FlyBase Allele Report: Dmel\arm[S10.UAS.Tag:MYC]

General Information

Symbol

Dmel\arm^{S10.UAS.Tag:MYC}

Species

D. melanogaster

Name

FlyBase ID

FBal0061501

Feature type

allele

Associated gene

Dmel\arm

Associated Insertion(s)

Carried in Construct

P{UAS-arm.S10}

Also Known As

UAS-Arm^S10, UAS-ArmS10, arm^S10, UAS-arm^act, UAS-Arm*, Arm^act, armadillo^s10, UASarm^S10, UAS-arm.S10, UASarm*

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

in vitro construct - regulatory fusion

(Bilder and Scott, 1998, Cadigan et al., 1998, Gallet et al., 1998, Steitz et al., 1998, Boyle et al., 1997, van de Wetering et al., 1997)

in vitro construct - coding region fusion

(Pai et al., 1997)

in vitro construct - deletion

(Cadigan et al., 1998)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{UAS-arm.S10}

Cytology

Nature of the lesion

Statement

Reference

A truncated arm protein, lacking amino acids 34 to 87 and tagged with Tag:MYC, is expressed under the control of UASt regulatory sequences. The protein produced is constitutively active in wg signalling, but functions normally at adherens junctions.

(Pai et al., 1997)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

arm

Tagged with

Tag:MYC

epitope tag

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Functions normally at adherens junctions; shows ectopic accumulation in cytoplasm and nucleus.

(Pai et al., 1997)

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Dupont et al., 2012)

exacerbates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

ameliorates intellectual disability

modeled by Hsap\HUWE1^UAS.cVa

(Vandewalle et al., 2013)

exacerbates cancer

modeled by Hipk^UAS.Tag:HA

(Blaquiere et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell migration | larval stage, with Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

abnormal cell shape | embryonic stage, with Scer\GAL4^svp.PT

(Trujillo et al., 2016)

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PU

(Dupont et al., 2012)

abnormal neuroanatomy | adult stage, with Scer\GAL4^ato.3.6

(Vandewalle et al., 2013)

abnormal size, with Scer\GAL4^btl.PS

(Llimargas, 2000)

abnormal size, with Scer\GAL4^nub-AC-62, Scer\GAL80^ts.αTub84B

(Baena-Lopez et al., 2009)

abnormal size | adult stage, with Scer\GAL4^GMR.PU

(Padash Barmchi et al., 2016)

abnormal size | adult stage, with Scer\GAL4^Mef2.PR

(Lee et al., 2014)

decreased cell number, with Scer\GAL4^btl.PS

(Llimargas, 2000)

decreased cell number | adult stage, with Scer\GAL4^elav.PU

(Dupont et al., 2012)

short lived, with Scer\GAL4^elav.PU

(Dupont et al., 2012)

viable, with Scer\GAL4^pros.PMG

(Akong et al., 2002)

visible, with Scer\GAL4^bbg-C96

(Pancratov et al., 2013)

visible, with Scer\GAL4^bi.PU

(Pereira et al., 2006)

visible, with Scer\GAL4^bs-1348

(Verheyen et al., 2001)

visible, with Scer\GAL4^Bx-MS1096

(Von Ohlen and Hooper, 1999)

visible, with Scer\GAL4^dpp.blk1

(Kopp et al., 1999)

visible, with Scer\GAL4^GF1

(Takacs et al., 2008)

visible, with Scer\GAL4^GMR.PF

(Bhambhani et al., 2011)

visible, with Scer\GAL4^nub-AC-62, Scer\GAL80^ts.αTub84B

(Baena-Lopez et al., 2009)

visible, with Scer\GAL4^sd-SG29.1

(Brennan et al., 1999)

visible | adult stage, with Scer\GAL4^GMR.PU

(Padash Barmchi et al., 2016)

Phenotype Manifest In

abdominal adult fat mass, with Scer\GAL4^Mef2.PR

(Lee et al., 2014)

abdominal sternite bristle | ectopic, with Scer\GAL4^GF1

(Takacs et al., 2008)

abdominal ventral acute muscle 1 founder cell | increased number, with Scer\GAL4^Mef2.PR

(Cox and Baylies, 2005)

abdominal ventral acute muscle 1 founder cell | increased number, with Scer\GAL4^twi.PB

(Cox and Baylies, 2005)

abdominal ventral acute muscle 2 founder cell | increased number, with Scer\GAL4^Mef2.PR

(Cox and Baylies, 2005)

abdominal ventral acute muscle 2 founder cell | increased number, with Scer\GAL4^twi.PB

(Cox and Baylies, 2005)

abdominal ventral acute muscle 3 founder cell | increased number, with Scer\GAL4^Mef2.PR

(Cox and Baylies, 2005)

abdominal ventral acute muscle 3 founder cell | increased number, with Scer\GAL4^twi.PB

(Cox and Baylies, 2005)

abdominal ventral denticle belt, with Scer\GAL4^arm.PS

(Greer et al., 2013, Jones et al., 2010)

antennal disc, with Scer\GAL4^dpp.blk1

(Brás-Pereira and Casares, 2008)

denticle, with Scer\GAL4^69B

(Angelats et al., 2002)

denticle, with Scer\GAL4^unspecified

(Thompson, 2004)

denticle belt, with Scer\GAL4^69B

(Pai et al., 1997)

denticle belt, with Scer\GAL4^arm.PS

(Thompson et al., 2002)

denticle belt, with Scer\GAL4^e22c

(Cox et al., 1999, Payre et al., 1999, Pai et al., 1997)

denticle belt, with Scer\GAL4^{VP16.mat.αTub67C}

(Tolwinski and Wieschaus, 2001)

denticle row 1, with Scer\GAL4^en-e16E

(Takaesu et al., 2005, Pai et al., 1997)

direct flight muscle, with Scer\GAL4¹¹⁵¹

(Sudarsan et al., 2001)

dorsal cluster neuron | adult stage, with Scer\GAL4^ato.3.6

(Vandewalle et al., 2013)

dorsal denticle, with Scer\GAL4^arm.PS

(Hatini et al., 2000)

dorsal fine hair | ectopic, with Scer\GAL4^arm.PS

(Hatini et al., 2000)

dorsal fine hair | ectopic, with Scer\GAL4^ptc-559.1

(Hatini et al., 2000)

dorsal hair, with Scer\GAL4^VP16.arm

(McEwen et al., 2000)

dorsal margin photoreceptor | ectopic, with Scer\GAL4^GMR.long

(Wernet et al., 2003)

dorsal thick hair, with Scer\GAL4^arm.PS

(Hatini et al., 2000)

embryonic/first instar larval cuticle, with Scer\GAL4^69B

(Gallet et al., 1998)

embryonic/first instar larval cuticle, with Scer\GAL4^arm.PS

(Tolwinski and Wieschaus, 2004)

embryonic/first instar larval cuticle, with Scer\GAL4^e22c

(Cox et al., 1999, van de Wetering et al., 1997)

embryonic/first instar larval cuticle, with Scer\GAL4^hs.PB

(Gallet et al., 1998)

embryonic/first instar larval cuticle, with Scer\GAL4^unspecified

(Thompson, 2004)

embryonic/first instar larval cuticle, with Scer\GAL4^αTub84B.PK

(Kramps et al., 2002)

embryonic/first instar larval cuticle & denticle, with Scer\GAL4^da.G32

(Hoffmans and Basler, 2004)

embryonic/first instar larval cuticle & denticle belt, with Scer\GAL4^da.G32

(Hoffmans et al., 2005)

embryonic/first instar larval cuticle | dorsal, with Scer\GAL4^VP16.arm

(McEwen et al., 2000)

embryonic/larval cuticle | ventral, with Scer\GAL4^arm.PS

(Greer et al., 2013)

embryonic/larval dorsal trunk, with Scer\GAL4^btl.PS

(Loureiro et al., 2001, Llimargas, 2000)

embryonic/larval ostium | embryonic stage, with Scer\GAL4^svp.PT

(Trujillo et al., 2016)

embryonic/larval visceral branch, with Scer\GAL4^btl.PS

(Chihara and Hayashi, 2000, Llimargas, 2000)

embryonic epidermis, with Scer\GAL4^e22c

(Payre et al., 1999)

embryonic epidermis | dorsal, with Scer\GAL4^arm.PS

(Hatini et al., 2000)

embryonic epidermis | dorsal, with Scer\GAL4^ptc-559.1

(Hatini et al., 2000)

embryonic epidermis | dorsal, with Scer\GAL4^VP16.arm

(McEwen et al., 2000)

embryonic midgut constriction 1, with Scer\GAL4^how-24B

(Yu et al., 1999)

embryonic midgut constriction 2, with Scer\GAL4^how-24B

(Steitz et al., 1998)

eye, with Scer\GAL4^GMR.PF

(Bhambhani et al., 2011, Freeman and Bienz, 2001)

eye, with Scer\GAL4^GMR.PU

(Padash Barmchi et al., 2016)

eye, with Scer\GAL4^hs.2sev

(Jackson et al., 2002)

eye photoreceptor cell, with Scer\GAL4^elav.PU

(Dupont et al., 2012)

eye photoreceptor cell, with Scer\GAL4^GMR.long

(Benchabane et al., 2011)

eye photoreceptor cell, with Scer\GAL4^hs.2sev

(Mirkovic et al., 2011)

interommatidial bristle, with Scer\GAL4^GMR.PF

(Rousset et al., 2001)

interommatidial bristle, with Scer\GAL4^hs.2sev

(Jackson et al., 2002)

lipid droplet | adult stage, with Scer\GAL4^Mef2.PR

(Lee et al., 2014)

lymph gland derived hemocyte | third instar larval stage, with Scer\GAL4^dome-PG14

