FlyBase Allele Report: Dmel\CycA[C8LR1]

General Information

Symbol

Dmel\CycA^C8LR1

Species

D. melanogaster

Name

FlyBase ID

FBal0065308

Feature type

allele

Associated gene

Dmel\CycA

Associated Insertion(s)

Carried in Construct

Also Known As

CycA^C8, Cyclin A^c8LR1

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Sigrist and Lehner, 1997)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdominal segment 2 & cardioblast

(Han and Bodmer, 2003)

abdominal segment 3 & cardioblast

(Han and Bodmer, 2003)

abdominal segment 4 & cardioblast

(Han and Bodmer, 2003)

abdominal segment 5 & cardioblast

(Han and Bodmer, 2003)

abdominal segment 6 & cardioblast

(Han and Bodmer, 2003)

abdominal segment 7 & cardioblast

(Han and Bodmer, 2003)

dorsal vessel wall cell

(Han and Bodmer, 2003)

embryonic/larval ganglionic tracheal branch

(Butí et al., 2014)

embryonic epidermis

(Reber et al., 2006)

embryonic epidermis | embryonic cycle 16

(Dienemann and Sprenger, 2004)

embryonic ganglion mother cell

(Reber et al., 2006)

embryonic pericardial cell

(Han and Bodmer, 2003)

eye disc | somatic clone | third instar larval stage

(Kim et al., 2017)

ganglion mother cell GMC4-2a

(Bhalerao et al., 2005)

larval glial cell

(Silies and Klämbt, 2010)

larval tracheal system

(Butí et al., 2014)

mitotic cell cycle

(Han and Bodmer, 2003)

RP2sib neuron

(Bhalerao et al., 2005)

S phase | ectopic

(Sigrist and Lehner, 1997)

Detailed Description

Statement

Reference

CycA^C8LR1 homozygous somatic clones in third instar larval eye discs do not enter S transition during the second mitotic wave.

(Kim et al., 2017)

Sleep defects are observed in CycA^EY11746 mutant heterozygotes.

(Afonso et al., 2015)

In CycA^C8LR1 mutant embryos, tracheal branches are formed and migrate to their destinations with only half the normal number of cells and accomplish a standard tube diameter and length, with ganglionic branches invading the ventral nerve cord as in the wild-type.

(Butí et al., 2014)

The number of glial cells is reduced in mutant embryos compared to controls.

(Silies and Klämbt, 2010)

Progression through mitosis 16 does not occur in CycA^C8LR1 mutant embryos and all epidermal cells remain in G2.

(Althoff et al., 2009)

CycA^C8LR1 embryos show a general failure of epidermal cells to progress through mitosis 16. There are some mitotic cells that progress through this cycle in CycA^C8LR1 embryos, but these are restricted mainly to the prospective anterior spiracle region in the epidermis and are unusual in that they progress through an additional division cycle compared to cells in wild-type embryos, so that the mutant cells complete 17 rounds of mitosis instead of 16.

The terminal mitoses of ganglion mother cells are preferentially inhibited in CycA^C8LR1 embryos. In contrast, the asymmetric neuroblast divisions, which are not terminal mitoses, are less inhibited in these mutants.

(Reber et al., 2006)

In CycA^C8LR1 embryos, the GMC4-2a cell differentiates into only one RP2 neuron, instead of a RP2 neuron and a RP2sib neuron.

(Bhalerao et al., 2005)

Mitosis 16 does not occur in the epidermal layer in mutant embryos, resulting in embryos with fewer but bigger cells compared to wild type.

(Dienemann and Sprenger, 2004)

Mutant embryos lack eve expressing pericardial cells and have only a single odd expressing pericardial cell per hemisegment. DA1 muscles form as in wild-type. The DO2 founders are also present. A halving is also seen in the number of myocardial cells seen in segments A2 to A7, though the number seen in segments T3 to A1 remain normal.

