FlyBase Allele Report: Dmel\Mer[4]

General Information

Symbol

Dmel\Mer⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0061731

Feature type

allele

Associated gene

Dmel\Mer

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Willecke et al., 2006)

Mutagen

ethyl methanesulfonate

(Fehon et al., 1997)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q170term.

(LaJeunesse et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:19,692,450..19,692,450 [-]

Nucleotide change:

C19692450T

Amino acid change:

Q170term | Mer-PA; Q170term | Mer-PB

Reported amino acid change:

Q170term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(LaJeunesse et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA with ex^e1

(Hamaratoglu et al., 2006)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Charcot-Marie-Tooth disease type 4B1

modeled by mtm^ΔC

(Hu et al., 2022)

exacerbates viral infectious disease

modeled by EBV\BRLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

exacerbates infectious mononucleosis

modeled by EBV\BRLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

exacerbates Epstein-Barr virus hepatitis

modeled by EBV\BRLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

elongation stage spermatid

(Dorogova et al., 2008)

eye | somatic clone

(Baumgartner et al., 2010)

eye | somatic clone - tissue specific

(Hu et al., 2022)

eye-antennal disc | third instar larval stage

(Maitra et al., 2006)

individualization stage spermatid

(Dorogova et al., 2008)

interommatidial bristle & eye disc & pupa

(Maitra et al., 2006)

interommatidial bristle | increased number

(Yin et al., 2013, Willecke et al., 2006)

interommatidial bristle | somatic clone

(Ling et al., 2010)

interommatidial cell | P-stage | increased number | somatic clone - tissue specific

(Hu et al., 2022)

wing disc

(Maitra et al., 2006)

Detailed Description

Statement

Reference

Mer⁴ homozygous mutant embryos do not display any significant increase in the frequency of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage.

(Keder et al., 2015)

Eyes homozygous for Mer⁴ (generated using the eyFLP method) show overgrowth compared to controls.

Eyes that are partially homozygous for Mer⁴ (generated using the eyFLP method without cell lethal) show mild overgrowth compared to controls.

(Baumgartner et al., 2010)

Pupal retinae composed of homozygous Mer⁴ mutant cells show an increase in the number of interommatidial cells.

(Ling et al., 2010)

A few hemizygotes survive to the pharate adult stage. These males show an abnormality in nuclear grouping in elongating spermatid cysts, with the nuclei either being arranged in two groups or scattered.

Mutant spermatids at the late stage of spermatid elongation frequently contain two paracrystalline bodies within the major mitochondrial derivative compared to one in control cysts. Mutant spermatids are grossly disorganized compared to control cysts, which display cell-cell contact. Excessive cytoplasmic fragments are seen in mutant cysts.

The paired arrangement of axoneme with mitochondrial derivatives is often lost in individualisation stage spermatids. Mutant spermatids with multiple paracrystalline body-filled derivatives but with no axoneme, or with two axonemes are seen. Mutant cysts show cytoplasmic fragmentation together with condensed cytoplasmic remnants and gigantic cytoplasmic bodies.

Mutant cysts show normal 9+2 microtubule formation of the axoneme structure.

(Dorogova et al., 2008)

Females heterozygous for Mer⁴ do not show any chromosome nondisjunction and chromosomes appear structurally normal. Nondisjunction events are observed when the Mer⁴ heterozygotes are additionally heterozygous for In(1)FM7.

(Yudina et al., 2008)

In Mer⁴ third instar eye-antennal discs, many cells posterior to the second mitotic wave fail to exit the cell cycle.

In Mer⁴ pupal eye discs (24hrs after pupariation) exhibit extra interommatidial cells, often forming double rows surrounding the ommatidia. The number of cone cells does not change in the mutants.

Mer⁴ mutants exhibit overgrown wing imaginal discs.

(Maitra et al., 2006)

Mer⁴ mutants do not exhibit any defect in photoreceptor differentiation.

(Maitra et al., 2006)

Mer⁴ mutant retinae exhibit some extra interommatidial cells.

