Cdc422/Y males have mushroom body axon growth and guidance defects.
The hatching rate of eggs derived from homozygous females is reduced compared to wild type, regardless of the zygotic state.
Mutant larvae fail to encapsulate eggs when parasitised by the avirulent L. boulardi wasp strain G486 (no melanisation is seen). Plasmatocytes and lamellocytes fully cover the egg.
Homozygous larvae fail to encapsulate eggs of the avirulent wasp strain L. boulardi G486.
Isolated plasmatocytes from homozygous larvae show a reduced ability to phagocytose E. coli and S. aureus in a phagocytosis assay.
Cdc422 heterozygous larvae exhibit wild-type neuromuscular junction length and total bouton number, but satellite bouton formation is slightly elevated.
Cdc422 third instar larvae exhibit synaptic overgrowth and an increase in bouton number in segment A3, muscle 6/7 compared to controls.
Cdc424/Cdc422 flies show normal resistance to infection with P.aeruginosa by septic injury.
Cdc422 mutants exhibit a delay in F-actin enrichment and accumulation in rhabdomeres.