(Han and Bodmer, 2003)

In CycA^C8LR1 mutants, cell cycle arrest occurs at mitosis 16.

(Grosskortenhaus and Sprenger, 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

CycA^C8LR1 has abnormal mitotic cell cycle phenotype, enhanceable by Rca1²/Rca1²

(Grosskortenhaus and Sprenger, 2002)

Suppressed by

Statement

Reference

CycA^C8LR1 has abnormal mitotic cell cycle | embryonic stage phenotype, suppressible by Scer\GAL4^prd.RG1/CycE^UAS.cLa

(Reber et al., 2006)

CycA^C8LR1 has decreased cell number | embryonic stage phenotype, suppressible by Scer\GAL4^prd.RG1/CycB^{UAS.Tag:HA,Tag:NLS(SV40-largeT)}

(Dienemann and Sprenger, 2004)

CycA^C8LR1 has decreased occurrence of cell division | embryonic stage phenotype, suppressible by Scer\GAL4^prd.RG1/CycB^{UAS.Tag:HA,Tag:NLS(SV40-largeT)}

(Dienemann and Sprenger, 2004)

NOT suppressed by

Statement

Reference

CycA^C8LR1 has abnormal sleep | dominant phenotype, non-suppressible by Cdk1[+]/Cdk1^GT-000294

(Afonso et al., 2015)

CycA^C8LR1 has abnormal mitotic cell cycle phenotype, non-suppressible by Scer\GAL4^prd.RG1/CycJ^UAS.C.EGFP

(Althoff et al., 2009)

CycA^C8LR1 has abnormal mitotic cell cycle | embryonic stage phenotype, non-suppressible by CycB^Δ90/CycB3^Δ/Cdk1^hs.PS

(Reber et al., 2006)

CycA^C8LR1 has abnormal mitotic cell cycle | embryonic stage phenotype, non-suppressible by CycB^Δ90/CycB3^Δ/stg^hs.PE2

(Reber et al., 2006)

CycA^C8LR1 has abnormal mitotic cell cycle | embryonic stage phenotype, non-suppressible by Cdk1^AF.hs/CycB^hs.PK/CycB3^hs.PS

(Reber et al., 2006)

CycA^C8LR1 has abnormal mitotic cell cycle | embryonic stage phenotype, non-suppressible by dap⁴

(Reber et al., 2006)

CycA^C8LR1 has abnormal mitotic cell cycle | embryonic stage phenotype, non-suppressible by Cdk1^AF.hs

(Reber et al., 2006)

CycA^C8LR1 has decreased cell number | embryonic stage phenotype, non-suppressible by Scer\GAL4^prd.RG1/CycB^UAS.Tag:HA

(Dienemann and Sprenger, 2004)

CycA^C8LR1 has decreased cell number | embryonic stage phenotype, non-suppressible by Scer\GAL4^prd.RG1/CycB^{UAS.Tag:HA,Tag:NLS(SV40-largeT)}

(Dienemann and Sprenger, 2004)

CycA^C8LR1 has decreased occurrence of cell division | embryonic stage phenotype, non-suppressible by Scer\GAL4^prd.RG1/CycB^UAS.Tag:HA

(Dienemann and Sprenger, 2004)

CycA^C8LR1 has decreased occurrence of cell division | embryonic stage phenotype, non-suppressible by Scer\GAL4^prd.RG1/CycB^{UAS.Tag:HA,Tag:NLS(SV40-largeT)}

(Dienemann and Sprenger, 2004)

Enhancer of

Statement

Reference

CycA^C8LR1/CycA[+] is an enhancer of abnormal sleep phenotype of Scer\GAL4^elav.PU, tara^JF01421, tara^NIG.6889R

(Afonso et al., 2015)

CycA^C8LR1/CycA^C8LR1 is an enhancer of abnormal mitotic cell cycle phenotype of Rca1²

(Grosskortenhaus and Sprenger, 2002)