(Willecke et al., 2006)

Homozygous clones in the eye show essentially normal differentiation of ommatidia, with only a few disruptions of ommatidial organisation. The clones are significantly larger than their wild-type sister clones.

(LaJeunesse et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Mer⁴ has increased cell number | P-stage | somatic clone - tissue specific phenotype, enhanceable by mtm^ΔC/mtm^ΔC

(Hu et al., 2022)

Mer⁴ has increased cell number | P-stage | somatic clone - tissue specific phenotype, enhanceable by mtm^ΔN/mtm^ΔN

(Hu et al., 2022)

Mer⁴ has increased size | adult stage | somatic clone - tissue specific phenotype, enhanceable by mtm^null/mtm^null

(Hu et al., 2022)

Mer⁴ has increased cell number | P-stage | somatic clone - tissue specific phenotype, enhanceable by mtm^null/mtm^null

(Hu et al., 2022)

Mer⁴ has visible | somatic clone phenotype, enhanceable by kibra^del

(Yu et al., 2010)

Suppressed by

Statement

Reference

Mer⁴ has lethal phenotype, suppressible by Scer\GAL4^T80/Hsap\NF2^{UAS.Iso2.Tag:FLAG}

(Gavilan et al., 2014)

Mer⁴ has lethal phenotype, suppressible by Hsap\NF2^{L64P.UAS.Tag:FLAG}/Scer\GAL4^T80

(Gavilan et al., 2014)

Mer⁴ has lethal phenotype, suppressible by Hsap\NF2^{K413E.UAS.Tag:FLAG}/Scer\GAL4^T80

(Gavilan et al., 2014)

Mer⁴ has lethal phenotype, suppressible by Hsap\NF2^{R466X.UAS.Tag:FLAG}/Scer\GAL4^T80

(Gavilan et al., 2014)

Mer⁴ has lethal phenotype, suppressible by Hsap\NF2^{UAS.Iso1.Tag:FLAG}/Scer\GAL4^T80

(Gavilan et al., 2014)

NOT suppressed by

Statement

Reference

Mer⁴ has lethal phenotype, non-suppressible by Hsap\NF2^{Δ2-3.UAS.Tag:FLAG}/Scer\GAL4^T80

(Gavilan et al., 2014)

Mer⁴ has lethal phenotype, non-suppressible by Hsap\NF2^{1-301.UAS.Tag:FLAG}/Scer\GAL4^T80

(Gavilan et al., 2014)

Mer⁴ has lethal phenotype, non-suppressible by Scer\GAL4^T80/Hsap\NF2^{351-595.UAS.Tag:FLAG}

(Gavilan et al., 2014)

Mer⁴ has lethal phenotype, non-suppressible by Hsap\NF2^{1-356.UAS.Tag:FLAG}/Scer\GAL4^T80

(Gavilan et al., 2014)

Mer⁴ has lethal phenotype, non-suppressible by Hsap\NF2^{300-595.UAS.Tag:FLAG}/Scer\GAL4^T80

(Gavilan et al., 2014)

Mer⁴ has visible | somatic clone phenotype, non-suppressible by kibra^UAS.cBa/Scer\GAL4^GMR.PF

(Baumgartner et al., 2010)

Enhancer of

Statement

Reference

Mer⁴/Mer⁴ is an enhancer of increased cell number | P-stage | somatic clone - tissue specific phenotype of mtm^ΔC

(Hu et al., 2022)

Mer⁴/Mer⁴ is an enhancer of increased cell number | P-stage | somatic clone - tissue specific phenotype of mtm^ΔN

(Hu et al., 2022)

Mer⁴/Mer⁴ is an enhancer of increased size | adult stage | somatic clone - tissue specific phenotype of mtm^null

(Hu et al., 2022)

Mer⁴/Mer⁴ is an enhancer of increased cell number | P-stage | somatic clone - tissue specific phenotype of mtm^null

(Hu et al., 2022)

Mer[+]/Mer⁴ is an enhancer of visible phenotype of Hsap\NF2^{UAS.Iso2.Tag:FLAG}, Scer\GAL4^ap.PU

