|Feature type||allele||Associated gene||Dmel\ab|
|Map ( GBrowse )||
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Caused by insertion|
|Phenotype Manifest In|
autophagic vacuole & larval fat body | somatic clone | cell autonomous
lysosome & larval fat body | somatic clone | cell autonomous
mitochondrion & larval fat body | somatic clone | cell autonomous
ab[k02807] clones in fat bodies from well-fed early third instar larvae accumulate lysosomes, as indicated by elevated LysoTracker staining, and show redistribution of the Atg8a product into autophagosomes. Mitochondria in ab[k02807] cells aggregate in large clumps.
Targeting of dendrites to antennal lobe glomeruli occurs normally in antennal lobe projection neurons that are part of ab[k02807] homozygous somatic clones.
abk02807 mutants show a significant reduction in the number of class I neurons, an effect that is most pronounced in the dorsal cluster of PNS neurons.
abclu-1/abk02807 transheterozygotes hatch and grow normally until 30 hours AEL. The ddaE neurons of abclu-1/abk02807 larvae do not display such a comb-like design of dendritic arbors as wild-type ddaE neurons. Instead, mutant neurons produce supernumerary terminals that do not necessarily show oriented growth. About 20% of mutant ddaE cells do not extend lateral primary branches and in extreme cases, a single mutant ddaE extends two primary branches dorsally instead. Time-lapse recording of mutant ddaE shows that secondary branches appear with curved morphology and remain associated with fine higher-order branches that are oriented in dorsal and ventral directions. Ventral class I ventral posterior da (vpda) neurons also show dendritic pattern defects. ddaD and ddaE abclu-1 mutant neuron clones in heterozygous mature larvae take on an abnormal shape abd produce branch terminals in excess. The ddaD neuron shows a statistically significant increase in the dendritic arbor area size while the area size of ddaE neurons is not significantly different. Class II, III and IV neuron clones do not show dendritic pattern defects.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Fails to complement|
|Stocks ( 3 )|
|Notes on Origin|
This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (email@example.com).
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 3 )|
|Secondary FlyBase IDs|
|References ( 12 )|
|Personal communication to FlyBase|