FB2025_01 , released February 20, 2025
Allele: Dmel\kayFbz.UAS
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General Information
Symbol
Dmel\kayFbz.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0060700
Feature type
allele
Associated gene
Dmel\kay
Associated Insertion(s)
Carried in Construct
P{UAS-Fra.Fbz}
Also Known As
UAS-fosDN, UAS-Fbz, UAS-kayDN, UAS-Fos-DN, UAS-fosDN, UAS-dFosDN
Key Links
Transgenic product class
dominant_negative_variant
(Eresh et al., 1997)
inframe_deletion
(Eresh et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Eresh et al., 1997)
inframe_deletion
(Eresh et al., 1997)
Mutagen
in vitro construct
(Eresh et al., 1997)
Progenitor genotype
Carried in construct
P{UAS-Fra.Fbz}
Cytology
Description

UASt regulatory sequences drive expression of amino acids 252-337 (the bZIP region) of kay.

(Eresh et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
kay
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  nervous system disease
      modeled by unc-104P350, unc-104bris
      (Li et al., 2017)
      ameliorates  fragile X syndrome
      modeled by Fmr1Δ50M
      (Russo and DiAntonio, 2019)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      adult midgut progenitor cell, with Scer\GAL448Y

      (Riese et al., 1997)

      adult thorax, with Scer\GAL4pnr-MD237

      (Mok and Choi, 2021)

      anterior crossvein, with Scer\GAL4dpp.blk1

      (Ciapponi et al., 2001)

      anterior crossvein, with Scer\GAL4en-e16E

      (Ciapponi et al., 2001)

      axon, with Scer\GAL4ey-OK107

      (Rallis et al., 2010)

      bouton, with Scer\GAL4BG380

      (Collins et al., 2006)

      bouton, with Scer\GAL4elav-C155

      (Sanyal et al., 2002)

      copper cell, with Scer\GAL448Y

      (Riese et al., 1997)

      copper cell, with Scer\GAL4hs.PB

      (Riese et al., 1997)

      copper cell, with Scer\GAL4unspecified

      (Eresh et al., 1997)

      dendrite | somatic clone, with Scer\FLP1UAS.cUa, Scer\GAL4Act.PU, Scer\GAL4eve.RRK

      (Hartwig et al., 2008)

      embryonic/larval plasmatocyte | embryonic stage, with Scer\GAL4srp.Hemo

      (Belyaeva et al., 2022)

      eye, with Scer\GAL4ey.3.5.Exel

      (Franciscovich et al., 2008)

      eye, with Scer\GAL4h-1J3

      (Ciapponi et al., 2001)

      eye, with Scer\GAL4hs.2sev

      (Ciapponi et al., 2001)

      eye, with Scer\GAL4unspecified

      (Eresh et al., 1997)

      eye photoreceptor cell, with Scer\GAL4h-1J3

      (Ciapponi et al., 2001)

      eye photoreceptor cell, with Scer\GAL4hs.2sev

      (Ciapponi et al., 2001)

      filamentous actin | embryonic stage, with Scer\GAL4srp.Hemo

      (Belyaeva et al., 2022)

      germ band, with Scer\GAL4srp.Hemo

      (Belyaeva et al., 2022)

      Kenyon cell, with Scer\GAL4ey-OK107

      (Rallis et al., 2010)

      larval RP2 motor neuron | somatic clone, with Scer\FLP1UAS.cUa, Scer\GAL4Act.PU, Scer\GAL4eve.RRK

      (Hartwig et al., 2008)

      larval segmental nerve | conditional, with Scer\GAL4tey-5053A

      (Xiong et al., 2010)

      midgut interstitial cell, with Scer\GAL448Y

      (Riese et al., 1997)

      motor neuron, with Scer\GAL4futsch-C380, Scer\GAL80ChAT.3.3P

      (Hartwig et al., 2008)

      neuromuscular junction, with Scer\GAL4BG380

      (Collins et al., 2006)

      neuromuscular junction | larval stage, with Scer\GAL4elav-C155

      (Sanyal et al., 2002)

      ommatidium, with Scer\GAL4h-1J3

      (Ciapponi et al., 2001)

      ommatidium, with Scer\GAL4hs.2sev

      (Ciapponi et al., 2001)

      synapse, with Scer\GAL4elav-C155

      (Franciscovich et al., 2008)

      terminal bouton, with Scer\GAL4elav-C155

      (Franciscovich et al., 2008)

      wing, with Scer\GAL4bbg-C96

      (Mok and Choi, 2021)

      wing vein, with Scer\GAL4en-e16E

      (Ciapponi et al., 2001)

      wing vein, with Scer\GAL4sd-SG29.1, kay1

      (Ciapponi et al., 2001)

      wing vein L2, with Scer\GAL4sd-SG29.1

      (Ciapponi et al., 2001)

      wing vein L3, with Scer\GAL4dpp.blk1, kay1

      (Ciapponi et al., 2001)

      wing vein L4, with Scer\GAL4sd-SG29.1

      (Ciapponi et al., 2001)

      wing vein L5, with Scer\GAL4en-e16E

      (Ciapponi et al., 2001)

      wing vein L5, with Scer\GAL4en-e16E, kay1

      (Ciapponi et al., 2001)

      wing vein L5, with Scer\GAL4sd-SG29.1

      (Ciapponi et al., 2001)
      Detailed Description
      Statement
      Reference

