FB2020_06, released Dec 22, 2020

Allele: Dmel\cnkk16314

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General Information
Symbol
Dmel\cnkk16314
Species
D. melanogaster
Name
FlyBase ID
FBal0064057
Feature type
allele
Associated gene
Dmel\cnk
Associated Insertion(s)
P{lacW}cnkk16314
Carried in Construct
Genomic Maps
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Roch et al., 1998, BDGP Project Members, 1994-1999)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
transposable element insertion site
2R:17,419,346..17,419,353 [-]
(Laberge et al., 2005, Spradling et al., 1999, Roch et al., 1998, Therrien et al., 1998, BDGP Project Members, 1994-1999)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology
      Nature of the lesion
      Statement
      Reference

      Excision of the P{lacW} reverts the lethality of this chromosome.

      (Therrien et al., 1998)
      Insertion components
      P{lacW}cnkk16314
      Product class / Tool use(s)
      Encoded product / tool
      lacZ
      Tagged with
      Tag:NLS(P)
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cnkk16314 homozygous clones in the dorsal air sac primordium grow more slowly than wild-type clones and never contribute to the tip of the primordium.

      (Cabernard and Affolter, 2005)

      Mutants exhibit visible disc abnormalities: discs are small. Clones induced in wild type discs are abnormal: clones in the wing cause small cells, lack of veins and non-autonomous reduction in the size of neighbouring territories.

      (Roch et al., 1998)

      Clones in the wing prevent wing vein formation.

      (Therrien et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      cnk[+]/cnkk16314 is a suppressor | partially of size defective | pupal stage phenotype of Scer\GAL4elav-C155, jebUAS.cVa

      (Wolfstetter et al., 2017)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The reduced pupal size characteristic for animals expressing jebScer\UAS.cVa under the control of Scer\GAL4elav-C155 is partially suppressed by combination with a single copy of cnkk16314.

      (Wolfstetter et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      jebk05644

      (Wolfstetter et al., 2017)

      Alk1

      (Wolfstetter et al., 2017)

      Alk10

      (Wolfstetter et al., 2017)

      jebweli

      (Wolfstetter et al., 2017)
      Fails to complement

      cnksag32-3

      (Wolfstetter et al., 2017)

      cnksag13L

      (Wolfstetter et al., 2017)
      Rescued by

      cnkk16314 is rescued by cnkfTRG01248.sfGFP-TVPTBF

      (Wolfstetter et al., 2017)

      cnkk16314 is rescued by cnkfTRG01248.sfGFP-TVPTBF

      (Wolfstetter et al., 2017)
      Partially rescued by

      cnkk16314/cnkE-1088 is partially rescued by cnkISmut.Tag:FLAG

      (Douziech et al., 2006)

      cnkk16314/cnkE-1088 is partially rescued by cnkTag:FLAG

      (Douziech et al., 2006)

      cnkk16314/cnkE-1088 is partially rescued by cnkΔRIM.hs.sev.Tag:FLAG

      (Laberge et al., 2005)

      cnkk16314/cnkE-1088 is partially rescued by cnkRIRmut-Y1163F.hs.sev.Tag:FLAG

      (Laberge et al., 2005)

      cnkk16314/cnkE-1088 is partially rescued by cnkTag:FLAG

      (Laberge et al., 2005)
      Not rescued by

      cnkk16314/cnkE-1088 is not rescued by cnkRIMmut.Tag:FLAG

      (Douziech et al., 2006)

      cnkk16314/cnkE-1088 is not rescued by cnkRIMmut.ISmut.Tag:FLAG

      (Douziech et al., 2006)

      cnkk16314/cnkE-1088 is not rescued by cnkSAMmut.Tag:FLAG

      (Douziech et al., 2006)

      cnkk16314/cnkE-1088 is not rescued by cnkCRICmut.Tag:FLAG

      (Douziech et al., 2006)

      cnkk16314/cnkE-1088 is not rescued by cnkY1163F.hs.sev.Tag:FLAG

      (Laberge et al., 2005)
      Comments

      The lethality of cnkk16314 mutants is rescued by combination with cnkfTRG1248.

      (Wolfstetter et al., 2017)

      cnk+t5.5.T:Zzzz\FLAG rescues 21.9% of flies to adult viability, while cnkISmut.T:Zzzz\FLAG rescues 22.1% of flies to adult viability.

      (Douziech et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      I. Kiss.

      (BDGP Project Members, 1994-1999)
      Comments
      Comments

      Complements: upok05916. Complements: l(2)k06904k06904. Complements: l(2)k01209k08901a. Complements: Lack11012b.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      163/14
      (Roch et al., 1998)
      cnkk16314
      (Wolfstetter et al., 2017, Christensen and Cook, 2006.8.29)
      cnkl(2)16314
      (Cabernard and Affolter, 2005)
      cnkl(2)k05916
      (Laberge et al., 2005)
      cnkl(2)k16314
      (Douziech et al., 2006)
      l(2)k16314
      (Spradling et al., 1999)
      l(2)k16314k16314
      Name Synonyms
      Secondary FlyBase IDs
        References (14)