FlyBase Allele Report: Scer\GAL4[BG487]

General Information

Symbol

Scer\GAL4^BG487

Species

S. cerevisiae

Name

FlyBase ID

FBal0061912

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

P{GawB}BG487

Carried in Construct

Also Known As

BG487-GAL4, BG487

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Tejedor et al., 1997, Thomas et al., 1997, Budnik et al., 1996)

Progenitor genotype

Associated Insertion(s)

P{GawB}BG487

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GawB}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

intersegmental muscle cell

(Cheng et al., 1998)

larval somatic muscle cell

(Gorczyca et al., 2007)

Additional Information

Statement

Reference

Drives expression in a strong anteroposterior gradient in a subset of body wall muscles, starting at abdominal 1 ventral internal muscle 1 (muscle 31) in abdominal segment 1 and decreasing in ventral longitudinal muscles 3 and 4 (muscles 6 and 7) of every abdominal segment. No or very low levels were detected in muscles other than ventral longitudinal muscles 3 and 4 in A2-A8. About 5 neural sensory cell bodies per hemisegment also exhibit strong levels of expression in the body wall.

(FlyBase Curators, 2017)

Expression in a strong anteroposterior gradient in a subset of body wall muscles, starting at longitudinal muscle 31 in A1 and decreasing in longitudinal muscles 6 and 7 (FlyBase terms: ventral longitudinal muscles 3 and 4) of every abdominal segment. No or very low levels were detected in muscles other than longitudinal muscles 6 and 7 in A2-A8. About 5 neural sensory cell bodies per hemisegment also exhibit strong levels of expression in the body wall.

(Budnik et al., 1996)

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

bouton, with aPKC^M.UAS

(Ruiz-Canada et al., 2004)

bouton, with Nlg1^UAS.cMa

(Mozer and Sandstrom, 2012)

embryonic/larval neuromuscular junction, with Ctet\tetX^TNT-LC.UAS

(Mathew et al., 2003)

embryonic/larval neuromuscular junction, with Nsf2^EQ.UAS

(Mathew et al., 2003)

embryonic/larval neuromuscular junction | third instar larval stage, with Past1^UAS.EGFP

(Koles et al., 2015)

microtubule & synapse, with aPKC^M.UAS

(Ruiz-Canada et al., 2004)

muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage, with LamC^E174K.UAS, LamC^EX296/LamC^EX265

(Li et al., 2016)

muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage, with LamC^E174K.UAS, LamC^unspecified

(Li et al., 2016)

muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage, with LamC^EX296/LamC^EX265, LamC^R564C.UAS

(Li et al., 2016)

muscle cell of A1-7 ventral longitudinal muscle 4 | third instar larval stage, with LamC^E174K.UAS, LamC^EX296/LamC^EX265

(Li et al., 2016)

muscle cell of A1-7 ventral longitudinal muscle 4 | third instar larval stage, with LamC^E174K.UAS, LamC^unspecified

(Li et al., 2016)

muscle cell of A1-7 ventral longitudinal muscle 4 | third instar larval stage, with LamC^EX296/LamC^EX265, LamC^R564C.UAS

(Li et al., 2016)

neuromuscular junction, with Fas2^UAS.cAa

(Ashley et al., 2005)

NMJ bouton, with Fas2^UAS.cAa

(Ashley et al., 2005)

nuclear lamina | third instar larval stage, with LamC^E174K.UAS, LamC^EX296/LamC^EX265

(Li et al., 2016)

nuclear lamina | third instar larval stage, with LamC^E174K.UAS, LamC^unspecified

(Li et al., 2016)

nuclear lamina | third instar larval stage, with LamC^EX296/LamC^EX265, LamC^R564C.UAS

(Li et al., 2016)

postsynaptic membrane, with dlg1^UAS.cBa

(Budnik et al., 1996)

subsynaptic reticulum, with dlg1^UAS.cBa

(Gorczyca et al., 2007)

synapse, with Nlg1^UAS.cMa

(Mozer and Sandstrom, 2012)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Nlg1^UAS.cMa, Scer\GAL4^BG487 has abnormal neuroanatomy phenotype, suppressible by Nrx-1²⁷³