      The expression of kayFbz.UAS under the control of Scer\GAL4bbg-C96 (and Dicer-2 for a more efficient RNAi) induces notches along the wing margin.

      The expression of kayFbz.UAS under the control of Scer\GAL4pnr-MD237 leads to a thorax cleft phenotype.

      (Mok and Choi, 2021)

      Expressing kayFbz.UAS under the control of Scer\GAL4tey-5053A (together with Dicer-2, for efficient RNAI) does not provide protection against (injury-induced) Wallerian degeneration of third instar larval motoneurons.

      (Hao et al., 2019)

      Overexpression of kayFbz.Scer\UAS in combination with Scer\GAL4Scer\UAS.cHa driven by Scer\GAL4Tab2-201Y does not affect axon pruning.

      (Bornstein et al., 2015)

      Neuronal expression of kayFbz.Scer\UAS under the control of Scer\GAL4RapGAP1-OK6 or Scer\GAL4nSyb.PS does not affect neuromuscular junction growth in a wild-type genetic background.

      (West et al., 2015)

      ddaC neurons show robust dendrite regeneration after dendrite removal in animals expressing kayFbz.Scer\UAS under the control of Scer\GAL4477.

      ddaE neurons show robust dendrite regeneration after dendrite removal in animals expressing kayFbz.Scer\UAS under the control of Scer\GAL4221.

      (Stone et al., 2014)

      Expression of kayFbz.Scer\UAS under the control of Scer\GAL4BG380 has no effect on maximum bouton diameter at the larval neuromuscular junction.

      (Klinedinst et al., 2013)

      Expression of 2 copies of kayFbz.Scer\UAS using Scer\GAL4ey-OK107 results in axon overextension.

      (Rallis et al., 2010)

      Axonal sprouting of the injured axon after a crush injury to the segmental nerve in third instar larvae is significantly inhibited in animals expressing kayFbz.Scer\UAS under the control of Scer\GAL4tey-5053A.

      (Xiong et al., 2010)

      Expression of kayFbz.Scer\UAS in the eye disc using Scer\GAL4ey.3.5.Exel generates a small eye phenotype.

      Expression of kayFbz.Scer\UAS in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155 results in synapses that are approximately 67-69% of the size of control synapses (measured by the number of synaptic boutons).

      Expression of kayFbz.Scer\UAS in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155 reduces transmitter release.

      (Franciscovich et al., 2008)

      Expression of kayFbz.Scer\UAS in the RP2 motor neurons (using the Scer\GAL4eve.RRK driver to drive expression of Scer\FLP1Scer\UAS.cUa which then induces clones of cells expressing Scer\GAL4Act.PU) results in a significant decrease in RP2 dendrite volume compared to controls.

      Cultured motor neurons expressing kayFbz.Scer\UAS under the control of Scer\GAL4futsch-C380 (in the presence of Scer\GAL80Cha.PK to suppress expression in cholinergic neurons) show a significant decrease in both neurite length and branch number compared to controls.

      (Hartwig et al., 2008)

      Expression of kayFbz.Scer\UAS, under the control of Scer\GAL4BG380 reduces the bouton number and branching and increasing the intensity of staining for synaptic vesicle markers at the synapse, compared to wild-type.

      (Collins et al., 2006)

      Expression of kayFbz.Scer\UAS under the control of Scer\GAL4elav-C155 results in an approximately 30% reduction in EJC amplitude (synaptic strength) and bouton number at the larval neuromuscular junction. mEJC amplitude is not significantly altered.

      (Sanyal et al., 2002)

      When kayFbz.Scer\UAS is driven by Scer\GAL4dpp.blk1 loss of the anterior crossvein in the wing is seen. When driven by Scer\GAL4en-e16E loss of the anterior crossvein and partial loss of the longitudinal vein V is seen. When driven by Scer\GAL4sd-SG29.1 longitudinal vein V and parts of veins II and IV are missing. When kayFbz.Scer\UAS is expressed under the control of Scer\GAL4dpp.blk1 in a kay1 heterozygote, there is an almost complete loss of longitudinal vein III. When kayFbz.Scer\UAS is expressed under the control of Scer\GAL4en-e16E in a kay1 heterozygote a more complete loss of longitudinal vein V is seen. When kayFbz.Scer\UAS is expressed under the control of Scer\GAL4sd-SG29.1 in a kay1 heterozygote all wing vein is strongly reduced. When kayFbz.Scer\UAS is driven by Scer\GAL4h-1J3 or Scer\GAL4hs.2sev, eyes lack photoreceptor cells and have misoriented ommatidia.

