FB2021_02, released April 13, 2021

Allele: Hsap\RAF1Δ305.hs

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General Information
Symbol
Hsap\RAF1Δ305.hs
Species
H. sapiens
Name
FlyBase ID
FBal0060649
Feature type
allele
Associated gene
Hsap\RAF1
Associated Insertion(s)
Carried in Construct
P{ΔH-raf}
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct
(Casanova et al., 1994)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{ΔH-raf}
      Cytology
      Nature of the lesion
      Statement
      Reference

      Deletion of the first 305 amino acids of the wild-type protein, removing the amino terminal regulatory domain. Expression is driven by an Hsp70 promoter.

      (Casanova et al., 1994)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      Hsp70
      Encoded product / tool
      Hsap\RAF1
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heat induced expression in wild-type embryos during early embryogenesis (prior to the onset of gastrulation) gives rise to first instar larvae that show partial deletion of several abdominal and thoracic segments.

      (Casanova et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      Hsap\RAF1Δ305.hs, torrv66 has abdomen phenotype

      (Casanova et al., 1994)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Heat induced expression in torrv66 embryos deletes the middle body segments, 5-20% embryos also show terminal structures.

      (Casanova et al., 1994)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsap\RAF1Δ305.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (1)