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General Information
Symbol
Dmel\kst1
Species
D. melanogaster
Name
FlyBase ID
FBal0064835
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Encodes a truncated protein.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Elongation of rhabdomeres is not affected in kst1/kst2 photoreceptors.

Rhabdomeres of kst1/kst2 mutant eyes show defects in rhabdomere shape similar to, but less marked than those of crb mutants. Stalk membranes are 10% shorter than wild type and lack the wild type deep folds.

Mutant embryos hatch, but mutant pupae are present at less than 10% of the expected number, suggesting that most individuals die as larvae. There seems to be little pupal lethality and kst mutants eclose 2-4 days behind their wild-type siblings. Adult escapers are very infertile and lay few eggs. Hemizygous and kst1/kst2 adult escapers have rough eyes. The R7 photoreceptor cell is missing in many ommatidia in kst1/Df(3L)HR232 escapers. Many ommatidia are missing in the eyes of kst1/Df(3L)1226 escapers. kst1/kst2 adult escapers have wings that typically curve downwards in an "inverted spoon" shape. Hemizygous adult escapers show a visible extrusion of melanised material from the abdominal spiracles.

Homozygotes generally die as larvae. Surviving adults have defects in the eyes, wings and tracheal system.

Hemizygotes have irregular or missing facets in a region of variable size at the posterior margin of the eye. The wings show a variable degree of downward curvature and the flies tend to "leak" haemolymph, particularly through the spiracles of the abdomen.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

kst1/kst2 has lethal phenotype, enhanceable by crb11A22/crb[+]

kstB1-14.1/kst1 has lethal phenotype, enhanceable by crb11A22/crb[+]

Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

kst[+]/kst1 is a non-enhancer of lethal | embryonic stage | partially | recessive phenotype of peb308

NOT Suppressor of
Statement
Reference

kst[+]/kst1 is a non-suppressor of lethal | embryonic stage | partially | recessive phenotype of peb308

Phenotype Manifest In
Enhanced by
Statement
Reference

kst1/kst2 has rhabdomere | somatic clone phenotype, enhanceable by crb11A22/crb[+]

Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

kst1 is a suppressor | partially of wing vein L5 phenotype of rhove-1

kst1 is a suppressor of wing vein L2 phenotype of rhove-1

kst1 is a suppressor of wing vein L3 phenotype of rhove-1

kst1 is a suppressor of wing vein L4 phenotype of rhove-1

Other
Additional Comments
Genetic Interactions
Statement
Reference

Heterozygosity for kst1 significantly enhances the rough-eye phenotype induced by overexpression of trioScer\UAS.cBa via Scer\GAL4GMR.PFa.

Introduction of one copy of kst1 into a homozygous rhove-1 background completely suppresses the wing vein defect for L2-L4 and partially suppresses the defects in L5.

crb2/crb+, kst1/kst2 mutants have normal zonula adherens but photoreceptor stalk membranes are much shorter than in wild type, kst homozygous or crb heterozygous photoreceptor cells.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
  • FBal0101352
References (12)