bratk06028 mutants form brain tumors; neuroblasts from these tumors show a severe increase in the frequency of tetraploidy, but not of aneuploidy, polyploidy or mutations, as compared to controls.
bratk06028 homozygous third instar larval brains exhibit ganglion mother cell dedifferentiation and severe tumor phenotypes, as compared to controls.
Homozygous larval brain tissue develops into tumours after allograft into adult host flies (taking over the entire abdomen of the host) in 80% of cases.
When pieces of brain from bratk06028 9-12-day-old larvae, which show tissue overgrowth, are transplanted into the abdomens of adult hosts, tumors of the abdomen develop.
The brain hemispheres of mutant third instar larvae are highly enlarged compared to wild type, while the imaginal discs are not affected.