NOT Enhancer of

Statement

Reference

CycA^C8LR1/CycA[+] is a non-enhancer of abnormal sleep | dominant phenotype of DAT^fmn

(Afonso et al., 2015)

CycA^C8LR1 is a non-enhancer of visible phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

CycA^C8LR1 is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Suppressor of

Statement

Reference

CycA^C8LR1/CycA[+] is a suppressor | partially of abnormal neuroanatomy | embryonic stage phenotype of cato^unspecified

(zur Lage and Jarman, 2010)

CycA^C8LR1/CycA[+] is a suppressor of abnormal neuroanatomy phenotype of babo³²/babo⁵²

(Zhu et al., 2008)

CycA^C8LR1/CycA[+] is a suppressor of visible phenotype of E(mus304)[+]/PolA1^Emus304, mei-41^29D

(LaRocque et al., 2007)

CycA^C8LR1/CycA[+] is a suppressor of increased cell death phenotype of E(mus304)[+]/PolA1^Emus304, mei-41^29D

(LaRocque et al., 2007)

CycA^C8LR1/CycA[+] is a suppressor of increased cell death phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

NOT Suppressor of

Statement

Reference

CycA^C8LR1 is a non-suppressor of visible phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

CycA^C8LR1 is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Other

Statement

Reference

Cdk1^AF.hs, CycA^C8LR1, CycB3^Δ, CycB^Δ90 has abnormal mitotic cell cycle | embryonic stage phenotype

(Reber et al., 2006)

CycA^C8LR1, CycE^AR95 has abnormal mitotic cell cycle | embryonic stage phenotype

(Reber et al., 2006)

CycA^C8LR1, fzr^ie28 has abnormal mitotic cell cycle | embryonic stage phenotype

(Reber et al., 2006)

CycA::tor^UAS.Tag:HA, CycA^C8LR1, Scer\GAL4^prd.RG1 has abnormal cytokinesis phenotype

(Dienemann and Sprenger, 2004)

CycA::tor^UAS.Tag:HA, CycA^C8LR1, Scer\GAL4^prd.RG1 has increased cell number phenotype

(Dienemann and Sprenger, 2004)

CycA^C8LR1/CycA[+], CycD¹ has partially lethal phenotype

(Emmerich et al., 2004)

CycA^C8LR1/CycA[+], CycD² has viable phenotype

(Emmerich et al., 2004)

CycA^C8LR1, CycD² has viable phenotype

(Emmerich et al., 2004)

CycA^C8LR1, CycB3^L6540, Df(2R)599-5 has lethal phenotype

(Jacobs et al., 1998)

CycA^C8LR1, CycB3^L6540 has lethal phenotype

(Jacobs et al., 1998)

CycA^C8LR1, Df(2R)599-5 has decreased occurrence of cell division | embryonic cycle 15 phenotype

(Jacobs et al., 1998)

CycA^C8LR1, CycB² has decreased occurrence of cell division | embryonic cycle 15 phenotype

(Jacobs et al., 1998)

CycA^C8LR1, Df(1)bi-D3 has increased occurrence of cell division | embryonic cycle 16 phenotype

(Sigrist and Lehner, 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

CycA^C8LR1 has dorsal vessel wall cell phenotype, enhanceable by CycB²

(Han and Bodmer, 2003)

CycA^C8LR1 has mitotic cell cycle phenotype, enhanceable by CycB²

(Han and Bodmer, 2003)

Suppressed by

Statement

Reference

CycA^C8LR1 has embryonic epidermis phenotype, suppressible by Scer\GAL4^prd.RG1/CycE^UAS.cLa

(Reber et al., 2006)

NOT suppressed by

Statement

Reference

CycA^C8LR1 has embryonic epidermis phenotype, non-suppressible by Cdk1^AF.hs

(Reber et al., 2006)

CycA^C8LR1 has embryonic epidermis phenotype, non-suppressible by CycB^Δ90/CycB3^Δ/Cdk1^hs.PS

(Reber et al., 2006)