(Mozer and Sandstrom, 2012)

Nlg1^UAS.cMa, Scer\GAL4^BG487 has abnormal neurophysiology phenotype, suppressible by Nrx-1²⁷³

(Mozer and Sandstrom, 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

Fas2^UAS.cAa, Scer\GAL4^BG487 has NMJ bouton phenotype, enhanceable by Scer\GAL4^futsch-C380/Appl^sd.UAS

(Ashley et al., 2005)

Suppressed by

Statement

Reference

Nlg1^UAS.cMa, Scer\GAL4^BG487 has synapse phenotype, suppressible by Nrx-1²⁷³

(Mozer and Sandstrom, 2012)

Nlg1^UAS.cMa, Scer\GAL4^BG487 has bouton phenotype, suppressible by Nrx-1²⁷³

(Mozer and Sandstrom, 2012)

Scer\GAL4^BG487, dlg1^UAS.cBa has subsynaptic reticulum phenotype, suppressible | partially by Syx18^UAS.cGa/Scer\GAL4^BG487

(Gorczyca et al., 2007)

Enhancer of

Statement

Reference

Fas2^UAS.cAa/Scer\GAL4^BG487 is an enhancer of NMJ bouton phenotype of Appl^sd.UAS, Scer\GAL4^futsch-C380

(Ashley et al., 2005)

Suppressor of

Statement

Reference

Syx18^UAS.cGa/Scer\GAL4^BG487 is a suppressor | partially of subsynaptic reticulum phenotype of Scer\GAL4^BG487, dlg1^UAS.cBa

(Gorczyca et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

tnc^UAS.cWa/Scer\GAL4^BG487 rescues Df(3R)BSC655/tnc^EY03355

(Wang et al., 2018)

fz2^{UAS.6x.Tag:MYC}/Scer\GAL4^BG487 rescues Df(3L)ED4782/fz2^C1

(Mathew et al., 2005)

scrib^UAS.cBa/Scer\GAL4^BG487 rescues scrib¹

(Roche et al., 2002)

scrib^UAS.cBa/Scer\GAL4^BG487 rescues scrib⁶⁷³

(Roche et al., 2002)

dlg1^UAS.cBa/Scer\GAL4^BG487 rescues dlg1¹⁴

(Tejedor et al., 1997)

Partially rescues

fz2^{UAS.6x.Tag:MYC}/Scer\GAL4^BG487 partially rescues Df(3L)ED4782/fz2^C1

(Mathew et al., 2005)

dlg1^UAS.cBa/Scer\GAL4^BG487 partially rescues dlg1¹⁴/Df(1)N71

(Karunanithi et al., 2002)

dlg1^UAS.cBa/Scer\GAL4^BG487 partially rescues dlg1¹⁴

(Budnik et al., 1996)

Fails to rescue

fz2^{ΔSGKTLESW.UAS.Tag:MYC}/Scer\GAL4^BG487 fails to rescue Df(3L)ED4782/fz2^C1

(Mathew et al., 2005)

fz2^{C.UAS.NLS.Tag:MYC}/Scer\GAL4^BG487 fails to rescue Df(3L)ED4782/fz2^C1

(Mathew et al., 2005)

fz2^{ΔSGKTLESW.UAS.Tag:MYC}/Scer\GAL4^BG487 fails to rescue Df(3L)ED4782/fz2^C1

(Mathew et al., 2005)

fz2^{C.UAS.NLS.Tag:MYC}/Scer\GAL4^BG487 fails to rescue Df(3L)ED4782/fz2^C1

(Mathew et al., 2005)

Adcy1^UAS.cZa/Scer\GAL4^BG487 fails to rescue Adcy1^rut-2080

(Zhong and Wu, 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

51634

P{GawB}BG487

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

GAL4^BG485

GAL4^BG487

Scer\GAL4^BG487

Name Synonyms

Secondary FlyBase IDs

FBal0058813

References (37)

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