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General Information
Symbol
Dmel\tkvk16713
Species
D. melanogaster
Name
FlyBase ID
FBal0063746
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
tkv-lacZ, tkv16713, tkvk16713-lacZ
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{lacW} insertion in second intron.

P{lacW} insertion maps 600bp upstream of P{PZ} insertion of tkv04415 within the tkv-2 cDNA second intron.

Insertion components
P{lacW}tkvk16713
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
ameliorates  Angelman syndrome
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

tkv8/tkvk16713 third instar larvae have a significant decrease in total boutons (and satellite boutons) at the neuromuscular junction, compared to wild type.

The neuromuscular junction synapses of homozygous tkv7/tkvk16713 mutants are undergrown but the total number of boutons is similar to heterozygous controls.

Heterozygotes show a direct effect on the shape of the wing.

tkvk16713/tkv7 larvae show a significant decrease in bouton number at the neuromuscular junction.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement
Reference
Suppressor of
Statement
Reference
Other
Statement
Reference
Phenotype Manifest In
NOT suppressed by
Statement
Reference
NOT Enhancer of
Statement
Reference

tkvk16713/tkv[+] is a non-enhancer of wing vein | ectopic phenotype of Snr1E1

Suppressor of
NOT Suppressor of
Statement
Reference

tkvk16713/tkv[+] is a non-suppressor of wing vein | ectopic phenotype of Snr1E1

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

tkv8/tkvk16713;Ube3a35/Ube3a35 third instar larvae have a significant decrease in total boutons (and satellite boutons) at the neuromuscular junction, compared to wild type (similar to tkv8/tkvk16713, suppressing the increase seen in Ube3a35/Ube3a35 mutants).

When present in the genetic background, heterozygous tkvk16713 reduces the synaptic overgrowth in Rab81/Rab8B229 mutants.

When present in the genetic background, trans-heterozygous tkv7/tkvk16713 reduces the synaptic overgrowth in Rab81/Rab8B229 mutants.

One copy of tkvk16713 in a DysE6/+ background results in posterior crossvein defects.

spictmut neuromuscular junction overgrowth phenotypes are fully suppressed in tkv7/tkvk16713 mutants. The synaptic undergrowth phenotypes in larvae homozygous for spictmut in a tkv7/tkvk16713 background are indistinguishable from that of tkv7/tkvk16713 mutants alone.

spin10403/spink09905 animals which are also mutant for tkv7/tkvk16713 show a decrease in bouton number.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (spradling@mail1.ciwemb.edu).

Complements: cype03771. Complements: l(2)k01302k01302. Complements: vrik05901.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (10)
References (20)