FlyBase Allele Report: Scer\GAL4[179Y]

General Information

Symbol

Scer\GAL4^179Y

Species

S. cerevisiae

Name

FlyBase ID

FBal0063411

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

P{GawB}Nup205^179Y

Carried in Construct

Also Known As

179Y-GAL4, 179Y, P{GawB}179Y

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Manseau et al., 1997)

Progenitor genotype

Associated Insertion(s)

P{GawB}Nup205^179Y

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GawB}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:19,851,479..19,851,479 [+]X:19,853,131..19,853,131

(Malzer et al., 2018, Lee and Spradling, 2014, Pirooznia et al., 2012, Lorbeck et al., 2011, Skora and Spradling, 2010, Stempfle et al., 2010, Sage et al., 2008, Garg et al., 2007, Rusu et al., 2007, Andrenacci et al., 2006, Armstrong et al., 2006, Morris et al., 2006, Pereanu et al., 2005, Gunawardena et al., 2003, Gunawardena and Goldstein, 2001, Manseau et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

organism | striped

(Manseau et al., 1997)

embryonic stage 17

embryonic/larval salivary gland

(Sage et al., 2008)

larval stage

nervous system

(Gunawardena and Goldstein, 2001)

first instar larval stage

embryonic/larval salivary gland

(Sage et al., 2008)

larval central nervous system

(Sage et al., 2008)

imaginal disc

(Sage et al., 2008)

second instar larval stage

embryonic/larval salivary gland

(Sage et al., 2008)

larval central nervous system

(Sage et al., 2008)

imaginal disc

(Sage et al., 2008)

third instar larval stage

embryonic/larval salivary gland

(Sage et al., 2008)

larval central nervous system

(Sage et al., 2008)

eye disc posterior to the morphogenetic furrow

(Sage et al., 2008)

wandering third instar larval stage

larval central nervous system

(Manseau et al., 1997)

pupal stage

salivary gland

(Sage et al., 2008)

adult stage

second segment of antenna

(Armstrong et al., 2006)

third segment of antenna

(Armstrong et al., 2006)

vibrissal bristle

(Armstrong et al., 2006)

maxillary palp

(Armstrong et al., 2006)

adult stage | female

ovary

(Sage et al., 2008)

adult stage | male

testis

(Sage et al., 2008)

adult stage & oogenesis

follicle cell

(Manseau et al., 1997)

Additional Information

Statement

Reference

In embryos, late expression in a segmentally repeated pattern of stripes. In the larva, expression in the CNS and the lamina anlagen (near the central brain boundary); no expression observed in eye discs. In ovary, high levels of expression in follicle cells over oocyte.

(Manseau et al., 1997)

Marker for

Reflects expression of

Nup205

(Armstrong et al., 2006)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | larval stage, with Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Gunawardena et al., 2003)

abnormal locomotor behavior | larval stage, with Zzzz\CAG^{127Q.UAS.Tag:HA}

(Gunawardena et al., 2003)

abnormal locomotor behavior | larval stage, with Zzzz\CAG^Q108.UAS

(Gunawardena et al., 2003)

abnormal neurophysiology, with Hsap\APP^UAS.Tag:MYC

(Rusu et al., 2007)

abnormal neurophysiology, with Hsap\APP^{ΔBASS.UAS.Tag:MYC}

(Rusu et al., 2007)

abnormal neurophysiology, with Mmus\Mapk8ip1^ΔJBD.UAS

(Rusu et al., 2007)

increased cell death, with Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Gunawardena et al., 2003)

increased cell death, with Hsap\HTT^Q93.ex1.UAS

(Gunawardena et al., 2003)

increased cell death, with rpr^UAS.C

(Gunawardena et al., 2003)

increased cell death, with Zzzz\CAG^{127Q.UAS.Tag:HA}

(Gunawardena et al., 2003)

increased cell death | third instar larval stage, with Hsap\APP^{695.UAS.Tag:MYC}

(Pirooznia et al., 2012)

increased cell death | third instar larval stage, with Tip60^E431Q.UAS

(Pirooznia et al., 2012)

increased mortality during development, with Tip60^E431Q.UAS

(Pirooznia et al., 2012)

lethal, with BacA\p35^UAS.cHa

(Morris et al., 2006)

lethal, with E2f1^UAS.cNa

(Morris et al., 2006)

lethal, with rpr^UAS.cZa

(Morris et al., 2006)

lethal, with Tip60^E431Q.UAS

(Pirooznia et al., 2012)

lethal | heat sensitive, with Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Gunawardena et al., 2003)

lethal | heat sensitive, with Zzzz\CAG^{127Q.UAS.Tag:HA}

(Gunawardena et al., 2003)

lethal | male limited, with Hsap\APP^695.T.UAS

(Gunawardena and Goldstein, 2001)

lethal - all die before end of larval stage, with Hsap\ATXN3^{Q77.UAS.Tag:HA,Tag:NES(HIV-1-Rev)}

