FlyBase Allele Report: Dmel\lolal[k11212]

General Information

Symbol

Dmel\lolal^k11212

Species

D. melanogaster

Name

FlyBase ID

FBal0064582

Feature type

allele

Associated gene

Dmel\lolal

Associated Insertion(s)

P{lacW}lolal^k11212

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Roch et al., 1998, BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}lolal^k11212

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Roch et al., 1998)

lethal - all die before end of first instar larval stage | recessive

(Faucheux et al., 2003)

some die during first instar larval stage | recessive

(Faucheux et al., 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

Lethality occurs at an early stage of development, mutants are underdeveloped even under prolonged incubation periods.

(Roch et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

lolal^k11212 is a suppressor of visible | recessive | homeotic phenotype of Pc¹⁶

(Faucheux et al., 2003)

lolal^k11212 is a suppressor of visible | recessive | homeotic phenotype of ph-p⁴¹⁰

(Faucheux et al., 2003)

Phenotype Manifest In

Suppressor of

Statement

Reference

lolal^k11212 is a suppressor of mesothoracic leg phenotype of Pc¹⁶

(Faucheux et al., 2003)

lolal^k11212 is a suppressor of metathoracic leg phenotype of Pc¹⁶

(Faucheux et al., 2003)

lolal^k11212 is a suppressor of prothoracic leg | ectopic phenotype of Pc¹⁶

(Faucheux et al., 2003)

lolal^k11212 is a suppressor of mesothoracic leg phenotype of ph-p⁴¹⁰

(Faucheux et al., 2003)

lolal^k11212 is a suppressor of metathoracic leg phenotype of ph-p⁴¹⁰

(Faucheux et al., 2003)

lolal^k11212 is a suppressor of prothoracic leg | ectopic phenotype of ph-p⁴¹⁰

(Faucheux et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Mutants heterozygous for lolal^k11212, when also heterozygous for ph-p⁴¹⁰, Pc¹⁶, Pc¹, Pc³ or Pc¹⁵, exhibit a contrabithorax phenotype, which is a wing-to-haltere transformation due to ectopic expression of Ubx in the posterior part of the wing disc, often resulting in curvature of the wing. This phenotype is further enhanced in the viable lolal^k11212/lolal^311a heteroallelic combinations, when also heterozygous for ph-p⁴¹⁰, Pc¹⁶, Pc¹, Pc³ or Pc¹⁵.

(Faucheux et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

lolal^k02512

(BDGP Project Members, 1994-1999)

lolal^k11215

(BDGP Project Members, 1994-1999)

Rescued by

lolal^k11212 is rescued by Scer\GAL4^da.G32/lolal^UAS.Tag:FLAG

(Faucheux et al., 2003)

lolal^k11212 is rescued by lolal^UAS.EGFP/Scer\GAL4^da.G32

(Faucheux et al., 2003)

lolal^k11212 is rescued by lolal^+tBB

(Faucheux et al., 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

102785

y¹ w^67c23 ; P{lacW}lolal^k11212 / CyO

Notes on Origin

Discoverer

I. Kiss.

(BDGP Project Members, 1994-1999)

Comments

Lethality may be due to a specific larval function of the affected locus or is the consequence of the gene being required during embryonic development.

(Roch et al., 1998)

Complements: Hsf⁰³⁰⁹¹. Complements: pAbp^k10109. Complements: Pcl^s1859.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

112/12

(Roch et al., 1998)

ban^l(2)k11212

(Faucheux et al., 2003)

l(2)k02512^k11212

(BDGP Project Members, 1994-1999)

l(2)k11212

(Faucheux et al., 2003, Faucheux et al., 2000)

lolal^k11212

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close