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General Information
Symbol
Dmel\bratk06028
Species
D. melanogaster
Name
FlyBase ID
FBal0064943
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
l(2)k06028
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{lacW} insertion in exon 4 after nucleotide 32500.

Insertion components
P{lacW}bratk06028
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

bratk06028 mutants form brain tumors; neuroblasts from these tumors show a severe increase in the frequency of tetraploidy, but not of aneuploidy, polyploidy or mutations, as compared to controls.

bratk06028 homozygous third instar larval brains exhibit ganglion mother cell dedifferentiation and severe tumor phenotypes, as compared to controls.

brat11/bratk06028 larval brains contain supernumerary type II neuroblasts.

Homozygous larval brain tissue develops into tumours after allograft into adult host flies (taking over the entire abdomen of the host) in 80% of cases.

When pieces of brain from bratk06028 9-12-day-old larvae, which show tissue overgrowth, are transplanted into the abdomens of adult hosts, tumors of the abdomen develop.

Embryos laid by bratk06028/bratfs3 mothers have 5 to 8 abdominal segments. bratk06028/bratk06028 embryos generated by germ-line clone have 6 to 8 abdominal segments.

The brain hemispheres of mutant third instar larvae are highly enlarged compared to wild type, while the imaginal discs are not affected.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Enhancer of
Statement
Reference
NOT Enhancer of
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

The presence of bratk06028/+ does not change the number of neuroblasts per brain lobe seen in larval brains expressing both bansponge.Scer\UAS.T:Disc\RFP and NScer\UAS.T:SV5\V5,T:Zzzz\His6 under the control of Scer\GAL4insc-Mz1407.

The formation of supernumerary type II neuroblasts is suppressed in homozygous kluunspecified type II neuroblast clones in brat11/bratk06028 larval brains.

The frequency with which bratk06028 larval brain tissue develops into tumours after allograft into adult host flies (taking over the entire abdomen of the host) is not significantly altered if the transplanted tissue is also homozygous for piwi1.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Excision of the P{lacW} element can result in viable, fertile revertants.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
References (20)