(Gavilan et al., 2014)

Mer⁴ is an enhancer of visible | somatic clone phenotype of kibra^del

(Yu et al., 2010)

Mer⁴ is an enhancer of increased cell number | adult stage | somatic clone phenotype of ft⁸

(Silva et al., 2006)

NOT Suppressor of

Statement

Reference

ex[+], ex^BQ, Mer[+], Mer⁴ is a non-suppressor of increased cell death phenotype of Scer\GAL4^GMR.PF, hpo^UAS.cUa

(Hamaratoglu et al., 2006)

Other

Statement

Reference

Mer⁴, mtm^ΔC has increased size | adult stage | somatic clone - tissue specific phenotype

(Hu et al., 2022)

Mer⁴, Rab11^{S25N.UASp.YFP}, Scer\GAL4^αTub84B.PL has increased cell number | P-stage | somatic clone - tissue specific phenotype

(Hu et al., 2022)

Mer⁴, mtm^ΔN has increased size | adult stage | somatic clone - tissue specific phenotype

(Hu et al., 2022)

Mer[+]/Mer⁴, cno² has abnormal neuroanatomy | embryonic stage phenotype

(Keder et al., 2015)

Mer⁴, ex^e1 has visible phenotype

(Hamaratoglu et al., 2006)

Mer⁴, ex^e1 has hyperplasia | somatic clone phenotype

(Hamaratoglu et al., 2006)

Mer⁴, ex^e1 has visible | recessive | somatic clone phenotype

(McCartney et al., 2000)

Mer⁴, ex^e1 has neoplasia | somatic clone | adult stage phenotype

(McCartney et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

Mer⁴ has interommatidial cell | P-stage | increased number | somatic clone - tissue specific phenotype, enhanceable by mtm^ΔC/mtm^ΔC

(Hu et al., 2022)

Mer⁴ has interommatidial cell | P-stage | increased number | somatic clone - tissue specific phenotype, enhanceable by mtm^ΔN/mtm^ΔN

(Hu et al., 2022)

Mer⁴ has eye | somatic clone - tissue specific phenotype, enhanceable by mtm^null/mtm^null

(Hu et al., 2022)

Mer⁴ has interommatidial cell | P-stage | increased number | somatic clone - tissue specific phenotype, enhanceable by mtm^null/mtm^null

(Hu et al., 2022)

Mer⁴ has interommatidial bristle | increased number phenotype, enhanceable by sav³

(Yin et al., 2013)

Mer⁴ has interommatidial bristle | somatic clone phenotype, enhanceable by crb^82-04

(Ling et al., 2010)

Mer⁴ has eye | somatic clone phenotype, enhanceable by kibra^del

(Yu et al., 2010)

Mer⁴ has ommatidium | somatic clone phenotype, enhanceable by kibra^del

(Yu et al., 2010)

Mer⁴ has interommatidial bristle | increased number phenotype, enhanceable by ex^e1

(Willecke et al., 2006)

Mer⁴ has interommatidial bristle phenotype, enhanceable by ft⁴²²

(Willecke et al., 2006)

NOT suppressed by

Statement

Reference

Mer⁴ has eye | somatic clone phenotype, non-suppressible by kibra^UAS.cBa/Scer\GAL4^GMR.PF

(Baumgartner et al., 2010)

Enhancer of

Statement

Reference

Mer⁴/Mer⁴ is an enhancer of interommatidial cell | P-stage | increased number | somatic clone - tissue specific phenotype of mtm^ΔC

(Hu et al., 2022)

Mer⁴/Mer⁴ is an enhancer of interommatidial cell | P-stage | increased number | somatic clone - tissue specific phenotype of mtm^ΔN

(Hu et al., 2022)

Mer⁴/Mer⁴ is an enhancer of eye | somatic clone - tissue specific phenotype of mtm^null

(Hu et al., 2022)

Mer⁴/Mer⁴ is an enhancer of interommatidial cell | P-stage | increased number | somatic clone - tissue specific phenotype of mtm^null

(Hu et al., 2022)

