FlyBase Allele Report: Dmel\hh[unspecified]

General Information

Symbol

Dmel\hh^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0064870

Feature type

allele

Associated gene

Dmel\hh

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Moore et al., 1998)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Tearle and Nusslein-Volhard, 1987)

segment polarity phenotype | embryonic stage | recessive

(Tearle and Nusslein-Volhard, 1987)

some die during embryonic stage | recessive

(Tearle and Nusslein-Volhard, 1987)

Phenotype Manifest In

Detailed Description

Statement

Reference

Stage 15 hh^unspecified embryos have only ~13 genital disc precursor cells, instead of the wild-type number of 22.

(Chen et al., 2005)

Some mild defects in germ cell migration are seen in hh^unspecified/+ embryos: fewer than 20% of the stage 13 to 16 embryos have four or more mispositioned germ cells(n=25).

hh^Mrt/+ embryos have defects in germ cell migration: and about 60% of the stage 13 to 16 embryos have four or more mispositioned germ cells (n=25). These defects are more severe in hh^Mrt/hh^unspecified embryos: >90% of stage 13 to 16 have ten or more mispositioned germ cells (n = 20).

(Deshpande and Schedl, 2005)

Mutants show dramatic increase in the number of midline glial cells. By the end of embryogenesis most of the midline glial cells are missing. Midline neurons are reduced in number. Commissure formation is delayed. In stage 13 only a few commissural axons have crossed the midline. In stage 16 embryos, commissures have formed but are reduced in size.

(Hummel et al., 1999)

Formation of the visceral mesoderm is normal in homozygous embryos, and the visceral mesoderm migrates to cover the gut and form midgut constrictions.

(Bilder and Scott, 1998)

Embryos show a germ cell migration defect and a significant reduction in the number of gonadal mesodermal cells.

(Moore et al., 1998)

The posterior naked section of the ventral part of each segment is deleted in hh^unspecified mutant embryos and is replaced by a mirror image duplication of the anterior denticle belts. Segment boundaries appear to be missing.

(Tearle and Nusslein-Volhard, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

hh^unspecified has primordial germ cell | dorsal closure stage phenotype, enhanceable by disp[+]/disp^unspecified

(Deshpande and Schedl, 2005)

hh^unspecified has primordial germ cell | dorsal closure stage phenotype, enhanceable by Hmgcr^unspecified/Hmgcr[+]

(Deshpande and Schedl, 2005)

hh^unspecified has phenotype, enhanceable by oro¹

(Tanda et al., 1996)

Enhancer of

Statement

Reference

hh^unspecified/Scer\GAL4^dpp.blk1 is an enhancer of wing vein L3 | temperature conditional phenotype of Bant\EF^UAS.cGa

(Guichard et al., 2006)

hh^unspecified/Scer\GAL4^dpp.blk1 is an enhancer of wing cell | temperature conditional phenotype of Bant\EF^UAS.cGa

(Guichard et al., 2006)

hh[+]/hh^unspecified is an enhancer of primordial germ cell | dorsal closure stage phenotype of Hmgcr^unspecified

(Deshpande and Schedl, 2005)

NOT Suppressor of

Statement

Reference

hh^unspecified is a non-suppressor of phenotype of arm³

(Cox et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The mild germ cell migration defects seen in hh^unspecified/+ embryos are strongly enhanced by disp^unspecified/+: nearly 90% of stage 13 to 16 embryos have ten or more mispositioned germ cells (n = 20).

The mild germ cell migration defects seen in Hmgcr^unspecified/+ embryos are enhanced by hh^unspecified/+.

(Deshpande and Schedl, 2005)

Enhances the lethality of Dfd¹³/Dfd³ flies grown at 29^oC - leaving nearly zero survivors.

(Gellon et al., 1997)

Xenogenetic Interactions

Statement

Reference

Expression of Zzzz\EF^Scer\UAS.cGa under the control of Scer\GAL4^dpp.blk1 in a hh^unspecified background significantly enhances the Zzzz\EF^Scer\UAS.cGa phenotype.

(Guichard et al., 2006)

Complementation and Rescue Data

Fails to complement

hh^Gal4

(Tanimoto et al., 2000)

hh^Mir

(Kopp et al., 1997)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

7 mutants are isolated.

(Moore et al., 1998)

Four alleles isolated in this screen.

(Gellon et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

hh^unspecified

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

Open Close