CycA^C8LR1 has embryonic epidermis phenotype, non-suppressible by CycB^Δ90/CycB3^Δ/stg^hs.PE2

(Reber et al., 2006)

CycA^C8LR1 has embryonic epidermis phenotype, non-suppressible by Cdk1^AF.hs/CycB^hs.PK/CycB3^hs.PS

(Reber et al., 2006)

CycA^C8LR1 has embryonic epidermis phenotype, non-suppressible by dap⁴

(Reber et al., 2006)

CycA^C8LR1 has RP2sib neuron phenotype, non-suppressible by numb^S52F

(Bhalerao et al., 2005)

CycA^C8LR1 has ganglion mother cell GMC4-2a phenotype, non-suppressible by numb^S52F

(Bhalerao et al., 2005)

NOT Enhancer of

Statement

Reference

CycA^C8LR1 is a non-enhancer of eye phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

CycA^C8LR1 is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Suppressor of

Statement

Reference

CycA^C8LR1/CycA[+] is a suppressor | partially of egg chamber | increased number phenotype of Ras85D^V12.cZa.UASp, Scer\GAL4^{VP16.nanos.UTR}

(Zhang et al., 2024)

CycA^C8LR1/CycA[+] is a suppressor | partially of lch1 neuron phenotype of cato^unspecified

(zur Lage and Jarman, 2010)

CycA^C8LR1/CycA[+] is a suppressor of axon & eye photoreceptor cell phenotype of babo³²/babo⁵²

(Zhu et al., 2008)

CycA^C8LR1/CycA[+] is a suppressor of lamina phenotype of babo³²/babo⁵²

(Zhu et al., 2008)

CycA^C8LR1/CycA[+] is a suppressor of eye phenotype of E(mus304)[+]/PolA1^Emus304, mei-41^29D

(LaRocque et al., 2007)

CycA^C8LR1/CycA[+] is a suppressor of wing disc phenotype of E(mus304)[+]/PolA1^Emus304, mei-41^29D

(LaRocque et al., 2007)

CycA^C8LR1/CycA[+] is a suppressor of eye phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

CycA^C8LR1/CycA[+] is a suppressor of ommatidium phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

CycA^C8LR1/CycA[+] is a suppressor of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Khurana et al., 2006)

CycA^C8LR1 is a suppressor | partially of larval cuticle & larval abdomen phenotype of Cks30A^KO/Cks30A^RA74

(Swan et al., 2005)

CycA^C8LR1/CycA[+] is a suppressor of aster | embryonic cycle 5 phenotype of CycB^+t10

(Ji et al., 2002)

CycA^C8LR1/CycA[+] is a suppressor of aster | embryonic cycle 6 phenotype of CycB^+t10

(Ji et al., 2002)

CycA^C8LR1/CycA[+] is a suppressor of aster | embryonic cycle 7 phenotype of CycB^+t10

(Ji et al., 2002)

CycA^C8LR1/CycA[+] is a suppressor of mitotic domain 1 | embryonic cycle 10 phenotype of CycB^+t10

(Ji et al., 2002)

CycA^C8LR1/CycA[+] is a suppressor of mitotic domain 1 | embryonic cycle 14 phenotype of CycB^+t10

(Ji et al., 2002)

NOT Suppressor of

Statement

Reference

CycA^C8LR1 is a non-suppressor of embryonic/larval salivary gland | embryonic stage phenotype of hkb³⁵¹

(Matthew et al., 2024)

CycA^C8LR1 is a non-suppressor of eye phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

CycA^C8LR1 is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Other

Statement

Reference

Cdk1^AF.hs, CycA^C8LR1, CycB3^Δ, CycB^Δ90 has embryonic epidermis phenotype

(Reber et al., 2006)

CycA^C8LR1, CycE^AR95 has embryonic epidermis phenotype

(Reber et al., 2006)

CycA^C8LR1, fzr^ie28 has embryonic epidermis phenotype

(Reber et al., 2006)

