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General Information
Symbol
Dmel\vrik05901
Species
D. melanogaster
Name
FlyBase ID
FBal0063677
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
vri5
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{lacW} insertion in the first intron. The orientation of the P{lacW} element is the same as the direction of vri transcription.

P{lacW} insertion maps to position 757 within the first intron of cDNA e2.

Insertion components
P{lacW}vrik05901
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

15% of stage 11-13 vri2/vrik05901 embryos show tracheal defects. During stages 14-17, 80% of vri2/vrik05901 embryos show weak tracheal defects (the general architecture of the trachea is preserved, but breaking of branches occurs and elongation and branching are abnormal) and 12% show strong tracheal defects (the tracheal architecture is strongly affected with complete disorganization and formation of sacs).

vriKG01220/vrik05901 flies have wings which are shorter than normal and which bend downwards, and the posterior scutellar bristles are upturned. Homozygous clones in the wing have pigmented regions that could result from necrosis. Clones at the anterior wing margin have smaller and thinner stout mechanosensory bristles than normal. The space between bristles is reduced, which is characteristic of smaller cells, and the margin is concave. The mean number of ommatidia in the eyes of mosaic flies in which the eyes are homozygous for vrik05901 is reduced by 10% compared to wild type.

The period length of the locomotor activity rhythm is significantly shorter in heterozygotes than in wild-type flies.

Homozygous embryo head skeleton is defective. In some embryos the germ band remains extended, suggesting defects in germ band retraction. Some embryos are convoluted, the ventral denticles extend laterally and filzkorper are internal and present an abnormal morphology. Hemizygotes die as larvae. A large number of undeveloped eggs are recovered from germline clones, phenotype can be rescued by paternal contribution of wild type vri.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

vri[+]/vrik05901 is a suppressor of visible | heat sensitive phenotype of peb1

Phenotype Manifest In
Enhancer of
Statement
Reference

vrik05901 is an enhancer of phenotype of dpphr4

vrik05901 is an enhancer of phenotype of dpphr27

vrik05901 is an enhancer of phenotype of ea161.13

Suppressor of
Statement
Reference

vri[+]/vrik05901 is a suppressor of eye | heat sensitive phenotype of peb1

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

Complements: cype03771. Complements: tkv04415. Complements: l(2)0488404884. Complements: l(2)k01302k01302. Complements: tkvk16713.

Mobilisation of the P{lacW} reveals the insertion is responsible for the mutant phenotype. 23 lethal revertant lines are selected and the lines that have a similar phenotype to vri1 and vri2 also die as larvae when hemizygous.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (10)