      (Ciapponi et al., 2001)

      Scer\GAL4-mediated expression in the eye imaginal disc interferes with proper eye development. Expression in the embryonic endoderm interferes with copper cell development.

      (Eresh et al., 1997)

      When expression is driven by Scer\GAL448Y the number of copper cells is strikingly (though variably) reduced. In 5% of the larave copper cells were missing all together. Interstitial cells are reduced in number, and large flat cells increased in number. When expression is driven by Scer\GAL4hs.PB, with heat shocks at the second larval stage, numbers of copper cells are greatly reduced, or completely suppressed.

      (Riese et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      NOT Enhanced by
      Suppressed by
      NOT suppressed by
      Enhancer of
      Suppressor of
      Statement
      Reference

      Scer\GAL4tey-5053A/kayFbz.UAS is a suppressor of abnormal neuroanatomy | larval stage phenotype of Scer\GAL4tey-5053A, rawKK104042

      (Waller and Collins, 2023)

      Scer\GAL4Toll-6-D42/kayFbz.UAS is a suppressor of abnormal neuroanatomy | larval stage phenotype of Scer\GAL4Toll-6-D42, rawKK104042

      (Waller and Collins, 2023)

      kayFbz.UAS, Scer\GAL4Toll-6-D42 is a suppressor of abnormal neuroanatomy | larval stage phenotype of SarmEP3610, Scer\GAL4Toll-6-D42

      (Waller and Collins, 2023)

      Scer\GAL4tey-5053A/kayFbz.UAS is a suppressor | partially of abnormal neuroanatomy | recessive | third instar larval stage | conditional phenotype of rawdcp-1

      (Hao et al., 2019)

      Scer\GAL4Toll-6-D42/kayFbz.UAS is a suppressor of abnormal neuroanatomy | larval stage phenotype of Eaat1hypo

      (Peng et al., 2019)

      Scer\GAL4Toll-6-D42/kayFbz.UAS is a suppressor | partially of abnormal neurophysiology | larval stage phenotype of Eaat1hypo

      (Peng et al., 2019)

      Scer\GAL4elav.PU/kayFbz.UAS is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Fmr1Δ50M

      (Russo and DiAntonio, 2019)

      Scer\GAL4ptc-559.1/kayFbz.UAS is a suppressor | partially of abnormal cell migration | third instar larval stage phenotype of Scer\GAL4ptc-559.1, pucGD1515

      (Zhang et al., 2019)

      kayFbz.UAS, Scer\GAL4rn-GAL4-5 is a suppressor of visible | adult stage phenotype of CtBP334Δ4, Scer\GAL4rn-GAL4-5, egrUAS.cUa

      (Worley et al., 2018)

      Scer\GAL4rn-GAL4-5/kayFbz.UAS is a suppressor | partially of increased cell death | third instar larval stage phenotype of Scer\GAL4rn-GAL4-5, egrUAS.cUa

      (Worley et al., 2018)

      Scer\GAL4RapGAP1-OK6/kayFbz.UAS is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Rab81/Rab8B229

      (West et al., 2015)

      Scer\GAL4nSyb.PS/kayFbz.UAS is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Rab81/Rab8B229

      (West et al., 2015)

      Scer\GAL4Su(H).GBE/kayFbz.UAS is a suppressor | partially of neoplasia phenotype of Sox21a6

      (Zhai et al., 2015)

      Scer\GAL4elav.PU/kayFbz.UAS is a suppressor | partially of abnormal neuroanatomy | maternal effect | larval stage phenotype of SkpAGD65

      (Brace et al., 2014)

      Scer\GAL4elav.PU/kayFbz.UAS is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of shotVV/shot3

      (Valakh et al., 2013)

      Scer\GAL4unspecified/kayFbz.UAS is a suppressor of abnormal neuroanatomy | larval stage phenotype of SERCAKum170, comt6

      (Freeman et al., 2010)

      Scer\GAL4unspecified/kayFbz.UAS is a suppressor of abnormal neurophysiology | larval stage phenotype of SERCAKum170, comt6

      (Freeman et al., 2010)

      kayFbz.UAS, Scer\GAL4unspecified is a suppressor of abnormal neuroanatomy | larval stage phenotype of Ras85DV12.S35.UAS, Scer\GAL4unspecified

