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General Information
Symbol
Dmel\ttkp88.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0060850
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-ttk88
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a cDNA clone expressing the p88 isoform of ttk.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of ttkp88.Scer\UAS under the control of Scer\GAL4twi.PB and Scer\GAL4how-24B does not lead to an obvious adult phenotype, as compared to controls.

Scer\GAL4hs.2sev-mediated expression of ttkp88.Scer\UAS induces the loss of at least one cone cell in about 90% of the ommatidia.

Has no effect on mushroom body development when driven by Scer\GAL4c739.

When ttkp88.Scer\UAS is driven by Scer\GAL4Bx-MS1096 all dorsal chemosensory bristles are removed within the triple row, but the ventral chemosensory and medial mechanosensory bristles numbers are merely reduced. No effect is seen on wing blade area and cell proliferation.

Expression of ttkp88.Scer\UAS under the control of Scer\GAL4GMR.PF does not abolish the second mitotic wave in the eye disc.

Flies expressing ttkp88.Scer\UAS under the control of Scer\GAL4cb19 are moderately viable.

Expression of ttkp88.Scer\UAS under the control of Scer\GAL4dpp.blk1 has no effect on furrow initiation in the eye disc.

The polar and equatorial cone cells are not present in any 12-cell stage ommatidia in eye discs expressing ttkp88.Scer\UAS under the control of Scer\GAL4hs.2sev (the four cone cells have normally been recruited by this stage in wild-type discs). Instead, R3 and R4 photoreceptor cells adopt an abnormally apical position within each ommatidium.

Scer\GAL4Kr.PM-mediated expression leads to a partial block of neuronal development in the PNS but no obvious defects in the CNS.

The external facet array is disorganised and all bristles are missing in the eyes of flies expressing ttkp88.Scer\UAS under the control of Scer\GAL4GMR.PF. No photoreceptors are seen and the remaining tissue is vacuolated. Lenses are present on the eye surface. The external facet array is moderately disrupted and some bristles are present in the eyes of flies expressing ttkp88.Scer\UAS under the control of Scer\GAL4hs.2sev. Ommatidia usually contain 4 outer photoreceptors and 1 central photoreceptor, which is an R8 cell.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference
Enhancer of
Additional Comments
Genetic Interactions
Statement
Reference

ttkp88.Scer\UAS Scer\GAL4hs.2sev, svsev.PS pupal eye discs have additional cone cells in about 40% of their ommatidia , with a maximum of seven cone cells observed in 1% of the ommatidia.

One supernumerary cone cell is generated in most ttkp88.Scer\UAS Scer\GAL4hs.2sev, svsev.PS ommatidia, while up to three additional cone cells are generated in only 4% of the ommatidia.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

ttkp88.Scer\UAS (driven by Scer\GAL4hs.PB fails to rescue the chorion and dorsal appendage phenotypes of ttktwp/ttk1e11 eggs under any heat shock conditions.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
ttkp88.Scer\UAS
ttkp88.UAS
Name Synonyms
Secondary FlyBase IDs
    References (18)