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General Information
Symbol
Dmel\miltk06704
Species
D. melanogaster
Name
FlyBase ID
FBal0064530
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{lacW} insertion in the first intron of the milt-RA transcription unit.

P{lacW} insertion in the first intron.

Insertion components
P{lacW}miltk06704
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

egg chamber & mitochondrion | germ-line clone

follicle cell & mitochondrion | germ-line clone

germline cyst & mitochondrion | germ-line clone

oocyte & mitochondrion | germ-line clone

Detailed Description
Statement
Reference

Mitochondria aggregate prematurely near and within the oocyte in prefollicular cysts from miltk06704 germ-line clones. The mitochondria produce a giant Balbiani body that fills the ooplasm of the oocyte at follicle formation. Mitochondrial number remains elevated at stage 5, but normalizes by stage 9. However, these mitochondria concentrate abnormally at microtubule minus ends in the anterior corners of the follicles.

The fusomes of miltk06704 cysts are indistinguishable from wild type throughout oogenesis and organelles that associate with the Balbiani body, such as Golgi elements, concentrate and move into the oocyte normally.

miltk06704 females lay eggs with normal mitochondrial DNA content which can form pole cells and that can be fertilized to give rise to viable, fertile adults.

Mitochondria cluster at the apical side of miltk06704 young mutant follicle cells (from germline clones) but the mitochondrial distribution is normal in follicles older than stage 7. In miltk06704 mutant germline stem cells, all the mitochondria are clumped at the opposite side from the spectrosome, instead of being clustered around the spectrosome as in wild-type stem cells.

Homozygotes die as adults. They can survive for at least a week, but scarcely move, right themselves with great difficulty and more typically dies soon after eclosion.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Symbol Synonym
l(2)K06704
l(2)k04704k06704
miltl(2)K06704
Name Synonyms
Secondary FlyBase IDs
    References (7)