FlyBase Allele Report: Dmel\ninaE[Δ356]

General Information

Symbol

Dmel\ninaE^Δ356

Species

D. melanogaster

Name

FlyBase ID

FBal0063840

Feature type

allele

Associated gene

Dmel\ninaE

Associated Insertion(s)

Carried in Construct

P{Rh1^Δ356}

Also Known As

Rh1^Δ356, Rh1Δ356

Key Links

Allele class

Mutagen

in vitro construct

Nature of the Allele

Allele class

Mutagen

in vitro construct

(Vinos et al., 1997)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{Rh1^Δ356}

Cytology

Nature of the lesion

Statement

Reference

Construct: Eliminates the last 18 amino acids residues that include the Ser and Thr in the cytoplasmic tail.

(Vinos et al., 1997)

Allele components

Product class / Tool use(s)

Encoded product / tool

ninaE

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal visual behavior

(Chyb et al., 1999)

Phenotype Manifest In

endocytic vesicle

(Satoh and Ready, 2005)

photoreceptor neuron

(Chyb et al., 1999)

Detailed Description

Statement

Reference

The electroretinogram response of light-adapted ninaE^Δ356;ninaE¹⁷,rdgC³⁰⁶ flies to oscillating light of gradually increasing frequencies is comparable to controls at both lower and higher frequencies. Dark-adapted flies show no significant changes in the onset of the frequency-locked response to oscillating light of either low (10Hz) or high (70Hz) frequency compared to wild-type flies, no defects are observed in light-adapted flies at high frequency either.

(Voolstra et al., 2017)

Light-induced translocation of Arr1 and ninaE endocytosis in pupal eyes is reduced in ninaE^Δ356 mutants.

(Satoh and Ready, 2005)

The reduction in electroretinogram (ERG) amplitude seen in flies exposed to constant light is greatly suppressed by ninaE^Δ356. The initiation of retinal degeneration (assayed by loss of the deep pseudopupil) appears to occur earlier in ninaE^Δ356 flies exposed to constant light compared to wild-type flies exposed to constant light.

(Lee and Montell, 2004)

When IBMX is applied to ninaE^Δ356 mutant flies the macroscopic response is slowed in a way that is no different to that of wild type flies exposed to IBMX.

(Chyb et al., 1999)

Transgenic adults exhibit normal retinal morphology. ERGs demonstrate the photoreceptors display normal kinetics of activation and deactivation.

(Vinos et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

ninaE^StoA/ninaE^Δ356 is a suppressor of abnormal neuroanatomy phenotype of norpA^P24

(Kristaponyte et al., 2012)

ninaE^Δ356 is a suppressor of abnormal neuroanatomy phenotype of norpA^P24

(Kristaponyte et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

ninaE¹⁷/ninaE^Δ356 is a suppressor of rhabdomere phenotype of norpA^P24

(Kristaponyte et al., 2012)

ninaE¹⁷/ninaE^Δ356 is a suppressor of photoreceptor neuron phenotype of norpA^P24

(Kristaponyte et al., 2012)

ninaE^Δ356 is a suppressor of phenotype of rdgC³⁰⁶

(Vinos et al., 1997)

NOT Suppressor of

Statement

Reference

ninaE^Δ356 is a non-suppressor of eye phenotype of norpA^EE5

(Alloway et al., 2000)

ninaE^Δ356 is a non-suppressor of retina phenotype of norpA^EE5

(Alloway et al., 2000)

ninaE^Δ356 is a non-suppressor of rhabdomere R1 phenotype of norpA^EE5

(Alloway et al., 2000)

ninaE^Δ356 is a non-suppressor of rhabdomere R2 phenotype of norpA^EE5

(Alloway et al., 2000)

ninaE^Δ356 is a non-suppressor of rhabdomere R3 phenotype of norpA^EE5

(Alloway et al., 2000)

ninaE^Δ356 is a non-suppressor of rhabdomere R4 phenotype of norpA^EE5

(Alloway et al., 2000)

ninaE^Δ356 is a non-suppressor of rhabdomere R5 phenotype of norpA^EE5

(Alloway et al., 2000)

ninaE^Δ356 is a non-suppressor of rhabdomere R6 phenotype of norpA^EE5

(Alloway et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Twenty-day old norpA³⁶ flies expressing ninaE^Δ356 exhibit the full complement of R1-R6 rhabdomeres and display no sign of retinal degeneration. Rhabdomere degeneration is delayed in norpA³⁶ flies expressing one copy of ninaE^Δ356 in a ninaE¹⁷ mutant background, as rhabdomeres retain wild-type morphology for at least 3 weeks post-eclosion. At 4 weeks, some ommatidia exhibit signs of deterioration as characterised by missing and/or reduced rhabdomeres in norpA³⁶ flies co-expressing ninaE^Δ356 (in a ninaE¹⁷ background)

(Kristaponyte et al., 2012)

The addition of ninaE^Δ356 to norpA⁷ mutants has no effect on the retinal phenotype.

(Alloway et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Rh1^Δ356

(Kristaponyte et al., 2012, Liu et al., 2008)

Rh1Δ356

(Satoh and Ready, 2005, Alloway et al., 2000)

ninaE^Δ356

(Cao et al., 2011)

ninaE^Δ365

(Cao et al., 2011)

rh1^Δ356

(Voolstra et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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