(Sinenko et al., 2009)

medulla | adult stage, with Scer\GAL4^ato.3.6

(Vandewalle et al., 2013)

morphogenetic furrow, with Scer\GAL4^dpp.blk1

(Cadigan et al., 2002)

ommatidium, with Scer\GAL4^GMR.PF

(Rousset et al., 2001)

ommatidium, with Scer\GAL4^hs.2sev

(Jackson et al., 2002)

pleural membrane, with Scer\GAL4^GF1

(Takacs et al., 2008)

pleurum, with Scer\GAL4^dpp.blk1

(Kopp et al., 1999)

sensory mother cell & dorsal mesothoracic disc | ectopic, with Scer\GAL4^sd-SG29.1

(Brennan et al., 1999)

stalk follicle cell | increased number | heat sensitive, with Scer\GAL4^hs.PB

(Song and Xie, 2003)

sternite, with Scer\GAL4^GF1

(Takacs et al., 2008)

T1 beard, with Scer\GAL4^69B

(Angelats et al., 2002)

terminal tracheal cell, with Scer\GAL4^btl.PS

(Caviglia and Luschnig, 2013)

testis, with Scer\GAL4^nos.PU

(Pancratov et al., 2013)

testis, with Scer\GAL4^tj.PU

(Pancratov et al., 2013)

tracheal fusion cell | increased number, with Scer\GAL4^btl.PS

(Caviglia and Luschnig, 2013)

wing, with Scer\GAL4^30A

(Kiger et al., 2007)

wing, with Scer\GAL4^bbg-C96

(Helms et al., 1999)

wing, with Scer\GAL4^bi.PU

(Pereira et al., 2006)

wing, with Scer\GAL4^Bx-MS1096

(Von Ohlen and Hooper, 1999)

wing, with Scer\GAL4^nub-AC-62, Scer\GAL80^ts.αTub84B

(Baena-Lopez et al., 2009)

wing disc, with Scer\GAL4^Dll-md23

(Kubota et al., 2003)

wing disc, with Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018, Hayward et al., 2005, Brennan et al., 1999)

wing disc, with Scer\GAL4^dpp.PU

(Sanders et al., 2009)

wing disc, with Scer\GAL4^sd-SG29.1

(Giraldez et al., 2002)

wing disc anterior compartment, with Scer\GAL4^sd-SG29.1

(Brennan et al., 1999)

wing hair, with Scer\GAL4^nub-AC-62, Scer\GAL80^ts.αTub84B

(Baena-Lopez et al., 2009)

wing hinge, with Scer\GAL4^sd-SG29.1

(Brennan et al., 1999)

wing margin bristle, with Scer\GAL4^Bx-MS1096

(Von Ohlen and Hooper, 1999)

wing margin bristle | ectopic, with Scer\GAL4⁴⁰⁵

(Bajpai et al., 2004)

wing margin bristle | ectopic, with Scer\GAL4^bbg-C96

(Helms et al., 1999)

wing margin bristle | ectopic, with Scer\GAL4^sd-SG29.1

(Brennan et al., 1999)

wing margin bristle | ectopic, with Scer\GAL4^vg.PM

(Bajpai et al., 2004)

wing margin bristle | increased number, with Scer\GAL4^bbg-C96

(Pancratov et al., 2013)

wing pouch | ectopic, with Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

wing vein | ectopic, with Scer\GAL4^bs-1348

(Lee et al., 2009, Verheyen et al., 2001)

Detailed Description

Statement

Reference

Expressing arm^{S10.UAS.Tag:MYC} under the control of Scer\GAL4^dpp.blk1 induces an ectopic wing pouch-like structure in the notum region of the wing disc, but the Dpp-positive domain appears relatively normal; cells originating from the wing disc's Dpp-positive domain show some invasiveness.

(Blaquiere et al., 2018)

The expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.PU leads to a decrease in adult eye size, as compared to controls.

(Padash Barmchi et al., 2016)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the Scer\GAL4^svp.PT driver resulted in more elongated ostia cell shape.

(Trujillo et al., 2016)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^wor.PA does not induced the formation of supernumerary type II neuroblasts in the larval brain.

(Komori et al., 2014)

Adults expressing arm^{S10.UAS.Tag:MYC} under the control of Scer\GAL4^Mef2.PR have a reduced abdominal fat body with smaller lipid droplets than controls.

(Lee et al., 2014)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} in eye disc clones under the control of a GAL4 driver does not significantly increase apoptosis levels compared to controls.

(Zhang et al., 2014)

Embryos expressing arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^btl.PS have supernumerary tracheal fusion cells in the dorsal trunk, visceral branch and transverse connective. The number of terminal tracheal cells is normal in most branches and only slightly reduced in the visceral branch.

(Caviglia and Luschnig, 2013)

Scer\GAL4^arm.PS-mediated expression of arm^{S10.Scer\UAS.T:Hsap\MYC} results in embryos with excess naked cuticle at the expense of denticles.

(Greer et al., 2013)

Flies expressing arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^bbg-C96 have extra wing margin bristles.

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of either Scer\GAL4^tj.PU or Scer\GAL4^nos.PU results in the formation of ectopic germ cell clusters in the testis.

(Pancratov et al., 2013)

When arm^{S10.Scer\UAS.T:Hsap\MYC} is expressed in dorsal cluster neurons under the control of Scer\GAL4^ato.3.6 the branching pattern in the adult medulla is disturbed, giving rise to a reduced number of branches at the 3rd branching point of the grid-like structure.

(Vandewalle et al., 2013)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} in the heart under the control of Scer\GAL4^tin.CΔ4 does not appear to alter cardiac function as fractional shortening is comparable with controls.

(Casad et al., 2012)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} driven by Scer\GAL4^elav.PU leads to photoreceptor loss in the retina (obvious at 1 day old), locomotor defects (reduced climbing ability) and a shorter lifespan compared to controls.

(Dupont et al., 2012)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.long results in shortened photoreceptors, which are visible in apical cross sections of the retina, but do not extend to its base.

(Benchabane et al., 2011)

Overexpression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.PF causes a small eye phenotype.

(Bhambhani et al., 2011)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^hs.2sev at 25[o]C results in frequent apoptosis of photoreceptor cells.

(Mirkovic et al., 2011)

Scer\GAL4^arm.PS-driven expression of arm^{S10.Scer\UAS.T:Hsap\MYC} transforms most of the ventral denticle-secreting epidermal cells to a naked-cuticle cell fate.

(Jones et al., 2010)

Ectopic expression of arm^{S10.Scer\UAS.T:Hsap\MYC} at moderate levels driven by Scer\GAL4^nub-AC-62 and Scer\GAL80^ts.αTub84B produces a small number of ectopic wing bristles and induces extra wing growth compared with wild-type controls.

(Baena-Lopez et al., 2009)

Ectopic expression of arm^{S10.Scer\UAS.T:Hsap\MYC} in the wing using Scer\GAL4^bs-1348 results in ectopic vein formation.

(Lee et al., 2009)

Scer\GAL4^dpp.PU-mediated expression of arm^{S10.Scer\UAS.T:Hsap\MYC} results in changes in gross morphology and alterations in cell fate in a region-specific manner within the wing disc, with little or no effect on the overall size of the wing pouch or cell proliferation. There is expansion of the hinge region and deformation of the wing pouch, and a slight overgrowth in the scutellar region.

(Sanders et al., 2009)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^dome-PG14 blocks differentiation of hemocyte precursors in the lymph gland.

(Sinenko et al., 2009)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^dpp.blk1 result in antennal duplications in the antennal disc.

(Brás-Pereira and Casares, 2008)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GF1 results in expansion of sternal territory in the abdomen and ectopic sternal bristles, at the expense of the pleura.

(Takacs et al., 2008)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} in the wing (under the control of Scer\GAL4^30A) causes cells to fail to delaminate.

(Kiger et al., 2007)

Somatic clones overexpressing arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^e22c, separate from their neighbours and display smooth clone borders.

Overexpression of arm^{S10.Scer\UAS.T:Hsap\MYC}, under the control of Scer\GAL4^vg.PM, along the DV boundary induces ectopic wing margin bristles.

(Jaiswal et al., 2006)

When arm^{S10.Scer\UAS.T:Hsap\MYC} is driven by Scer\GAL4^twi.PB or Scer\GAL4^Mef2.PR the cII cluster of slou expressing muscle founder cells is expanded. The cI cluster of slou expressing muscle founder cells is unaffected.

(Cox and Baylies, 2005)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^dpp.blk1 results in alteration in growth in the wing disc.

(Hayward et al., 2005)

Ubiquitous expression of arm^{S10.Scer\UAS.T:Hsap\MYC}, under the control of Scer\GAL4^da.G32, results in a naked cuticle phenotype, in which embryos have no denticle belts.

(Hoffmans et al., 2005)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} via Scer\GAL4^en-e16E results in the first row of denticles in all segments being transformed into naked cuticle.

(Takaesu et al., 2005)

arm^{S10.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^vg.PM and arm^{S10.Scer\UAS.T:Hsap\MYC}; Scer\GAL4⁴⁰⁵ flies have tufts of ectopic wing margin bristles on their wing blades.