Mer[+]/Mer⁴ is an enhancer of wing phenotype of Hsap\NF2^{UAS.Iso2.Tag:FLAG}, Scer\GAL4^ap.PU

(Gavilan et al., 2014)

Mer⁴ is an enhancer of interommatidial bristle | increased number phenotype of sav³

(Yin et al., 2013)

Mer⁴ is an enhancer of eye phenotype of EBV\BRLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

Mer⁴ is an enhancer of eye | somatic clone phenotype of kibra^del

(Yu et al., 2010)

Mer⁴ is an enhancer of ommatidium | somatic clone phenotype of kibra^del

(Yu et al., 2010)

Mer⁴ is an enhancer of interommatidial cell | adult stage | somatic clone phenotype of ft⁸

(Silva et al., 2006)

NOT Suppressor of

Statement

Reference

ex^BQ, ex^BQ, Mer⁴, Mer⁴ is a non-suppressor | somatic clone of interommatidial cell | pupal stage phenotype of Scer\GAL4^GMR.PF, hpo^UAS.cUa

(Hamaratoglu et al., 2006)

Other

Statement

Reference

Mer⁴, mtm^ΔC has eye | somatic clone - tissue specific phenotype

(Hu et al., 2022)

Mer⁴, Rab11^{S25N.UASp.YFP}, Scer\GAL4^αTub84B.PL has interommatidial cell | increased number | P-stage | somatic clone - tissue specific phenotype

(Hu et al., 2022)

Mer⁴, mtm^ΔN has eye | somatic clone - tissue specific phenotype

(Hu et al., 2022)

Mer[+]/Mer⁴, cno² has larval RP2 motor neuron | embryonic stage phenotype

(Keder et al., 2015)

Mer⁴, ex^e1 has interommatidial cell | somatic clone | pupal stage phenotype

(Hamaratoglu et al., 2006)

Mer⁴, ex⁶⁹⁷ has wing disc phenotype

(Maitra et al., 2006)

Mer⁴, ex^e1 has eye photoreceptor cell | somatic clone phenotype

(Maitra et al., 2006)

Mer⁴, ex⁶⁹⁷ has eye photoreceptor cell | somatic clone phenotype

(Maitra et al., 2006)

Mer⁴, ex⁶⁹⁷ has antennal disc | somatic clone phenotype

(Maitra et al., 2006)

Mer⁴, ex⁶⁹⁷ has antennal disc | ectopic | somatic clone phenotype

(Maitra et al., 2006)

Mer⁴, ex⁶⁹⁷ has embryonic primordium of adult eye | somatic clone phenotype

(Maitra et al., 2006)

Df(1)N-54l9/Mer⁴, ex^e1 has wing | somatic clone phenotype

(Maitra et al., 2006)

Mer⁴, ex^e1 has ommatidium | somatic clone phenotype

(McCartney et al., 2000)

Mer⁴, ex^e1 has eye | somatic clone phenotype

(McCartney et al., 2000)

Mer⁴, ex^e1 has wing vein | somatic clone phenotype

(McCartney et al., 2000)

Mer⁴, ex^e1 has posterior crossvein | somatic clone phenotype

(McCartney et al., 2000)

Mer⁴, ex^e1 has wing cell | somatic clone phenotype

(McCartney et al., 2000)

Mer⁴, ex^e1 has adult head & cuticle | ectopic | somatic clone phenotype

(McCartney et al., 2000)

Mer⁴, ex^e1 has eye disc morphogenetic furrow | larval stage phenotype

(McCartney et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Ack^{Scer\UAS.T:SV5\V5} under the control of Scer\GAL4^Ubi.PU in the Mer⁴ homozygous somatic clones (induced using the eyFLP method) promotes tissue overgrowth in the adult eye.

(Hu et al., 2016)

The proportion of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage is significantly increased in cno²/+;Mer⁴/+ double heterozygous embryos compared to either of the single heterozygotes or wild type.

(Keder et al., 2015)

Mer⁴/sav³ double mutant eyes exhibit a massive increase in the number of supernumerary interommatidial cells, compared to either single mutant.

