Allele Dmel\ed^k01102

General Information
Symbol	Dmel\ed^k01102	Species	D. melanogaster
Name		FlyBase ID	FBal0064604
Feature type	allele	Associated gene	Dmel\ed
Also Known As	l(2)k01102, k01102

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	P-element activity (BDGP Project Members, 1994-1999)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 2L:4,031,769..4,031,769 (BDGP Project Members, 1994-1999, Spencer and Cagan, 2003, Rawlins et al., 2003, Ahmed et al., 2003, Bai et al., 2001, Spradling et al., 1999, Swan et al., 2006, Swan et al., 2006, Dworkin and Gibson, 2006)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion in the first intron of ed. (Ahmed et al., 2003) Insertion of P{lacW} into the first intron of ed, upstream of the coding region. (Bai et al., 2001)
Caused by insertion	P{lacW}ed^k01102 (BDGP Project Members, 1994-1999, Spencer and Cagan, 2003, Rawlins et al., 2003, Ahmed et al., 2003, Bai et al., 2001, Spradling et al., 1999, Swan et al., 2006, Swan et al., 2006, Dworkin and Gibson, 2006)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| larval stage \| recessive (Spencer and Cagan, 2003) lethal \| pupal stage (with ed^m1) (Ahmed et al., 2003) lethal \| pupal stage \| recessive (Bai et al., 2001) lethal \| recessive (BDGP Project Members, 1994-1999, Spradling et al., 1999, Dworkin and Gibson, 2006) partially lethal - majority die \| pupal stage (with Df(2L)ed-dp) (Rawlins et al., 2003) partially lethal - majority die \| pupal stage (with ed^6.1) (Rawlins et al., 2003) partially lethal - majority die \| pupal stage (with ed^lH23) (Rawlins et al., 2003) visible \| dominant (Dworkin and Gibson, 2006)
Phenotype Manifest In
	chemosensory ventral triple row & microchaeta \| ectopic (with ed^lH23) (Rawlins et al., 2003) dorsal triple row & microchaeta \| ectopic (with ed^lH23) (Rawlins et al., 2003) dorsocentral bristle \| ectopic (with Df(2L)ed-dp) (Rawlins et al., 2003) dorsocentral bristle \| ectopic (with ed^6.1) (Rawlins et al., 2003) dorsocentral bristle \| ectopic (with ed^lH23) (Rawlins et al., 2003) eye (with ed^m1) (Ahmed et al., 2003) photoreceptor cell R7 \| somatic clone \| supernumerary (Spencer and Cagan, 2003) photoreceptor cell R8 \| somatic clone \| supernumerary (Spencer and Cagan, 2003) photoreceptor cell R8 \| supernumerary (Spencer and Cagan, 2003) photoreceptor cell R8 \| supernumerary (with Df(2L)ed-dp) (Rawlins et al., 2003) photoreceptor cell R8 \| supernumerary (with ed^slA12) (Spencer and Cagan, 2003) scutellar bristle \| ectopic (with Df(2L)ed-dp) (Rawlins et al., 2003) scutellar bristle \| ectopic (with ed^6.1) (Rawlins et al., 2003) scutellar bristle \| ectopic (with ed^lH23) (Rawlins et al., 2003) sex comb (with ed^m1) (Ahmed et al., 2003) wing (Dworkin and Gibson, 2006)
Detailed Description
	Statement Reference Heterozygotes show a direct effect on the shape of the wing. (Dworkin and Gibson, 2006) ed^k01102/ed^m1 animals usually die as pupae, but adult escapers are sometimes produced in low density cultures. These escapers have mild defects in the leg; the legs have the correct number of segments, but the sex combs are malformed in males. They also have a rough eye phenotype. (Ahmed et al., 2003) Twinning of R8 photoreceptor cells is seen in ed^k01102/Df(2L)ed-dp animals. (Rawlins et al., 2003) ed^lH23/ed^k01102 flies have extra dorsocentral, scutellar and recurved wing margin bristles (chemosensory ventral triple row + dorsal triple row). ed^6.1/ed^k01102 and ed^k01102/Df(2L)ed-dp flies have extra dorsocentral and scutellar bristles. (Rawlins et al., 2003) Homozygotes are viable until the late third larval instar. Homozygous and ed^k01102/ed^slA12 eye discs contain ommatidia with multiple R8 cells. This phenotype is also seen in homozygous clones in mosaic eye discs. Ommatidia in homozygous clones in the eye sometimes contain extra R7 cells and in all cases where ommatidia contain extra R7 cells, extra R8 cells are also present. (Spencer and Cagan, 2003)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference ed[+]/ed^k01102 is an enhancer of visible \| dominant phenotype of Egfr^E1 (Spencer and Cagan, 2003)
Suppressor of
Statement Reference ed[+]/ed^k01102 is a suppressor of visible \| heat sensitive phenotype of peb¹ (Wilk et al., 2004) ed^k01102 is a suppressor of visible phenotype of H^Scer\UAS.cMa/H^Scer\UAS.cMa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mueller et al., 2005)
Phenotype Manifest In
Enhanced by
Statement Reference ed^k01102 has photoreceptor cell R8 \| supernumerary phenotype, enhanceable by aos^W11 (Spencer and Cagan, 2003) ed^k01102 has photoreceptor cell R8 \| supernumerary phenotype, enhanceable by aos^Δ7/argos[+] (Spencer and Cagan, 2003)
Enhancer of
Statement Reference ed[+]/ed^k01102 is an enhancer of eye phenotype of Egfr^E1 (Spencer and Cagan, 2003)
Suppressor of
Statement Reference ed[+]/ed^k01102 is a suppressor of eye \| heat sensitive phenotype of peb¹ (Wilk et al., 2004) ed^k01102 is a suppressor of eye phenotype of H^Scer\UAS.cMa/H^Scer\UAS.cMa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mueller et al., 2005)
Additional Comments
Genetic Interactions
Statement Reference ed^k01102/+ strongly enhances the Egfr^E1/+ phenotype, resulting in eyes that are approximately 1/3 the size of those of Egfr^E1/+ flies. argos^Δ7/+ mildly enhances the ed^k01102 phenotype; the number of ommatidia with multiple R8 cells is increased from 18% to 34% in the double mutant flies. argos^W11 enhances the ed^k01102 phenotype; the number of ommatidia with multiple R8 cells is increased from 21% to 46% in the double mutant flies. (Spencer and Cagan, 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	ed^1X5 (Bai et al., 2001) ed^2B8 (Ahmed et al., 2003) ed^k01104 (BDGP Project Members, 1994-1999) ed^lF20 (Bai et al., 2001)
Comments
Stocks ( 2 )
Bloomington	10490 y¹ w^67c23; P{lacW}ed^k01102/CyO
Kyoto	111134 y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{lacW}ed^k01102 P{neoFRT}40A/CyO y⁺
Notes on Origin
Discoverer	I. Kiss.
	Separable from: a second site lethal mutation on the second chromosome. (Spencer and Cagan, 2003)
Comments
	Excision of the P{lacW} element reverts the lethality of ed^k01102 and its interaction with Egfr^E1. (Spencer and Cagan, 2003) Complements: slp1⁰⁵⁹⁶⁵. Complements: l(2)06708⁰⁶⁷⁰⁸. (BDGP Project Members, 1994-1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	ed^k01102 (Dworkin and Gibson., 2006, ) ed^l(2)k01102 (Rawlins et al., 2003) k01102 (Dworkin and Gibson, 2006, Dworkin et al., 2011) l(2)k01102 (Spencer and Cagan, 2003, Rawlins et al., 2003, Spradling et al., 1999) l(2)k01102^k01102 (BDGP Project Members, 1994-1999, )
Name Synonym
Secondary FlyBase IDs