(Bajpai et al., 2004)

The cuticles formed by arm^{S10.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^da.G32 embryos lack most denticles.

(Hoffmans and Basler, 2004)

Ubiquitous expression of arm^{S10.Scer\UAS.T:Hsap\MYC} in embryos using Scer\GAL4^unspecified produces ectopic naked cuticle.

(Thompson, 2004)

When arm^{S10.Scer\UAS.T:Hsap\MYC} is driven by Scer\GAL4^arm.PS a naked cuticle phenotype is seen.

(Tolwinski and Wieschaus, 2004)

When arm^{S10.Scer\UAS.T:Hsap\MYC} is driven by Scer\GAL4^Dll-md23 a reduction is seen in the number of wing disc cells.

(Kubota et al., 2003)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^hs.PB using four days of pulsed heat shock treatment consistently produces more follicle cells that accumulate between egg chambers. These extra follicle cells form long stalks with multiple rows of cells instead of one row in the wild type.

(Song and Xie, 2003)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.long results in a dramatic expansion of the dorsal rim area (DRA) throughout the dorsal eye.

(Wernet et al., 2003)

When expression of arm^{S10.Scer\UAS.T:Hsap\MYC} is driven by Scer\GAL4^pros.PMG neuroblast development is not disrupted.

(Akong et al., 2002)

When arm^{S10.Scer\UAS.T:Hsap\MYC} is driven by Scer\GAL4^69B all denticles fail to form except the T1 beard, which has more denticles than wild-type.

(Angelats et al., 2002)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^dpp.blk1 blocks progression of the morphogenetic furrow.

(Cadigan et al., 2002)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^sd-SG29.1 results in duplication of the wing pouch in the wing disc.

(Giraldez et al., 2002)

arm^{S10.Scer\UAS.T:Hsap\MYC} when driven by Scer\GAL4^hs.2sev leads to a mildly reduced eye with disordered bristles.

(Jackson et al., 2002)

larvae derived from mothers in which arm^{S10.Scer\UAS.T:Hsap\MYC} is driven by Scer\GAL4^αTub84B.PK have a naked cuticle phenotype.

(Kramps et al., 2002)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^arm.PS in embryos suppresses the formation of denticles and results in nearly naked cuticles.

(Thompson et al., 2002)

When arm^{S10.Scer\UAS.T:Hsap\MYC} is driven by Scer\GAL4^GMR.PF, flies have very narrow, rough and glazed eyes.

(Freeman and Bienz, 2001)

When arm^{S10.Scer\UAS.T:Hsap\MYC} is driven by Scer\GAL4^c306 or Scer\GAL4^slbo.2.6 no effect is seen on border cell migration. When arm^{S10.Scer\UAS.T:Hsap\MYC} is driven by Scer\GAL4^elav-C155 no effect is seen on axon outgrowth in embryos. When arm^{S10.Scer\UAS.T:Hsap\MYC} is driven by Scer\GAL4^btl.PS many aspects of tracheal development are unaffected. However in many segments a pronounced hypertrophy of the presumptive dorsal longitudinal trunk is seen, often with a corresponding reduction in the presumptive visceral branch. The resulting dorsal trunk is misshapen, often forming loops ventral to and reconnecting to the dorsal longitudinal trunk, or ventral outgrowths. These loops have a diameter more similar to that of the dorsal longitudinal trunk than that of the transverse connective.

(Loureiro et al., 2001)

arm^{S10.Scer\UAS.T:Hsap\MYC} when driven buy Scer\GAL4^GMR.PF causes bristle loss in the eye, and a failure of proper ommatidial development.

(Rousset et al., 2001)

arm^{S10.Scer\UAS.T:Hsap\MYC}; Scer\GAL4¹¹⁵¹ flies some direct flight muscles are lost, while those that remain are much reduced in size.

(Sudarsan et al., 2001)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^arm.PS results in the complete absence of denticles from the cuticle.

(Tolwinski and Wieschaus, 2001)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^bs-1348 results in the formation of moderate ectopic veins which emanate from the posterior crossvein, in addition to more severe ectopic veins along L2.

(Verheyen et al., 2001)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^btl.PS results in loss of the tracheal visceral branch.

(Chihara and Hayashi, 2000)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^arm.PS results in replacement of 1^o-3^o fates in the dorsal cuticle (dorsal denticles, smooth cuticle and thick hairs respectively) with 4^o fates (fine hairs). Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^ptc-559.1 results in the global specification of 4^o cell types in the dorsal cuticle.

(Hatini et al., 2000)

The tracheal dorsal trunk (DT) is hypertrophied when arm^{S10.Scer\UAS.T:Hsap\MYC} is expressed under the control of Scer\GAL4^btl.PS, often showing ectopic branches with DT features. The visceral branches are shortened or even completely missing and contain fewer cells than in wild type (the rest of the branches contain roughly the normal number of cells). No extra tracheal cell proliferation is seen in these embryos.

(Llimargas, 2000)

When expression is driven by Scer\GAL4^{arm.T:Hsim\VP16}, embryos show puckering of dorsal epidermis with loss of dorsal hair identity and a naked scar at the dorsal midline.

(McEwen et al., 2000)

Overexpression of arm^{S10.Scer\UAS.T:Hsap\MYC} driven by Scer\GAL4^sd-SG29.1 greatly increases the size of the hinge region but does not affect the viability of the cells. Wings in these adult flies are wild-type in size but with many ectopic bristles. When expression of arm^{S10.Scer\UAS.T:Hsap\MYC} is driven by Scer\GAL4^sd-SG29.1, the of the anterior compartment of the wing disc is covered in evenly spaced SOPs (sensory organ precursors). This phenotype is weaker than seen withy overexpression of dsh^Scer\UAS.cAa and wg^Scer\UAS.cGa. These effects increase as development proceeds. Expression of wg^Scer\UAS.cGa during the induction of the wing primordia in the early phases of wing development by Scer\GAL4^dpp.blk1, leads to an increased wing primordia which distorts the disc as the primordia invades the notum.

(Brennan et al., 1999)

Expression of arm^{R.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^e22c in embryos results in a strong conversion of denticles to naked cuticle.

(Cox et al., 1999)

arm^{S10.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^C96 flies show additional margin bristles and ectopic bristles, as well as bubbles at the distal end.

(Helms et al., 1999)

When expression is driven by Scer\GAL4^dpp.blk1 almost the entire pleura is transformed to tergite and sternite identities.

(Kopp et al., 1999)

Ubiquitous expression of arm^{S10.Scer\UAS.T:Hsap\MYC} driven by Scer\GAL4^e22c mimics constitutive action of the wg pathway, producing naked cuticle.

(Payre et al., 1999)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^Bx-MS1096 results in overgrowth of the wing and mispatterning of the wing margin.

(Von Ohlen and Hooper, 1999)

When expression is driven by Scer\GAL4^how-24B, the anterior midgut construction is obliterated. Phenotype is similar to that caused by Apc2 RNAi mutants.

(Yu et al., 1999)

Flies expressing arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^hs.PB have a wild-type tissue polarity phenotype in the wing.

(Axelrod et al., 1998)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^69B results in embryos having naked cuticle with almost no ventral denticle belts. These embryos contain a large prothoracic beard. Overexpression of arm^{S10.Scer\UAS.T:Hsap\MYC} in embryos using Scer\GAL4^hs.PB between stages 7 and 10 results in a naked cuticle phenotype.

(Gallet et al., 1998)

Embryos expressing arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^how-24B have an abnormal second midgut constriction.

(Steitz et al., 1998)

Embryos in which arm^{S10.Scer\UAS.T:Hsap\MYC} is expressed using Scer\GAL4^twi.PB show an increase in the number of somatic gonadal precursor cells.

(Boyle et al., 1997)

Ubiquitous expression of arm^{S10.Scer\UAS.T:Hsap\MYC} using Scer\GAL4^e22c or Scer\GAL4^69B gives rise to embryos with only naked cuticle or a few denticles. Head structures remain nearly normal in these embryos. The naked cuticle phenotype is unaltered if arm^{S10.Scer\UAS.T:Hsap\MYC} is expressed using Scer\GAL4^e22c in a wg^l-8 mutant background. The first row of denticles is replaced by naked cuticle in embryos expressing arm^{S10.Scer\UAS.T:Hsap\MYC} using Scer\GAL4^en-e16E. arm⁴ embryos expressing arm^{S10.Scer\UAS.T:Hsap\MYC} (using Scer\GAL4^e22c) differentiate essentially only naked cuticle, similar to the phenotype of embryos expressing arm^{S10.Scer\UAS.T:Hsap\MYC} (using Scer\GAL4^e22c) in a wild-type background. These embryos are shorter than wild-type. Embryos that are zygotically and maternally mutant for arm⁸ and are expressing arm^{S10.Scer\UAS.T:Hsap\MYC} (using Scer\GAL4^e22c) essentially secrete only naked cuticle. The integrity of the cuticle of embryos that are zygotically and maternally mutant for arm³ is dramatically improved if these embryos are also expressing arm^{S10.Scer\UAS.T:Hsap\MYC} (using Scer\GAL4^e22c), and the secreted cuticle is naked.

(Pai et al., 1997)

Scer\GAL4^e22c-mediated expression transforms all cells to posterior cell fates. Action of the protein is largely inhibited when expressed in pan^13a, pan² or pan³ embryos, embryos exhibit alternate denticles and naked cuticle with portions of the lateral naked cuticle converted to denticles.

