FlyBase Allele Report: Dmel\Klp64D[n123]

General Information

Symbol

Dmel\Klp64Dⁿ¹²³

Species

D. melanogaster

Name

FlyBase ID

FBal0060615

Feature type

allele

Associated gene

Dmel\Klp64D

Associated Insertion(s)

Carried in Construct

Also Known As

Klp64D^A8.n123

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Perez and Steller, 1996)

Progenitor genotype

P{PZ}A8

(Perez and Steller, 1996)

Cytology

Description

Imprecise excision of the P-element insertion resulting in a deletion.

(Perez and Steller, 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Perez and Steller, 1996)

lethal | recessive

(Ray et al., 1999)

Phenotype Manifest In

Johnston's organ & scolopidial cilium (with Klp64D^k1)

(Sarpal et al., 2003)

scolopidial cilium (with Klp64D^k1)

(Han et al., 2003)

Detailed Description

Statement

Reference

Klp64D^k1/Klp64Dⁿ¹²³ mutants lack cilia in the chordotonal organs.

(Han et al., 2003)

In Klp64D^k1/Klp64Dⁿ¹²³ mutant animals, the sensory cilia from Johnston's organ are absent, but inner-dendritic segment and desmosomal junctions appear normal.

(Sarpal et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Klp64D^k1/Klp64Dⁿ¹²³ has lethal phenotype, suppressible by Mmus\Kif3a^UAS.cRa/Scer\GAL4^elav.PLu

(Ray et al., 1999)

Other

Statement

Reference

Klp64D^k1/Klp64Dⁿ¹²³, Mmus\Kif3a^UAS.cRa, Scer\GAL4^elav.PLu has viable phenotype

(Ray et al., 1999)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The lethality of Klp64D^k1/Klp64Dⁿ¹²³ flies is completely rescued by Mmus\Kif3a^Scer\UAS.cRa expressed under the control of Scer\GAL4^elav.PLu.

(Ray et al., 1999)

Complementation and Rescue Data

Fails to complement

Klp64D^k1

(Ray et al., 1999)

Klp64D^k33

(Ray et al., 1999)

Klp64D^k5

(Ray et al., 1999)

Rescued by

Klp64D^k1/Klp64Dⁿ¹²³ is rescued by Klp64D^UAS.cRa

(Ray et al., 1999)

Klp64D^k5/Klp64Dⁿ¹²³ is rescued by Klp64D^UAS.cRa

(Ray et al., 1999)

Comments

Klp64D^Scer\UAS.cRa rescues the lethality and uncoordinated behaviour of Klp64D^k1 and Klp64D^k5, in transheterozygous combination with Klp64Dⁿ¹²³, in the absence of a Scer\GAL4 driver.

(Ray et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

5674

y¹ w¹; Klp64Dⁿ¹²³/TM3, y⁺ Ser¹

Kyoto

108354

y¹ w¹; Klp64Dⁿ¹²³/TM3, y⁺ Ser¹

Notes on Origin