|Feature type||allele||Associated gene||Dmel\tutl|
|Also Known As||l(2)k14703|
|Allele class||hypomorphic allele - genetic evidence|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Caused by insertion|
|Phenotype Manifest In|
In tutl[k14703] embryos, the ISNb motor axons succesfully reach the vicinity of their respective targets. However, once there, many fail to send one or more of the final axon branches to contact their muscle targets. Around a quarter of the hemisegments also lack ISNd nerves. Approximately 20% of tutl[k14703] homozygotes reach adulthood. They exhibit an optic chiasm that is disorganised and exhibits graps in the R7 termination line. Flies with eyes composed of tutl[k14703] mutant cells and brains expressing wild-type levels of tutl (generated using the EGUF technique) exhibit smaller eyes than wild-type, although the optic chiasma and R7 projections appear normal, indicating that the source of retinal axon defects in tutl[k14703] mutants is reduced tutl levels in the optic lobe, rather than in the retinal axons.
Most homozygotes are able to survive to adulthood if competition with heterozygous siblings is eliminated. However, competition from heterozygous siblings results in the death of homozygous animals (85-100% lethality) before adulthood. General morphology of the mutant larvae is normal. Homozygous larvae have a severely compromised ability to roll over from an inverted position; the time required to right themselves is significantly longer than control larvae. Homozygous adults cannot fly, although they walk normally and energetically on a level surface. The jump response is intact and robust, but attempts at flight result in the flies flipping themselves onto their backs, where continued efforts to fly are shown by the adults flapping their wings at high speeds (this only results in the flies spinning frantically in circles). Adults that become inverted are rarely able to right themselves, despite what appears to be an intense effort to roll over. Only 12-36% of adults are able to roll over after 60 seconds, in contrast to wild-type which roll over immediately, almost always in less than one second.
tutlk14703/tutl[+] is a suppressor of lethal | embryonic stage | partially | recessive phenotype of peb308
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Fails to complement|
Expression of either tutl[GH15753.Scer\UAS] or tutl[AT02763.Scer\UAS] driven by the pan-neuronal driver Scer\GAL4[elav-C155] rescues most aspects of tutl[k14703]/tutl[ex383] mutant eye defects.
|Stocks ( 2 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 5 )|
|Secondary FlyBase IDs|
|References ( 11 )|
|Personal communication to FlyBase|