(Yin et al., 2013)

The eye overgrowth phenotype seen in eyes homozygous for Mer⁴ (generated using the eyFLP method) is not suppressed by expression of kibra^Scer\UAS.cBa under the control of Scer\GAL4^GMR.PF.

Eyes doubly homozygous for Mer⁴ and kibra³ (generated using the eyFLP method) show stronger overgrowth than eyes singly homozygous for Mer⁴.

(Baumgartner et al., 2010)

Pupal retinae composed of crb^82-04 Mer⁴ double mutant cells show a massive increase in the number of interommatidial cells.

(Ling et al., 2010)

Mer⁴ ; kibra^del double mutant clones in the eye show a more severe eye overgrowth phenotype and a greater number of interommatidial cells per ommatidium than is seen in either single mutant.

(Yu et al., 2010)

Somatic clones homozygous for Mer⁴ and ex^e1 in the antenna or in the dorsal thorax are massively overgrown. In the mid-pupal retina, these clones contain a large excess of inter-ommatidial cells. In the late third instar eye disc, cells in these clones show increased levels of mitosis after (posterior to) the second mitotic wave. Later, at around 25 hours APF, the widespread apotosis seen throughout the developing retina in wild-type and heterozygous cells, is largely suppressed in these clones.

Neither the adult eye phenotype seen in hpo^Scer\UAS.cUa; Scer\GAL4^GMR.PF animals, nor the loss of interommmatidial cells and increased cell death seen in mid-pupal retinas of these animals is suppressed in ex^BQ Mer⁴ double homozygous clones.

(Hamaratoglu et al., 2006)

Mer⁴; ex⁶⁹⁷ double mutants exhibit overgrown wing imaginal discs.

(Maitra et al., 2006)

Mer⁴; ex⁶⁹⁷ double mutant eye-antennal imaginal discs have severely reduced eye primordia with a substantial reduction in or total absence of photoreceptors. In these mutants, photoreceptor development and overall eye field size are severely reduced. The antennal portion is normal or slightly larger than normal and in some cases is duplicated. Apoptosis does not seem to be affected.

Mer⁴; ex⁶⁹⁷ somatic clones in contact with the posterior or lateral margin of the eye fail to produce photoreceptors. Those somatic clones located in the middle of the eye field can produce photoreceptors.

Mer⁴; ex^e1 somatic clones in contact with the posterior or lateral margin of the eye fail to produce photoreceptors. Those somatic clones located in the middle of the eye field can produce photoreceptors.

Mer⁴; ex^e1 double mutant clones exhibit defects in membrane trafficking of proteins such as N and Egfr.

Df(1)N-54l9 Mer⁴; ex^e1 triple transheterozygous mutants suppress the Df(1)N-54l9 heterozygous wing notch phenotype.

(Maitra et al., 2006)

Clones of cells in the eye, doubly-mutant for ft⁸ and Mer⁴ exhibit a dramatic increase in the number of interommatidial cells compared to the more moderate increases seen in single mutants.

(Silva et al., 2006)

ex^e1;Mer⁴ double mutants exhibit a large excess of interommatidial cells, in a very similar manner to hpo mutants.

ft⁴²²;Mer⁴ double mutants exhibit a large excess of interommatidial cells, in a very similar manner to hpo mutants.

(Willecke et al., 2006)

Both vein and intervein cells can differentiate in Mer⁴; ex^e1 double mutant clones in the wing. Clones that intersect the position of the posterior crossvein disrupt its development. Clones in the position of the anterior crossvein develop normally. Within the mutant intervein and vein clones, apparent defects in proliferation control are seen; in the proximal region of the wing, clonal vein tissue forms a raised protrusion. In other regions of the wing, bulges in the veins are also seen, although more frequently vein clones are merely broadened when compared with the surrounding vein. In the intervein regions, the clonal tissue appears to bulge and crinkle within the confines of the normal tissue, suggesting overproliferation. Cells within the intervein clones appear to differentiate as intervein cells, however, the cuticle deposited at the base of each wing hair within the clone appears to be thickened, and is distinct from cuticle produced by either the surrounding heterozygous intervein or vein cells. Mer⁴; ex^e1 double mutant clones in the eye appear to disrupt the progression of the morphogenetic furrow, being seen either as small scars with associated clusters of bristles or as elongated scars and associated indentations running from within the eye field towards the anterior margin. These clones do not differentiate ommatidia. The clones are often associated with overproliferated head cuticle.

