Allele Dmel\Asx^xen-72-3

General Information
Symbol	Dmel\Asx^xen-72-3	Species	D. melanogaster
Name		FlyBase ID	FBal0063668
Feature type	allele	Associated gene	Dmel\Asx

Allele class	loss of function allele
Mutagen	X ray
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Bischoff et al., 2009)
Mutagen	X ray (Prout et al., 1997)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference A fourteen base-pair deletion (nucleotides 3706-3718 of the coding region) in the eighth exon in Asx. The deletion leads to a frame shift and an early stop codon. (Bischoff et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class
	cell size defective \| recessive \| somatic clone (Bischoff et al., 2009) lethal \| larval stage \| recessive (Prout et al., 1997) visible \| recessive \| somatic clone (Bischoff et al., 2009) visible \| somatic clone (Prout et al., 1997, Prout, 1997.3.19)
Phenotype Manifest In
	larva (Prout et al., 1997) wing \| somatic clone (Prout et al., 1997, Prout, 1997.3.19) wing blade \| somatic clone (Bischoff et al., 2009) wing hair \| somatic clone (Bischoff et al., 2009)
Detailed Description
	Statement Reference Homozygous Asx[xen-72-3] mutant clones cause wing defects. The abnormalities include wing blisters, crumpling of the wing, bending or folding of the wing along the mutant clone, and dual-lobed wings. Patches of necrotic cells associated with Asx[xen-72-3] mutant clones can be observed at low frequency. Asx[xen-72-3] mutant clone adult wings have patched of small cells containing more than one hair. (Bischoff et al., 2009) Homozygotes die as early larvae. Homozygous clones in the wing produce discrete, round blisters of variable size. These blisters can be located anywhere on the wing. Wing venation is normal. Homozygous embryos show no gross morphological abnormalities at hatching. Hatched larvae fail to grow. (Prout et al., 1997) Homozygous clones in the wing produce a blistered phenotype. (Prout, 1997.3.19)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Asx^xen-72-3 has visible \| recessive \| somatic clone phenotype, suppressible \| partially by Ubx^unspecified (Bischoff et al., 2009)
Suppressor of
Statement Reference xen[+]/Asx^xen-72-3 is a suppressor of viable phenotype of Ubx^bx-3 (Bischoff et al., 2009) xen[+]/Asx^xen-72-3 is a suppressor of viable phenotype of Ubx^pbx-1/Ubx¹⁰¹ (Bischoff et al., 2009)
Phenotype Manifest In
Suppressed by
Statement Reference Asx^xen-72-3 has wing blade \| somatic clone phenotype, suppressible \| partially by Ubx^unspecified (Bischoff et al., 2009)
Additional Comments
Genetic Interactions
Statement Reference The severity of wing phenotypes caused by homozygous Asx[xen-72-3] mutant clones is reduced in a heterozygous Ubx[unspecified] mutant background. For example, no necrotic or dual-lobed wings are observed. In addition, the percentage of wing blisters or folded/bent wings is reduced and fewer flies have crumpled wings. In some cases, ripples are associated with visible clones containing small cells, whereas other ripples are not associated with the presence of smaller cells. (Bischoff et al., 2009) Shows no interaction with mys^b9 or mys⁸. (Prout et al., 1997)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	Asx^C849 (Bischoff et al., 2009) Asx^XF23 (Bischoff et al., 2009)
Comments
Stocks ( 1 )
Bloomington	2290 y¹ w¹; P{neoFRT}42D Asx^xen-72-3 P{white-un1}47A/CyO, P{act-lacZ.B}CB1
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Asx^xen-72-3 Asx^xen (Bischoff et al., 2009) unnamed (Prout et al., 1997) xen^72-3 (Bischoff et al., 2009)
Name Synonym	xenicid (Bischoff et al., 2009)
Secondary FlyBase IDs

References ( 3 )
Research paper	Bischoff et al., 2009, PLoS ONE 4(12): e8106 Wing defects in Drosophila xenicid mutant clones are caused by C-terminal deletion of additional sex combs (Asx). [FBrf0209467] Prout et al., 1997, Genetics 146(1): 275--285 Autosomal mutations affecting adhesion between wing surfaces in Drosophila melanogaster. [FBrf0093664]
Personal communication to FlyBase	Prout, 1997.3.19, [title not yet available] [title not yet available] [FBrf0099001]

Allele Dmel\Asxxen-72-3

Allele Dmel\Asx^xen-72-3