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General Information
Symbol
Dmel\armS10.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0061501
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-ArmS10, UAS-ArmS10, armS10, UAS-armact, UAS-Arm*, Armact, armadillos10, UASarmS10, UASarm*, UAS-Arm-S10
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
A truncated arm protein, lacking amino acids 34 to 87 and tagged with Tag:MYC, is expressed under the control of UASt regulatory sequences. The protein produced is constitutively active in wg signalling, but functions normally at adherens junctions.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
Functions normally at adherens junctions; shows ectopic accumulation in cytoplasm and nucleus.
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
embryonic/first instar larval cuticle & denticle, with Scer\GAL4da.G32
embryonic/first instar larval cuticle & denticle belt, with Scer\GAL4da.G32
sensory mother cell & dorsal mesothoracic disc | ectopic, with Scer\GAL4sd-SG29.1
Detailed Description
Statement
Reference
Expressing armS10.UAS.Tag:MYC under the control of Scer\GAL4dpp.blk1 induces an ectopic wing pouch-like structure in the notum region of the wing disc, but the Dpp-positive domain appears relatively normal; cells originating from the wing disc's Dpp-positive domain show some invasiveness.
The expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PU leads to a decrease in adult eye size, as compared to controls.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the Scer\GAL4svp.PT driver resulted in more elongated ostia cell shape.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4wor.PA does not induced the formation of supernumerary type II neuroblasts in the larval brain.
Adults expressing armS10.UAS.Tag:MYC under the control of Scer\GAL4Mef2.PR have a reduced abdominal fat body with smaller lipid droplets than controls.
Expression of armS10.Scer\UAS.T:Hsap\MYC in eye disc clones under the control of a GAL4 driver does not significantly increase apoptosis levels compared to controls.
Embryos expressing armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4btl.PS have supernumerary tracheal fusion cells in the dorsal trunk, visceral branch and transverse connective. The number of terminal tracheal cells is normal in most branches and only slightly reduced in the visceral branch.
Scer\GAL4arm.PS-mediated expression of armS10.Scer\UAS.T:Hsap\MYC results in embryos with excess naked cuticle at the expense of denticles.
Flies expressing armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4bbg-C96 have extra wing margin bristles. Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of either Scer\GAL4tj.PU or Scer\GAL4nos.PU results in the formation of ectopic germ cell clusters in the testis.
When armS10.Scer\UAS.T:Hsap\MYC is expressed in dorsal cluster neurons under the control of Scer\GAL4ato.3.6 the branching pattern in the adult medulla is disturbed, giving rise to a reduced number of branches at the 3rd branching point of the grid-like structure.
Expression of armS10.Scer\UAS.T:Hsap\MYC in the heart under the control of Scer\GAL4tin.CΔ4 does not appear to alter cardiac function as fractional shortening is comparable with controls.
Expression of armS10.Scer\UAS.T:Hsap\MYC driven by Scer\GAL4elav.PU leads to photoreceptor loss in the retina (obvious at 1 day old), locomotor defects (reduced climbing ability) and a shorter lifespan compared to controls.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.long results in shortened photoreceptors, which are visible in apical cross sections of the retina, but do not extend to its base.
Overexpression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PF causes a small eye phenotype.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4hs.2sev at 25[o]C results in frequent apoptosis of photoreceptor cells.
Scer\GAL4arm.PS-driven expression of armS10.Scer\UAS.T:Hsap\MYC transforms most of the ventral denticle-secreting epidermal cells to a naked-cuticle cell fate.
Ectopic expression of armS10.Scer\UAS.T:Hsap\MYC at moderate levels driven by Scer\GAL4nub-AC-62 and Scer\GAL80ts.αTub84B produces a small number of ectopic wing bristles and induces extra wing growth compared with wild-type controls.
Ectopic expression of armS10.Scer\UAS.T:Hsap\MYC in the wing using Scer\GAL4bs-1348 results in ectopic vein formation.
Scer\GAL4dpp.PU-mediated expression of armS10.Scer\UAS.T:Hsap\MYC results in changes in gross morphology and alterations in cell fate in a region-specific manner within the wing disc, with little or no effect on the overall size of the wing pouch or cell proliferation. There is expansion of the hinge region and deformation of the wing pouch, and a slight overgrowth in the scutellar region.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4dome-PG14 blocks differentiation of hemocyte precursors in the lymph gland.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4dpp.blk1 result in antennal duplications in the antennal disc.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4GF1 results in expansion of sternal territory in the abdomen and ectopic sternal bristles, at the expense of the pleura.
