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General Information
Symbol
Dmel\Jra1
Species
D. melanogaster
Name
FlyBase ID
FBal0063161
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
jun1, Djun1
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
sequence variant
Amino acid change:

F177@

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Mutation is expected to produce a truncated product that lacks the basic region and leucine zipper.

Amino acid replacement: F177term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Jra1 neuroblast clones in the mushroom body have no gross axonal phenotypes.

Jra1/+ flies show no thoracic abnormalities.

Mutant embryos die in mid to late embryogenesis with large anterior and dorsal holes in the cuticle. Mitotic clones in the eye cause no abnormal defects in eye development. Microscopic inspection of tangential sections reveals minor defects, the occasional missing photoreceptor.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

Jra1/Jra[+] is a suppressor of planar polarity defective phenotype of dshhs.sev.B

Jra1/Jra[+] is a suppressor of visible | heat sensitive phenotype of peb1

Jra1/Jra[+] is a suppressor of visible phenotype of Scer\GAL469B, nmoc5-1.UAS

Phenotype Manifest In
Enhancer of
Statement
Reference

Jra1/Jra[+] is an enhancer of adult thorax phenotype of Mnn1UAS.cCa, Scer\GAL4pnr-MD237

Suppressor of
Statement
Reference

Jra1/Jra[+] is a suppressor of eye phenotype of ebi1-334.GMR

Jra1/Jra[+] is a suppressor of retina | progressive phenotype of ebi1-334.GMR

Jra1/Jra[+] is a suppressor of ommatidium phenotype of dshhs.sev.B

Jra1/Jra[+] is a suppressor of eye | heat sensitive phenotype of peb1

Jra1/Jra[+] is a suppressor of posterior crossvein phenotype of Scer\GAL469B, nmoc5-1.UAS

Jra1/Jra[+] is a suppressor of wing vein | ectopic phenotype of Scer\GAL469B, nmoc5-1.UAS

Jra1/Jra[+] is a suppressor | partially of ommatidium phenotype of peb1

Jra1 is a suppressor of ommatidium phenotype of Rac1V12.hs.sev

Jra1 is a suppressor of phenotype of dshhs.sev.B

Jra1 is a suppressor of wing phenotype of EgfrE3

Jra1 is a suppressor of eye photoreceptor cell | ectopic phenotype of rlSem

Jra1/Jra[+] is a suppressor of eye photoreceptor cell phenotype of sevS11.Tag:MYC

NOT Suppressor of
Statement
Reference

Jra1 is a non-suppressor of phenotype of arm3

Additional Comments
Genetic Interactions
Statement
Reference

Jra1/+ suppresses the rough eye phenotype seen in flies with two copies of ebi1-334.GMR.

Jra1/+ suppresses the late-onset retinal degeneration phenotype of ebi1-334.GMR/+ flies.

One copy of Jra1 suppresses the formation of symmetrical ommatidia that is seen in animals expressing dshhs.sev.B.

Expression of Mnn1Scer\UAS.cCa under the control of Scer\GAL4pnr-MD237 in a Jra1/+ background results in an enhanced thoracic cleft compared to Mnn1Scer\UAS.cCa expression in a wild-type background.

Heterozygosity for Jra1 can suppress the wing-vein defects, as well as wing shape and size defects seen in Scer\GAL469B, nmoc5-1.Scer\UAS adults.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

FlyBase curator comment: The Jra1 allele, first referred to as 'jun[1]' by Kockel et al., 1997 (FBrf0095439), is NOT the same as Jra76-19, first referred to as 'Djun[1]' by Hou et al., 1997 (FBrf0095018). The Materials and Methods section of FBrf0095018 states that their 'Djun[1]' was originally named '76-19' by Bour et al, 1995 (FBrf0079902), and this is the superscript used for this allele in FlyBase.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
References (17)