CycA^C8LR1, fzr^ie28 has mitotic anaphase phenotype

(Reber et al., 2006)

CycA^C8LR1, fzr^ie28 has mitotic telophase phenotype

(Reber et al., 2006)

CycA^C8LR1, numb¹⁵ has larval RP2 motor neuron phenotype

(Bhalerao et al., 2005)

CycA^C8LR1, numb¹⁵ has RP2sib neuron phenotype

(Bhalerao et al., 2005)

CycA^C8LR1, numb¹⁵ has ganglion mother cell GMC4-2a phenotype

(Bhalerao et al., 2005)

CycA^C8LR1, numb¹ has pericardial cell phenotype

(Han and Bodmer, 2003)

CycA^C8LR1, numb¹ has muscle cell of A1-7 dorsal acute muscle 1 phenotype

(Han and Bodmer, 2003)

CycA^C8LR1, numb¹ has muscle cell of mesothoracic dorsal acute muscle 1 phenotype

(Han and Bodmer, 2003)

CycA^C8LR1, numb¹ has muscle cell of metathoracic dorsal acute muscle 1 phenotype

(Han and Bodmer, 2003)

CycA^C8LR1, CycB3^L6540, Df(2R)599-5 has embryo | embryonic cycle 15 phenotype

(Jacobs et al., 1998)

CycA^C8LR1, CycB3^L6540 has spindle phenotype

(Jacobs et al., 1998)

CycA^C8LR1, CycB3^L6540 has embryo | embryonic cycle 15 phenotype

(Jacobs et al., 1998)

CycA^C8LR1, Df(2R)599-5 has mitotic spindle | embryonic cycle 13 phenotype

(Jacobs et al., 1998)

CycA^C8LR1, CycB² has mitotic spindle | embryonic cycle 13 phenotype

(Jacobs et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of CycA^C8LR1 enhances the sleep defects seen in flies co-expressing tara^NIG.6889R and tara^JF01421 under the control of Scer\GAL4^elav.PU.

One copy of CycA^C8LR1 does not enhance the sleep defects seen in DAT^fmn mutant heterozygotes.

One copy of Cdk1^GT-000294 does not suppress the sleep defects seen in CycA^C8LR1 mutant flies.

(Afonso et al., 2015)

The number of glial cells in rap^ie28 CycA^C8LR1 double mutant embryos is the same as in wild-type embryos, but they fail to migrate.

(Silies and Klämbt, 2010)

The duplication of v'ch1 neurons that is seen in cato^unspecified embryos is partially suppressed by CycA^C8LR1/+.

(zur Lage and Jarman, 2010)

Expression of CycJ^{Scer\UAS.C.T:Avic\GFP-EGFP} in epidermal regions under the control of Scer\GAL4^prd.RG1 in CycA^C8LR1 mutants does not rescue the cell cycle arrest in G2 of cycle 16.

(Althoff et al., 2009)

The photoreceptor axon targeting and lamina neuron defects seen in babo³²/babo⁵² mutants are substantially suppressed by CycA^C8LR1/+.

(Zhu et al., 2008)

The lethality seen in mei-41^29D males in which excision of an insertion of P{hsw^a} is induced during development is partly suppressed by CycA^C8LR1/+.

The lethality seen in mei-41^29D males in which excision of an insertion of P{hsw^a} is induced during development is completely suppressed if the female parent carries CycA^C8LR1 and if the male progeny carries both CycA^C8LR1 and CycB².

(LaRocque et al., 2007)

The rough eye phenotype seen in mei-41^29D ; DNApol-α180^Emus304/+ adults is completely rescued by CycA^C8LR1/+. The increased apoptosis seen in the wing discs of mei-41^29D ; DNApol-α180^Emus304/+ mutants is rescued by CycA^C8LR1/+ to levels indistinguishable from those of mei-41^29D single mutants or mei-41^29D ; CycA^C8LR1/+ mutants.