      (Freeman et al., 2010)

      kayFbz.UAS, Scer\GAL4unspecified is a suppressor of abnormal neurophysiology | larval stage phenotype of Ras85DV12.S35.UAS, Scer\GAL4unspecified

      (Freeman et al., 2010)
      NOT Suppressor of
      Other
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Scer\GAL4bbg-C96, kayFbz.UAS has wing phenotype, enhanceable by Mnat9UAS.ORF.GW.Tag:HA, Scer\GAL4bbg-C96

      (Mok and Choi, 2021)

      Scer\GAL4pnr-MD237, kayFbz.UAS has adult thorax phenotype, enhanceable by Mnat9UAS.ORF.GW.Tag:HA, Scer\GAL4pnr-MD237

      (Mok and Choi, 2021)

      Scer\GAL4ey.3.5.Exel, kayFbz.UAS has eye phenotype, enhanceable by Sema2aEY08184/Scer\GAL4ey.3.5.Exel

      (Franciscovich et al., 2008)

      Scer\GAL4ey.3.5.Exel, kayFbz.UAS has eye phenotype, enhanceable by Scer\GAL4ey.3.5.Exel/cnkEY06675

      (Franciscovich et al., 2008)

      Scer\GAL4ey.3.5.Exel, kayFbz.UAS has eye phenotype, enhanceable by Pde8EY10143, Scer\GAL4ey.3.5.Exel

      (Franciscovich et al., 2008)

      Scer\GAL4ey.3.5.Exel, kayFbz.UAS has eye phenotype, enhanceable by Fkbp14EY02405, Scer\GAL4ey.3.5.Exel

      (Franciscovich et al., 2008)

      Scer\GAL4ey.3.5.Exel, kayFbz.UAS has eye phenotype, enhanceable by styEY11239/Scer\GAL4ey.3.5.Exel

      (Franciscovich et al., 2008)

      Scer\GAL4ey.3.5.Exel, kayFbz.UAS has eye phenotype, enhanceable by Scer\GAL4ey.3.5.Exel/pigeonEY06835

      (Franciscovich et al., 2008)

      Scer\GAL4elav-C155, kayFbz.UAS has synapse phenotype, enhanceable by Scer\GAL4elav-C155/cnkEY06675

      (Franciscovich et al., 2008)

      Scer\GAL4elav-C155, kayFbz.UAS has synapse phenotype, enhanceable by Fkbp14EY02405, Scer\GAL4elav-C155

      (Franciscovich et al., 2008)

      Scer\GAL4elav-C155, kayFbz.UAS has synapse phenotype, enhanceable by Pde8EY10143, Scer\GAL4elav-C155

      (Franciscovich et al., 2008)

      Scer\GAL4elav-C155, kayFbz.UAS has synapse phenotype, enhanceable by Scer\GAL4elav-C155/sggEY02862

      (Franciscovich et al., 2008)

      Scer\GAL4ey.3.5.Exel, kayFbz.UAS has eye phenotype, enhanceable by Cnx99AEP3522, Scer\GAL4ey.3.5.Exel

      (Franciscovich et al., 2008)

      Scer\GAL4ey.3.5.Exel, kayFbz.UAS has eye phenotype, enhanceable by SdcEY04602/Scer\GAL4ey.3.5.Exel

      (Franciscovich et al., 2008)
      NOT Enhanced by
      Suppressed by
      Statement
      Reference

      Scer\GAL4srp.Hemo, kayFbz.UAS has embryonic/larval plasmatocyte | embryonic stage phenotype, suppressible by diaΔDad.UASp.EGFP/Scer\GAL4srp.Hemo

      (Belyaeva et al., 2022)

      Scer\GAL4srp.Hemo, kayFbz.UAS has germ band phenotype, suppressible by diaΔDad.UASp.EGFP/Scer\GAL4srp.Hemo

      (Belyaeva et al., 2022)

      Scer\GAL4srp.Hemo, kayFbz.UAS has embryonic/larval plasmatocyte | embryonic stage phenotype, suppressible by diaHMS00308/LamGD1478, Scer\GAL4srp.Hemo

      (Belyaeva et al., 2022)

      Scer\GAL4srp.Hemo, kayFbz.UAS has embryonic/larval plasmatocyte | embryonic stage phenotype, suppressible by diaHMS00308/LamKK102399, Scer\GAL4srp.Hemo

      (Belyaeva et al., 2022)

      Scer\GAL4srp.Hemo, kayFbz.UAS has embryonic/larval plasmatocyte | embryonic stage phenotype, suppressible by LamCJF01406/diaHMS00308, Scer\GAL4srp.Hemo

      (Belyaeva et al., 2022)

