FlyBase Allele Report: Dmel\TER94[k15502]

General Information

Symbol

Dmel\TER94^k15502

Species

D. melanogaster

Name

FlyBase ID

FBal0064742

Feature type

allele

Associated gene

Dmel\TER94

Associated Insertion(s)

P{lacW}TER94^k15502

Carried in Construct

Also Known As

l(2)k15502, VCP^k15502

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}TER94^k15502

Cytology

Description

Insertion in the 5' non-coding region.

(Higashiyama et al., 2002)

Insertion in the 5' UTR of TER94. Site of insertion in TER94^k15502 and TER94⁰³⁷⁷⁵ are identical.

(Ruden et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:9,989,178..9,989,185 [+]

(Liu et al., 2022, Chang et al., 2011, Rumpf et al., 2011, Higashiyama et al., 2002, Leon and McKearin, 1999, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1

CEA

(Zhang et al., 2017)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates amyotrophic lateral sclerosis

modeled by caz^VDRC.cUa

(Azuma et al., 2014)

ameliorates retinitis pigmentosa

modeled by ninaE^P37H

(Griciuc et al., 2010)

ameliorates Parkinson's disease 2

modeled by Mul1^A6, park²⁵

(Zhang et al., 2017)

exacerbates frontotemporal dementia and/or amyotrophic lateral sclerosis 7

modeled by Hsap\CHMP2B^Intron5.UAS

(Lu et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Adulthood-induced TER94^k15502 homozygous clones in mosaic midguts are larger (i.e. with more cells) than control clones.

(Liu et al., 2022)

TER94^k15502 mutants show locomotive defects in the third instar larval stage (crawling speed and distance) and in 3 days old adults, but not 10 and 30 days old adults (climbing score).

(Jantrapirom et al., 2018)

Heterozygosity for TER94^k15502 ameliorates the rough eye and photoreceptor cell phenotypes resulting from the overexpression of TER94^{R152H.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

Heterozygosity for TER94^k15502 ameliorates the rough eye and photoreceptor cell phenotypes resulting from the overexpression of TER94^{R188Q.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

Heterozygosity for TER94^k15502 ameliorates the rough eye and photoreceptor cell phenotypes resulting from the overexpression of TER94^{A229E.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

(Chang et al., 2011)

At the third instar stage, the morphology of TER94^k15502 mutant neuronal clones is also wild-type, although these cells die shortly after the onset of the pupal stage.

(Rumpf et al., 2011)

TER94^k15502/+ mutant adults do not exhibit significant defects in phototaxis at 20 days of light exposure (dle), nor any defects in geotaxis at 20 or 30 dle, as compared to controls.

(Griciuc et al., 2010)

Female germ-line clones formed germaria that give rise to stage six or seven egg chambers before degeneration occurs.

(Ruden et al., 2000)

Females carrying homozygous germline clones do not lay eggs. Homozygous clones on the head, scutellum or sternopleurum result in bristle loss.

(Leon and McKearin, 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

TER94^k15502 has increased cell number | somatic clone | adult stage phenotype, suppressible by Scer\GAL4^Act.PU/bsk^HMS00777

(Liu et al., 2022)

TER94^k15502 has increased cell number | somatic clone | adult stage phenotype, suppressible by Scer\GAL4^Act.PU/bsk^K53R.UAS

(Liu et al., 2022)

Enhancer of

Statement

Reference

TER94[+]/TER94^k15502 is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^GMR.PS, caz^VDRC.cUa

(Azuma et al., 2014)

TER94[+]/TER94^k15502 is an enhancer of abnormal locomotor behavior | progressive phenotype of Scer\GAL4^elav.PLu, caz^VDRC.cUa

(Azuma et al., 2014)

TER94[+]/TER94^k15502 is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^elav.PLu, caz^VDRC.cUa

(Azuma et al., 2014)

Suppressor of

Statement

Reference

TER94^k15502 is a suppressor of abnormal locomotor behavior | third instar larval stage phenotype of Scer\GAL4^elav.PLu, Ubqn^KK100857

(Jantrapirom et al., 2018)

TER94^k15502 is a suppressor of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^elav.PLu, Ubqn^KK100857

(Jantrapirom et al., 2018)

TER94[+]/TER94^k15502 is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.PF, atl^UAS.Tag:MYC

(O'Sullivan et al., 2013)

TER94[+]/TER94^k15502 is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PF, atl^UAS.Tag:MYC

(O'Sullivan et al., 2013)

TER94[+]/TER94^k15502 is a suppressor of decreased cell number | adult stage | progressive phenotype of ninaE^P37H

(Griciuc et al., 2010)

TER94[+]/TER94^k15502 is a suppressor of abnormal phototaxis | adult stage phenotype of ninaE^P37H

(Griciuc et al., 2010)

TER94[+]/TER94^k15502 is a suppressor of abnormal neuroanatomy | adult stage | progressive phenotype of ninaE^P37H

(Griciuc et al., 2010)

Other

Statement

Reference

Der-1^UAS.cLa, Scer\GAL4^GMR.PF, TER94[+]/TER94^k15502 has lethal phenotype

(Liang et al., 2014)

Phenotype Manifest In

Suppressed by

Statement

Reference

TER94^k15502 has adult midgut epithelium | somatic clone phenotype, suppressible by Scer\GAL4^Act.PU/bsk^HMS00777