Expression of armS10.Scer\UAS.T:Hsap\MYC in the wing (under the control of Scer\GAL430A) causes cells to fail to delaminate.
Somatic clones overexpressing armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4e22c, separate from their neighbours and display smooth clone borders. Overexpression of armS10.Scer\UAS.T:Hsap\MYC, under the control of Scer\GAL4vg.PM, along the DV boundary induces ectopic wing margin bristles.
When armS10.Scer\UAS.T:Hsap\MYC is driven by Scer\GAL4twi.PB or Scer\GAL4Mef2.PR the cII cluster of slou expressing muscle founder cells is expanded. The cI cluster of slou expressing muscle founder cells is unaffected.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4dpp.blk1 results in alteration in growth in the wing disc.
Ubiquitous expression of armS10.Scer\UAS.T:Hsap\MYC, under the control of Scer\GAL4da.G32, results in a naked cuticle phenotype, in which embryos have no denticle belts.
Expression of armS10.Scer\UAS.T:Hsap\MYC via Scer\GAL4en-e16E results in the first row of denticles in all segments being transformed into naked cuticle.
armS10.Scer\UAS.T:Hsap\MYC; Scer\GAL4vg.PM and armS10.Scer\UAS.T:Hsap\MYC; Scer\GAL4405 flies have tufts of ectopic wing margin bristles on their wing blades.
The cuticles formed by armS10.Scer\UAS.T:Hsap\MYC; Scer\GAL4da.G32 embryos lack most denticles.
Ubiquitous expression of armS10.Scer\UAS.T:Hsap\MYC in embryos using Scer\GAL4unspecified produces ectopic naked cuticle.
When armS10.Scer\UAS.T:Hsap\MYC is driven by Scer\GAL4arm.PS a naked cuticle phenotype is seen.
When armS10.Scer\UAS.T:Hsap\MYC is driven by Scer\GAL4Dll-md23 a reduction is seen in the number of wing disc cells.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4hs.PB using four days of pulsed heat shock treatment consistently produces more follicle cells that accumulate between egg chambers. These extra follicle cells form long stalks with multiple rows of cells instead of one row in the wild type.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.long results in a dramatic expansion of the dorsal rim area (DRA) throughout the dorsal eye.
When expression of armS10.Scer\UAS.T:Hsap\MYC is driven by Scer\GAL4pros.PMG neuroblast development is not disrupted.
When armS10.Scer\UAS.T:Hsap\MYC is driven by Scer\GAL469B all denticles fail to form except the T1 beard, which has more denticles than wild-type.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4dpp.blk1 blocks progression of the morphogenetic furrow.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4sd-SG29.1 results in duplication of the wing pouch in the wing disc.
armS10.Scer\UAS.T:Hsap\MYC when driven by Scer\GAL4hs.2sev leads to a mildly reduced eye with disordered bristles.
larvae derived from mothers in which armS10.Scer\UAS.T:Hsap\MYC is driven by Scer\GAL4αTub84B.PK have a naked cuticle phenotype.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4arm.PS in embryos suppresses the formation of denticles and results in nearly naked cuticles.
When armS10.Scer\UAS.T:Hsap\MYC is driven by Scer\GAL4GMR.PF, flies have very narrow, rough and glazed eyes.
When armS10.Scer\UAS.T:Hsap\MYC is driven by Scer\GAL4c306 or Scer\GAL4slbo.2.6 no effect is seen on border cell migration. When armS10.Scer\UAS.T:Hsap\MYC is driven by Scer\GAL4elav-C155 no effect is seen on axon outgrowth in embryos. When armS10.Scer\UAS.T:Hsap\MYC is driven by Scer\GAL4btl.PS many aspects of tracheal development are unaffected. However in many segments a pronounced hypertrophy of the presumptive dorsal longitudinal trunk is seen, often with a corresponding reduction in the presumptive visceral branch. The resulting dorsal trunk is misshapen, often forming loops ventral to and reconnecting to the dorsal longitudinal trunk, or ventral outgrowths. These loops have a diameter more similar to that of the dorsal longitudinal trunk than that of the transverse connective.
