FlyBase Allele Report: Dmel\capt[k01217]

General Information

Symbol

Dmel\capt^k01217

Species

D. melanogaster

Name

FlyBase ID

FBal0064686

Feature type

allele

Associated gene

Dmel\capt

Associated Insertion(s)

P{lacW}capt^k01217

Carried in Construct

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(BDGP Project Members, 1994-1999)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

P{lacW} insertion in the first intron, downstream of an untranslated 85bp exon.

(Benlali et al., 2000)

Insertion components

P{lacW}capt^k01217

Product class / Tool use(s)

Encoded product / tool

Tagged with

nuclear protein localization tag

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotype Manifest In

oocyte & actin filament | ectopic | germ-line clone

(Baum et al., 2000)

Detailed Description

Statement

Reference

In capt^k01217 germ-line clones, ectopic F-actin cables form in the oocyte at stages 5-6 of oogenesis, only to disappear at stages 8-9. Actin aggregates later at the cortex of capt mutant eggs.

(Baum et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

capt^k01217/capt[+] is an enhancer of abnormal neuroanatomy phenotype of sli²

(Wills et al., 2002)

capt^k01217/capt[+] is an enhancer of abnormal neuroanatomy | recessive phenotype of lea[+]/robo2⁸, robo1¹

(Wills et al., 2002)

Other

Statement

Reference

Abl², capt^k01217/capt[+] has abnormal neuroanatomy phenotype

(Wills et al., 2002)

Df(2L)ast2, capt^k01217 has abnormal neuroanatomy phenotype

(Wills et al., 2002)

Abl², capt^k01217 has abnormal neuroanatomy phenotype

(Wills et al., 2002)

Phenotype Manifest In

Enhancer of

Statement

Reference

capt^k01217/capt[+] is an enhancer of presumptive embryonic/larval central nervous system phenotype of sli²

(Wills et al., 2002)

capt^k01217/capt[+] is an enhancer of presumptive embryonic/larval central nervous system phenotype of lea[+]/robo2⁸, robo1¹

(Wills et al., 2002)

capt^k01217 is an enhancer of oocyte | germline clone phenotype of Pka-R1^BDK.UAS, Scer\GAL4^{VP16.mat.αTub67C}

(Baum et al., 2000)

Other

Statement

Reference

Abl², capt^k01217/capt[+] has presumptive embryonic/larval central nervous system phenotype

(Wills et al., 2002)

Df(2L)ast2, capt^k01217 has presumptive embryonic/larval central nervous system phenotype

(Wills et al., 2002)

Abl², capt^k01217 has presumptive embryonic/larval central nervous system phenotype

(Wills et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Central nervous system axons are seen to cross the midline in Abl² capt^k01217 double heterozygous embryos. The frequency of ectopic crossing of the midline by axons in the central nervous system seen in sli² heterozygous embryos is increased if they are also heterozygous for capt^k01217. One copy of capt^k01217 enhances the frequency of midline crossing defects seen in robo¹ lea^robo2-8 double mutant heterozygotes. capt^k01217/Df(2L)ast2 embryos show ectopic midline crossing by axons in the central nervous system. Midline glia are still present in these embryos.

(Wills et al., 2002)

The combination of capt^k01217 and Pka-R1^BDK.Scer\UAS in germ-line clones produces an exaggerated phenotype, with complete fusion of the germline and ectopic actin aggregates at the posterior pole of the syncytium.

(Baum et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

capt⁰⁶⁹⁵⁵

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

10367

y¹ w^67c23; P{lacW}capt^k01217/CyO

Kyoto

111068

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{lacW}capt^k01217 P{neoFRT}40A/CyO y⁺

Notes on Origin

Discoverer

I. Kiss.

(BDGP Project Members, 1994-1999)

Comments

Complements: l(2)10685¹⁰⁶⁸⁵.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

P367

(Baum, 1999.9.26)

cap⁷

(Baum et al., 2000)

capt⁷

(Wills et al., 2002)

capt^k01217

(Medina et al., 2008)

capulet^k01217

(Otani et al., 2011)

l(2)06955^k01217

(BDGP Project Members, 1994-1999)

l(2)k01217

(Spradling et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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