(van de Wetering et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^dpp.blk1, arm^{S10.UAS.Tag:MYC} has abnormal cell migration | larval stage phenotype, enhanceable by Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, arm^{S10.UAS.Tag:MYC} has visible phenotype, enhanceable by CtBP^{Mono.UAS.Tag:FLAG}, Scer\GAL4^GMR.PF

(Bhambhani et al., 2011)

Suppressed by

Statement

Reference

Scer\GAL4^bbg-C96, arm^{S10.UAS.Tag:MYC} has visible phenotype, suppressible by mir-311^{UAS.cluster.DsRed(Unk)}/Scer\GAL4^bbg-C96/mir-313^{UAS.cluster.DsRed(Unk)}/mir-310^{UAS.cluster.DsRed(Unk)}/mir-312^{UAS.cluster.DsRed(Unk)}

(Pancratov et al., 2013)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, arm^{S10.UAS.Tag:MYC} has visible phenotype, suppressible by CtBP^UAS.Tag:FLAG, Scer\GAL4^GMR.PF

(Bhambhani et al., 2011)

Scer\GAL4^btl.PS, arm^{S10.UAS.Tag:MYC} has abnormal size phenotype, suppressible | partially by tkv^{Q253D.UAS.cLa}/Scer\GAL4^btl.PS

(Llimargas, 2000)

Enhancer of

Statement

Reference

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^dpp.blk1 is an enhancer of neoplasia | larval stage phenotype of Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

Scer\GAL4^wor.PA/arm^{S10.UAS.Tag:MYC} is an enhancer of abnormal neuroanatomy | larval stage phenotype of brat^DG19310/brat¹¹

(Komori et al., 2014)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^unspecified is an enhancer of increased cell death | somatic clone phenotype of Rbf^HMS03004, Scer\GAL4^unspecified

(Zhang et al., 2014)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^elav.PU is an enhancer of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU

(Dupont et al., 2012)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^hs.2sev is an enhancer of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^ey.PS is an enhancer of visible | adult stage phenotype of N^ICN.UAS, Scer\GAL4^ey.PS

(Fre et al., 2009)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^ey.PS is an enhancer of abnormal size | adult stage phenotype of N^ICN.UAS, Scer\GAL4^ey.PS

(Fre et al., 2009)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^ey.PS is an enhancer of abnormal size | third instar larval stage phenotype of N^ICN.UAS, Scer\GAL4^ey.PS

(Fre et al., 2009)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^hs.2sev is an enhancer of visible phenotype of Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

NOT Enhancer of

Statement

Reference

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^dpp.blk1 is a non-enhancer of abnormal cell migration | larval stage phenotype of Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^GMR.PU is a non-enhancer of visible | adult stage phenotype of HPV18\E6^UAS.Tag:MYC, Hsap\UBE3A^UAS.cRa, Scer\GAL4^GMR.PU

(Padash Barmchi et al., 2016)

Suppressor of

Statement

Reference

fz^KK108004/arm^{S10.UAS.Tag:MYC}, Scer\GAL4^repo is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^bbg-C96 is a suppressor of visible phenotype of Klp64D^NIG.10642R, Scer\GAL4^bbg-C96

(Vuong et al., 2014)

Scer\GAL4^unspecified/arm^{S10.UAS.Tag:MYC} is a suppressor of FlyBase_internaltransgene_features:cell lethal:cell lethal | somatic clone phenotype of Scer\GAL4^unspecified, mir-310^{UAS.cluster.DsRed(Unk)}, mir-311^{UAS.cluster.DsRed(Unk)}, mir-312^{UAS.cluster.DsRed(Unk)}, mir-313^{UAS.cluster.DsRed(Unk)}

(Pancratov et al., 2013)

Scer\GAL4^bbg-C96/arm^{S10.UAS.Tag:MYC} is a suppressor of visible phenotype of Scer\GAL4^bbg-C96, mir-310^{UAS.cluster.DsRed(Unk)}, mir-311^{UAS.cluster.DsRed(Unk)}, mir-312^{UAS.cluster.DsRed(Unk)}, mir-313^{UAS.cluster.DsRed(Unk)}

(Pancratov et al., 2013)

Scer\GAL4^sd.PU/arm^{S10.UAS.Tag:MYC} is a suppressor of increased cell number | somatic clone phenotype of lace²

(Sasamura et al., 2013)

Scer\GAL4^sd.PU/arm^{S10.UAS.Tag:MYC} is a suppressor of increased cell number | somatic clone phenotype of ACC¹

(Sasamura et al., 2013)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^ato.3.6 is a suppressor | partially of abnormal neuroanatomy | adult stage phenotype of Hsap\HUWE1^UAS.cVa, Scer\GAL4^ato.3.6

(Vandewalle et al., 2013)

Scer\GAL4^ebd1.PB/arm^{S10.UAS.Tag:MYC} is a suppressor of flightless phenotype of Scer\GAL4^ebd1.PB, pan^ΔN.UAS

(Benchabane et al., 2011)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^αTub84B.PL is a suppressor of increased cell death | somatic clone | third instar larval stage phenotype of Su(H)^del47

(Sanders et al., 2009)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^bi.PU is a suppressor | partially of visible phenotype of Hsap\CDH1^UAS.cPa, Scer\GAL4^bi.PU

(Pereira et al., 2006)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^bi.PU is a suppressor | partially of visible phenotype of Hsap\CDH1^A634V.UAS, Scer\GAL4^bi.PU

(Pereira et al., 2006)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^bi.PU is a suppressor of visible phenotype of Hsap\CDH1^V832M.UAS, Scer\GAL4^bi.PU

(Pereira et al., 2006)

Scer\GAL4^bbg-C96/arm^{S10.UAS.Tag:MYC} is a suppressor of visible phenotype of Scer\GAL4^bbg-C96, dlp^UAS.cBa

(Baeg et al., 2001)

NOT Suppressor of

Statement

Reference

fz^KK108004/arm^{S10.UAS.Tag:MYC}, Scer\GAL4^repo is a non-suppressor of neoplasia | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^dpp.blk1 is a non-suppressor of abnormal cell migration | larval stage phenotype of Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

Scer\GAL4^Act.PU/arm^{S10.UAS.Tag:MYC} is a non-suppressor | somatic clone of decreased cell number | somatic clone | adult stage phenotype of mys¹¹

(Lin et al., 2013)

Scer\GAL4^Act.PU/arm^{S10.UAS.Tag:MYC} is a non-suppressor | somatic clone of decreased cell number | somatic clone | adult stage phenotype of mys^M2

(Lin et al., 2013)

Scer\GAL4^αTub84B.PBb/arm^{S10.UAS.Tag:MYC} is a non-suppressor of increased cell death | somatic clone | cell non-autonomous phenotype of Myc^αTub84B.PBb

(Moreno and Basler, 2004)

Other

Statement

Reference

Scer\GAL4^Bx-MS1096, arm^{S10.UAS.Tag:MYC}, ci^{m1-4.UAS.Tag:HA} has hyperplasia phenotype

(Skwarek et al., 2014)

Hsap\CDH1^V832M.UAS, Scer\GAL4^bi.PU, arm^{S10.UAS.Tag:MYC} has visible phenotype

(Pereira et al., 2006)

Scer\GAL4^VP16.arm, arm^{S10.UAS.Tag:MYC}, tsh^UAS.cGa has lethal | somatic clone phenotype

(Erkner et al., 1999)

Scer\GAL4^Bx-MS1096, arm^{S10.UAS.Tag:MYC}, ci::pan^DΔ.UAS has lethal phenotype

(Von Ohlen and Hooper, 1999)

Scer\GAL4^Bx-MS1096, arm^{S10.UAS.Tag:MYC}, ci::pan^DΔ.UAS has lethal | pupal stage phenotype

(Von Ohlen and Hooper, 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^dpp.blk1, arm^{S10.UAS.Tag:MYC} has wing disc phenotype, enhanceable by Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, arm^{S10.UAS.Tag:MYC} has eye phenotype, enhanceable by CtBP^{Mono.UAS.Tag:FLAG}, Scer\GAL4^GMR.PF

(Bhambhani et al., 2011)

Scer\GAL4^69B, arm^{S10.UAS.Tag:MYC} has T1 beard phenotype, enhanceable by ci⁹⁴/ci⁹⁴

(Angelats et al., 2002)

Scer\GAL4^hs.2sev, arm^{S10.UAS.Tag:MYC} has interommatidial bristle phenotype, enhanceable by Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

Scer\GAL4^hs.2sev, arm^{S10.UAS.Tag:MYC} has ommatidium phenotype, enhanceable by Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

Scer\GAL4^hs.2sev, arm^{S10.UAS.Tag:MYC} has eye phenotype, enhanceable by Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

NOT Enhanced by

Statement

Reference

Scer\GAL4^vg.PM, arm^{S10.UAS.Tag:MYC} has wing margin bristle | ectopic phenotype, non-enhanceable by tws[+]/tws^j11C8

(Bajpai et al., 2004)

Suppressed by

Statement

Reference

Scer\GAL4^arm.PS, arm^{S10.UAS.Tag:MYC} has embryonic/larval cuticle | ventral phenotype, suppressible | partially by pbl^{DH-PH.UAS.Tag:HA}/Scer\GAL4^arm.PS

(Greer et al., 2013)