armS10.Scer\UAS.T:Hsap\MYC when driven buy Scer\GAL4GMR.PF causes bristle loss in the eye, and a failure of proper ommatidial development.
armS10.Scer\UAS.T:Hsap\MYC; Scer\GAL41151 flies some direct flight muscles are lost, while those that remain are much reduced in size.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4arm.PS results in the complete absence of denticles from the cuticle.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4bs-1348 results in the formation of moderate ectopic veins which emanate from the posterior crossvein, in addition to more severe ectopic veins along L2.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4btl.PS results in loss of the tracheal visceral branch.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4arm.PS results in replacement of 1o-3o fates in the dorsal cuticle (dorsal denticles, smooth cuticle and thick hairs respectively) with 4o fates (fine hairs). Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4ptc-559.1 results in the global specification of 4o cell types in the dorsal cuticle.
The tracheal dorsal trunk (DT) is hypertrophied when armS10.Scer\UAS.T:Hsap\MYC is expressed under the control of Scer\GAL4btl.PS, often showing ectopic branches with DT features. The visceral branches are shortened or even completely missing and contain fewer cells than in wild type (the rest of the branches contain roughly the normal number of cells). No extra tracheal cell proliferation is seen in these embryos.
When expression is driven by Scer\GAL4arm.T:Hsim\VP16, embryos show puckering of dorsal epidermis with loss of dorsal hair identity and a naked scar at the dorsal midline.
Overexpression of armS10.Scer\UAS.T:Hsap\MYC driven by Scer\GAL4sd-SG29.1 greatly increases the size of the hinge region but does not affect the viability of the cells. Wings in these adult flies are wild-type in size but with many ectopic bristles. When expression of armS10.Scer\UAS.T:Hsap\MYC is driven by Scer\GAL4sd-SG29.1, the of the anterior compartment of the wing disc is covered in evenly spaced SOPs (sensory organ precursors). This phenotype is weaker than seen withy overexpression of dshScer\UAS.cAa and wgScer\UAS.cGa. These effects increase as development proceeds. Expression of wgScer\UAS.cGa during the induction of the wing primordia in the early phases of wing development by Scer\GAL4dpp.blk1, leads to an increased wing primordia which distorts the disc as the primordia invades the notum.
Expression of armR.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4e22c in embryos results in a strong conversion of denticles to naked cuticle.
armS10.Scer\UAS.T:Hsap\MYC, Scer\GAL4C96 flies show additional margin bristles and ectopic bristles, as well as bubbles at the distal end.
When expression is driven by Scer\GAL4dpp.blk1 almost the entire pleura is transformed to tergite and sternite identities.
Ubiquitous expression of armS10.Scer\UAS.T:Hsap\MYC driven by Scer\GAL4e22c mimics constitutive action of the wg pathway, producing naked cuticle.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Bx-MS1096 results in overgrowth of the wing and mispatterning of the wing margin.
When expression is driven by Scer\GAL4how-24B, the anterior midgut construction is obliterated. Phenotype is similar to that caused by Apc2 RNAi mutants.
Flies expressing armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4hs.PB have a wild-type tissue polarity phenotype in the wing.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL469B results in embryos having naked cuticle with almost no ventral denticle belts. These embryos contain a large prothoracic beard. Overexpression of armS10.Scer\UAS.T:Hsap\MYC in embryos using Scer\GAL4hs.PB between stages 7 and 10 results in a naked cuticle phenotype.
Embryos expressing armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4how-24B have an abnormal second midgut constriction.
Embryos in which armS10.Scer\UAS.T:Hsap\MYC is expressed using Scer\GAL4twi.PB show an increase in the number of somatic gonadal precursor cells.
