FB2025_05 , released December 11, 2025
Allele: Dmel\Dad1k12914
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General Information
Symbol
Dmel\Dad1k12914
Species
D. melanogaster
Name
FlyBase ID
FBal0064150
Feature type
allele
Associated gene
Dmel\Dad1
Associated Insertion(s)
P{lacW}Dad1k12914
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(BDGP Project Members, 1994-1999)
Progenitor genotype
Associated Insertion(s)
P{lacW}Dad1k12914
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Dad1k12914 homozygous animals are lethal; Dad1k12914 homozygous clones in the adult eye and the third instar larvae wing discs are smaller than control clones, but the overall size of mosaic adult eyes and wings is not significantly affected; Dad1k12914 clones in third instar larval wing discs display increase in apoptosis and less mitotic cells than controls.

      (Zhang et al., 2016)

      l(2)k12914k12914 clones in fat bodies from well-fed early third instar larvae accumulate lysosomes, as indicated by elevated LysoTracker staining.

      (Arsham and Neufeld, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Dad1k14509

      (BDGP Project Members, 1994-1999)
      Rescued by

      Dad1k12914 is rescued by Dad1UAS.Tag:HA/Scer\GAL4Tub.PU

      (Zhang et al., 2016)
      Comments

      The expression of Dad1Scer\UAS.T:Ivir\HA1 driven by Scer\GAL4tub.PU rescues both the lethality of Dad1k12914 homozygotes and the increased apoptosis observed in Dad1k12914 homozygous clones in third instar larval wing discs.

      (Zhang et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      I. Kiss.

      (BDGP Project Members, 1994-1999)
      Comments
      Comments

      Complements: snRNA:U6atac:29Bk01105. Complements: l(2)k07118bk07118b. Complements: embk16715.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      CG13393k12914
      (Arsham and Neufeld, 2009)
      Dad1k12914
      dDad1l(2)k12914
      (Zhang et al., 2016)
      l(2)k12914
      (Spradling et al., 1999)
      l(2)k12914k12914
      (Kamemura et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)