FlyBase Allele Report: Scer\GAL4[GH298]

Drives expression in mostly GABAergic antennal lobe local interneurons, and in a subset of olfactory projection neurons and olfactory receptor neurons.

(FlyBase Curators, 2017)

ScerGAL4^GH298 drives expression in neurons with cell bodies located lateral to the antennal lobes (AL). Some of the labeled neurons innervate the AL.

(Thum et al., 2011)

ScerGAL4^GH298 is expressed in 30-32 local neurons of the antennal lobe, with almost all being GABAergic.

(Acebes et al., 2011)

Expression of ScerGAL4^GH298 is seen in cell bodies found in the local interneuron cluster located lateral and dorsolateral to the antennal lobe. Most labelled cells are ipsilaterally projecting interneurons.

(Chou et al., 2010)

ScerGAL4^H24 drives expression in mostly GABAergic antennal lobe local interneurons, and in a subset of olfactory projection neurons and olfactory receptor neurons.

(Chou et al., 2010)

There are an average 21 ScerGAL4^GH298-positive lPN cells.

(Lai et al., 2008)

An estimated 81% cells expressing ScerGAL4^GH298 are GABAergic.

(Shang et al., 2007)

The neurites of the AL LNs collectively fill the antennal lobes. Expression of ScerGAL4^GH298 generally colocalizes with GABA-immunoreactivity, though approximately one-fifth of the GFP positive cells are not GABA-immunopositive.

(Wilson and Laurent, 2005)

In adult brain, expression observed in about 20 neurons with arborization in the antennal lobe (AL), most with cell bodies lateral to the AL; pattern fits the shape of 'LocI' (FBrf0051437); expression observed in a subset of neurons in the subesophageal ganglion. No expression observed in the AL in third instar larvae or early pupae; starts to develop at 48h APF.

(Stocker et al., 1997)

Marker for

antennal lobe glomerulus V

(Hummel and Zipursky, 2004)

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal chemosensory behavior | third instar larval stage, with ChT^KK109385

(Hamid et al., 2021)

abnormal learning | third instar larval stage, with ChT^JF03028

(Hamid et al., 2021)

abnormal learning | third instar larval stage, with ChT^KK109385

(Hamid et al., 2021)

abnormal memory | adult stage, with Dop2R^RNAi.UAS.cDa

(Scholz-Kornehl and Schwärzel, 2016)

abnormal memory | adult stage, with Pde4^RNAi.UAS.WIZ

(Scheunemann et al., 2012)

abnormal neuroanatomy, with Pi3K92E^{D954A.UAS.Tag:MYC}

(Acebes et al., 2011)

abnormal neuroanatomy, with Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^{kra-krasavietz}

(Acebes et al., 2011)

abnormal neuroanatomy, with Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL80^ChAT.3.3P

(Acebes et al., 2011)

abnormal neuroanatomy, with sgg^UAS.cBa

(Acebes et al., 2011)

abnormal neurophysiology | adult stage, with nompC^E1511A.UAS

(Gong et al., 2013)

abnormal neurophysiology | adult stage, with nompC^L.UAS

(Gong et al., 2013)

abnormal neurophysiology | adult stage | chemical conditional, with mAChR-A^JF02725

(Rozenfeld et al., 2021)

abnormal smell perception, with Pi3K92E^{D954A.UAS.Tag:MYC}

(Acebes et al., 2011)

abnormal smell perception, with Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL80^ChAT.3.3P

(Acebes et al., 2011)

abnormal smell perception, with Scer\GAL80^ts.αTub84B, sgg^UAS.cBa

(Acebes et al., 2011)

abnormal smell perception, with sgg^UAS.cBa

(Acebes et al., 2011)

abnormal smell perception | adult stage, with Prps^GL00463

(Brown et al., 2019)

Phenotype Manifest In

adult antennal lobe local neuron, with nompC^E1511A.UAS

(Gong et al., 2013)

adult antennal lobe local neuron, with nompC^L.UAS

(Gong et al., 2013)

adult antennal lobe local neuron | chemical conditional, with mAChR-A^JF02725

(Rozenfeld et al., 2021)

antennal lobe, with Pi3K92E^{D954A.UAS.Tag:MYC}

(Acebes et al., 2011)

antennal lobe, with Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^{kra-krasavietz}

(Acebes et al., 2011)

antennal lobe, with sgg^UAS.cBa

(Acebes et al., 2011)

antennal lobe glomerulus DM2, with Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^{kra-krasavietz}

(Acebes et al., 2012)

antennal lobe glomerulus DM2, with Pi3K92E^UAS.Tag:MYC

(Acebes et al., 2012)

antennal lobe glomerulus DM2, with sgg^UAS.cBa

(Acebes et al., 2012)

intrinsic neuron, with Pi3K92E^{D954A.UAS.Tag:MYC}

(Acebes et al., 2011)

intrinsic neuron, with Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^{kra-krasavietz}

(Acebes et al., 2011)

intrinsic neuron, with sgg^UAS.cBa

(Acebes et al., 2011)

synapse, with Pi3K92E^{D954A.UAS.Tag:MYC}

(Acebes et al., 2011)

synapse, with Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^{kra-krasavietz}

(Acebes et al., 2011)

synapse, with sgg^UAS.cBa

(Acebes et al., 2011)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^GH298/mAChR-A^UAS.cRa rescues mAChR-A^KK

(Rozenfeld et al., 2021)

Scer\GAL4^GH298, Pde4^UAS.cCa, Scer\GAL4^ey-OK107 rescues Pde4^dnc-1

(Scheunemann et al., 2012)

Scer\GAL4^GH298, Pde4^UAS.cCa, Scer\GAL4^17d rescues Pde4^dnc-1

(Scheunemann et al., 2012)

Scer\GAL4^GH298, Pde4^UAS.cCa, Scer\GAL4^NP1131 rescues Pde4^dnc-1

(Scheunemann et al., 2012)

Scer\GAL4^GH298, Pde4^UAS.cCa, Scer\GAL4^c320 rescues Pde4^dnc-1

(Scheunemann et al., 2012)

Scer\GAL4^GH298, Pde4^UAS.cCa, Scer\GAL4^c305a rescues Pde4^dnc-1

(Scheunemann et al., 2012)

Scer\GAL4^GH298, Pde4^UAS.cCa, Scer\GAL4^Mef2.247 rescues Pde4^dnc-1

(Scheunemann et al., 2012)

Partially rescues

Scer\GAL4^GH298/ChT^UAS.cHa partially rescues ChT^KK109385

(Hamid et al., 2021)

Fails to rescue

mAChR-A^JF02725/Scer\GAL4^GH298 fails to rescue mAChR-A^KK

(Rozenfeld et al., 2021)

Scer\GAL4^GH298/mAChR-A^UAS.cRa fails to rescue mAChR-A^KK

(Rozenfeld et al., 2021)

Scer\GAL4^GH298/Dop2R^UAS.cSa fails to rescue Dop2R^Δ1

(Scholz-Kornehl and Schwärzel, 2016)

Scer\GAL4^GH298/Pde4^UAS.cCa fails to rescue Pde4^dnc-1

(Scheunemann et al., 2012)

Scer\GAL4^GH298/rg^UAS.cVa fails to rescue rg^γ5

(Volders et al., 2012)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

37294

w^*; P{GawB}GH298

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

GAL4^GH298

Scer\GAL4^GH298

Name Synonyms

Secondary FlyBase IDs

References (37)

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