FlyBase Allele Report: Dmel\Xbp1[k13803]

(Yang et al., 2022, Coelho et al., 2014, Coelho et al., 2013, Loewen and Feany, 2010, Souid et al., 2007, Spradling et al., 1999, Roch et al., 1998, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates retinitis pigmentosa

modeled by ninaE^G69D

(Ryoo et al., 2007)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{3-42.E3Q.UAS.Tag:SS(rPENK)}

(Tsuda et al., 2017)

exacerbates cancer

modeled by Ras85D^V12.cUa.UAS, dlg1^GD4689

(Yang et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | recessive

(Ryoo et al., 2007)

decreased cell growth rate | second instar larval stage | conditional

(Song et al., 2015)

decreased cell growth rate | second instar larval stage | conditional (with Df(2R)BSC484)

(Song et al., 2015)

decreased rate of movement | first instar larval stage | recessive

(Souid et al., 2007)

increased cell number | adult stage | somatic clone

(Wang et al., 2014)

lethal

(Johnson et al., 2020)

lethal (with Df(2R)CC2)

(Souid et al., 2007)

lethal (with Df(2R)XE3030)

(Johnson et al., 2020)

lethal | recessive

(Spradling et al., 1999, Roch et al., 1998)

lethal - all die before end of first instar larval stage | recessive

(Souid et al., 2007)

lethal - all die before end of second instar larval stage | recessive

(Ryoo et al., 2007)

some die during first instar larval stage | recessive

(Souid et al., 2007)

some die during second instar larval stage | recessive

(Ryoo et al., 2007)

visible | larval stage (with Df(2R)XE3030)

(Johnson et al., 2020)

Phenotype Manifest In

autophagic vacuole & larval fat body | somatic clone | cell autonomous

(Arsham and Neufeld, 2009)

embryonic/larval cuticle | larval stage (with Df(2R)XE3030)

(Johnson et al., 2020)

imaginal disc (with Df(2R)F36)

(Ryoo et al., 2007)

lysosome & larval fat body | somatic clone | cell autonomous

(Arsham and Neufeld, 2009)

midgut | adult stage | somatic clone

(Wang et al., 2014)

mouthpart | larval stage (with Df(2R)XE3030)

(Johnson et al., 2020)

Detailed Description

Statement

Reference

Axon regeneration is mildly reduced in Xbp1^k13803/Xbp1^k13803 larvae and significantly reduced in Xbp1^k13803/Df(2R)BSC484 larvae.

(Song et al., 2015)

Xbp1^k13803 homozygous midgut clones present a significantly increased cell number at 3 and 7 days after clone induction, as compared to control clones.

(Wang et al., 2014)

Heterozygous Xbp1^k13803 mutants do not exhibit an increase in apoptosis.

(Loewen and Feany, 2010)

Xbp1^k13803 clones in fat bodies from well-fed early third instar larvae accumulate lysosomes, as indicated by elevated LysoTracker staining, and show redistribution of the Atg8a product into autophagosomes.

(Arsham and Neufeld, 2009)

At day 4 of development, Xbp1^k13803 larvae are significantly retarded in their growth compared to their heterozygous siblings.

Xbp1^k13803/Df(2R)F36 mutant larvae lack imaginal discs.

(Ryoo et al., 2007)

95% of homozygotes hatch (these animals appear indistinguishable from controls at the time of hatching). The homozygous larvae remain at the first instar stage, become sluggish and sick before dying after two to four says.

(Souid et al., 2007)

Lethality occurs at an early stage of development, mutants are underdeveloped even under prolonged incubation periods.