(Gunawardena et al., 2003)

lethal - all die before end of pupal stage, with Hsap\ATXN3^{Q65.UAS.Tag:NLS(Unk)}

(Gunawardena et al., 2003)

majority die during P-stage, with Hsap\APP^{695.UAS.Tag:MYC}

(Pirooznia et al., 2012)

majority die during third instar larval stage, with Tip60^E431Q.UAS

(Pirooznia et al., 2012)

partially lethal - majority die, with Kal1^C85S.UAS

(Andrenacci et al., 2006)

partially lethal - majority die, with Kal1^N236K.UAS

(Andrenacci et al., 2006)

partially lethal - majority die, with Kal1^{R159T.R161L.UAS}

(Andrenacci et al., 2006)

partially lethal - majority die, with Kal1^UAS.cAa

(Andrenacci et al., 2006)

partially lethal - majority die, with Tip60^E431Q.UAS

(Lorbeck et al., 2011)

partially lethal - majority die, with Tip60^UAS.cPa

(Pirooznia et al., 2012)

some die during larval stage, with Hsap\ATXN3^{Q77.UAS.Tag:HA,Tag:NES(HIV-1-Rev)}

(Gunawardena et al., 2003)

some die during pupal stage, with Hsap\ATXN3^{Q65.UAS.Tag:NLS(Unk)}

(Gunawardena et al., 2003)

Phenotype Manifest In

axon, with Hsap\ATXN3^{Q77.UAS.Tag:HA,Tag:NES(HIV-1-Rev)}

(Gunawardena et al., 2003)

axon, with Hsap\HTT^Q93.ex1.UAS

(Gunawardena et al., 2003)

cephalopharyngeal skeleton, with Kal1^C85S.UAS

(Andrenacci et al., 2006)

cephalopharyngeal skeleton, with Kal1^{C127.128S.UAS}

(Andrenacci et al., 2006)

cephalopharyngeal skeleton, with Kal1^{C127.128S+N236K.UAS}

(Andrenacci et al., 2006)

cephalopharyngeal skeleton, with Kal1^{R159T.R161L.UAS}

(Andrenacci et al., 2006)

hypostomal sclerite, with Kal1^UAS.cAa

(Andrenacci et al., 2006)

larval brain | third instar larval stage, with Hsap\APP^{695.UAS.Tag:MYC}

(Pirooznia et al., 2012)

larval brain | third instar larval stage, with Tip60^E431Q.UAS

(Pirooznia et al., 2012)

larval nervous system, with Hsap\APLP2::Hsap\APP^UAS.Tag:MYC

(Gunawardena and Goldstein, 2001)

larval nervous system, with Hsap\APP^695.T.UAS

(Gunawardena and Goldstein, 2001)

larval nervous system, with Hsap\APP^{695SPA4CT.UAS.Tag:MYC}

(Gunawardena and Goldstein, 2001)

larval nervous system, with Hsap\APP^{695-Swedish.UAS}

(Gunawardena and Goldstein, 2001)

larval nervous system, with Hsap\APP^{V717F.LOND.UAS}

(Gunawardena and Goldstein, 2001)

lateral process of cephalopharyngeal skeleton, with Kal1^UAS.cAa

(Andrenacci et al., 2006)

median tooth, with Kal1^N236K.UAS

(Andrenacci et al., 2006)

median tooth, with Kal1^UAS.cAa

(Andrenacci et al., 2006)

mouth hook, with Kal1^C85S.UAS

(Andrenacci et al., 2006)

mouth hook, with Kal1^N236K.UAS

(Andrenacci et al., 2006)

mouth hook, with Kal1^UAS.cAa

(Andrenacci et al., 2006)

neuron, with Hsap\ATXN3^{Q65.UAS.Tag:NLS(Unk)}

(Gunawardena et al., 2003)

neuron, with Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Gunawardena et al., 2003)

neuron, with Zzzz\CAG^{127Q.UAS.Tag:HA}

(Gunawardena et al., 2003)

transport vesicle, with Hsap\APBB1^UAS.Tag:HA

(Rusu et al., 2007)

transport vesicle, with Hsap\APP^UAS.Tag:MYC

(Rusu et al., 2007)

transport vesicle, with Hsap\APP^{ΔBASS.UAS.Tag:MYC}

(Rusu et al., 2007)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^179Y, Tip60^E431Q.UAS has increased mortality during development phenotype, enhanceable by Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^179Y

(Pirooznia et al., 2012)

Scer\GAL4^179Y, Tip60^E431Q.UAS has increased cell death | third instar larval stage phenotype, enhanceable by Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^179Y

(Pirooznia et al., 2012)