Ubiquitous expression of armS10.Scer\UAS.T:Hsap\MYC using Scer\GAL4e22c or Scer\GAL469B gives rise to embryos with only naked cuticle or a few denticles. Head structures remain nearly normal in these embryos. The naked cuticle phenotype is unaltered if armS10.Scer\UAS.T:Hsap\MYC is expressed using Scer\GAL4e22c in a wgl-8 mutant background. The first row of denticles is replaced by naked cuticle in embryos expressing armS10.Scer\UAS.T:Hsap\MYC using Scer\GAL4en-e16E. arm4 embryos expressing armS10.Scer\UAS.T:Hsap\MYC (using Scer\GAL4e22c) differentiate essentially only naked cuticle, similar to the phenotype of embryos expressing armS10.Scer\UAS.T:Hsap\MYC (using Scer\GAL4e22c) in a wild-type background. These embryos are shorter than wild-type. Embryos that are zygotically and maternally mutant for arm8 and are expressing armS10.Scer\UAS.T:Hsap\MYC (using Scer\GAL4e22c) essentially secrete only naked cuticle. The integrity of the cuticle of embryos that are zygotically and maternally mutant for arm3 is dramatically improved if these embryos are also expressing armS10.Scer\UAS.T:Hsap\MYC (using Scer\GAL4e22c), and the secreted cuticle is naked.
Scer\GAL4e22c-mediated expression transforms all cells to posterior cell fates. Action of the protein is largely inhibited when expressed in pan13a, pan2 or pan3 embryos, embryos exhibit alternate denticles and naked cuticle with portions of the lateral naked cuticle converted to denticles.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Suppressed by
Enhancer of
NOT Enhancer of
Suppressor of
Statement
Reference
NOT Suppressor of
Other
Phenotype Manifest In
Enhanced by
NOT Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Enhancer of
NOT Enhancer of
Suppressor of
Statement
Reference
armS10.UAS.Tag:MYC/Scer\GAL4da.G32 is a suppressor of embryonic leading edge cell primordium & microtubule phenotype of wgl-17
NOT Suppressor of
Other
Statement
Reference
NECN.UAS, Scer\GAL4sd-SG29.1, armS10.UAS.Tag:MYC has dorsal mesothoracic disc & sensory mother cell phenotype
NECN.UAS, Scer\GAL4sd-SG29.1, armS10.UAS.Tag:MYC has sensory mother cell & dorsal mesothoracic disc phenotype
Additional Comments
Genetic Interactions
Statement
Reference
Expression of armS10.Scer\UAS.T:Hsap\MYC in type II neuroblasts or ase- immature intermediate neural progenitors (INPs) enhances the supernumerary neuroblast phenotype seen in bratDG19310/brat11 larval brains, whereas expression in ase+ immature INPs does not (different insertions of Scer\GAL4GMR9D11 are used to drive expression in each case).
Wing disc cells co-expressing armS10.Scer\UAS.T:Hsap\MYC and cim1-4.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Bx-MS1096 show a degree of hyperplastic overgrowth, but retain normal polarity and tissue architecture.
Expression of armS10.Scer\UAS.T:Hsap\MYC strongly suppresses the wing notching seen when Klp64DNIG.10642R is expressed under the control of Scer\GAL4bbg-C96. The wing margin bristles are partially restored.
Co-expression of armS10.Scer\UAS.T:Hsap\MYC restores dorsal trunk formation and tracheal fusion cell specification in embryos expressing AxnScer\UAS.T:Avic\GFP under the control of Scer\GAL4btl.PS.
Scer\GAL4arm.PS-mediated co-expression of armS10.Scer\UAS.T:Hsap\MYC and pblScer\UAS.T:Ivir\HA1 or pblΔBRCT.Scer\UAS.T:Hsap\MYC produces severe developmental defects. Co-expression of pblDH-PH.Scer\UAS.T:Ivir\HA1, but not pblDH-PH-V531D.Scer\UAS.T:Ivir\HA1, partially suppresses the excess naked cuticle phenotype seen in Scer\GAL4arm.PS armS10.Scer\UAS.T:Hsap\MYC embryos.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4sd.PU significantly suppresses the overproliferation seen in lace2 mutant wing disc clones, in terms of both frequency and severity of the phenotype. Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4sd.PU significantly suppresses the severity of overproliferation seen in ACC1 mutant wing disc clones, but does not reduce the frequency of discs exhibiting overgrowth.
Co-expression of armS10.Scer\UAS.T:Hsap\MYC suppresses the loss of indirect flight muscles and loss of flight ability which is caused by expression of panΔN.Scer\UAS under the control of Scer\GAL4ebd1.PB. ebd1240/Df(3L)ED4136 suppresses the shortened photoreceptor phenotype caused by expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.long.