Scer\GAL4^arm.PS, arm^{S10.UAS.Tag:MYC} has abdominal ventral denticle belt phenotype, suppressible | partially by pbl^{DH-PH.UAS.Tag:HA}/Scer\GAL4^arm.PS

(Greer et al., 2013)

Scer\GAL4^bbg-C96, arm^{S10.UAS.Tag:MYC} has wing margin bristle | increased number phenotype, suppressible by mir-311^{UAS.cluster.DsRed(Unk)}/Scer\GAL4^bbg-C96/mir-313^{UAS.cluster.DsRed(Unk)}/mir-310^{UAS.cluster.DsRed(Unk)}/mir-312^{UAS.cluster.DsRed(Unk)}

(Pancratov et al., 2013)

Scer\GAL4^GMR.long, arm^{S10.UAS.Tag:MYC} has eye photoreceptor cell phenotype, suppressible by ebd1²⁴⁰/Df(3L)ED4136

(Benchabane et al., 2011)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, arm^{S10.UAS.Tag:MYC} has eye phenotype, suppressible by CtBP^UAS.Tag:FLAG, Scer\GAL4^GMR.PF

(Bhambhani et al., 2011)

Scer\GAL4^arm.PS, arm^{S10.UAS.Tag:MYC} has abdominal ventral denticle belt phenotype, suppressible | partially by Scer\GAL4^arm.PS/tum^UAS.cSa

(Jones et al., 2010)

Scer\GAL4^arm.PS, arm^{S10.UAS.Tag:MYC} has abdominal ventral denticle belt phenotype, suppressible | partially by Scer\GAL4^arm.PS/pav^UASp.mGFP6

(Jones et al., 2010)

N^55e11, Scer\GAL4^αTub84B.PL, arm^{S10.UAS.Tag:MYC} has wing disc | somatic clone phenotype, suppressible by N^{intra.CD8.UAS.EGFP}, Scer\GAL4^αTub84B.PL

(Sanders et al., 2009)

N^55e11, Scer\GAL4^dpp.PU, arm^{S10.UAS.Tag:MYC} has wing disc | somatic clone phenotype, suppressible by N^{intra.CD8.UAS.EGFP}, Scer\GAL4^dpp.PU

(Sanders et al., 2009)

N^55e11, Scer\GAL4^dpp.PU, arm^{S10.UAS.Tag:MYC} has wing disc | somatic clone phenotype, suppressible by N^FLN.UAS, Scer\GAL4^dpp.PU

(Sanders et al., 2009)

Scer\GAL4^dpp.blk1, arm^{S10.UAS.Tag:MYC} has wing disc phenotype, suppressible by N::tor^UAS.cSa, Scer\GAL4^dpp.blk1

(Hayward et al., 2005)

Scer\GAL4^dpp.blk1, arm^{S10.UAS.Tag:MYC} has morphogenetic furrow phenotype, suppressible by Scer\GAL4^dpp.blk1/da^UAS.cGa

(Cadigan et al., 2002)

Scer\GAL4^αTub84B.PK, arm^{S10.UAS.Tag:MYC} has embryonic/first instar larval cuticle phenotype, suppressible by lgs^unspecified

(Kramps et al., 2002)

Scer\GAL4^btl.PS, arm^{S10.UAS.Tag:MYC} has embryonic/larval dorsal trunk phenotype, suppressible | partially by tkv^{Q253D.UAS.cLa}/Scer\GAL4^btl.PS

(Llimargas, 2000)

Scer\GAL4^e22c, arm^{S10.UAS.Tag:MYC} has embryonic epidermis phenotype, suppressible by ovo^UAS.cPa/Scer\GAL4^e22c

(Payre et al., 1999)

Scer\GAL4^e22c, arm^{S10.UAS.Tag:MYC} has denticle belt phenotype, suppressible by ovo^UAS.cPa/Scer\GAL4^e22c

(Payre et al., 1999)

Scer\GAL4^69B, arm^{S10.UAS.Tag:MYC} has embryonic/first instar larval cuticle phenotype, suppressible by tsh⁸

(Gallet et al., 1998)

NOT suppressed by

Statement

Reference

Scer\GAL4^dpp.blk1, arm^{S10.UAS.Tag:MYC} has wing pouch | ectopic phenotype, non-suppressible by Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

Scer\GAL4^arm.PS, arm^{S10.UAS.Tag:MYC} has embryonic/larval cuticle | ventral phenotype, non-suppressible by Scer\GAL4^arm.PS/pbl^{DH-PH-V531D.UAS.Tag:HA}

(Greer et al., 2013)

Scer\GAL4^arm.PS, arm^{S10.UAS.Tag:MYC} has abdominal ventral denticle belt phenotype, non-suppressible by Scer\GAL4^arm.PS/pbl^{DH-PH-V531D.UAS.Tag:HA}

(Greer et al., 2013)

Scer\GAL4^arm.PS, arm^{S10.UAS.Tag:MYC} has abdominal ventral denticle belt phenotype, non-suppressible by Scer\GAL4^arm.PS/nkd^UAS.cZa

(Jones et al., 2010)

Scer\GAL4^arm.PS, arm^{S10.UAS.Tag:MYC} has abdominal ventral denticle belt phenotype, non-suppressible by tum^ΔNLS.UAS/Scer\GAL4^arm.PS

(Jones et al., 2010)

Scer\GAL4^arm.PS, arm^{S10.UAS.Tag:MYC} has abdominal ventral denticle belt phenotype, non-suppressible by pav^{NLS4-7*.UASp.mGFP6}/Scer\GAL4^arm.PS

(Jones et al., 2010)

Scer\GAL4^vg.PM, arm^{S10.UAS.Tag:MYC} has wing margin bristle | ectopic phenotype, non-suppressible by tws[+]/tws^j11C8

(Bajpai et al., 2004)

Scer\GAL4^69B, arm^{S10.UAS.Tag:MYC} has denticle phenotype, non-suppressible by tsh^UAS.cGa/Scer\GAL4^69B, ci⁹⁴/ci⁹⁴

(Angelats et al., 2002)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, arm^{S10.UAS.Tag:MYC} has interommatidial bristle phenotype, non-suppressible by nkd^UAS.Tag:MYC/Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Rousset et al., 2001)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, arm^{S10.UAS.Tag:MYC} has ommatidium phenotype, non-suppressible by nkd^UAS.Tag:MYC/Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Rousset et al., 2001)

Scer\GAL4^how-24B/Scer\GAL4^how-24B, arm^{S10.UAS.Tag:MYC} has embryonic midgut constriction 2 phenotype, non-suppressible by sgg^UAS.cSa/Scer\GAL4^how-24B/Scer\GAL4^how-24B

(Steitz et al., 1998)

Enhancer of

Statement

Reference

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^dpp.blk1 is an enhancer of wing disc phenotype of Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

Scer\GAL4^wor.PA/arm^{S10.UAS.Tag:MYC} is an enhancer of type II neuroblast | increased number phenotype of brat^DG19310/brat¹¹

(Komori et al., 2014)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^unspecified is an enhancer of eye disc | somatic clone phenotype of Rbf^HMS03004, Scer\GAL4^unspecified

(Zhang et al., 2014)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^hs.2sev is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^ey.PS is an enhancer of eye phenotype of N^ICN.UAS, Scer\GAL4^ey.PS

(Fre et al., 2009)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^ey.PS is an enhancer of eye disc | third instar larval stage phenotype of N^ICN.UAS, Scer\GAL4^ey.PS

(Fre et al., 2009)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^ey.PS is an enhancer of morphogenetic furrow | third instar larval stage phenotype of N^ICN.UAS, Scer\GAL4^ey.PS

(Fre et al., 2009)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^hs.2sev is an enhancer of eye phenotype of Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^hs.2sev is an enhancer of interommatidial bristle phenotype of Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^hs.2sev is an enhancer of ommatidium phenotype of Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

NOT Enhancer of

Statement

Reference

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of HPV18\E6^UAS.Tag:MYC, Hsap\UBE3A^UAS.cRa, Scer\GAL4^GMR.PU

(Padash Barmchi et al., 2016)

Suppressor of

Statement

Reference

fz^KK108004/arm^{S10.UAS.Tag:MYC}, Scer\GAL4^repo is a suppressor | partially of synapse | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

fz^KK108004/arm^{S10.UAS.Tag:MYC}, Scer\GAL4^repo is a suppressor | partially of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

Ecol\lexA^GMR27E08, arm^{S10.UAS.Tag:MYC}, Scer\FLP1^L.8xlexAop, wg^{KO.FRT.wg.FRT.NRT-wg} is a suppressor of embryonic/larval glial cell | somatic clone | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

Ecol\lexA^GMR27E08, arm^{S10.UAS.Tag:MYC}, Scer\FLP1^L.8xlexAop, wg^{KO.FRT.wg.FRT.NRT-wg} is a suppressor of glial cell projection | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^bbg-C96 is a suppressor of wing margin phenotype of Klp64D^NIG.10642R, Scer\GAL4^bbg-C96

(Vuong et al., 2014)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^btl.PS is a suppressor of embryonic/larval dorsal trunk phenotype of Axn^UAS.GFP, Scer\GAL4^btl.PS

(Caviglia and Luschnig, 2013)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^btl.PS is a suppressor of tracheal fusion cell phenotype of Axn^UAS.GFP, Scer\GAL4^btl.PS

(Caviglia and Luschnig, 2013)

