Allele Dmel\snRNA:U6atac:29B^k01105

General Information
Symbol	Dmel\snRNA:U6atac:29B^k01105	Species	D. melanogaster
Name		FlyBase ID	FBal0064601
Feature type	allele	Associated gene	Dmel\snRNA:U6atac:29B
Also Known As	l(2)k01105^k01105, l(2)k01105

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity (BDGP Project Members, 1994-1999, Roch et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 2L:8,389,793..8,389,793 (BDGP Project Members, 1994-1999, Otake et al., 2002, Roch et al., 1998, Spradling et al., 1999, Pessa et al., 2010, Praveen et al., 2012)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{lacW} is inserted at nucleotide 71 of snRNA:U6atac:29B. (Otake et al., 2002)
Caused by insertion	P{lacW}snRNA:U6atac:29B^k01105 (BDGP Project Members, 1994-1999, Otake et al., 2002, Roch et al., 1998, Spradling et al., 1999, Pessa et al., 2010, Praveen et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Spradling et al., 1999, Roch et al., 1998, Otake et al., 2002)
Phenotype Manifest In
	crystal cell (Milchanowski et al., 2004) imaginal disc (Roch et al., 1998)
Detailed Description
	Statement Reference The average number of crystal cells per embryo is reduced (to 10.8) in homozygous stage 13-14 embryos compared to wild type (36 +/- 2.2 cells on average). (Milchanowski et al., 2004) Lethality occurs during third instar larval or pupal stages. Mutants exhibit visible disc abnormalities: very small or no discs. Clones induced in wild type discs are of normal size and shape. (Roch et al., 1998)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescued by	snRNA:U6atac:29B^k01105 is partially rescued by snRNA:U6atac:29B^+t206 (Otake et al., 2002)
Comments
Stocks ( 2 )
Bloomington	10492 y¹ w^67c23; P{lacW}snRNA:U6atac:29B^k01105/CyO
Kyoto	114341 y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{lacW}snRNA:U6atac:29B^k01105 P{neoFRT}40A/CyO y⁺
Notes on Origin
Discoverer	I. Kiss.

Comments
	Complements: l(2)k12914^k12914. Complements: emb^k16715. (BDGP Project Members, 1994-1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	11/5 (Roch et al., 1998) l(2)k01105 (Spradling et al., 1999, Pessa et al., 2010) l(2)k01105^k01105 (Otake et al., 2002, BDGP Project Members, 1994-1999, ) P10492 (Milchanowski et al., 2004) snRNA:U6atac:29B^k01105 U6atac^K01105 (Lotti et al., 2012)
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Lotti et al., 2012, Cell 151(2): 440--454 An SMN-Dependent U12 Splicing Event Essential for Motor Circuit Function. [FBrf0219670] Praveen et al., 2012, Cell Rep. 1(6): 624--631 A Drosophila Model of Spinal Muscular Atrophy Uncouples snRNP Biogenesis Functions of Survival Motor Neuron from Locomotion and Viability Defects. [FBrf0218971] Pessa et al., 2010, PLoS ONE 5(10): e13215 Gene expression profiling of U12-type spliceosome mutant Drosophila reveals widespread changes in metabolic pathways. [FBrf0212091] Milchanowski et al., 2004, Genetics 168(1): 325--339 Identification and characterization of genes involved in embryonic crystal cell formation during Drosophila hematopoiesis. [FBrf0180297] Otake et al., 2002, Mol. Cell 9(2): 439--446 The divergent U12-type spliceosome is required for pre-mRNA splicing and is essential for development in Drosophila. [FBrf0145116] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Roch et al., 1998, Mol. Gen. Genet. 257(2): 103--112 Screening of larval/pupal P-element induced lethals on the second chromosome in Drosophila melanogaster: clonal analysis and morphology of imaginal discs. [FBrf0100624]
Personal communication to FlyBase	BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]

Allele Dmel\snRNA:U6atac:29Bk01105

Allele Dmel\snRNA:U6atac:29B^k01105