Open Close
General Information
Symbol
Dmel\captk01217
Species
D. melanogaster
Name
FlyBase ID
FBal0064686
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{lacW} insertion in the first intron, downstream of an untranslated 85bp exon.

Insertion components
P{lacW}captk01217
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

oocyte & actin filament | ectopic | germ-line clone

Detailed Description
Statement
Reference

In captk01217 germ-line clones, ectopic F-actin cables form in the oocyte at stages 5-6 of oogenesis, only to disappear at stages 8-9. Actin aggregates later at the cortex of capt mutant eggs.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

captk01217/capt[+] is an enhancer of abnormal neuroanatomy phenotype of sli2

captk01217/capt[+] is an enhancer of abnormal neuroanatomy | recessive phenotype of lea[+]/robo28, robo11

Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Central nervous system axons are seen to cross the midline in Abl2 captk01217 double heterozygous embryos. The frequency of ectopic crossing of the midline by axons in the central nervous system seen in sli2 heterozygous embryos is increased if they are also heterozygous for captk01217. One copy of captk01217 enhances the frequency of midline crossing defects seen in robo1 learobo2-8 double mutant heterozygotes. captk01217/Df(2L)ast2 embryos show ectopic midline crossing by axons in the central nervous system. Midline glia are still present in these embryos.

The combination of captk01217 and Pka-R1BDK.Scer\UAS in germ-line clones produces an exaggerated phenotype, with complete fusion of the germline and ectopic actin aggregates at the posterior pole of the syncytium.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)