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General Information
Symbol
Dmel\ebik16213
Species
D. melanogaster
Name
FlyBase ID
FBal0064059
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ebiP
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{lacW} is inserted into the 5' UTR of the ebi transcript.

Insertion components
P{lacW}ebik16213
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

One week after eclosion, homozygous ebik16213 eye clones form ommatidia with a near-normal set of photoreceptors. At 5 weeks, however, these cells show a severely degenerated phenotype in a cell-autonomous manner. Several scar-like defects appear in the retinas along with abnormal ommatidia with a reduced number of photoreceptor cells.

Eyes containing large ebik16213 clones have a mildly rough phenotype.

Flies with retinae containing large ebik16213 clones cultured under constant illumination show severe degeneration by 14 days after eclosion, whereas wild- type ommatidia do not show any structural changes under the same conditions. In contrast, when mutant flies are raised under constant darkness, the eye phenotype remains mild 4 weeks after eclosion.

ebiP7/ebik16213 wings are 82% the size of control wings. Gross defects in wing patterning are not apparent. There is no significant decrease in the size of other organs or the whole organism.

The average number of crystal cells per embryo is reduced (to 13.6) in homozygous stage 13-14 embryos compared to wild type (36 +/- 2.2 cells on average). Mutant stage 14 embryos show cell cycle defects in the head region.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

ebi[+]/ebik16213 is a non-enhancer of visible | dominant phenotype of EgfrE1

Suppressor of
Statement
Reference

ebi[+]/ebik16213 is a suppressor of visible phenotype of RetMEN2B.GMR

ebi[+]/ebik16213 is a suppressor of visible phenotype of RetMEN2A.GMR

ebi[+]/ebik16213 is a suppressor of visible phenotype of RetGMR.PR

NOT Suppressor of
Statement
Reference

ebi[+]/ebik16213 is a non-suppressor of visible | dominant phenotype of EgfrE1

Other
Statement
Reference

ebi[+]/ebik16213, sinah1 has visible phenotype

Phenotype Manifest In
Enhanced by
Statement
Reference

ebik16213 has eye | somatic clone phenotype, enhanceable by pucE69/puc[+]

Suppressed by
Statement
Reference

ebik16213 has eye | somatic clone phenotype, suppressible by hep[+]/hepr75

Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

ebi[+]/ebik16213 is a non-enhancer of wing vein phenotype of Scer\GAL4Bx-MS1096, aosUAS.cMa

ebi[+]/ebik16213 is a non-enhancer of eye phenotype of EgfrE1

Suppressor of
Statement
Reference

ebi[+]/ebik16213 is a suppressor of eye phenotype of RetMEN2B.GMR

ebi[+]/ebik16213 is a suppressor of eye phenotype of RetMEN2A.GMR

ebi[+]/ebik16213 is a suppressor of eye phenotype of RetGMR.PR

NOT Suppressor of
Statement
Reference

ebi[+]/ebik16213 is a non-suppressor of eye phenotype of EgfrE1

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

hepr75/+ suppresses while pucE69/+ enhances the mild rough eye phenotype seen in eyes containing large ebik16213 clones.

Heterozygosity for ebik16213 enhances the small wing phenotype induced by Scer\GAL4Bx-MS1096-mediated expression of Pi3K92ED954A.Scer\UAS.T:Hsap\MYC.

Heterozygosity for ebik16213 enhances the notched wing margin phenotype seen in sdETX4 hemizygous males.

ebik16213/+ ; sinah1/sinah1 flies have an extra dorsocentral bristle; on average flies contain 0.82 extra bristles and one or more extra bristles are seen in 36% of males and 68% of females. The dorsocentral bristles are aligned and spaced in an anterior to posterior row as in wild type, but because of the extra bristle(s), the row extends further anteriorly than in wild type.

Enhances the rough eye phenotype of E2fGMR.PD DpGMR.PD BacA\p35GMR.PH, increasing the irregular arrangement of the ommatidial facets. A large number of inter-ommatidial bristle duplications are also seen.

Xenogenetic Interactions
Statement
Reference

Enhances the rough eye phenotype of E2fGMR.PD DpGMR.PD BacA\p35GMR.PH, increasing the irregular arrangement of the ommatidial facets. A large number of inter-ommatidial bristle duplications are also seen.

Complementation and Rescue Data
Rescued by
Comments

ebi+t7.5 rescues the homozygous lethality of ebik16213.

Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer

Separable from: A second site lethal mutation.

The P{lacW}ebik16213 chromosome contains at least two lethal mutations: ebik16213, and a second site lethal mutation that can be removed by recombination.

Comments
Comments

Excision of the P{lacW} element reverts the lethality associated with this allele.

Complements: ex01270. Complements: lwr01519a. Complements: ex02278. Complements: ds05142. Complements: α-Adaptin06694. Complements: exk01115. Complements: RpI135k16513.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (8)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (11)