|Feature type||allele||Associated gene||Dmel\ttk|
|Mutagen||in vitro construct - regulatory fusion|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Carried in construct|
(Pi et al., 2001, Yuasa et al., 2003, Hummel et al., 2002, French et al., 2003, Ward et al., 2002, Merabet et al., 2002, Nicolai et al., 2003, Kumar and Moses, 2001, Li et al., 1997, Giesen et al., 1997, Kumar and Moses, 2001, Li et al., 2009, Boyle and Berg, 2009, Siddall et al., 2009, Araujo et al., 2007)
|Phenotype Manifest In|
Follicular cells expressing ttk[p69.Scer\UAS] under the control of Scer\GAL4[e22c] are reduced in size.
Expression of ttk[p69.Scer\UAS] under the control of Scer\GAL4[lz-gal4] results in severely disrupted adult eyes that show scarring and lack ommatidial structures. In third instar larval eye discs ommatidia show reduced numbers of cone cells and R1, R6 and R7 photoreceptor cells. Expression of ttk[p69.Scer\UAS] under the control of Scer\GAL4[GMR.PF] results in severely perturbed adult eyes, displaying no ommatidial structure. Ommatidia show reduced numbers of cone cells and R1, R6 and R7 photoreceptor cells.
Expression of ttk[p69.Scer\UAS] under the control of Scer\GAL4[btl.PS] results in impaired tracheal branch fusion.
When expression is driven by Scer\GAL4c739, ttkp69.Scer\UAS shows a mushroom body Class I phenotype; neuron number reduced. This phenotype is similar to, but less extreme than, that caused by ttkUY181 driven by Scer\GAL4c739. Loss of neurons is not accompanied by increase in number of glial cells.
When Scer\GAL4c527 is expressed under the control of Scer\GAL4c527 in third instar larvae, defects are seen in glial cell migration in the developing eye. In about 20% of these animals surface glial cells do not enter the eye disc and R cell axons fail to enter the optic stalk forming a mass of R cell axons in the basal region of the disc. In the remaining larvae, fewer surface glial cells are found in the eye disc. In these discs R cell axons project into the optic stalk, but are highly disorganised.
Flies expressing ttkp69.Scer\UAS under the control of Scer\GAL4cb12, Scer\GAL4cb19, Scer\GAL4cb35, Scer\GAL4cb36, Scer\GAL4cb37 or Scer\GAL4cb38 are moderately viable. Flies expressing ttkp69.Scer\UAS under the control of Scer\GAL4cb05 or Scer\GAL4cb23 are viable at 18oC.
Expression of ttkp69.Scer\UAS under the control of Scer\GAL4dpp.blk1 affects furrow reincarnation but not birth in the eye disc.
Expression of ttkp69.Scer\UAS under the control of Scer\GAL4Eq1 results in a lack of most microchaetae.
Scer\GAL4Kr.PM-mediated expression leads to a partial block of neuronal development in the PNS and CNS. Scer\GAL4sca-537.4-mediated expression impairs neuronal differentiation. In late stage 16/17 embryos cell death is observed.
|Phenotype Manifest In|
Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, ttkp69.Scer\UAS has cone cell | third instar larval stage phenotype, suppressible | partially by lzGMR.PD
Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, ttkp69.Scer\UAS has ommatidium | third instar larval stage phenotype, suppressible | partially by lzGMR.PD
Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, ttkp69.Scer\UAS has photoreceptor cell R1 | third instar larval stage phenotype, suppressible | partially by lzGMR.PD
Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, ttkp69.Scer\UAS has photoreceptor cell R6 | third instar larval stage phenotype, suppressible | partially by lzGMR.PD
Over-expression of lz[GMR.PD] in flies expressing ttk[p69.Scer\UAS] in under the control of Scer\GAL4[GMR.PF] partially suppresses the loss cone cells and R1, R6 and R7 photoreceptor cells.
Co-expression of repoScer\UAS.cYa and ttkp69.Scer\UAS under the control of Scer\GAL4sca-T3 results in a synergistic suppression of neuronal development in embryos.
|Complementation & Rescue Data|
Expression of ttk[p69.Scer\UAS] under the control of Scer\GAL4[btl.PS] in ttk[D2-50] mutant animals rescues the tracheal intercalation defects. Terminal branch fusion defects of the lateral trunk are also rescued in these animals.
Short heat shocks and moderate temperatures in ttktwp/ttktwp, ttkp69.Scer\UAS Scer\GAL4hs.PB animals lead to significant partial rescue of dorsal appendage and chorion defects. Eggs are normal in shape and size and dorsal appendages are significantly longer than seen in the mutants alone. Longer heat shocks lead to a dramatic decline in rescue frequency accompanied by an increase in defects early in oogenesis.
|Stocks ( 1 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 15 )|