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General Information
Symbol
Dmel\mxc22a-6
Species
D. melanogaster
Name
FlyBase ID
FBal0061017
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
complex substitution
Inserted_sequence:

GTGTCAGCTG

Comment:

Residues AA at position N480 are replaced with GTGTCAGCTG.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Residues AA at position N480 are replaced with GTGTCAGCTG.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Hemizygous third instar larvae show gut melanisation not accompanied by tissue overgrowth or hemocyte encapsulation. A large number of heterozygous larvae also develop melanisations in the gut walls.

Hemizygous embryos hatch with normal cuticles. No transformation of anterior segments toward abdominal segment A8 is seen. These larvae are smaller than wild-type and attain the second instar with approximately a 24 hour delay. Most of the larvae die several days later without undergoing a second moult. All the major imaginal discs are smaller than in wild-type larvae. Almost all second instar larvae have melanotic pseudotumours. Areas of melanisation are seen touching the imaginal hindgut ring and hindgut. No homozygous clones are seen on individuals irradiated earlier than 48 hours before puparium formation (BPF). Only very few, tiny clones are seen on the hemi-notum of flies irradiated between 0 and 48 hours BPF, and clones are not seen on the abdomen in these flies. Does not rescue the lack of abdominal segment differentiation seen in the progeny of hb4 nosL7/nosL7 females. mxcSO/mxc22a-6 females die as pharate adults with extremely reduced eyes and head structures. Antennal segments 1 and 2 appear normal, whereas antennal segment 3, the arista and maxillary palps are reduced. Head structures derived from the labial and clypeo-labial discs, such as the proboscis, labrum and clypeus appear normal. These flies have melanotic spots.

Homozygotes die as first or second instar larvae. mxcG9/mxc22a-6 females lay many small eggs with a thin chorion and small dorsal appendages that collapse after oviposition. mxcM1/mxc22a-6 and mxcG46/mxc22a-6 females have reduced viability and do not lay eggs. Some egg chambers contain the normal number of nurse cells, but oogenesis appears arrested before stage 7-8. Egg chambers degenerate in older flies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Somatic clonal analysis indicates that loss of zygotic mxc function results in cell autonomous lethality and that mxc- cells divide only a few times before dying.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)