FlyBase Allele Report: Dmel\cnk[k16314]

General Information

Symbol

Dmel\cnk^k16314

Species

D. melanogaster

Name

FlyBase ID

FBal0064057

Feature type

allele

Associated gene

Dmel\cnk

Associated Insertion(s)

P{lacW}cnk^k16314

Carried in Construct

Key Links

Genomic Maps

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Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Roch et al., 1998, BDGP Project Members, 1994-1999)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:17,419,346..17,419,353 [-]

(Laberge et al., 2005, Spradling et al., 1999, Roch et al., 1998, Therrien et al., 1998, BDGP Project Members, 1994-1999)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Excision of the P{lacW} reverts the lethality of this chromosome.

(Therrien et al., 1998)

Insertion components

P{lacW}cnk^k16314

Product class / Tool use(s)

Encoded product / tool

Tagged with

nuclear protein localization tag

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

dorsal air sac primordium | somatic clone

(Cabernard and Affolter, 2005)

imaginal disc

(Roch et al., 1998)

wing

(Roch et al., 1998)

wing vein

(Roch et al., 1998, Therrien et al., 1998)

Detailed Description

Statement

Reference

cnk^k16314 homozygous clones in the dorsal air sac primordium grow more slowly than wild-type clones and never contribute to the tip of the primordium.

(Cabernard and Affolter, 2005)

Mutants exhibit visible disc abnormalities: discs are small. Clones induced in wild type discs are abnormal: clones in the wing cause small cells, lack of veins and non-autonomous reduction in the size of neighbouring territories.

(Roch et al., 1998)

Clones in the wing prevent wing vein formation.

(Therrien et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

cnk[+]/cnk^k16314 is a suppressor | partially of abnormal size | pupal stage phenotype of Scer\GAL4^elav-C155, jeb^UAS.cVa

(Wolfstetter et al., 2017)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The reduced pupal size characteristic for animals expressing jeb^Scer\UAS.cVa under the control of Scer\GAL4^elav-C155 is partially suppressed by combination with a single copy of cnk^k16314.

(Wolfstetter et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

cnk^sag13L

(Wolfstetter et al., 2017)

cnk^sag32-3

(Wolfstetter et al., 2017)

Rescued by

cnk^k16314 is rescued by cnk^{fTRG01248.sfGFP-TVPTBF}