FB2025_01 , released February 20, 2025
Allele: Dmel\DllUAS.cGa
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General Information
Symbol
Dmel\DllUAS.cGa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Gorfinkiel
FlyBase ID
FBal0065271
Feature type
allele
Associated gene
Dmel\Dll
Associated Insertion(s)
Carried in Construct
P{UAS-Dll.G}
Also Known As
UAS-Dll
Key Links
Transgenic product class
cDNA
(Gorfinkiel et al., 1997)
wild_type
(Gorfinkiel et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Gorfinkiel et al., 1997)
wild_type
(Gorfinkiel et al., 1997)
Mutagen
in vitro construct
(Gorfinkiel et al., 1997)
Progenitor genotype
Carried in construct
P{UAS-Dll.G}
Cytology
Description

A fragment of a Dll cDNA (containing the entire open reading frame) is expressed under the control of UAS regulatory sequences.

(Gorfinkiel et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Dll
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Clones expressing DllScer\UAS.cGa, generated under the control of Scer\GAL4tub.PU using the MARCM system, show what appears to be ectopic proximal leg tissues in the wing. Distal leg tissue is not generated.

      (Estella and Mann, 2010)

      Male and female genitalia are abnormal in animals expressing DllScer\UAS.cGa under the control of Scer\GAL4dpp.blk1, but they are not transformed into leg.

      (Estrada and Sanchez-Herrero, 2001)

      DllScer\UAS.cGa driven by Scer\GAL4cad-em459 causes a reduction of anal primordium. Adult flies show no hindgut structure and the anal plates are also reduced.

      (Gorfinkiel et al., 1999)

      Produces fusions of the tarsi when expressed using Scer\GAL4Dll-em212. Clones in the proximal part of the leg expressing DllScer\UAS.cGa under the control of Scer\GAL4Act5C.PP cause leg duplications. Ectopic leg tissue emerging from the hinge and proximal regions of the wing and ectopic antennal tissue emerging from the eye is produced when DllScer\UAS.cGa is expressed under the control of Scer\GAL4E132. Ectopic leg tissue emerging from the haltere is produced when DllScer\UAS.cGa is expressed under the control of Scer\GAL4ap-md544. Ectopic antennal tissue emerging from the head is produced when DllScer\UAS.cGa is expressed under the control of Scer\GAL4ptc-559.1 or Scer\GAL4C-68a.

      (Gorfinkiel et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of DllScer\UAS.cGa is unable to rescue the aberrant leg phenotype seen when Df(1)btd-Sp1 mutant clones are generated during embryogenesis (in a minute background under the control of Scer\GAL4Dll-em212). The resulting legs are still severely truncated.

      (Estella and Mann, 2010)

      Coexpression of btdScer\UAS.cSa and DllScer\UAS.cGa, under the control of Scer\GAL4btd-MD808, cause ectopic formation of Keilin's organs in otherwise normal abdominal segments. These ectopic organs have more than the wild-type number of three sensory hairs.

      (Franch-Marro et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      DllScer\UAS.cGa
      DllUAS.cGa
      UAS-Dll
      (Gonzalez-Crespo et al., 1998)
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Gorfinkiel
      (Gorfinkiel et al., 1997)
      Secondary FlyBase IDs
        References (13)