FlyBase Allele Report: Hsap\RAF1[gof.hs]

General Information

Symbol

Hsap\RAF1^gof.hs

Species

H. sapiens

Name

FlyBase ID

FBal0063223

Feature type

allele

Associated gene

Hsap\RAF1

Associated Insertion(s)

Carried in Construct

P{Hsp70-Hraf.gof}

Key Links

Allele class

Mutagen

in vitro construct - regulatory fusion

Nature of the Allele

Allele class

Mutagen

in vitro construct - regulatory fusion

(Brand and Perrimon, 1994)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{Hsp70-Hraf.gof}

Cytology

Nature of the lesion

Statement

Reference

Hsap\RAF1^gof.hs coding sequence is driven from an Hsp70 promoter.

(Brand and Perrimon, 1994)

Allele components

Product class / Tool use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

Hsap\RAF1

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | maternal effect | heat sensitive

(Brand and Perrimon, 1994)

some die during embryonic stage | maternal effect | heat sensitive

(Brand and Perrimon, 1994)

Phenotype Manifest In

dorsal appendage | maternal effect | heat sensitive

(Brand and Perrimon, 1994)

egg chorion | maternal effect | heat sensitive

(Brand and Perrimon, 1994)

embryo | maternal effect | heat sensitive

(Brand and Perrimon, 1994)

follicle cell | maternal effect | heat sensitive

(Brand and Perrimon, 1994)

Detailed Description

Statement

Reference

Females homozygous for Hsap\RAF1^gof.hs lay very few eggs after the third day of heat shock, of which two thirds are severely dorsalized.

(Brand and Perrimon, 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Constitutively active form of Hsap\RAF1.

(Brand and Perrimon, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hsap\RAF1^gof.hs

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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