Scer\GAL4^unspecified/arm^{S10.UAS.Tag:MYC} is a suppressor of wing disc | somatic clone phenotype of Scer\GAL4^unspecified, mir-310^{UAS.cluster.DsRed(Unk)}, mir-311^{UAS.cluster.DsRed(Unk)}, mir-312^{UAS.cluster.DsRed(Unk)}, mir-313^{UAS.cluster.DsRed(Unk)}

(Pancratov et al., 2013)

Scer\GAL4^bbg-C96/arm^{S10.UAS.Tag:MYC} is a suppressor of wing margin phenotype of Scer\GAL4^bbg-C96, mir-310^{UAS.cluster.DsRed(Unk)}, mir-311^{UAS.cluster.DsRed(Unk)}, mir-312^{UAS.cluster.DsRed(Unk)}, mir-313^{UAS.cluster.DsRed(Unk)}

(Pancratov et al., 2013)

Scer\GAL4^sd.PU/arm^{S10.UAS.Tag:MYC} is a suppressor of wing disc posterior compartment | somatic clone phenotype of lace²

(Sasamura et al., 2013)

Scer\GAL4^hh.PU/arm^{S10.UAS.Tag:MYC} is a suppressor of wing disc posterior compartment | somatic clone phenotype of ACC¹

(Sasamura et al., 2013)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^ato.3.6 is a suppressor | partially of dorsal cluster neuron | adult stage phenotype of Hsap\HUWE1^UAS.cVa, Scer\GAL4^ato.3.6

(Vandewalle et al., 2013)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^ato.3.6 is a suppressor | partially of medulla | adult stage phenotype of Hsap\HUWE1^UAS.cVa, Scer\GAL4^ato.3.6

(Vandewalle et al., 2013)

Scer\GAL4^ebd1.PB/arm^{S10.UAS.Tag:MYC} is a suppressor of indirect flight muscle phenotype of Scer\GAL4^ebd1.PB, pan^ΔN.UAS

(Benchabane et al., 2011)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^bi.PU is a suppressor | partially of wing phenotype of Hsap\CDH1^UAS.cPa, Scer\GAL4^bi.PU

(Pereira et al., 2006)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^bi.PU is a suppressor | partially of wing phenotype of Hsap\CDH1^A634V.UAS, Scer\GAL4^bi.PU

(Pereira et al., 2006)

arm^{S10.UAS.Tag:MYC}, Scer\GAL4^bi.PU is a suppressor of wing margin phenotype of Hsap\CDH1^V832M.UAS, Scer\GAL4^bi.PU

(Pereira et al., 2006)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^vg.PM is a suppressor of wing margin phenotype of tws^j11C8

(Bajpai et al., 2004)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^da.G32 is a suppressor of embryonic leading edge cell primordium & microtubule phenotype of wg^l-17

(Morel and Arias, 2004)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^da.G32 is a suppressor of embryonic leading edge cell primordium phenotype of wg^l-17

(Morel and Arias, 2004)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^da.G32 is a suppressor of denticle | ectopic phenotype of wg^l-17

(Morel and Arias, 2004)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^69B is a suppressor of denticle belt phenotype of ci⁹⁴

(Angelats et al., 2002)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^69B is a suppressor | partially of amnioserosa phenotype of hep¹

(Kaltschmidt et al., 2002)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^69B is a suppressor | partially of embryonic dorsal epidermis phenotype of hep¹

(Kaltschmidt et al., 2002)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^69B is a suppressor | partially of embryonic/first instar larval cuticle | dorsal phenotype of hep¹

(Kaltschmidt et al., 2002)

Scer\GAL4^bbg-C96/arm^{S10.UAS.Tag:MYC} is a suppressor of wing margin phenotype of Scer\GAL4^bbg-C96, dlp^UAS.cBa

(Baeg et al., 2001)

Scer\GAL4^bbg-C96/arm^{S10.UAS.Tag:MYC} is a suppressor of wing sensillum phenotype of Scer\GAL4^bbg-C96, dlp^UAS.cBa

(Baeg et al., 2001)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^btl.PS is a suppressor of dorsal trunk primordium phenotype of Wnt2^unspecified, wg^l-17

(Llimargas and Lawrence, 2001)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^455.2 is a suppressor | partially of hindgut visceral muscle primordium phenotype of wg^l-17

(San Martin and Bate, 2001)

Scer\GAL4^twi.PB/arm^{S10.UAS.Tag:MYC} is a suppressor | partially of hindgut visceral muscle primordium phenotype of wg^l-17

(San Martin and Bate, 2001)

Scer\GAL4^bbg-C96/arm^{S10.UAS.Tag:MYC} is a suppressor of wing phenotype of Scer\GAL4^bbg-C96, mam^N.UAS

(Helms et al., 1999)

NOT Suppressor of

Statement

Reference

fz^KK108004/arm^{S10.UAS.Tag:MYC}, Scer\GAL4^repo is a non-suppressor of embryonic/larval brain | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

fz^KK108004/arm^{S10.UAS.Tag:MYC}, Scer\GAL4^repo is a non-suppressor of embryonic/larval glial cell | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

fz^KK108004/arm^{S10.UAS.Tag:MYC}, Scer\GAL4^repo is a non-suppressor of glial cell projection | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

Scer\GAL4^Act.PU/arm^{S10.UAS.Tag:MYC} is a non-suppressor | somatic clone of adult posterior midgut epithelium | somatic clone phenotype of mys¹¹

(Lin et al., 2013)

Scer\GAL4^Act.PU/arm^{S10.UAS.Tag:MYC} is a non-suppressor | somatic clone of adult posterior midgut epithelium | somatic clone phenotype of mys^M2

(Lin et al., 2013)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^332.3 is a non-suppressor of embryonic leading edge cell primordium & microtubule phenotype of wg^l-17

(Morel and Arias, 2004)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^332.3 is a non-suppressor of embryonic leading edge cell primordium phenotype of wg^l-17

(Morel and Arias, 2004)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^69B is a non-suppressor of embryonic leading edge cell & actin filament phenotype of hep¹

(Kaltschmidt et al., 2002)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^arm.PS is a non-suppressor of embryonic/first instar larval cuticle | germline clone phenotype of pygo^S28

(Thompson et al., 2002)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^arm.PS is a non-suppressor of embryonic/first instar larval cuticle | germline clone phenotype of pygo^S123

(Thompson et al., 2002)

Scer\GAL4^how-24B, Scer\GAL4^how-24B, arm^{S10.UAS.Tag:MYC} is a non-suppressor of hindgut visceral muscle primordium phenotype of wg^l-17

(San Martin and Bate, 2001)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^VP16.arm is a non-suppressor of embryonic epidermis | dorsal phenotype of kay²

(McEwen et al., 2000)

Other

Statement

Reference

Scer\GAL4^Bx-MS1096, arm^{S10.UAS.Tag:MYC}, ci^{m1-4.UAS.Tag:HA} has wing disc phenotype

(Skwarek et al., 2014)

Scer\GAL4^en-e16E, arm^{S10.UAS.Tag:MYC} has embryonic leading edge cell phenotype

(Gettings et al., 2010)

N^55e11, Scer\GAL4^αTub84B.PL, arm^{S10.UAS.Tag:MYC} has wing disc | somatic clone phenotype

(Sanders et al., 2009)

N^55e11, Scer\GAL4^dpp.PU, arm^{S10.UAS.Tag:MYC} has wing disc | somatic clone phenotype

(Sanders et al., 2009)

Df(1)N-81k1, Scer\GAL4^dpp.PU, arm^{S10.UAS.Tag:MYC} has wing disc phenotype

(Sanders et al., 2009)

Scer\GAL4^αTub84B.PL, Su(H)^del47, arm^{S10.UAS.Tag:MYC} has wing disc | somatic clone phenotype

(Sanders et al., 2009)

Hsap\CDH1^V832M.UAS, Scer\GAL4^bi.PU, arm^{S10.UAS.Tag:MYC} has wing vein phenotype

(Pereira et al., 2006)

Scer\GAL4^bbg-C96, arm^{S10.UAS.Tag:MYC}, dlp^UAS.cBa has wing margin bristle | ectopic phenotype

(Baeg et al., 2001)

N^ECN.UAS, Scer\GAL4^sd-SG29.1, arm^{S10.UAS.Tag:MYC} has wing disc phenotype

(Brennan et al., 1999)

N^ECN.UAS, Scer\GAL4^sd-SG29.1, arm^{S10.UAS.Tag:MYC} has dorsal mesothoracic disc & sensory mother cell phenotype

(Brennan et al., 1999)

N^ECN.UAS, Scer\GAL4^sd-SG29.1, arm^{S10.UAS.Tag:MYC} has sensory mother cell & dorsal mesothoracic disc phenotype

(Brennan et al., 1999)

Scer\GAL4^en-e16E, arm^{S10.UAS.Tag:MYC}, wg^l-17 has embryonic epidermis phenotype

(Gritzan et al., 1999)

Scer\GAL4^en-e16E, arm^{S10.UAS.Tag:MYC}, wg^l-17 has denticle belt phenotype

(Gritzan et al., 1999)

Scer\GAL4^Bx-MS1096, arm^{S10.UAS.Tag:MYC}, ci::pan^DΔ.UAS has wing disc phenotype

(Von Ohlen and Hooper, 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} in type II neuroblasts or ase- immature intermediate neural progenitors (INPs) enhances the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ larval brains, whereas expression in ase+ immature INPs does not (different insertions of Scer\GAL4^GMR9D11 are used to drive expression in each case).

