|Feature type||allele||Associated gene||Dmel\Cdc42|
|Map ( GBrowse )|
|Allele class||hypomorphic allele - genetic evidence|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Nucleotide substitution: T311A. Mutation in splice donor consensus site.
Mutation in the splice donor sequence of the small internal intron.
|Phenotype Manifest In|
actin filament & rhabdomere | somatic clone
The hatching rate of eggs derived from homozygous females is reduced compared to wild type, regardless of the zygotic state.
Mutant larvae fail to encapsulate eggs when parasitised by the avirulent L. boulardi wasp strain G486 (no melanisation is seen). Plasmatocytes and lamellocytes fully cover the egg.
Homozygous larvae fail to encapsulate eggs of the avirulent wasp strain L. boulardi G486. Isolated plasmatocytes from homozygous larvae show a reduced ability to phagocytose E. coli and S. aureus in a phagocytosis assay.
Cdc42 heterozygous larvae exhibit wild-type neuromuscular junction length and total bouton number, but satellite bouton formation is slightly elevated.
Cdc42 third instar larvae exhibit synaptic overgrowth and an increase in bouton number in segment A3, muscle 6/7 compared to controls.
|Phenotype Manifest In|
Cdc422 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, enhanceable by nwk1
Cdc422 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, enhanceable by nwk1/nwk2
Cdc422 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, enhanceable by nwk2
Cdc422, nwk2 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, suppressible by Cdc42Ubi-p63E.T:Hsap\MYC
|NOT suppressed by|
Cdc42[+]/Cdc422 is an enhancer of wing hair | supernumerary phenotype of Scer\GAL4ap-md544, trcT453A.Scer\UAS
Cdc422 is an enhancer of embryonic/larval neuromuscular junction | third instar larval stage phenotype of nwk1
Cdc422 is an enhancer of embryonic/larval neuromuscular junction | third instar larval stage phenotype of nwk2
|NOT Suppressor of|
Zir[BG00267]/+ ; Cdc42/+ double heterozygous larvae have a reduced rate of encapsulation (37%) of eggs of the avirulent wasp strain L. boulardi G486 compared to the rate seen in either single heterozygote.
Cdc42; Cip4 double heterozygotes exhibit an increase in total bouton number, satellite bouton formation and neuromuscular junction length. Cdc42/+; Cip4/+; WASp/+ trans-heterozygous larvae exhibit an increase in total bouton number, neuromuscular junction length and in particular satellite bouton formation.
Cdc42 nwk double mutants exhibit more severe synaptic overgrowth and an increased number of boutons and satellite boutons compared to either single mutant. Cdc42 nwk double mutants exhibit more severe synaptic overgrowth and an increased number of boutons and satellite boutons compared to either single mutant. Cdc42 nwk/nwk double mutants exhibit an increased number of satellite boutons in segment A2-A3, muscle 4 compared to either Cdc42 or nwk homozygous single mutants. Expression of Cdc42[Ubi-p63E.T:Hsap\MYC] rescues the synaptic overgrowth and increased bouton and satellite bouton number phenotypes seen in nwk Cdc42 double mutant larvae.
A Cdc422/+ background enhances the splitting wing hair phenotype of flies that express trcT453A.Scer\UAS under the control of Scer\GAL4ap-md544.
|Complementation & Rescue Data|
|Stocks ( 1 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 4 )|
|Secondary FlyBase IDs|
|References ( 13 )|