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General Information
Symbol
Dmel\eg18B
Species
D. melanogaster
Name
FlyBase ID
FBal0062866
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Deficiency that removes the first two exons and the translational start of eg.

Imprecise excision of the P{GawB} element, removing at least 7kb of the eg locus, including exons A1, A2 and B. Part of the 5' end of the P{GawB} element remains.

Insertion components
P{5'GawB}eg18B
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In the ventral nerve cords of stage 16 eg18B mutant embryos, there is a loss of ability to take up serotonin in approximately 70% of hemisegments.

Lethality is during late embryonic and early larval stages. Many hemisegments show loss of serotonin neurons: mutants exhibit a single cell instead of the normal mitotic pair. nub and zfh2 staining reveals the more medial serotonin cell of the mitotic pair is lost: the EW1 neuron.

Serotonergic cells are almost entirely lacking in the central nervous system of eg18B first instar larvae.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

eg18B is a non-enhancer of embryo | dorsal closure stage phenotype of kay1/kay2

NOT Suppressor of
Statement
Reference

eg18B is a non-suppressor of embryo | dorsal closure stage phenotype of kay1/kay2

Other
Additional Comments
Genetic Interactions
Statement
Reference

eg18B flies expressing rlSem.C.Scer\UAS under the control of Scer\GAL432B have a held out wing phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
eg18B
Name Synonyms
Secondary FlyBase IDs
    References (4)