|Feature type||allele||Associated gene||Dmel\inaD|
|Also Known As||inaD1|
|Map ( GBrowse )|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Nucleotide substitution: ?811?. Amino acid replacement: ?270@. Amber nonsense mutation falls in the second PDZ domain.
|Phenotype Manifest In|
Compound action potentials can be evoked by sound in the antennal nerve of mutant flies, but the sound particle velocities required to elicit the response is increased compared to wild type. The displacement response of the antenna over a range of sound particle velocities is linearised, indicating loss of mechanical amplification.
The photoreceptors of newly eclosed flies expressing inaD[ninaE.T669A] in a inaD[T1] mutant background show a slower response to brief (1ms) flashes containing ~75 effectively absorbed photons. Peak amplitude is similar to wild type but the time to peak is delayed and the decay time course is slower. Following 1s light steps of increasing intensity wild type responses consist of an initial peak that rapidly declines to minimum (the "notch"); this "notch" is more pronounced in inaD[T1] inaD[ninaE.T669A] mutant flies. Although the intensity dependence of both the peak and plateau in mutants are indistinguishable from wild-type, the "notch" develops at 2-3 fold lower intensities than in controls.
Inhibition of trpl[ninaE.T:Avic\GFP-EGFP] internalisation is observed in inaD[T1] mutant photoreceptors.
Mutants have single photon responses that are grossly disorganised, with large defects in amplitude, latency and deactivation. Quantum bumps have amplitudes less than one fifth of those of controls, latencies that are roughly six times greater than wild type and responses that fail to terminate normally, with single photons producing several microbumps. Double mutants with of Camunspecified with inaDT1 show a noisy, continuous response to a single photon of light, and do not produce individual bumps.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Fails to complement|
|Partially rescued by|
Light-raised inaD[ttd10] in trans with inaD[T1] shows partial translocation of trpl[ninaE.T:Avic\GFP-EGFP] from the rhabdomere to the cell body. It should be noted that the trpl[ninaE.T:Avic\GFP-EGFP] translocation defect in homozygous inaD[ttd10] mutants is more severe than in trans with inaD[T1]. inaD[ttd10]/inaD[T1] flies exhibit almost normal internalisation in some photoreceptor cells of each ommatidium whereas the internalisation defect is observed in all photoreceptor cells in homozygous inaD[ttd10] mutants.
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 3 )|
(Scott and Zuker, 1998, Tsunoda et al., 1997, Tsunoda et al., 2001, Baehner et al., 2002, Meyer et al., 2006, Mishra et al., 2007, Chorna-Ornan et al., 2005, Popescu et al., 2006, Meyer et al., 2008, Wes et al., 1999, Sanxaridis and Tsunoda, 2010, Venkatachalam et al., 2010, Peng et al., 2008, Sanxaridis et al., 2007, Senthilan et al., 2012)
|Secondary FlyBase IDs|
|References ( 18 )|