Allele Dmel\EcR^k06210

General Information
Symbol	Dmel\EcR^k06210	Species	D. melanogaster
Name		FlyBase ID	FBal0065262
Feature type	allele	Associated gene	Dmel\EcR

Map ( GBrowse )	Untitled Document
Allele class	hypomorphic allele - genetic evidence
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (D'Avino and Thummel, 2000)
Mutagen	P-element activity (BDGP Project Members, 1994-1999)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 2R:2,025,171..2,025,171 (BDGP Project Members, 1994-1999, Spradling et al., 1999, Gates et al., 2004, Sedkov et al., 2003, D'Avino and Thummel, 2000, FlyBase Genome Annotators, 2004)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion maps within first exon of CG14589 which itself maps within EcR. (FlyBase Genome Annotators, 2004) A P{lacW} insertion between EcR-A exon3 and EcR-B1/B2 transcription start. (D'Avino and Thummel, 2000)
Caused by insertion	P{lacW}EcR^k06210 (BDGP Project Members, 1994-1999, Spradling et al., 1999, Gates et al., 2004, Sedkov et al., 2003, D'Avino and Thummel, 2000, FlyBase Genome Annotators, 2004)
Cytology
Phenotypic Data
Phenotypic Class
	lethal (D'Avino and Thummel, 2000) lethal \| recessive (BDGP Project Members, 1994-1999, Spradling et al., 1999) partially lethal - majority die \| pharate adult stage \| recessive (D'Avino and Thummel, 2000)
Phenotype Manifest In
	anterior crossvein \| ectopic (D'Avino and Thummel, 2000) leg \| pharate adult stage (Pentek et al., 2009) wing (D'Avino and Thummel, 2000) wing vein (D'Avino and Thummel, 2000) wing vein \| ectopic (D'Avino and Thummel, 2000) wing vein L3 \| ectopic (D'Avino and Thummel, 2000)
Detailed Description
	Statement Reference Mutant pharate adults show a bent leg phenotype. (Pentek et al., 2009) No eye phenotype is seen in these mutants. (Sedkov et al., 2003) 2/3 of homozygotes die as pharate adults, while the remainder survive to adulthood. These adults die after about 1 week at 25^oC, but are fertile and can survive up to three weeks at 18^oC. These flies also exhibit cell adhesion and morphogenetic defects. 1/4 display venation defects, 1/3 display wing blisters. These blisters are usually small and centrally located, although blistering of the whole wing (a balloon wing) can occasionally be seen. The most frequent venation defects include a small, extra vein that originates from the third longitudinal vein, an additional anterior crossvein, and a "delta" thickening at the intersection between the posterior crossvein and the fourth longitudinal vein. EcR^k06210/EcR^M554fs flies are fully lethal. FlyBase curator comment: Since the "k06210" insertion lies within EcR and the EcR-intronic CG14589 it is not clear which disruption might be responsible for the lethality. (D'Avino and Thummel, 2000) FlyBase curator comment: Since the "k06210" insertion lies within EcR and the EcR-intronic CG14589 it is not clear which disruption might be responsible for the lethality. (BDGP Project Members, 1994-1999, Spradling et al., 1999)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement Reference EcR^k06210/EcR[+] is a suppressor of eye phenotype of trr⁴ (Sedkov et al., 2003) EcR^k06210/EcR[+] is a suppressor of morphogenetic furrow phenotype of trr⁴ (Sedkov et al., 2003) EcR^k06210/EcR[+] is a suppressor of ommatidium phenotype of trr⁴ (Sedkov et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially complements	EcR²¹⁴ (D'Avino and Thummel, 2000)
Fails to complement	EcR^k04314 (BDGP Project Members, 1994-1999) EcR^k04504 (BDGP Project Members, 1994-1999)
Comments	21% of EcR^k06210/EcR²¹⁴ flies survive to adulthood. (D'Avino and Thummel, 2000)
Stocks ( 2 )
Bloomington	10614 y¹ w^67c23; P{lacW}EcR^k06210 CG14589^k06210/CyO
Kyoto	102456 y¹ w^67c23 ; P{lacW}EcR^k06210 / CyO
Notes on Origin
Discoverer	I. Kiss.
	Associated with: CG14589^k06210. (FlyBase Genome Annotators, 2004)
Comments
	Complements: jing⁰¹⁰⁹⁴. Complements: l(2)05315⁰⁵³¹⁵. Complements: l(2)k03204^k03204. Complements: l(2)k09848^k09848. Complements: Src42A^k10108. Complements: l(2)k14710^k14710. Complements: l(2)k14805^k14805. Complements: l(2)k14710^k15603. Fails to complement: esg^k05332b. (BDGP Project Members, 1994-1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	EcR^k06210 (Pentek et al., 2009) EcR^l(2)k06210 (Gates et al., 2004) l(2)k06210 (Spradling et al., 1999)
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Pentek et al., 2009, genesis 47(4): 261--273 Follistatin preferentially antagonizes activin rather than BMP signaling in Drosophila. [FBrf0207743] Gates et al., 2004, Development 131(1): 25--36 rigor mortis encodes a novel nuclear receptor interacting protein required for ecdysone signaling during Drosophila larval development. [FBrf0167527] D'Avino and Thummel, 2000, Dev. Biol. 220(2): 211--224 The ecdysone regulatory pathway controls wing morphogenesis and integrin expression during Drosophila metamorphosis. [FBrf0127048] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489]
Personal communication to FlyBase	Beaton, 1999.12.12, Alleles of the lines in the P-element paper. Alleles of the lines in the P-element paper. [FBrf0125032] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
FlyBase analysis	FlyBase Genome Annotators, 2004, Changes affecting gene model number or type in release 3.2 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 3.2 of the annotated D.melanogaster genome. [FBrf0166453]
Letter	Sedkov et al., 2003, Nature 426(6962): 78--83 Methylation of lysine 4 of histone H3 in ecdysone-dependent development of Drosophila. [FBrf0173071]

Allele Dmel\EcRk06210

Allele Dmel\EcR^k06210