      Scer\GAL4srp.Hemo, kayFbz.UAS has embryonic/larval plasmatocyte | embryonic stage phenotype, suppressible by TM4SFUAS.cBa/Scer\GAL4srp.Hemo

      (Belyaeva et al., 2022)

      Scer\GAL4srp.Hemo, kayFbz.UAS has germ band phenotype, suppressible by TM4SFUAS.cBa/Scer\GAL4srp.Hemo

      (Belyaeva et al., 2022)

      Scer\GAL4srp.Hemo, kayFbz.UAS has germ band phenotype, suppressible by diaHMS00308/LamGD1478, Scer\GAL4srp.Hemo

      (Belyaeva et al., 2022)

      Scer\GAL4srp.Hemo, kayFbz.UAS has germ band phenotype, suppressible by diaHMS00308/LamKK102399, Scer\GAL4srp.Hemo

      (Belyaeva et al., 2022)

      Scer\GAL4srp.Hemo, kayFbz.UAS has germ band phenotype, suppressible by LamCJF01406/diaHMS00308, Scer\GAL4srp.Hemo

      (Belyaeva et al., 2022)

      Scer\GAL4ey.3.5.Exel, kayFbz.UAS has eye phenotype, suppressible by Scer\GAL4ey.3.5.Exel/pigeonEY06835

      (Franciscovich et al., 2008)

      Scer\GAL4ey.3.5.Exel, kayFbz.UAS has eye phenotype, suppressible by lbmEY02692/Scer\GAL4ey.3.5.Exel

      (Franciscovich et al., 2008)

      Scer\GAL4ey.3.5.Exel, kayFbz.UAS has eye phenotype, suppressible by Pvf1EP1624, Scer\GAL4ey.3.5.Exel

      (Franciscovich et al., 2008)

      Scer\GAL4ey.3.5.Exel, kayFbz.UAS has eye phenotype, suppressible by MbsEP3727, Scer\GAL4ey.3.5.Exel

      (Franciscovich et al., 2008)

      Scer\GAL4ey.3.5.Exel, kayFbz.UAS has eye phenotype, suppressible by Scer\GAL4ey.3.5.Exel/spagEY11196

      (Franciscovich et al., 2008)

      Scer\GAL4ey.3.5.Exel, kayFbz.UAS, kayUAS.cEa has eye phenotype, suppressible by JraUAS.cEa, Scer\GAL4ey.3.5.Exel

      (Franciscovich et al., 2008)

      Scer\GAL4elav-C155, kayFbz.UAS has synapse phenotype, suppressible | partially by Scer\GAL4elav-C155/pigeonEY06835

      (Franciscovich et al., 2008)

      Scer\GAL4elav-C155, kayFbz.UAS has synapse phenotype, suppressible | partially by Scer\GAL4elav-C155/lbmEY02692

      (Franciscovich et al., 2008)

      Scer\GAL4elav-C155, kayFbz.UAS has synapse phenotype, suppressible | partially by Cnx99AEP3522, Scer\GAL4elav-C155

      (Franciscovich et al., 2008)

      Scer\GAL4elav-C155, kayFbz.UAS has synapse phenotype, suppressible | partially by styEY11239/Scer\GAL4elav-C155

      (Franciscovich et al., 2008)

      JraUAS.cEa, Scer\GAL4ey.3.5.Exel, kayFbz.UAS has eye phenotype, suppressible by kayUAS.cEa, Scer\GAL4ey.3.5.Exel

      (Franciscovich et al., 2008)

      JraUAS.cEa, Scer\GAL4elav-C155, kayFbz.UAS has synapse phenotype, suppressible by cnkEY06675, Scer\GAL4elav-C155

      (Franciscovich et al., 2008)

      JraUAS.cEa, Scer\GAL4elav-C155, kayFbz.UAS has synapse phenotype, suppressible by Fkbp14EY02405, Scer\GAL4elav-C155

      (Franciscovich et al., 2008)

      JraUAS.cEa, Scer\GAL4elav-C155, kayFbz.UAS has synapse phenotype, suppressible by Pde8EY10143, Scer\GAL4elav-C155

      (Franciscovich et al., 2008)

      JraUAS.cEa, Scer\GAL4elav-C155, kayFbz.UAS has synapse phenotype, suppressible by sggEY02862, Scer\GAL4elav-C155

      (Franciscovich et al., 2008)

      JraUAS.cEa, Scer\GAL4elav-C155, kayFbz.UAS has synapse phenotype, suppressible by SdcEY04602, Scer\GAL4elav-C155

      (Franciscovich et al., 2008)
      NOT suppressed by
      Enhancer of
      Suppressor of
      Statement
      Reference

      Scer\GAL4tey-5053A/kayFbz.UAS is a suppressor of distal axon | larval stage phenotype of Scer\GAL4tey-5053A, rawKK104042