(Komori et al., 2014)

Wing disc cells co-expressing arm^{S10.Scer\UAS.T:Hsap\MYC} and ci^{m1-4.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Bx-MS1096 show a degree of hyperplastic overgrowth, but retain normal polarity and tissue architecture.

(Skwarek et al., 2014)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} strongly suppresses the wing notching seen when Klp64D^NIG.10642R is expressed under the control of Scer\GAL4^bbg-C96. The wing margin bristles are partially restored.

(Vuong et al., 2014)

Co-expression of arm^{S10.Scer\UAS.T:Hsap\MYC} restores dorsal trunk formation and tracheal fusion cell specification in embryos expressing Axn^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^btl.PS.

(Caviglia and Luschnig, 2013)

Scer\GAL4^arm.PS-mediated co-expression of arm^{S10.Scer\UAS.T:Hsap\MYC} and pbl^{Scer\UAS.T:Ivir\HA1} or pbl^{ΔBRCT.Scer\UAS.T:Hsap\MYC} produces severe developmental defects.

Co-expression of pbl^{DH-PH.Scer\UAS.T:Ivir\HA1}, but not pbl^{DH-PH-V531D.Scer\UAS.T:Ivir\HA1}, partially suppresses the excess naked cuticle phenotype seen in Scer\GAL4^arm.PS arm^{S10.Scer\UAS.T:Hsap\MYC} embryos.

(Greer et al., 2013)

Clones expressing P{UAS-DsRed-mir-310+mir-311+mir-312+mir-313.L} (carries mir-310^{Scer\UAS.cluster.T:Disc\RFP}, mir-311^{Scer\UAS.cluster.T:Disc\RFP}, mir-312^{Scer\UAS.cluster.T:Disc\RFP} and mir-313^{Scer\UAS.cluster.T:Disc\RFP}) under the control of Scer\GAL4^unspecified are difficult to recover in the wing imaginal disc. Co-expression of arm^{S10.Scer\UAS.T:Hsap\MYC} significantly rescues the viability of these clones.

Co-expression of arm^{S10.Scer\UAS.T:Hsap\MYC} rescues the wing notching seen in flies expressing P{UAS-DsRed-mir-310+mir-311+mir-312+mir-313.L} (carries mir-310^{Scer\UAS.cluster.T:Disc\RFP}, mir-311^{Scer\UAS.cluster.T:Disc\RFP}, mir-312^{Scer\UAS.cluster.T:Disc\RFP} and mir-313^{Scer\UAS.cluster.T:Disc\RFP}) under the control of Scer\GAL4^bbg-C96.

Co-expression of P{UAS-DsRed-mir-310+mir-311+mir-312+mir-313.L} (carries mir-310^{Scer\UAS.cluster.T:Disc\RFP}, mir-311^{Scer\UAS.cluster.T:Disc\RFP}, mir-312^{Scer\UAS.cluster.T:Disc\RFP} and mir-313^{Scer\UAS.cluster.T:Disc\RFP}) suppresses the specification of extra wing margin bristles caused by expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^bbg-C96.

(Pancratov et al., 2013)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^sd.PU significantly suppresses the overproliferation seen in lace² mutant wing disc clones, in terms of both frequency and severity of the phenotype.

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^sd.PU significantly suppresses the severity of overproliferation seen in ACC¹ mutant wing disc clones, but does not reduce the frequency of discs exhibiting overgrowth.

(Sasamura et al., 2013)

Co-expression of arm^{S10.Scer\UAS.T:Hsap\MYC} suppresses the loss of indirect flight muscles and loss of flight ability which is caused by expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^ebd1.PB.

ebd1²⁴⁰/Df(3L)ED4136 suppresses the shortened photoreceptor phenotype caused by expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.long.

(Benchabane et al., 2011)

CtBP^{Scer\UAS.T:Zzzz\FLAG} is able to suppress the small eye phenotype caused by Scer\GAL4^GMR.PF-dependent expression of arm^{S10.Scer\UAS.T:Hsap\MYC}.

Overexpression of CtBP^{Mono.Scer\UAS.T:Zzzz\FLAG} causes a significant enhancement of the small eye phenotype caused by Scer\GAL4^GMR.PF-dependent expression of arm^{S10.Scer\UAS.T:Hsap\MYC}.

(Bhambhani et al., 2011)

Co-expression of arm^{S10.Scer\UAS.T:Hsap\MYC} enhances the ommatidial over-rotation phenotype which is caused by expression of nmo^Scer\UAS.cUa under the control of Scer\GAL4^hs.2sev.

(Mirkovic et al., 2011)

The leading edge cell in the anterior compartment just anterior to the parasegment boundary is transformed into an ectopic mixer cell in wg^l-17 embryos expressing arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^en-e16E assayed by marker expression (in the abdominal segments of wild-type embryos at the end of dorsal closure, the "mixer cell" moves across the segment boundary from the anterior compartment to the posterior compartment, but the cell in the equivalent position relative to the parasegment boundary does not show this "mixing" behaviour).

(Gettings et al., 2010)

Co-expression of either tum^Scer\UAS.cSa or pav^{Scer\UAS.P\T.T:Avic\GFP-m6} driven by Scer\GAL4^arm.PS partially blocks the cell-fate transformation induced by arm^{S10.Scer\UAS.T:Hsap\MYC} expression and allows some denticle production.

Co-expression of nkd^Scer\UAS.cZa driven by Scer\GAL4^arm.PS is unable to block the cell-fate transformation induced by arm^{S10.Scer\UAS.T:Hsap\MYC} expression.

Co-expression of tum^{ΔNLS.Scer\UAS} driven by Scer\GAL4^arm.PS is unable to block the cell-fate transformation induced by arm^{S10.Scer\UAS.T:Hsap\MYC} expression.

Co-expression of pav^{NLS4-7*.Scer\UAS.P\T.T:Avic\GFP-m6} driven by Scer\GAL4^arm.PS is unable to block the cell-fate transformation induced by arm^{S10.Scer\UAS.T:Hsap\MYC} expression.

(Jones et al., 2010)

The co-expression of arm^{S10.Scer\UAS.T:Hsap\MYC} enhances the eye defects in adults expressing N^ICN.Scer\UAS driven by Scer\GAL4^ey.PS, with associated wrinkling and distortion of third instar larva eye discs, but no obvious differentiation defects are visible in these discs.

(Fre et al., 2009)

Outgrowths with tumorous appearance are produced when the wing disc is heterozygous for Df(1)N-81k1 and Df(1)N-81k1 somatic clones are generated in a arm^{S10.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^dpp.PU background. There are also some effects on cell fate.

Clones of cells generated at 24-48 or 48-72 hrs AEL which are mutant for N^55e11 and express arm^{S10.Scer\UAS.T:Hsap\MYC} via Scer\GAL4^αTub84B.PL (generated using the MARCM system) give rise to tightly packed spheres with large numbers of cells and abnormal polarity in the wing disc. Similar clones generated after 72hrs appear scattered through the tissue, lose basal contact and exhibit a variety of organizations.

Clones of cells doubly mutant for Dl^RevF10 and Ser^RX82 and also expressing arm^{S10.Scer\UAS.T:Hsap\MYC} via Scer\GAL4^αTub84B.PL (using the MARCM technique) remain integrated in the wing disc epithelium and do not exhibit growth defects.

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} via Scer\GAL4^αTub84B.PL in Su(H)^del47 clones (using the MARCM technique) increases the size and reduces the number of apoptotic cells compared to Su(H)^del47 clones. arm^{S10.Scer\UAS.T:Hsap\MYC} expression also makes the clones more rounded in appearance but cells do not lose their polarity.

The over-proliferation defect of clones of cells mutant for N^55e11 and expressing arm^{S10.Scer\UAS.T:Hsap\MYC} via Scer\GAL4^αTub84B.PL (generated using the MARCM system) are rescued by co-expression of N^{intra.Scer\UAS.T:Avic\GFP-EGFP,T:Mmus\Cd8a}.

Clones of cells which are mutant for N^55e11 and express arm^{S10.Scer\UAS.T:Hsap\MYC} via Scer\GAL4^dpp.PU are relatively few but contain a relatively large number of cells.

Clones of cells mutant for N^55e11 and expressing arm^{S10.Scer\UAS.T:Hsap\MYC} via Scer\GAL4^dpp.PU are smaller and more frequent when N^{intra.Scer\UAS.T:Avic\GFP-EGFP,T:Mmus\Cd8a} or N^FLN.Scer\UAS is coexpressed.

(Sanders et al., 2009)

The ectopic wing margin bristles of arm^{S10.Scer\UAS.T:Hsap\MYC} overexpression mutants is enhanced in ft⁸ heterozygotes.

(Jaiswal et al., 2006)

The change in wing disc shape caused by expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^dpp.blk1 is significantly suppressed by co-expression of N::tor^Scer\UAS.cSa.

(Hayward et al., 2005)

Ectopic wing margin bristles on the wings of arm^{S10.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^vg.PM animals are unaffected by tws^j11C8/+.

(Bajpai et al., 2004)

arm^{S10.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^da.G32 suppresses the transformation of naked ventral cuticle to denticles in wg^l-17 homozygous embryos. Many of the resulting embryos have the arm^{S10.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^da.G32 overexpression phenotype of a completely naked ventral cuticle. arm^{S10.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^da.G32 suppresses the dorsal-ventral elongation and orientation of microtubule bundles in the leading edge cells of stage 13 wg^l-17 homozygous embryos. arm^{S10.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^332.3 completely fails to suppress these phenotypes.

