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General Information
Symbol
Dmel\ninaEΔ356
Species
D. melanogaster
Name
FlyBase ID
FBal0063840
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Rh1Δ356, Rh1Δ356
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Construct: Eliminates the last 18 amino acids residues that include the Ser and Thr in the cytoplasmic tail.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The electroretinogram response of light-adapted ninaEΔ356;ninaE17,rdgC306 flies to oscillating light of gradually increasing frequencies is comparable to controls at both lower and higher frequencies. Dark-adapted flies show no significant changes in the onset of the frequency-locked response to oscillating light of either low (10Hz) or high (70Hz) frequency compared to wild-type flies, no defects are observed in light-adapted flies at high frequency either.

Light-induced translocation of Arr1 and ninaE endocytosis in pupal eyes is reduced in ninaEΔ356 mutants.

The reduction in electroretinogram (ERG) amplitude seen in flies exposed to constant light is greatly suppressed by ninaEΔ356. The initiation of retinal degeneration (assayed by loss of the deep pseudopupil) appears to occur earlier in ninaEΔ356 flies exposed to constant light compared to wild-type flies exposed to constant light.

When IBMX is applied to ninaEΔ356 mutant flies the macroscopic response is slowed in a way that is no different to that of wild type flies exposed to IBMX.

Transgenic adults exhibit normal retinal morphology. ERGs demonstrate the photoreceptors display normal kinetics of activation and deactivation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressor of
Statement
Reference

ninaEΔ356 is a suppressor of phenotype of rdgC306

NOT Suppressor of
Statement
Reference

ninaEΔ356 is a non-suppressor of eye phenotype of norpA7

ninaEΔ356 is a non-suppressor of retina phenotype of norpA7

ninaEΔ356 is a non-suppressor of rhabdomere R1 phenotype of norpA7

ninaEΔ356 is a non-suppressor of rhabdomere R2 phenotype of norpA7

ninaEΔ356 is a non-suppressor of rhabdomere R3 phenotype of norpA7

ninaEΔ356 is a non-suppressor of rhabdomere R4 phenotype of norpA7

ninaEΔ356 is a non-suppressor of rhabdomere R5 phenotype of norpA7

ninaEΔ356 is a non-suppressor of rhabdomere R6 phenotype of norpA7

Additional Comments
Genetic Interactions
Statement
Reference

Twenty-day old norpA36 flies expressing ninaEΔ356 exhibit the full complement of R1-R6 rhabdomeres and display no sign of retinal degeneration. Rhabdomere degeneration is delayed in norpA36 flies expressing one copy of ninaEΔ356 in a ninaE17 mutant background, as rhabdomeres retain wild-type morphology for at least 3 weeks post-eclosion. At 4 weeks, some ommatidia exhibit signs of deterioration as characterised by missing and/or reduced rhabdomeres in norpA36 flies co-expressing ninaEΔ356 (in a ninaE17 background)

The addition of ninaEΔ356 to norpA7 mutants has no effect on the retinal phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (11)