Hsap\ATXN3^{Q77.UAS.Tag:HA,Tag:NES(HIV-1-Rev)}, Scer\GAL4^179Y has lethal | larval stage phenotype, enhanceable by Df(2R)k10408

(Gunawardena et al., 2003)

Suppressed by

Statement

Reference

Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^179Y has majority die during P-stage phenotype, suppressible | partially by Tip60^UAS.cPa, Scer\GAL4^179Y

(Pirooznia et al., 2012)

Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^179Y has increased cell death | third instar larval stage phenotype, suppressible | partially by Tip60^UAS.cPa, Scer\GAL4^179Y

(Pirooznia et al., 2012)

NOT suppressed by

Statement

Reference

Scer\GAL4^179Y, Tip60^UAS.cPa has partially lethal - majority die phenotype, non-suppressible by Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^179Y

(Pirooznia et al., 2012)

Scer\GAL4^179Y, Tip60^UAS.cPa has partially lethal - majority die phenotype, non-suppressible by Hsap\APP^{695ΔCT.UAS.Tag:MYC}, Scer\GAL4^179Y

(Pirooznia et al., 2012)

Enhancer of

Statement

Reference

Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^179Y is an enhancer of increased mortality during development phenotype of Scer\GAL4^179Y, Tip60^E431Q.UAS

(Pirooznia et al., 2012)

Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^179Y is an enhancer of increased cell death | third instar larval stage phenotype of Scer\GAL4^179Y, Tip60^E431Q.UAS

(Pirooznia et al., 2012)

Suppressor of

Statement

Reference

Tip60^UAS.cPa, Scer\GAL4^179Y is a suppressor | partially of majority die during P-stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^179Y

(Pirooznia et al., 2012)

Tip60^UAS.cPa, Scer\GAL4^179Y is a suppressor | partially of increased cell death | third instar larval stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^179Y

(Pirooznia et al., 2012)

NOT Suppressor of

Statement

Reference

Hsap\APP^{695ΔCT.UAS.Tag:MYC}/Scer\GAL4^179Y is a non-suppressor of lethal phenotype of Scer\GAL4^337Y, Tip60^E431Q.UAS

(Pirooznia et al., 2012)

Hsap\APP^{695ΔCT.UAS.Tag:MYC}/Scer\GAL4^179Y is a non-suppressor of majority die during third instar larval stage phenotype of Scer\GAL4^337Y, Tip60^E431Q.UAS

(Pirooznia et al., 2012)

Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^179Y is a non-suppressor of partially lethal - majority die phenotype of Scer\GAL4^179Y, Tip60^UAS.cPa

(Pirooznia et al., 2012)

Hsap\APP^{695ΔCT.UAS.Tag:MYC}, Scer\GAL4^179Y is a non-suppressor of partially lethal - majority die phenotype of Scer\GAL4^179Y, Tip60^UAS.cPa

(Pirooznia et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^179Y, Tip60^E431Q.UAS has larval brain | third instar larval stage phenotype, enhanceable by Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^179Y

(Pirooznia et al., 2012)

Hsap\ATXN3^{Q77.UAS.Tag:HA,Tag:NES(HIV-1-Rev)}, Scer\GAL4^179Y has axon phenotype, enhanceable by Khc⁹

(Gunawardena et al., 2003)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^179Y has axon phenotype, enhanceable by Df(2R)k10408

(Gunawardena et al., 2003)

Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^179Y has axon phenotype, enhanceable by Khc⁹

(Gunawardena et al., 2003)

Suppressed by

Statement

Reference

Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^179Y has larval brain | third instar larval stage phenotype, suppressible | partially by Tip60^UAS.cPa, Scer\GAL4^179Y

(Pirooznia et al., 2012)

Hsap\ATXN3^{Q77.UAS.Tag:HA,Tag:NES(HIV-1-Rev)}, Scer\GAL4^179Y has axon phenotype, suppressible by Hsc70-4^UAS.cEa, Scer\GAL4^179Y

(Gunawardena et al., 2003)

Enhancer of

Statement

Reference

Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^179Y is an enhancer of larval brain | third instar larval stage phenotype of Scer\GAL4^179Y, Tip60^E431Q.UAS

(Pirooznia et al., 2012)

Suppressor of

Statement

Reference

Tip60^UAS.cPa, Scer\GAL4^179Y is a suppressor | partially of larval brain | third instar larval stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^179Y

(Pirooznia et al., 2012)

Hsc70-4^UAS.cEa, Scer\GAL4^179Y is a suppressor of axon phenotype of Hsap\ATXN3^{Q77.UAS.Tag:HA,Tag:NES(HIV-1-Rev)}, Scer\GAL4^179Y

(Gunawardena et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

3733

P{GawB}Nup205^179Y, w¹¹¹⁸

Kyoto

107205

P{GawB}Nup205^179Y, w¹¹¹⁸

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

GAL4^179Y

Scer\GAL4^179Y

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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