      (Waller and Collins, 2023)

      Scer\GAL4tey-5053A/kayFbz.UAS is a suppressor of embryonic/larval motor neuron | larval stage phenotype of Scer\GAL4tey-5053A, rawKK104042

      (Waller and Collins, 2023)

      Scer\GAL4Toll-6-D42/kayFbz.UAS is a suppressor of embryonic/larval neuromuscular junction | larval stage phenotype of Scer\GAL4Toll-6-D42, rawKK104042

      (Waller and Collins, 2023)

      Scer\GAL4Toll-6-D42/kayFbz.UAS is a suppressor of embryonic/larval motor neuron | larval stage phenotype of Scer\GAL4Toll-6-D42, rawKK104042

      (Waller and Collins, 2023)

      kayFbz.UAS, Scer\GAL4Toll-6-D42 is a suppressor of embryonic/larval neuromuscular junction | larval stage phenotype of SarmEP3610, Scer\GAL4Toll-6-D42

      (Waller and Collins, 2023)

      kayFbz.UAS, Scer\GAL4Toll-6-D42 is a suppressor of embryonic/larval motor neuron | larval stage phenotype of SarmEP3610, Scer\GAL4Toll-6-D42

      (Waller and Collins, 2023)

      Scer\GAL4tey-5053A/kayFbz.UAS is a suppressor | partially of axon | third instar larval stage | conditional phenotype of rawdcp-1

      (Hao et al., 2019)

      Scer\GAL4tey-5053A/kayFbz.UAS is a suppressor | partially of embryonic/larval motor neuron | third instar larval stage | conditional phenotype of rawdcp-1

      (Hao et al., 2019)

      Scer\GAL4Toll-6-D42/kayFbz.UAS is a suppressor | partially of embryonic/larval neuromuscular junction | larval stage phenotype of Eaat1hypo

      (Peng et al., 2019)

      Scer\GAL4Toll-6-D42/kayFbz.UAS is a suppressor of NMJ bouton | increased number | larval stage phenotype of Eaat1hypo

      (Peng et al., 2019)

      Scer\GAL4elav.PU/kayFbz.UAS is a suppressor of NMJ bouton | increased number | third instar larval stage phenotype of Fmr1Δ50M

      (Russo and DiAntonio, 2019)

      Scer\GAL4ptc-559.1/kayFbz.UAS is a suppressor | partially of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4ptc-559.1, pucGD1515

      (Zhang et al., 2019)

      kayFbz.UAS, Scer\GAL4rn-GAL4-5 is a suppressor of wing | ectopic phenotype of CtBP334Δ4, Scer\GAL4rn-GAL4-5, egrUAS.cUa

      (Worley et al., 2018)

      Scer\GAL4rn-GAL4-5/kayFbz.UAS is a suppressor | partially of wing disc | third instar larval stage phenotype of Scer\GAL4rn-GAL4-5, egrUAS.cUa

      (Worley et al., 2018)

      Scer\GAL4RapGAP1-OK6/kayFbz.UAS is a suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Rab81/Rab8B229

      (West et al., 2015)

      Scer\GAL4RapGAP1-OK6/kayFbz.UAS is a suppressor of NMJ bouton | third instar larval stage phenotype of Rab81/Rab8B229

      (West et al., 2015)

      Scer\GAL4nSyb.PS/kayFbz.UAS is a suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Rab81/Rab8B229

      (West et al., 2015)

      Scer\GAL4nSyb.PS/kayFbz.UAS is a suppressor of NMJ bouton | third instar larval stage phenotype of Rab81/Rab8B229

      (West et al., 2015)

      Scer\GAL4Su(H).GBE/kayFbz.UAS is a suppressor | partially of adult anterior midgut epithelium phenotype of Sox21a6

      (Zhai et al., 2015)

      Scer\GAL4elav.PU/kayFbz.UAS is a suppressor | partially of NMJ bouton | maternal effect | larval stage phenotype of SkpAGD65

      (Brace et al., 2014)

      Scer\GAL4elav.PU/kayFbz.UAS is a suppressor | partially of embryonic/larval neuromuscular junction | maternal effect | larval stage phenotype of SkpAGD65

      (Brace et al., 2014)

      Scer\GAL4elav.PU/kayFbz.UAS is a suppressor of NMJ bouton | increased number | third instar larval stage phenotype of shotVV/shot3

      (Valakh et al., 2013)

      Scer\GAL4unspecified/kayFbz.UAS is a suppressor of neuromuscular junction | larval stage phenotype of SERCAKum170, comt6

      (Freeman et al., 2010)

      kayFbz.UAS, Scer\GAL4unspecified is a suppressor of embryonic/larval neuromuscular junction | larval stage phenotype of Ras85DV12.S35.UAS, Scer\GAL4unspecified