(LaRocque et al., 2007)

Expression of cdc2^AF.hs in CycA^C8LR1 mutant embryos fails to restore mitosis 16 in the epidermis.

Coexpression of the transgenes, cdc2^AF.hs, CycB^Δ90, and CycB3^Δ, restores the entry of epidermal cells in CycA^C8LR1 embryos into mitosis 16. After entry into mitosis, the epidermal cells are unable to complete this division.

Coexpression of the transgenes, cdc2^hs.PS, CycB^Δ90, and CycB3^Δ, does not restore the entry of epidermal cells in CycA^C8LR1 embryos into mitosis 16. Likewise, coexpression of stg^hs.PE2, CycB^Δ90 and CycB3^Δ does not suppress the phenotype, nor does the coexpression of cdc2^AF.hs, CycB^hs.PK and CycB3^hs.PS.

The epidermis of rap^ie28; CycA^C8LR1 double mutant embryos shows an extra mitotic division cycle as with CycA^C8LR1 single mutant embryos. This is in contrast to CycA^C8LR1 single mutant embryos, where the 16th mitotic division does not occur. In addition to the extra round of mitosis, rap^ie28; CycA^C8LR1 double mutant embryonic epidermal cells show abnormal anaphase and telophase figures with chromatin bridges.

Expression of CycE^Scer\UAS.cLa under the control of Scer\GAL4^prd.RG1 suppresses the mitotic phenotype of CycA^C8LR1 embryos so that cells progress through mitosis 16 and a subsequent S phase.

In CycA^C8LR1; CycE^AR95 double mutant embryos, cells arrest before mitosis 15, a phenotype not seen in either single mutant.

The mitotic embryonic phenotype of CycA^C8LR1 single mutants, in which mitosis 16 does not occur, is not suppressed in dap⁴; CycA^C8LR1 double mutants. However, the double mutants do enter another S phase after the stage at which mitosis occurs in equivalent wild-type embryos.

(Reber et al., 2006)

In numb¹⁵; CycA^C8LR1 double mutants, GMC4-2a differentiates into a RP2sib in 85% of cases, while in numb^S52F; CycA^C8LR1 double mutants, an RP2 neuron is generated in 99% of cases.

(Bhalerao et al., 2005)

Reduction of CycA, in CycA^C8LR1 heterozygotes partially suppresses the Cks30A^KO/Cks30A^RA74 phenotype.

(Swan et al., 2005)

Expression of CycA::tor^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^prd.RG1 in a CycA^C8LR1 background results in only a slight increase in cell number in the Scer\GAL4^prd.RG1 expression domain compared to cells outside the Scer\GAL4^prd.RG1 expression domain, although there is a significant increase in the number of nuclei in the Scer\GAL4^prd.RG1 expression domain (a high number of binucleate cells are seen). Expression of CycB^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^prd.RG1 does not rescue the cell division defects seen in CycA^C8LR1 embryos; there is no significant increase in cell number in the Scer\GAL4^prd.RG1 expression domain. Expression of CycB^{Scer\UAS.T:Ivir\HA1,T:SV40\nls2} under the control of Scer\GAL4^prd.RG1 does not rescue the cell division defects seen in CycA^C8LR1 embryos; there is no significant increase in cell number in the Scer\GAL4^prd.RG1 expression domain. Expression of Rca1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^prd.RG1 partially rescues the cell division defects seen in CycA^C8LR1 embryos; there is some increase in cell number in the Scer\GAL4^prd.RG1 expression domain.

(Dienemann and Sprenger, 2004)

Adult viability of CycD¹/Y ; CycA^C8LR1/+ males is 89% of expected value.

(Emmerich et al., 2004)

CycA^C8LR1, CycB² double mutants arrest mesodermal division at mitosis 15 a more severe phenotype than CycA^C8LR1 alone. Also a further reduction in the number of myocardial cells is seen. In numb¹, CycA^C8LR1 double mutant embryos the formation of one non-myogenic eve expressing cell per segment is seen, apparently at the expense of DA1 muscle formation.