References ( 14 )
Research paper	Dworkin et al., 2011, Genetics 187(4): 1171--1184 The effects of weak genetic perturbations on the transcriptome of the wing imaginal disc and its association with wing shape in Drosophila melanogaster. [FBrf0214376] Dworkin and Gibson, 2006, Genetics 173(3): 1417--1431 Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster. [FBrf0193945] Swan et al., 2006, EMBO J. 25(15): 3640--3651 Complex interaction of Drosophila GRIP PDZ domains and Echinoid during muscle morphogenesis. [FBrf0192056] Mueller et al., 2005, Genetics 171(3): 1137--1152 Genetic modifier screens on hairless gain-of function phenotypes reveal genes involved in cell differentiation, cell growth and apoptosis in Drosophila melanogaster. [FBrf0190751] Wilk et al., 2004, Genetics 168(1): 281--300 Dose-sensitive autosomal modifiers identify candidate genes for tissue autonomous and tissue nonautonomous regulation by the Drosophila nuclear zinc-finger protein, hindsight. [FBrf0180294] Ahmed et al., 2003, Development 130(25): 6295--6304 echinoid mutants exhibit neurogenic phenotypes and show synergistic interactions with the Notch signaling pathway. [FBrf0167515] Rawlins et al., 2003, Development 130(26): 6475--6484 Echinoid facilitates Notch pathway signalling during Drosophila neurogenesis through functional interaction with Delta. [FBrf0167521] Rawlins et al., 2003, Development 130(16): 3715--3724 Echinoid limits R8 photoreceptor specification by inhibiting inappropriate EGF receptor signalling within R8 equivalence groups. [FBrf0160869] Spencer and Cagan, 2003, Development 130(16): 3725--3733 Echinoid is essential for regulation of Egfr signaling and R8 formation during Drosophila eye development. [FBrf0160973] Bai et al., 2001, Development 128(4): 591--601 The cell adhesion molecule Echinoid defines a new pathway that antagonizes the Drosophila EGF receptor signaling pathway. [FBrf0134572] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489]
Supplementary material	Dworkin and Gibson., 2006, Genetics 173(3): Supplemental Figures. [FBrf0199151] Swan et al., 2006, EMBO J. 25(15): Supplementary Methods. [FBrf0198715]
Personal communication to FlyBase	BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]

Allele Dmel\edk01102

Allele Dmel\ed^k01102