CtBPScer\UAS.T:Zzzz\FLAG is able to suppress the small eye phenotype caused by Scer\GAL4GMR.PF-dependent expression of armS10.Scer\UAS.T:Hsap\MYC. Overexpression of CtBPMono.Scer\UAS.T:Zzzz\FLAG causes a significant enhancement of the small eye phenotype caused by Scer\GAL4GMR.PF-dependent expression of armS10.Scer\UAS.T:Hsap\MYC.
Co-expression of armS10.Scer\UAS.T:Hsap\MYC enhances the ommatidial over-rotation phenotype which is caused by expression of nmoScer\UAS.cUa under the control of Scer\GAL4hs.2sev.
The leading edge cell in the anterior compartment just anterior to the parasegment boundary is transformed into an ectopic mixer cell in wgl-17 embryos expressing armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4en-e16E assayed by marker expression (in the abdominal segments of wild-type embryos at the end of dorsal closure, the "mixer cell" moves across the segment boundary from the anterior compartment to the posterior compartment, but the cell in the equivalent position relative to the parasegment boundary does not show this "mixing" behaviour).
Co-expression of either tumScer\UAS.cSa or pavScer\UAS.P\T.T:Avic\GFP-m6 driven by Scer\GAL4arm.PS partially blocks the cell-fate transformation induced by armS10.Scer\UAS.T:Hsap\MYC expression and allows some denticle production. Co-expression of nkdScer\UAS.cZa driven by Scer\GAL4arm.PS is unable to block the cell-fate transformation induced by armS10.Scer\UAS.T:Hsap\MYC expression. Co-expression of tumΔNLS.Scer\UAS driven by Scer\GAL4arm.PS is unable to block the cell-fate transformation induced by armS10.Scer\UAS.T:Hsap\MYC expression. Co-expression of pavNLS4-7*.Scer\UAS.P\T.T:Avic\GFP-m6 driven by Scer\GAL4arm.PS is unable to block the cell-fate transformation induced by armS10.Scer\UAS.T:Hsap\MYC expression.
The co-expression of armS10.Scer\UAS.T:Hsap\MYC enhances the eye defects in adults expressing NICN.Scer\UAS driven by Scer\GAL4ey.PS, with associated wrinkling and distortion of third instar larva eye discs, but no obvious differentiation defects are visible in these discs.
Outgrowths with tumorous appearance are produced when the wing disc is heterozygous for Df(1)N-81k1 and Df(1)N-81k1 somatic clones are generated in a armS10.Scer\UAS.T:Hsap\MYC, Scer\GAL4dpp.PU background. There are also some effects on cell fate. Clones of cells generated at 24-48 or 48-72 hrs AEL which are mutant for N55e11 and express armS10.Scer\UAS.T:Hsap\MYC via Scer\GAL4αTub84B.PL (generated using the MARCM system) give rise to tightly packed spheres with large numbers of cells and abnormal polarity in the wing disc. Similar clones generated after 72hrs appear scattered through the tissue, lose basal contact and exhibit a variety of organizations. Clones of cells doubly mutant for DlRevF10 and SerRX82 and also expressing armS10.Scer\UAS.T:Hsap\MYC via Scer\GAL4αTub84B.PL (using the MARCM technique) remain integrated in the wing disc epithelium and do not exhibit growth defects. Expression of armS10.Scer\UAS.T:Hsap\MYC via Scer\GAL4αTub84B.PL in Su(H)del47 clones (using the MARCM technique) increases the size and reduces the number of apoptotic cells compared to Su(H)del47 clones. armS10.Scer\UAS.T:Hsap\MYC expression also makes the clones more rounded in appearance but cells do not lose their polarity. The over-proliferation defect of clones of cells mutant for N55e11 and expressing armS10.Scer\UAS.T:Hsap\MYC via Scer\GAL4αTub84B.PL (generated using the MARCM system) are rescued by co-expression of Nintra.Scer\UAS.T:Avic\GFP-EGFP,T:Mmus\Cd8a. Clones of cells which are mutant for N55e11 and express armS10.Scer\UAS.T:Hsap\MYC via Scer\GAL4dpp.PU are relatively few but contain a relatively large number of cells. Clones of cells mutant for N55e11 and expressing armS10.Scer\UAS.T:Hsap\MYC via Scer\GAL4dpp.PU are smaller and more frequent when Nintra.Scer\UAS.T:Avic\GFP-EGFP,T:Mmus\Cd8a or NFLN.Scer\UAS is coexpressed.