(McCartney et al., 2000)

Xenogenetic Interactions

Statement

Reference

Scer\GAL4^T80 expression of Hsap\NF2^{Scer\UAS.Iso1.T:Zzzz\FLAG} partially suppresses lethality (approximately 60% rescue) in Mer⁴/y male flies; increased genetic dosage (two copies of Hsap\NF2^{Scer\UAS.Iso1.T:Zzzz\FLAG}) further suppresses lethality (72% rescue). Scer\GAL4^T80 expression of Hsap\NF2^{Scer\UAS.Iso2.T:Zzzz\FLAG} provides poor rescue of lethality (8%) in Mer⁴/y male flies; increased genetic dosage completely fails to suppress lethality (0%). Scer\GAL4^T80 expression of Hsap\NF2^{L64P.Scer\UAS.T:Zzzz\FLAG} (one or two copies) partially suppresses lethality (approximately 70% rescue) in Mer⁴/y male flies. Scer\GAL4^T80 expression of Hsap\NF2^{K413E.Scer\UAS.T:Zzzz\FLAG} (one copy) partially suppresses lethality (approximately 36% rescue) in Mer⁴/y male flies; two copies further suppresses lethality (62%). Scer\GAL4^T80 expression of Hsap\NF2^{Δ2-3.Scer\UAS.T:Zzzz\FLAG} or Hsap\NF2^{1-301.Scer\UAS.T:Zzzz\FLAG} or Hsap\NF2^{351-595.Scer\UAS.T:Zzzz\FLAG} or Hsap\NF2^{1-356.Scer\UAS.T:Zzzz\FLAG} or Hsap\NF2^{300-595.Scer\UAS.T:Zzzz\FLAG} (one or two copies) does not suppress lethality (0-2% rescue) in Mer⁴/y male flies. Scer\GAL4^T80 expression of two copies of Hsap\NF2^{R466X.Scer\UAS.T:Zzzz\FLAG} partially suppresses lethality (approximately 11% rescue) in Mer⁴/y male flies; one copy completely fails to suppress lethality (0%).

Mer⁴/+ enhances the severity of wing phenotypes seen in female flies with Hsap\NF2^{Scer\UAS.Iso2.T:Zzzz\FLAG} driven by Scer\GAL4^ap.PU.

(Gavilan et al., 2014)

Complementation and Rescue Data

Fails to complement

Mer^ts1

(MacDougall et al., 2001)

Rescued by

Mer⁴ is rescued by Scer\GAL4^unspecified/Mer^T559D.UAS

(Yudina et al., 2010)

Mer⁴ is rescued by Scer\GAL4^unspecified/Mer^UAS.Tag:MYC

(Yudina et al., 2010)

Mer⁴ is rescued by Scer\GAL4^Act5C.PU/Mer^UASp.Tag:MYC

(Dorogova et al., 2008)

Mer⁴ is rescued by Mer^+t36

(Dorogova et al., 2008)

Mer⁴ is rescued by Mer^3.UASp

(Yudina et al., 2008)

Mer⁴ is rescued by Mer^{1-600.UAS.Tag:MYC}/Scer\GAL4^T80

(LaJeunesse et al., 1998)

Mer⁴ is rescued by Mer^UAS.Tag:MYC/Scer\GAL4^T80

(LaJeunesse et al., 1998)

Partially rescued by

Mer⁴ is partially rescued by Scer\GAL4^Act5C.PU/Mer^{3.UASp.Tag:MYC}

(Dorogova et al., 2008)

Mer⁴ is partially rescued by Mer^{1-375.UAS.Tag:MYC}/Scer\GAL4^T80

(LaJeunesse et al., 1998)

