Allele Dmel\Tl^{8.bcd.3'UTR.bcd}

General Information
Symbol	Dmel\Tl^{8.bcd.3'UTR.bcd}	Species	D. melanogaster
Name		FlyBase ID	FBal0063021
Feature type	allele	Associated gene	Dmel\Tl

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Huang et al., 1997)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: 3.5kb NsiI-XbaI fragment of Tl⁸ cDNA is expressed from a bcd promoter and influenced by 900bp SacII-XbaI fragment of the bcd 3' UTR. (Huang et al., 1997)
Carried in construct	P{bcd-Toll^10b} (Stathopoulos and Levine, 2002, Towb et al., 1998, Huang et al., 1997, Chen et al., 2006, Cowden and Levine, 2003)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference Causes the formation of an ectopic anterior posterior (AP) dl nuclear gradient along the length of the embryo. Analysis of dl target genes suggests that the ectopic gradient is sufficient to generate the full repertory of dorsal ventral patterning responses along the AP axis of the embryo. (Huang et al., 1997)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Weak expression of Tl⁸ cDNA. (Huang et al., 1997)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Tl^{8.bcd.3'UTR.bcd} Toll^10b-bcd (Zhou et al., 1997)
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Chen et al., 2006, Curr. Biol. 16(12): 1183--1193 Weckle is a zinc finger adaptor of the Toll pathway in dorsoventral patterning of the Drosophila embryo. [FBrf0193565] Cowden and Levine, 2003, Dev. Biol. 262(2): 335--349 Ventral dominance governs sequential patterns of gene expression across the dorsal-ventral axis of the neuroectoderm in the Drosophila embryo. [FBrf0167459] Stathopoulos and Levine, 2002, Development 129(14): 3411--3419 Linear signaling in the Toll-Dorsal pathway of Drosophila: activated Pelle kinase specifies all threshold outputs of gene expression while the bHLH protein Twist specifies a subset. [FBrf0151261] Towb et al., 1998, Development 125(13): 2443--2450 Recruitment of tube and pelle to signaling sites at the surface of the Drosophila embryo. [FBrf0103055] Huang et al., 1997, Genes Dev. 11(15): 1963--1973 An anteroposterior Dorsal gradient in the Drosophila embryo. [FBrf0095021]
Review	Zhou et al., 1997, Cold Spring Harbor Symp. Quant. Biol. 62: 307--312 The regulation of enhancer-promoter interactions in the Drosophila embryo. [FBrf0102425]

Allele Dmel\Tl8.bcd.3'UTR.bcd

Allele Dmel\Tl^{8.bcd.3'UTR.bcd}