      (Freeman et al., 2010)

      Scer\GAL4BG380/kayFbz.UAS is a suppressor of neuromuscular junction phenotype of Scer\GAL4unspecified, wndUAS.cCa

      (Collins et al., 2006)

      Scer\GAL4BG380/kayFbz.UAS is a suppressor of bouton phenotype of Scer\GAL4unspecified, wndUAS.cCa

      (Collins et al., 2006)

      Scer\GAL432B/kayFbz.UAS is a suppressor of wing vein | ectopic phenotype of Scer\GAL432B, rlSem.C.UAS

      (Ciapponi et al., 2001)

      Scer\GAL432B/kayFbz.UAS is a suppressor of wing | ectopic phenotype of EgfrE3

      (Ciapponi et al., 2001)
      NOT Suppressor of
      Statement
      Reference

      kayFbz.UAS, Scer\GAL4ey.3.5.Exel is a non-suppressor of eye phenotype of Ras85DV12.S35.UAS, Scer\GAL4ey.3.5.Exel

      (Freeman et al., 2010)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      rawdcp-1 homozygotes show protection against (injury-induced) Wallerian degeneration in third instar larval motor neurons, which is considerably suppressed by the expression of kayFbz.UAS under the control of Scer\GAL4tey-5053A; in these double mutants, injured axons exhibit severely decreased new growth/sprouting compared to controls.

      (Hao et al., 2019)

      Co-expression of egrUAS.cUa and kayFbz.UAS under the control of Scer\GAL4rn-GAL4-5 (with tub-Gal80[ts] restricting expression to third instar larvae) does not lead to ectopic wings compared to controls.

      (Worley et al., 2018)

      Neuronal expression of kayFbz.Scer\UAS under the control of Scer\GAL4RapGAP1-OK6 is sufficient to completely alleviate the synaptic overgrowth in Rab81/Rab8B229 mutants.

      Neuronal expression of kayFbz.Scer\UAS under the control of Scer\GAL4nSyb.PS is sufficient to completely alleviate the synaptic overgrowth in Rab81/Rab8B229 mutants.

      (West et al., 2015)

      Expression of kayFbz.Scer\UAS in enteroblasts under the control of Scer\GAL4Su(H).GBE reduces tumor formation in the anterior midgut of Sox21a6 mutant flies.

      (Zhai et al., 2015)

      The synaptic overgrowth phenotype (increase in bouton number) seen at the neuromuscular junction in larvae derived from homozygous SkpAGD65 females is partially suppressed by expression of kayFbz.Scer\UAS under the control of Scer\GAL4elav.PU.

      (Brace et al., 2014)

      Expression of kayFbz.Scer\UAS under the control of Scer\GAL4elav.PU suppresses the increase in bouton number seen at the neuromuscular junction in shot3/shotVV third instar larvae.

      (Valakh et al., 2013)

      Expression of kayFbz.Scer\UAS in motor neurons under the control of Scer\GAL4unspecified suppresses the increased synaptic growth and transmitter release observed at the neuromuscular junction in comt6 Ca-P60AKum170 larvae.

      Co-expression of kayFbz.Scer\UAS suppresses the increased synaptic growth and transmitter release observed at the neuromuscular junction in larvae expressing Ras85DV12.S35.Scer\UAS in the motor neurons under the control of Scer\GAL4unspecified.

      Co-expression of kayFbz.Scer\UAS does not suppress the eye tumour phenotype caused by expression of Ras85DV12.S35.Scer\UAS under the control of Scer\GAL4ey.3.5.Exel.

      (Freeman et al., 2010)

      Co-expression of kayFbz.Scer\UAS and JraJbz.Scer\UAS results in axon degeneration phenotypes.

      Co-expression of one copy of kayFbz.Scer\UAS strongly enhances the axonal defects seen in Scer\GAL4ey-OK107, bskGD10555 animals.

      (Rallis et al., 2010)

      Expression of Cnx99AEP3522 enhances the small eye phenotype associated with kayFbz.Scer\UAS, when both are expressed under the control of Scer\GAL4ey.3.5.Exel.

      Expression of SdcEY04602 enhances the small eye phenotype associated with kayFbz.Scer\UAS, when both are expressed under the control of Scer\GAL4ey.3.5.Exel.

      Expression of Sema-2aEY08184 enhances the small eye phenotype associated with kayFbz.Scer\UAS, when both are expressed under the control of Scer\GAL4ey.3.5.Exel.

      Expression of cnkEY06675 enhances the small eye phenotype associated with kayFbz.Scer\UAS, when both are expressed under the control of Scer\GAL4ey.3.5.Exel.

