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General Information
Symbol
Dmel\Nup154k08204
Species
D. melanogaster
Name
FlyBase ID
FBal0064770
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{lacW} insertion approximately 100bp upstream from the start of the predicted Nup154 open reading frame. The insertion is in the opposite 5' to 3' orientation to the direction of Nup154 transcription.

Insertion components
P{lacW}Nup154k08204
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Larvae transheterozygous for Nup154k08204 and either Nup1542 or Nup15401501 die throughout the early larval stages, with survivors found until only just after the third instar larval moult. Until the end of the second instar stage, the larvae appear morphologically similar to their heterozygous siblings in body and tissue size. After the third instar moult, the larvae fail to grow and show a "classic mitotic mutant" phenotype, including reduced overall body size and a reduction in the size of larval organs that normally contain proliferating cells. Homozygous, hemizygous or transheterozygous third instar larvae have smaller brains than their age-matched control siblings. Although the neuropil is relatively normal in size, the optic lobes are greatly reduced and imaginal discs are tiny and difficult if not impossible to locate. The lymph glands are also reduced in size in third instar larvae.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Nup154k08204
l(2)01501k08204
Name Synonyms
Secondary FlyBase IDs
    References (5)