Allele Dmel\GstS1^k08805

General Information
Symbol	Dmel\GstS1^k08805	Species	D. melanogaster
Name		FlyBase ID	FBal0064316
Feature type	allele	Associated gene	Dmel\GstS1
Also Known As	l(2)k08805^k08805

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	P-element activity (BDGP Project Members, 1994-1999)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 2R:12,984,904..12,984,904 (BDGP Project Members, 1994-1999, Tomkiel, 2001.12.6, Singh et al., 2001)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion of P{lacW} between bases 29 and 30 of the transcript, in the 5' UTR. (Singh et al., 2001)
Caused by insertion	P{lacW}GstS1^k08805 (BDGP Project Members, 1994-1999, Tomkiel, 2001.12.6, Singh et al., 2001)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (BDGP Project Members, 1994-1999)
Phenotype Manifest In

Detailed Description
	Statement Reference GstS1^k08805 mutants have no effect on climbing ability. (Whitworth et al., 2005)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference GstS1^k08805/GstS1[+] is an enhancer of gravitaxis defective phenotype of park²⁵ (Whitworth et al., 2005)
NOT Enhancer of
Statement Reference GstS1^k08805 is a non-enhancer of gravitaxis defective phenotype of park²⁵ (Whitworth et al., 2005)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference The homozygous park²⁵ mutant climbing defect is enhanced when heterozygous with GstS1^k08805. GstS1^k08805 mutants have no effect on climbing ability in heterozygous park²⁵ mutants. (Whitworth et al., 2005)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	10803 y¹ w^67c23; P{lacW}GstS1^k08805/CyO
Kyoto	111246 y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}GstS1^k08805 /CyO y⁺
Notes on Origin
Discoverer	I. Kiss.

Comments
	Complements: GstS1⁰⁴²²⁷. Complements: Sply⁰⁵⁰⁹¹. Complements: l(2)06253⁰⁶²⁵³. Complements: l(2)k09303^k09303. Complements: l(2)k09854^k09854. Complements: l(2)k10815^k10815. Complements: l(2)k11301^k11301. Complements: l(2)k11405^k11405. (BDGP Project Members, 1994-1999) This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (spradling@mail1.ciwemb.edu).
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Gst2^k08805 (Singh et al., 2001, ) GstS1^K8805 (Whitworth et al., 2005) GstS1^k08805 k08805 (Ryder et al., 2004) l(2)k08805^k08805 (Tomkiel, 2001.12.6, BDGP Project Members, 1994-1999, )
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Whitworth et al., 2005, Proc. Natl. Acad. Sci. U.S.A. 102(22): 8024--8029 Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease. [FBrf0188281] Ryder et al., 2004, Genetics 167(2): 797--813 The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster. [FBrf0179424] Singh et al., 2001, Europ. J. Biochem. 268(10): 2912--2923 Catalytic function of Drosophila melanogaster glutathione S-transferase DmGSTS1-1 (GST-2) in conjugation of lipid peroxidation end products. [FBrf0135754]
Personal communication to FlyBase	Tomkiel, 2001.12.6, Df(2R)P803-delta15. Df(2R)P803-delta15. [FBrf0141808] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]

Allele Dmel\GstS1k08805

Allele Dmel\GstS1^k08805