(Liu et al., 2022)

TER94^k15502 has adult midgut epithelium | somatic clone phenotype, suppressible by Scer\GAL4^Act.PU/bsk^K53R.UAS

(Liu et al., 2022)

Enhancer of

Statement

Reference

TER94[+]/TER94^k15502 is an enhancer of eye phenotype of Scer\GAL4^GMR.PS, caz^VDRC.cUa

(Azuma et al., 2014)

TER94[+]/TER94^k15502 is an enhancer of ommatidium phenotype of Scer\GAL4^GMR.PS, caz^VDRC.cUa

(Azuma et al., 2014)

TER94[+]/TER94^k15502 is an enhancer of interommatidial bristle phenotype of Scer\GAL4^GMR.PS, caz^VDRC.cUa

(Azuma et al., 2014)

TER94[+]/TER94^k15502 is an enhancer of embryonic/larval motor neuron | larval stage phenotype of Scer\GAL4^elav.PLu, caz^VDRC.cUa

(Azuma et al., 2014)

TER94[+]/TER94^k15502 is an enhancer of NMJ bouton | larval stage phenotype of Scer\GAL4^elav.PLu, caz^VDRC.cUa

(Azuma et al., 2014)

Suppressor of

Statement

Reference

TER94[+]/TER94^k15502 is a suppressor | partially of eye phenotype of Scer\GAL4^ey.PH, atl^UAS.Tag:MYC

(O'Sullivan et al., 2013)

TER94[+]/TER94^k15502 is a suppressor of retina | adult stage | progressive phenotype of ninaE^P37H

(Griciuc et al., 2010)

TER94[+]/TER94^k15502 is a suppressor of eye photoreceptor cell | adult stage | progressive phenotype of ninaE^P37H

(Griciuc et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygous TER94^k15502 enhances the rough-eye phenotype induced by Scer\GAL4^GMR.PS>caz^VDRC.cUa.

Flies carrying TER94^k15502 and Scer\GAL4^elav.PLu>caz^VDRC.cUa have significantly worse locomotive ability than do flies with Scer\GAL4^elav.PLu>caz^VDRC.cUa alone.

The decreased branch length phenotype caused by Scer\GAL4^elav.PLu>caz^VDRC.cUa in motor neurons is significantly enhanced by TER94^k15502/+.

The decrease in the number of synaptic boutons in Scer\GAL4^elav.PLu>caz^VDRC.cUa-expressing larvae is significantly enhanced by TER94^k15502/+. However, there is significant differences in the size of synaptic boutons among these genotypes.

(Azuma et al., 2014)

Expression of Der-1^Scer\UAS.cLa under the control of Scer\GAL4^GMR.PF in a heterozygous TER94^k15502 mutant background results in lethality.

(Liang et al., 2014)

The small eye phenotype characteristic for adult flies expressing atl^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.PF is significantly ameliorated by combination with a single copy of TER94^k15502.

(O'Sullivan et al., 2013)

TER94^k15502/+ strongly suppresses the retinal degeneration and photoreceptor neuron loss seen in flies expressing ninaE^P37H at both 20 and 30 days of light exposure; and rescues the visual processing defects seen in these flies at 20 days of light exposure.

(Griciuc et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

TER94⁰³⁷⁷⁵

(Leon and McKearin, 1999)

TER94⁰³⁷⁷⁵

(BDGP Project Members, 1994-1999)

Partially rescued by

TER94^k15502 is partially rescued by Scer\GAL4^{VP16.nanos.UTR}/TER94^UAS.cMa

(Ruden et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

10454

y¹ w^67c23; P{lacW}TER94^k15502/CyO

Kyoto

111109

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}42D P{lacW}TER94^k15502 /CyO y⁺

Notes on Origin

Discoverer

I. Kiss.

(BDGP Project Members, 1994-1999)

Comments

Excision of the P{lacW} element fully reverts the lethal phenotype.

(Leon and McKearin, 1999)

Phenotypic analysis suggests an allelic series, starting from the strongest: TER94^k15502, TER94^26-8, TER94⁰³⁷⁷⁵, TER94^22-30, TER94^14-23, TER94^22-26, TER94^7-12 and TER94^43-8.

(Ruden et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

TER94^K15502

(Chang et al., 2021)

TER94^k15502

(Liu et al., 2022, Kahsai and Cook, 2018, O'Sullivan et al., 2013)

TER94^l(2)k15502

(Chang et al., 2011)

Ter94^K15502

(Lu et al., 2020, Jantrapirom et al., 2018)

Ter94^k15502

(Zhang et al., 2013, Zhang et al., 2013)

VCP^k15502

(O'Sullivan et al., 2013, Griciuc et al., 2010)

dVCP^mt

(Jantrapirom et al., 2018)

l(2)03775^k15502

(BDGP Project Members, 1994-1999)

l(2)k15502

(Higashiyama et al., 2002, Goldstein et al., 2001, Leon and McKearin, 1999, Spradling et al., 1999)

ter94^K15502

(Li et al., 2024, Kushimura et al., 2018, Azuma et al., 2014)

ter94^k15502

(Ruden et al., 2000)

vcp^K15502

(Zhang et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (23)

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