FlyBase Allele Report: Dmel\Cul1[k01207]

(Zhou et al., 2007, Kuo et al., 2006, Muzzopappa and Wappner, 2005, Doronkin et al., 2003, Heriche et al., 2003, Khush, 2003.2.25, Watts et al., 2003, Khush et al., 2002, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Kuo et al., 2006)

abnormal neuroanatomy | somatic clone

(Watts et al., 2003)

female sterile | germline clone

(Doronkin et al., 2003)

increased cell death

(Kuo et al., 2006)

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

lethal - all die before end of pupal stage

(Kuo et al., 2006)

some die during pupal stage

(Kuo et al., 2006)

Phenotype Manifest In

neuroblast | somatic clone

(Watts et al., 2003)

ovary | germline clone

(Doronkin et al., 2003)

Detailed Description

Statement

Reference

Cul1^k01207 mutant clones in sensory neurons in adult wing do not display any defects in injury-induced axon degeneration (following an axotomy, the severed axons are cleared away normally).

(Neukomm et al., 2017)

Mutant embryos cultured under hypoxic conditions (5% O[[2]]) show increased eclosion compared to controls raised under the same conditions.

(Zhou et al., 2007)

lin19^k01207 mutant C4da neuron clones exhibit an increase in cell death and die during early metamorphosis.

(Kuo et al., 2006)

Females carrying lin19^k01207 germ line clones generated using the FLP-FRT ovo^D1 method, never lay any eggs. Oogenesis in these flies arrests during the early stages, sometimes producing highly polyploid, one-cell cysts.

(Doronkin et al., 2003)

No defects are seen in axon pruning during metamorphosis, though a slight proliferation defect is seen when somatic clones are made in the neuroblast.

(Watts et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Cul1^k01207 is a non-suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut1-OK371

(Neukomm et al., 2017)

Other

Statement

Reference

CSN4^unspecified, Cul1^k01207 has increased cell death | oogenesis phenotype

(Doronkin et al., 2003)

CSN4^unspecified, Cul1^k01207 has abnormal cell number | oogenesis phenotype

(Doronkin et al., 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

Cul1^k01207/Cul1[+] is an enhancer of wing phenotype of Mmus\Cul1^UAS.cHa, Scer\GAL4^Bx-MS1096

(Heriche et al., 2003)

NOT Suppressor of

Statement

Reference

Cul1^k01207 is a non-suppressor of sensory neuron | somatic clone | adult stage phenotype of Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut1-OK371

(Neukomm et al., 2017)

Cul1^k01207 is a non-suppressor of axon | somatic clone | adult stage phenotype of Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut1-OK371

(Neukomm et al., 2017)

Other

Statement

Reference

CSN5^unspecified, Cul1^k01207 has ovary phenotype

(Doronkin et al., 2003)

CSN5^unspecified, Cul1^k01207 has nurse cell phenotype

(Doronkin et al., 2003)

CSN4^unspecified/CSN4[+], Cul1^k01207 has nurse cell phenotype

(Doronkin et al., 2003)

CSN4^unspecified/CSN4[+], Cul1^k01207 has stalk follicle cell phenotype

(Doronkin et al., 2003)

CSN5[+]/CSN5^unspecified, Cul1^k01207 has ovary phenotype

(Doronkin et al., 2003)

CSN5[+]/CSN5^unspecified, Cul1^k01207 has nurse cell phenotype

(Doronkin et al., 2003)

CSN5[+]/CSN5^unspecified, Cul1^k01207 has stalk follicle cell phenotype

(Doronkin et al., 2003)

CSN4^unspecified, Cul1^k01207 has ovary phenotype

(Doronkin et al., 2003)

CSN4^unspecified, Cul1^k01207 has nurse cell phenotype

(Doronkin et al., 2003)

CSN4^unspecified, Cul1^k01207 has stalk follicle cell phenotype

(Doronkin et al., 2003)

CSN4^unspecified, lin19[+]/Cul1^k01207 has ovary phenotype

(Doronkin et al., 2003)

CSN4^unspecified, lin19[+]/Cul1^k01207 has nurse cell phenotype

(Doronkin et al., 2003)

CSN5^unspecified, Cul1^k01207 has stalk follicle cell phenotype

(Doronkin et al., 2003)

CSN4^unspecified, lin19[+]/Cul1^k01207 has stalk follicle cell phenotype

(Doronkin et al., 2003)

CSN5^unspecified, lin19[+]/Cul1^k01207 has ovary phenotype

(Doronkin et al., 2003)

CSN5^unspecified, lin19[+]/Cul1^k01207 has nurse cell phenotype

(Doronkin et al., 2003)

CSN5^unspecified, lin19[+]/Cul1^k01207 has stalk follicle cell phenotype

(Doronkin et al., 2003)

CSN4^unspecified/CSN4[+], Cul1^k01207 has ovary phenotype

(Doronkin et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The axon degeneration in sensory neurons clones in the adult wing expressing Ect4^{ΔARM.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^VGlut-OK371 can be suppressed by combination with Cul1^k01207.

(Neukomm et al., 2017)

Unlike either single heterozygote, ovaries from CSN4^unspecified; lin19^k01207 or CSN5^unspecified; lin19^k01207 transheterozygous females display various defects: cell death, abnormal number of nurse cells per egg chamber, and loss of stalk cells.

(Doronkin et al., 2003)

Xenogenetic Interactions

Statement

Reference

Introduction of a single copy of Cul1^k01207 or Df(2R)NCX8 dominantly enhances the wing reduction phenotype in Mmus\Cul1^Scer\UAS.cHa Scer\GAL4^Bx-MS1096 mutants.

(Heriche et al., 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

10494

w^*; P{lacW}Cul1^k01207/CyO, P{sevRas1.V12}FK1

Kyoto

111137

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}42D P{lacW}Cul1^k01207 /CyO y⁺

Notes on Origin

Discoverer

I. Kiss.

(BDGP Project Members, 1994-1999)

Comments

Complements: l(2)08492⁰⁸⁴⁹². Complements: rnh1^k07409a. Complements: hrg^k07619. Complements: rnh1^k07624.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

Cul1^k01207

cul1^K01207

(Neukomm et al., 2017)

dCul1¹⁰⁴⁹⁴

(Muzzopappa and Wappner, 2005)

dCullin1^l(2)02074

(Khush et al., 2002)

k01207

(Watts et al., 2003)

l(2)k01207

(Khush, 2003.2.25, Spradling et al., 1999)

l(2)k01207^k01207

(BDGP Project Members, 1994-1999)

lin19^k01207

(Rumpf et al., 2014, Christensen and Cook, 2007.3.22, Silva et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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