(Roch et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Xbp1^k13803 is an enhancer of increased cell death phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155

(Loewen and Feany, 2010)

Xbp1^k13803 is an enhancer of abnormal neuroanatomy phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155

(Loewen and Feany, 2010)

Suppressor of

Statement

Reference

Xbp1^k13803 is a suppressor of increased cell growth rate | second instar larval stage | conditional phenotype of Rtca^NP5057

(Song et al., 2015)

Other

Statement

Reference

Hsap\TOR1A^ΔE.UAS, Scer\GAL4^elav-C155, Xbp1^k13803 has short lived phenotype

(Kim et al., 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

Xbp1[+]/Xbp1^k13803 is an enhancer of wing margin phenotype of ap^Xa

(Bronstein et al., 2010)

Xbp1[+]/Xbp1^k13803 is an enhancer of wing margin phenotype of Bx²

(Bronstein et al., 2010)

Xbp1[+]/Xbp1^k13803 is an enhancer of retina phenotype of ninaE^G69D

(Ryoo et al., 2007)

Suppressor of

Statement

Reference

Xbp1[+]/Xbp1^k13803 is a suppressor of scutellar bristle | increased number phenotype of Chi^e5.5

(Bronstein et al., 2010)

Xbp1[+]/Xbp1^k13803 is a suppressor of scutellar bristle | increased number phenotype of Ssdp^L7

(Bronstein et al., 2010)

Xbp1[+]/Xbp1^k13803 is a suppressor of eye phenotype of Dref^UAS.cSa

(Ida et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Enhanced axon regeneration seen in Rtca^NP5057/Rtca^NP5057 larvae is dampened in Rtca^NP5057;Xbp1^k13803 double mutants.

(Song et al., 2015)

A Xbp1^k13803/+ background significantly accelerates the retinal degeneration of ninaE^G69D/+ flies: the pseudopupil of approximately 30% of Xbp1^k13803/+ ninaE^G69D/+ flies starts to disappear by day 8 (i.e. 8 days earlier than in ninaE^G69D/+ flies) and no pseudopupils are observed after day 16.

(Ryoo et al., 2007)

Xenogenetic Interactions

Statement

Reference

Xbp1^k13803 induces early death in flies expressing Hsap\TOR1A^ΔE.Scer\UAS under the control of Scer\GAL4^elav-C155 compared with controls.

(Kim et al., 2015)

A heterozygous Xbp1^k13803 background significantly increases the level of apoptosis mediated by expression of Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav-C155.

(Loewen and Feany, 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

11104

y¹ w^67c23; P{lacW}Xbp1^k13803/CyO

Kyoto

111331

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}42D P{lacW}Xbp1^k13803 /CyO y⁺

Notes on Origin

Discoverer

I. Kiss.

(BDGP Project Members, 1994-1999)

Comments

Lethality may be due to a specific larval function of the affected locus or is the consequence of the gene being required during embryonic development.

(Roch et al., 1998)

Precise excision of the insertion in Xbp1^k13803 revert the mutant lethal phenotype.

(Souid et al., 2007)

Xbp1 transcript levels are severely reduced in 4-day-old Xbp1^k13803 larvae.

(Ryoo et al., 2007)

Complements: l(2)03050⁰³⁰⁵⁰. Complements: l(2)07206⁰⁷²⁰⁶. Complements: shg¹⁰⁴⁶⁹. Complements: shg^k03401. Complements: shg^k10220.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

138/3

(Roch et al., 1998)

Dxbp-1^k13803

(Souid et al., 2007)

XBP1^k13803

(Tsuda et al., 2017)

Xbp1^K13803

(Johnson et al., 2020)

Xbp1^LOF

(Sekiya et al., 2017)

Xbp1^k13803

(Yang et al., 2022, Vargas et al., 2020, Sekiya et al., 2017, Xu et al., 2016, Kim et al., 2015, Song et al., 2015, Wang et al., 2014, Bronstein et al., 2010, Loewen and Feany, 2010, Ida et al., 2009, Christensen et al., 2008.4.15)

l(2)k13803

(Spradling et al., 1999)

l(2)k13803^k13803

(BDGP Project Members, 1994-1999)

xbp1^k13803

(Sekine et al., 2013, Jafari et al., 2012, Ryoo et al., 2007)

xbp1K13803

(Souid et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (24)

Report Sections

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