(Morel and Arias, 2004)

Metameric furrows fail to form in arm^{S10.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^en-e16E embryos homozygous for ci^Ce-1 or hh^AC, but not ci⁹⁴. Failure of metameric furrow formation in arm^{S10.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^en-e16E embryos homozygous for hh^AC is not suppressed by wg^l-17/wg^l-17. In stage 13+ arm^{S10.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^en-e16E embryos homozygous for wg^l-17, the metameric furrows are duplicated - forming on both sides of the en expression stripes. In the lateral regions of these embryos, en expression is broken up into islands, each surrounded by an ectopic furrow.

(Larsen et al., 2003)

When arm^{S10.Scer\UAS.T:Hsap\MYC} (driven by Scer\GAL4^69B) is added to ci⁹⁴ homozygotes, denticles fail to form, except for the T1 beard, (already present and enlarged in arm^{S10.Scer\UAS.T:Hsap\MYC} embryos), which is enhanced by the addition of ci⁹⁴.

(Angelats et al., 2002)

Co-expression of da^Scer\UAS.cGa significantly rescues progression of the morphogenetic furrow in animals expressing arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^dpp.blk1.

(Cadigan et al., 2002)

arm^{S10.Scer\UAS.T:Hsap\MYC} with Scer\GAL4^69B weakly suppresses the dorsal hole phenotype of hep¹ mutants, as well as rescuing adhesion between the dorsal epidermis and the amnioserosa. However, it fails to rescue the formation of an actin cable in leading edge cells of these embryos.

(Kaltschmidt et al., 2002)

The addition of lgs^unspecified to arm^{S10.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^αTub84B.PK animals suppresses the naked cuticle phenotype.

(Kramps et al., 2002)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^arm.PS has no effect on the cuticle phenotype of pygo^S28 embryos derived from pygo^S28 germline clones. Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^arm.PS has no effect on the cuticle phenotype of pygo^S123 embryos derived from pygo^S123 germline clones.

(Thompson et al., 2002)

Co-expression of arm^{S10.Scer\UAS.T:Hsap\MYC} can rescue both the wing notching phenotype and loss of sensory bristles caused by expression of dlp^Scer\UAS.cBa under the control of Scer\GAL4^C96. In addition, ectopic margin bristles close to the wing margin are seen in these flies.

(Baeg et al., 2001)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^btl.PS can substantially rescue the dorsal trunk which is missing in wg^l-17 Wnt2^unspecified double mutant embryos.

(Llimargas and Lawrence, 2001)

The addition of nkd^Scer\UAS.cZa to arm^{S10.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^GMR.PF flies has no effect on the eye phenotype.

(Rousset et al., 2001)

The addition of nkd^{Scer\UAS.T:Hsap\MYC} to arm^{S10.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^GMR.PF flies has no effect on the eye phenotype.

(Rousset et al., 2001)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^ptc-559.1 in lin²/lin² embryos does not result in the global specification of 4^o cell types in the dorsal cuticle, the dorsal cuticle phenotype resembles that of lin mutants.

(Hatini et al., 2000)

When tkv^{Q253D.Scer\UAS.cLa} and arm^{S10.Scer\UAS.T:Hsap\MYC} are co-expressed using Scer\GAL4^btl.PS, a partial restoration of the dorsal trunk is seen in the tracheal system.

(Llimargas, 2000)

The addition of N^ECN.Scer\UAS to arm^{S10.Scer\UAS.T:Hsap\MYC}/Scer\GAL4^sd-SG29.1 leads to flies that have smaller wing pouches, In the adult wing they show a combination of the phenotypes seen in flies expressing N^ECN.Scer\UAS and arm^{S10.Scer\UAS.T:Hsap\MYC} alone i.e. the adults wings are small, lacking a margin and are covered in bristles. The addition of arm^{S10.Scer\UAS.T:Hsap\MYC} to N^ECN.Scer\UAS/Scer\GAL4^sd-SG29.1 flies leads to an increase in the area of the wing disc covered by SOPs, though they are not evenly spaced.

(Brennan et al., 1999)

When expression is driven by Scer\GAL4^en-e16E in a wg^l-17 background strips of segmentally repeated smooth cuticle occur. There are fewer large row 5 type denticles than in the single wg mutant, and row 6 type denticles do not develop. The denticles that do form are of the row 2 or 3 type. The denticle pattern shows some mirror symmetry. Denticles point away from the nearest region of smooth cuticle.

(Gritzan et al., 1999)

Suppresses the wing nicking phenotype seen in mam^N.Scer\UAS, Scer\GAL4^C96 flies.

(Helms et al., 1999)

Uniform expression of ovo^Scer\UAS.cPa in a background of arm^{S10.Scer\UAS.T:Hsap\MYC} driven by Scer\GAL4^e22c restores denticle formation.

(Payre et al., 1999)

The phenotype caused by expression of ci::pan^DΔ.Scer\UAS under the control of Scer\GAL4^Bx-MS1096 is enhanced by coexpression of arm^{S10.Scer\UAS.T:Hsap\MYC}; the resulting pupae fail to eclose and the wing discs are overgrown and distorted.

(Von Ohlen and Hooper, 1999)

The naked cuticle phenotype produced by arm^{S10.Scer\UAS.T:Hsap\MYC} expressed under the control of Scer\GAL4^69B is suppressed by tsh⁸.

(Gallet et al., 1998)

sgg^Scer\UAS.cSa does not alter the abnormal second midgut constriction phenotype seen in embryos expressing arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^how-24B.

(Steitz et al., 1998)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^prd.RG1 in sgl⁰⁸³¹⁰ embryos induces naked cuticle.

(Hacker et al., 1997)

Xenogenetic Interactions

Statement

Reference

The additional co-expression of arm^{S10.Scer\UAS.T:Hsap\MYC} does not modify the fully penetrant rough eye phenotype resulting from the co-expression of HPV18\E6^{Scer\UAS.T:Hsap\MYC} and Hsap\UBE3A^Scer\UAS.cRa under the control of Scer\GAL4^GMR.PU.

(Padash Barmchi et al., 2016)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} partially rescues the dorsal cluster neuron branching phenotype seen when Hsap\HUWE1^Scer\UAS.cVa is expressed under the control of Scer\GAL4^ato.3.6.

(Vandewalle et al., 2013)

Co-expression of arm^{S10.Scer\UAS.T:Hsap\MYC} significantly enhances the short lifespan seen in Scer\GAL4^elav.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS} flies.

(Dupont et al., 2012)

The wing defects caused by expression of either Hsap\CDH1^Scer\UAS.cPa or Hsap\CDH1^{A634V.Scer\UAS} under the control of Scer\GAL4^bi.PU are partially suppressed by co-expression of arm^{S10.Scer\UAS.T:Hsap\MYC}.

The wing margin notching caused by expression of Hsap\CDH1^{V832M.Scer\UAS} under the control of Scer\GAL4^bi.PU is suppressed by co-expression of arm^{S10.Scer\UAS.T:Hsap\MYC}. The double mutant flies show distal vein thickenings.

(Pereira et al., 2006)

Hsap\MAPT^GMR.Ex.PJ and arm^{S10.Scer\UAS.T:Hsap\MYC} (driven by Scer\GAL4^hs.2sev) enhance each other leading to markedly reduced eye, with a complete loss of ommatidial borders and bristles.

(Jackson et al., 2002)

Complementation and Rescue Data

Rescues

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^arm.PS rescues arm^043A01

(Tolwinski and Wieschaus, 2001)

arm^{S10.UAS.Tag:MYC}/Scer\GAL4^btl.PS rescues arm⁴

(Chihara and Hayashi, 2000)

Comments

Ubiquitous expression of arm^{S10.Scer\UAS.T:Hsap\MYC} in embryos using Scer\GAL4^da.G32 produces ectopic naked cuticle in the arm² background. Ubiquitous expression of arm^{S10.Scer\UAS.T:Hsap\MYC} using Scer\GAL4^arm.PS produces ectopic naked cuticle in embryos carrying arm^{S6.T:Hsap\MYC} in an arm⁴ background. Ubiquitous expression of arm^{S10.Scer\UAS.T:Hsap\MYC} using Scer\GAL4^arm.PS produces ectopic naked cuticle in embryos carrying arm^{S12.T:Hsap\MYC} in an arm⁴ background.

(Thompson, 2004)

The adhesion defect of arm^043A01 is rescued by expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^arm.PS.

(Tolwinski and Wieschaus, 2001)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^btl.PS rescues the formation of the tracheal dorsal trunk in arm⁴ embryos.

(Chihara and Hayashi, 2000)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

4782

P{UAS-arm.S10}C, y¹ w¹¹¹⁸

Kyoto

107877

P{UAS-arm.S10}C, y¹ w¹¹¹⁸

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

Arm^Act

(Halfon et al., 2000)

Arm^act

(Morel and Arias, 2004)

arm^{S10.Scer\UAS.T:Hsap\MYC}

arm^{S10.UAS.T:Myc}

arm^{S10.UAS.Tag:MYC}

arm^S10

(Blundon et al., 2016, Komori et al., 2014, Dupont et al., 2012, Axelrod et al., 1998, Steitz et al., 1998, Pai et al., 1997)

arm^s10

(Trujillo et al., 2016)

armadillo^s10

(Parker, 2006)

Name Synonyms

Secondary FlyBase IDs

References (161)

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