(Han and Bodmer, 2003)

Cell cycle arrest in CycA^C8LR1/CycA^C8LR1; Rca1²/Rca1² embryos, occurs earlier (cycle 15) than in either single mutant (both arrest at cycle 16).

(Grosskortenhaus and Sprenger, 2002)

CycB3^L6540 CycA^C8LR1 double mutants show delayed chromatin condensation during prophase during mitosis 15 and rare mitotic cells with aberrant multipolar spindles at stage 13. CycB3^L6540 CycB^- (Df(2R)599-5) CycA^C8LR1 triple mutants are blocked at mitosis 15. 50% of embryos complete syncytial cycles without obvious defects, although many embryos were highly abnormal. Endoreduplicating cells still undergo DNA synthesis, though mitotic cells of the CNS do not.

(Jacobs et al., 1998)

Df(1)bi-D3/Y ; CycA^C8LR1/CycA^C8LR1 double mutant embryos show normal progression through mitosis 16 followed by an ectopic S phase.

(Sigrist and Lehner, 1997)

Xenogenetic Interactions

Statement

Reference

The rough-eye phenotype observed in animals expressing Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is suppressed in a CycA^C8LR1/+ background.

(Khurana et al., 2006)

Complementation and Rescue Data

Partially rescued by

CycA^C8LR1 is partially rescued by Scer\GAL4^prd.RG1/CycA^UAS.cWa

(Reber et al., 2006)

CycA^C8LR1 is partially rescued by Scer\GAL4^prd.RG1/CycA^{UAS.Tag:HA,Tag:NLS(SV40-largeT)}

(Dienemann and Sprenger, 2004)

CycA^C8LR1 is partially rescued by Scer\GAL4^prd.RG1/CycA^{UAS.Tag:HA,Tag:NES(hPKI)}

(Dienemann and Sprenger, 2004)

CycA^C8LR1 is partially rescued by Scer\GAL4^prd.RG1/CycA^UAS.Tag:HA

(Dienemann and Sprenger, 2004)

Comments

Expression of CycA^Scer\UAS.cWa driven by Scer\GAL4^prd.RG1 rescues the mitosis 16 in epidermal cells in CycA^C8LR1 embryos in the segments where CycA^Scer\UAS.cWa is expressed. The intervening segments show the CycA^C8LR1 mitotic phenotype.

(Reber et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

6627

w^*; CycA^C8LR1/TM3, Sb¹ P{35UZ}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

C8LR1

(Mukherjee et al., 2006)

CycA^C8

(Johnson et al., 2007, Reber et al., 2006, Zhu et al., 2005, Han and Bodmer, 2003)

CycA^C8LR1

(Matthew et al., 2024, Carrasco-Rando et al., 2023, Darnat et al., 2022, Hur et al., 2020, Kondo and Hayashi, 2019, Ricolo et al., 2016, Afonso et al., 2015, Matsuda et al., 2015, Wang and Baker, 2015, Baumgardt et al., 2014, Kondo and Hayashi, 2013, Xu et al., 2012, zur Lage and Jarman, 2010, Althoff et al., 2009, Caussinus et al., 2008, LaRocque et al., 2007, LaRocque et al., 2007, Tanaka-Matakatsu et al., 2007, Khurana et al., 2006)

CycA^CL8R1

(Ricolo et al., 2016)

CycA^c8LR1

(Flora et al., 2018)

Cyclin A^c8LR1

(Zhu et al., 2008)

cycA^C8LR1

(Vasavan et al., 2024, Zhang et al., 2024, Wang et al., 2016, Silies and Klämbt, 2010, Heriche et al., 2003, Ji et al., 2002)

cyclin A^C8LR1

(Kim et al., 2017)

l(3)C8LRI

(Ohlmeyer and Schupbach, 2003)

Name Synonyms

Secondary FlyBase IDs

References (44)

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