      Expression of Pde8EY10143 enhances the small eye phenotype associated with kayFbz.Scer\UAS, when both are expressed under the control of Scer\GAL4ey.3.5.Exel.

      Expression of Fkbp13EY02405 enhances the small eye phenotype associated with kayFbz.Scer\UAS, when both are expressed under the control of Scer\GAL4ey.3.5.Exel.

      Expression of styEY11239 enhances the small eye phenotype associated with kayFbz.Scer\UAS, when both are expressed under the control of Scer\GAL4ey.3.5.Exel.

      Expression of pigeonEY06835 suppresses the small eye phenotype associated with kayFbz.Scer\UAS, when both are expressed under the control of Scer\GAL4ey.3.5.Exel.

      Expression of spagEY11196 suppresses the small eye phenotype associated with kayFbz.Scer\UAS, when both are expressed under the control of Scer\GAL4ey.3.5.Exel.

      Expression of lbmEY02692 suppresses the small eye phenotype associated with kayFbz.Scer\UAS, when both are expressed under the control of Scer\GAL4ey.3.5.Exel.

      Expression of MbsEP3727 suppresses the small eye phenotype associated with kayFbz.Scer\UAS, when both are expressed under the control of Scer\GAL4ey.3.5.Exel.

      Expression of Pvf1EP1624 suppresses the small eye phenotype associated with kayFbz.Scer\UAS, when both are expressed under the control of Scer\GAL4ey.3.5.Exel.

      Co-expression of sggA81T.Scer\UAS and kayFbz.Scer\UAS in post-mitotic neurons under the control of Scer\GAL4elav-C155 significantly reduces EJC amplitude, beyond either transgene alone.

      Co-expression of JraScer\UAS.cEa and kayScer\UAS.cEa rescues the small eye phenotype seen upon expression of kayFbz.Scer\UAS in the eye disc using Scer\GAL4ey.3.5.Exel.

      Expression of pigeonEY06835 enhances the small eye phenotype associated with kayFbz.Scer\UAS, when both are expressed under the control of Scer\GAL4ey.3.5.Exel.

      Co-expression of pigeonEY06835 with kayFbz.Scer\UAS in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155 partially suppresses the small synapse phenotype found in kayFbz.Scer\UAS mutants.

      Co-expression of lbmEY02692 with kayFbz.Scer\UAS in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155 partially suppresses the small synapse phenotype found in kayFbz.Scer\UAS mutants.

      Co-expression of Cnx99AEP3522 with kayFbz.Scer\UAS in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155 partially suppresses the small synapse phenotype found in kayFbz.Scer\UAS mutants.

      Co-expression of styEY11239 with kayFbz.Scer\UAS in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155 partially suppresses the small synapse phenotype found in kayFbz.Scer\UAS mutants.

      Co-expression of cnkEY06675 with kayFbz.Scer\UAS in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155 enhances the small synapse phenotype found in kayFbz.Scer\UAS mutants.

      Co-expression of Fkbp13EY02405 with kayFbz.Scer\UAS in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155 enhances the small synapse phenotype found in kayFbz.Scer\UAS mutants.

      Co-expression of Pde8EY10143 with kayFbz.Scer\UAS in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155 enhances the small synapse phenotype found in kayFbz.Scer\UAS mutants.

      Co-expression of sggEY02862 with kayFbz.Scer\UAS in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155 enhances the small synapse phenotype found in kayFbz.Scer\UAS mutants.

      Co-expression of SdcEY04602 with kayFbz.Scer\UAS in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155 has no effect on the small synapse phenotype found in kayFbz.Scer\UAS mutants.

      Co-expression of Sema-2aEY08184 with kayFbz.Scer\UAS in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155 has no effect on the small synapse phenotype found in kayFbz.Scer\UAS mutants.

      (Franciscovich et al., 2008)

      Expression of kayFbz.Scer\UAS, under the control of Scer\GAL4BG380, confers dramatic suppression of the hiwND8 synaptic phenotype, reducing bouton number and branching (42%) and increasing the intensity of staining for synaptic vesicle markers at the synapse.

      Co-expression of kayFbz.Scer\UAS, under the control of Scer\GAL4BG380, with wndScer\UAS.cCa in neurons suppresses the wnd gain-of-function phenotype, leading to a 38% reduction in synaptic bouton number, a 52% reduction in synaptic branching, a 54% increase in bouton size, and a 3.8-fold increase in the intensity of staining of synaptic vesicle markers.

      (Collins et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Protein acts as a dominant negative as the bZIP domain is able to dimerize and bind DNA without being able to stimulate transcription.

      (Eresh et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      DFosbZip
      (Riesgo-Escovar and Hafen, 1997)
      FraFbz.UAS
      kayFbz.Scer\UAS
      kayFbz.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (44)