Allele Dmel\mam^unspecified

General Information
Symbol	Dmel\mam^unspecified	Species	D. melanogaster
Name		FlyBase ID	FBal0062570
Feature type	allele	Associated gene	Dmel\mam

Allele class
Mutagen	X ray
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	X ray (Prout et al., 1997)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Tearle and Nusslein-Volhard, 1987, Prout et al., 1997)
Phenotype Manifest In
	presumptive embryonic/larval central nervous system (Tearle and Nusslein-Volhard, 1987) tendon cell (Nabel-Rosen et al., 1999) wing \| somatic clone (Prout et al., 1997) wing margin \| somatic clone (Prout et al., 1997) wing vein \| somatic clone (Prout et al., 1997)
Detailed Description
	Statement Reference Mutants show an increased number of tendon cells at late stages of embryonic development (after muscle binding has occurred) compared to wild type. (Nabel-Rosen et al., 1999) Homozygous clones in the wing produce discrete, round blisters of variable size. These blisters can be located anywhere on the wing and are associated with abnormalities in venation. Homozygous clones that include the wing margin cause scalloping due to cell death. (Prout et al., 1997) mam^unspecified mutant embryos show hypertrophy of the central nervous system. A maternal effect is seen in germline clones. (Tearle and Nusslein-Volhard, 1987)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference mam^unspecified/mam[+] is an enhancer of visible \| recessive phenotype of mys⁸ (Prout et al., 1997)
Phenotype Manifest In
Enhancer of
Statement Reference mam^unspecified/mam[+] is an enhancer of wing phenotype of mys⁸ (Prout et al., 1997)
Additional Comments
Genetic Interactions
Statement Reference Shows a weak genetic interaction with mys⁸; the frequency of wing blisters is increased from approximately 10% in mys⁸ single hemizygotes to approximately 20% in mys⁸ hemizygotes that are also heterozygous for mam^unspecified. Shows no interaction with mys^b9. (Prout et al., 1997)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	mam^BG02477 (Dworkin and Gibson, 2006) mam^KG02641 (Dworkin and Gibson, 2006)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	mam^unspecified unspecified (Prout et al., 1997)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Dworkin and Gibson, 2006, Genetics 173(3): 1417--1431 Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster. [FBrf0193945] Nabel-Rosen et al., 1999, Mol. Cell 4(4): 573--584 The balance between two isoforms of the Drosophila RNA-binding protein how controls tendon cell differentiation. [FBrf0111987] Prout et al., 1997, Genetics 146(1): 275--285 Autosomal mutations affecting adhesion between wing surfaces in Drosophila melanogaster. [FBrf0093664]
Stock list	Tearle and Nusslein-Volhard, 1987, D. I. S. 66: 209--269 Tubingen mutants and stock list. [FBrf0045941]

Allele Dmel\mamunspecified

Allele Dmel\mam^unspecified