nurse cell & actin filament | germ-line clone | maternal effect
Cdc423/+; Pak6/+ double heterozygotes display severe cardiomyocyte organization abnormalities and contractile abnormalities as compared with either single heterozygote, but no differences in heart beat defects and overall rhythmicity.
Cdc423/+; Df(2L)Exel9032/+ double heterozygotes and Cdc423/+; Df(3R)BSC397/+ double heterozygotes show significant defects in cardiomyocyte structure, significantly increased arrhythmia, but no significant differences in the overall length of diastolic and systolic intervals.
tin346/+; Cdc423/+ double heterozygotes exhibit a significantly increased pacing-induced heart failure rate, significantly increased arrhythmia and a tendency toward longer diastolic intervals, in addition to severe misalignment of cardiac myofibrils, as compared with controls. These flies do not exhibit differences in systolic intervals.
The Cdc423/+ heterozygous mutation does not suppress or enhance the GluRIIASP16 NMJ synaptic homeostasis phenotype. There is no deficit in synaptic bouton number in Cdc423/+ , GluRIIASP16 double mutants, compared to wild-type or GluRIIASP16 controls.
Synaptic homeostasis is completely blocked in larvae that are double heterozygotes for Cdc423/+ and ExnEY01953/+ in a GluRIIASP16 mutant genetic background. There is no deficit in synaptic bouton number in Cdc423/+ , ExnEY01953/+, GluRIIASP16 triple mutants, compared to wild-type or GluRIIASP16 controls.
Cdc423/+ has very little effect on the mutant wing phenotype caused by expression of LIMK1Scer\UAS.cCa under the control of Scer\GAL4en-e16E (the % of wings with normal morphology at 18oC is 10% compared to 9% for control flies expressing LIMK1Scer\UAS.cCa under the control of Scer\GAL4en-e16E in an otherwise wild-type background). The frequency of the malformed leg phenotype seen in Sb63b/+ heterozygotes (8%) is not increased if the flies are also heterozygous for Cdc423/+ (3%). The frequency of the malformed leg phenotype seen in Sb70/+ heterozygotes (7%) is not increased if the flies are also heterozygous for Cdc423/+ (7%).