The ectopic wing margin bristles of armS10.Scer\UAS.T:Hsap\MYC overexpression mutants is enhanced in ft8 heterozygotes.
The change in wing disc shape caused by expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4dpp.blk1 is significantly suppressed by co-expression of N::torScer\UAS.cSa.
Ectopic wing margin bristles on the wings of armS10.Scer\UAS.T:Hsap\MYC; Scer\GAL4vg.PM animals are unaffected by twsj11C8/+.
armS10.Scer\UAS.T:Hsap\MYC; Scer\GAL4da.G32 suppresses the transformation of naked ventral cuticle to denticles in wgl-17 homozygous embryos. Many of the resulting embryos have the armS10.Scer\UAS.T:Hsap\MYC; Scer\GAL4da.G32 overexpression phenotype of a completely naked ventral cuticle. armS10.Scer\UAS.T:Hsap\MYC; Scer\GAL4da.G32 suppresses the dorsal-ventral elongation and orientation of microtubule bundles in the leading edge cells of stage 13 wgl-17 homozygous embryos. armS10.Scer\UAS.T:Hsap\MYC; Scer\GAL4332.3 completely fails to suppress these phenotypes.
Metameric furrows fail to form in armS10.Scer\UAS.T:Hsap\MYC; Scer\GAL4en-e16E embryos homozygous for ciCe-1 or hhAC, but not ci94. Failure of metameric furrow formation in armS10.Scer\UAS.T:Hsap\MYC; Scer\GAL4en-e16E embryos homozygous for hhAC is not suppressed by wgl-17/wgl-17. In stage 13+ armS10.Scer\UAS.T:Hsap\MYC; Scer\GAL4en-e16E embryos homozygous for wgl-17, the metameric furrows are duplicated - forming on both sides of the en expression stripes. In the lateral regions of these embryos, en expression is broken up into islands, each surrounded by an ectopic furrow.
When armS10.Scer\UAS.T:Hsap\MYC (driven by Scer\GAL469B) is added to ci94 homozygotes, denticles fail to form, except for the T1 beard, (already present and enlarged in armS10.Scer\UAS.T:Hsap\MYC embryos), which is enhanced by the addition of ci94.
Co-expression of daScer\UAS.cGa significantly rescues progression of the morphogenetic furrow in animals expressing armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4dpp.blk1.
armS10.Scer\UAS.T:Hsap\MYC with Scer\GAL469B weakly suppresses the dorsal hole phenotype of hep1 mutants, as well as rescuing adhesion between the dorsal epidermis and the amnioserosa. However, it fails to rescue the formation of an actin cable in leading edge cells of these embryos.
The addition of lgsunspecified to armS10.Scer\UAS.T:Hsap\MYC, Scer\GAL4αTub84B.PK animals suppresses the naked cuticle phenotype.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4arm.PS has no effect on the cuticle phenotype of pygoS28 embryos derived from pygoS28 germline clones. Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4arm.PS has no effect on the cuticle phenotype of pygoS123 embryos derived from pygoS123 germline clones.
Co-expression of armS10.Scer\UAS.T:Hsap\MYC can rescue both the wing notching phenotype and loss of sensory bristles caused by expression of dlpScer\UAS.cBa under the control of Scer\GAL4C96. In addition, ectopic margin bristles close to the wing margin are seen in these flies.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4btl.PS can substantially rescue the dorsal trunk which is missing in wgl-17 Wnt2unspecified double mutant embryos.
The addition of nkdScer\UAS.cZa to armS10.Scer\UAS.T:Hsap\MYC, Scer\GAL4GMR.PF flies has no effect on the eye phenotype.
The addition of nkdScer\UAS.T:Hsap\MYC to armS10.Scer\UAS.T:Hsap\MYC, Scer\GAL4GMR.PF flies has no effect on the eye phenotype.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4ptc-559.1 in lin2/lin2 embryos does not result in the global specification of 4o cell types in the dorsal cuticle, the dorsal cuticle phenotype resembles that of lin mutants.
When tkvQ253D.Scer\UAS.cLa and armS10.Scer\UAS.T:Hsap\MYC are co-expressed using Scer\GAL4btl.PS, a partial restoration of the dorsal trunk is seen in the tracheal system.
