FlyBase Allele Report: Dmel\ast[K6]

General Information

Symbol

Dmel\ast^K6

Species

D. melanogaster

Name

FlyBase ID

FBal0062965

Feature type

allele

Associated gene

Dmel\ast

Associated Insertion(s)

P{}ast^K6

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Higson et al., 1993)

Mutagen

Delta2-3 transposase

(Higson et al., 1993)

Progenitor genotype

Associated Insertion(s)

P{}ast^K6

Cytology

Description

Insertion of a P-element 20bp upstream of the transcription start site.

(Kotarski et al., 1998)

P-element insertion 1.6kb to the right of coordinate -5.0.

(Higson et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible (with ast¹)

(Higson et al., 1993)

Phenotype Manifest In

ommatidium (with ast¹)

(Higson et al., 1993)

Detailed Description

Statement

Reference

Heterozygotes have normal eyes.

(Kotarski et al., 1998)

Transheterozygotes with ast¹ exhibit disranged ommatidia in nearly wild-type sized eyes. No wing vein abnormalities are found.

(Higson et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

ast^K6/ast[+] is an enhancer of visible | dominant phenotype of S⁵⁴

(Kotarski et al., 1998)

ast^K6/ast[+] is an enhancer of visible | dominant phenotype of Egfr^E1

(Kotarski et al., 1998)

ast^K6/ast[+] is an enhancer of visible phenotype of S¹

(Kotarski et al., 1998)

ast^K6/ast[+] is an enhancer of visible phenotype of S^L

(Kotarski et al., 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

ast^K6/ast[+] is an enhancer of eye phenotype of S⁵⁴

(Kotarski et al., 1998)

ast^K6/ast[+] is an enhancer of eye phenotype of S^L

(Kotarski et al., 1998)

ast^K6/ast[+] is an enhancer of ommatidium phenotype of S⁵⁴

(Kotarski et al., 1998)

ast^K6/ast[+] is an enhancer of eye phenotype of Egfr^E1

(Kotarski et al., 1998)

ast^K6/ast[+] is an enhancer of ommatidium phenotype of Egfr^E1

(Kotarski et al., 1998)

ast^K6/ast[+] is an enhancer of eye phenotype of S¹

(Kotarski et al., 1998)

NOT Enhancer of

Statement

Reference

ast^K6 is a non-enhancer of phenotype of rho^ve-1

(Kotarski et al., 1998)

ast^K6 is a non-enhancer of phenotype of ro¹

(Kotarski et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Dominantly enhances the eye phenotype of S⁵⁴, S¹, S^L, Df(2L)S3, Df(2L)ast2 and Egfr^E1. Double heterozygotes with spi¹, rho^ve-1, Df(3R)by10 or sim¹ do not have a visible phenotype. Does not dominantly alter the phenotype of ro¹ or rho^ve-1 homozygotes. sim¹/ast^K6 double heterozygotes do not have a visible phenotype.

(Kotarski et al., 1998)

Heterozygotes with S¹ are viable.

(Higson et al., 1993)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

ast¹

(Kotarski et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Class 1 ast mutation.

(Higson et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ast^K6

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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