, Development 127(15): 3271--3282 Genetic control of epithelial tube size in the Drosophila tracheal system. [FBrf0128394] Ray et al., 1999, J. Cell Biol. 147(3): 507--518 Kinesin-II is required for axonal transport of choline acetyltransferase in Drosophila. [FBrf0112015] Perez and Steller, 1996, Mech. Dev. 59(1): 11--27 Molecular and genetic analyses of lama, an evolutionarily conserved gene expressed in the precursors of the Drosophila first optic ganglion. [FBrf0090738]
Supplementary material	Lee et al., 2008, Curr. Biol. 18(24): Supplemental Data. [FBrf0207609]

Allele Dmel\Klp64Dn123

Allele Dmel\Klp64Dⁿ¹²³