The addition of NECN.Scer\UAS to armS10.Scer\UAS.T:Hsap\MYC/Scer\GAL4sd-SG29.1 leads to flies that have smaller wing pouches, In the adult wing they show a combination of the phenotypes seen in flies expressing NECN.Scer\UAS and armS10.Scer\UAS.T:Hsap\MYC alone i.e. the adults wings are small, lacking a margin and are covered in bristles. The addition of armS10.Scer\UAS.T:Hsap\MYC to NECN.Scer\UAS/Scer\GAL4sd-SG29.1 flies leads to an increase in the area of the wing disc covered by SOPs, though they are not evenly spaced.
When expression is driven by Scer\GAL4en-e16E in a wgl-17 background strips of segmentally repeated smooth cuticle occur. There are fewer large row 5 type denticles than in the single wg mutant, and row 6 type denticles do not develop. The denticles that do form are of the row 2 or 3 type. The denticle pattern shows some mirror symmetry. Denticles point away from the nearest region of smooth cuticle.
Suppresses the wing nicking phenotype seen in mamN.Scer\UAS, Scer\GAL4C96 flies.
Uniform expression of ovoScer\UAS.cPa in a background of armS10.Scer\UAS.T:Hsap\MYC driven by Scer\GAL4e22c restores denticle formation.
The phenotype caused by expression of ci::panDΔ.Scer\UAS under the control of Scer\GAL4Bx-MS1096 is enhanced by coexpression of armS10.Scer\UAS.T:Hsap\MYC; the resulting pupae fail to eclose and the wing discs are overgrown and distorted.
The naked cuticle phenotype produced by armS10.Scer\UAS.T:Hsap\MYC expressed under the control of Scer\GAL469B is suppressed by tsh8.
sggScer\UAS.cSa does not alter the abnormal second midgut constriction phenotype seen in embryos expressing armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4how-24B.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4prd.RG1 in sgl08310 embryos induces naked cuticle.
Xenogenetic Interactions
Statement
Reference
The additional co-expression of armS10.Scer\UAS.T:Hsap\MYC does not modify the fully penetrant rough eye phenotype resulting from the co-expression of HPV18\E6Scer\UAS.T:Hsap\MYC and Hsap\UBE3AScer\UAS.cRa under the control of Scer\GAL4GMR.PU.
Expression of armS10.Scer\UAS.T:Hsap\MYC partially rescues the dorsal cluster neuron branching phenotype seen when Hsap\HUWE1Scer\UAS.cVa is expressed under the control of Scer\GAL4ato.3.6.
Co-expression of armS10.Scer\UAS.T:Hsap\MYC significantly enhances the short lifespan seen in Scer\GAL4elav.PU>Hsap\HTTQ93.ex1p.Scer\UAS flies.
The wing defects caused by expression of either Hsap\CDH1Scer\UAS.cPa or Hsap\CDH1A634V.Scer\UAS under the control of Scer\GAL4bi.PU are partially suppressed by co-expression of armS10.Scer\UAS.T:Hsap\MYC. The wing margin notching caused by expression of Hsap\CDH1V832M.Scer\UAS under the control of Scer\GAL4bi.PU is suppressed by co-expression of armS10.Scer\UAS.T:Hsap\MYC. The double mutant flies show distal vein thickenings.
Hsap\MAPTGMR.Ex.PJ and armS10.Scer\UAS.T:Hsap\MYC (driven by Scer\GAL4hs.2sev) enhance each other leading to markedly reduced eye, with a complete loss of ommatidial borders and bristles.
Complementation and Rescue Data
Comments
Ubiquitous expression of armS10.Scer\UAS.T:Hsap\MYC in embryos using Scer\GAL4da.G32 produces ectopic naked cuticle in the arm2 background. Ubiquitous expression of armS10.Scer\UAS.T:Hsap\MYC using Scer\GAL4arm.PS produces ectopic naked cuticle in embryos carrying armS6.T:Hsap\MYC in an arm4 background. Ubiquitous expression of armS10.Scer\UAS.T:Hsap\MYC using Scer\GAL4arm.PS produces ectopic naked cuticle in embryos carrying armS12.T:Hsap\MYC in an arm4 background.
The adhesion defect of arm043A01 is rescued by expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4arm.PS.
Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4btl.PS rescues the formation of the tracheal dorsal trunk in arm4 embryos.
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