Mer⁴ is partially rescued by Mer^{1-351.UAS.Tag:MYC}/Scer\GAL4^T80

(LaJeunesse et al., 1998)

Mer⁴ is partially rescued by Mer^{3.UAS.Tag:MYC}/Scer\GAL4^T80

(LaJeunesse et al., 1998)

Not rescued by

Mer⁴ is not rescued by Scer\GAL4^unspecified/Mer^T559A.UAS

(Yudina et al., 2010)

Mer⁴ is not rescued by Scer\GAL4^unspecified/Mer^{1-169.UAS.Tag:MYC}

(Yudina et al., 2010)

Mer⁴ is not rescued by Mer^{1-379.UAS.Tag:MYC}/Scer\GAL4^unspecified

(Yudina et al., 2010)

Mer⁴ is not rescued by Scer\GAL4^unspecified/Mer^{345-635.UAS.Tag:MYC}

(Yudina et al., 2010)

Mer⁴ is not rescued by Mer^{3.UAS.Tag:MYC}/Scer\GAL4^unspecified

(Yudina et al., 2010)

Mer⁴ is not rescued by Mer^{ΔB.UAS.Tag:MYC}/Scer\GAL4^unspecified

(Yudina et al., 2010)

Mer⁴ is not rescued by Mer^{ΔBB.UAS.Tag:MYC}/Scer\GAL4^T80

(LaJeunesse et al., 1998)

Mer⁴ is not rescued by Mer^{1-169.UAS.Tag:MYC}/Scer\GAL4^T80

(LaJeunesse et al., 1998)

Mer⁴ is not rescued by Mer^{351-635.UAS.Tag:MYC}/Scer\GAL4^T80

(LaJeunesse et al., 1998)

Mer⁴ is not rescued by Scer\GAL4^T80/Mer^{351-601.UAS.Tag:MYC}

(LaJeunesse et al., 1998)

Mer⁴ is not rescued by Mer^{1-330.UAS.Tag:MYC}/Scer\GAL4^T80

(LaJeunesse et al., 1998)

Mer⁴ is not rescued by Mer^{BBA.UAS.Tag:MYC}/Scer\GAL4^T80

(LaJeunesse et al., 1998)

Mer⁴ is not rescued by Mer^{601-635.UAS.Tag:MYC}/Scer\GAL4^T80

(LaJeunesse et al., 1998)

Comments

Expression of Mer^{T559D.Scer\UAS} under the control of Scer\GAL4^unspecified can restore the fertility of Mer⁴ mutants.

Expression of Mer^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^unspecified can restore the fertility of Mer⁴ mutants.

(Yudina et al., 2010)

Expression of Mer^{3.Scer\UAS.P\T} under the control of Scer\GAL4^da.G32 rescues the lethality associated with Mer⁴.

(Yudina et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Mer⁰⁴

(Baumgartner et al., 2010, Baumgartner et al., 2010)

Mer⁴

(Tokamov et al., 2021, Su et al., 2017, Keder et al., 2015, Abeysundara et al., 2014, Gavilan et al., 2014, Fernández et al., 2011, Popodi et al., 2010-, Yudina et al., 2010, Genevet et al., 2009, Dorogova et al., 2008, Oh and Irvine, 2008, Yudina et al., 2008, Cho et al., 2006, Maitra et al., 2006, Maitra et al., 2006, Silva, 2006)

mer⁴

(Guo et al., 2024, Bunker et al., 2023, Hu et al., 2022, Aguilar-Aragon et al., 2020, Fletcher et al., 2018, Hu et al., 2016, Jukam et al., 2013, Jukam et al., 2013, Yin et al., 2013, Genevet et al., 2010, Ling et al., 2010, Yu et al., 2010, Yu et al., 2010, Sun et al., 2008, Pellock et al., 2007, Hamaratoglu et al., 2006, Willecke et al., 2006)

Name Synonyms

Merlin4

(Adamson and Lajeunesse, 2012)

Secondary FlyBase IDs

References (42)

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