Allele Dmel\vn^Scer\UAS.cYa

General Information
Symbol	Dmel\vn^Scer\UAS.cYa	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Yarnitzky	FlyBase ID	FBal0065638
Feature type	allele	Associated gene	Dmel\vn

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Yarnitzky et al., 1997)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: 3.4kb EcoRI fragment of vn cDNA is cloned into the pUAST vector. (Yarnitzky et al., 1997)
Carried in construct	P{UAS-vn.Y} (Martin-Bermudo, 2000, Nabel-Rosen et al., 1999, Golembo et al., 1999, Yarnitzky et al., 1998, Yarnitzky et al., 1997, Inbal et al., 2004)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	embryonic/larval somatic muscle, with Scer\GAL4^69B (Yarnitzky et al., 1998) embryonic/larval somatic muscle, with Scer\GAL4^Kr.PM (Yarnitzky et al., 1998) embryonic/larval somatic muscle, with Scer\GAL4^twi.PG (Yarnitzky et al., 1998) lch5 ligament attachment cell \| supernumerary, with Scer\GAL4^repo (Inbal et al., 2004)
Detailed Description
	Statement Reference Stage 16 vn^Scer\UAS.cYa; Scer\GAL4^repo embryos have increased numbers of lch5 ligament attachment cells. (Inbal et al., 2004) Embryos expressing vn^Scer\UAS.cYa under the control of Scer\GAL4^twi.PG or Scer\GAL4^Kr.PM have supernumerary eve- and Kr-positive muscle precursor clusters. Embryos expressing vn^Scer\UAS.cYa under the control of Scer\GAL4^69B have supernumerary eve-positive muscle precursor clusters. (Yarnitzky et al., 1998)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Statement Reference Scer\GAL4^69B, vn^Scer\UAS.cYa has somatic muscle \| ectopic \| embryonic stage phenotype, non-suppressible by rho^unspecified (Yarnitzky et al., 1998) Scer\GAL4^69B, vn^Scer\UAS.cYa has somatic muscle \| ectopic \| embryonic stage phenotype, non-suppressible by spi³ (Yarnitzky et al., 1998)
Suppressor of
Statement Reference vn^Scer\UAS.cYa/Scer\GAL4^69B is a suppressor of phenotype of mys¹¹ (Martin-Bermudo, 2000)
NOT Suppressor of
Statement Reference vn^Scer\UAS.cYa, Scer\GAL4^twi.PG, Scer\GAL4^how-24B, Scer\GAL4^how-24B is a non-suppressor of phenotype of mys¹¹ (Martin-Bermudo, 2000)
Additional Comments
Genetic Interactions
Statement Reference Expression of vn^Scer\UAS.cYa in the tendon cells under the control of Scer\GAL4^69B can rescue the phenotype of mys¹¹ embryos (that lack both maternal and zygotic mys function), while expression of vn^Scer\UAS.cYa in the mesoderm under the control of both Scer\GAL4^twi.PG and Scer\GAL4^how-24B cannot. (Martin-Bermudo, 2000) The production of extra eve-positive muscle precursor clusters seen in embryos expressing vn^Scer\UAS.cYa under the control of Scer\GAL4^69B is not altered in a spi³ or rho^unspecified background. (Yarnitzky et al., 1998)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	vn^Scer\UAS.cYa vn^UAS.cYa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Yarnitzky (Yarnitzky et al., 1997)
Secondary FlyBase IDs

References ( 6 )
Research paper	Inbal et al., 2004, Dev. Cell 7(2): 241--250 Recruitment of ectodermal attachment cells via an EGFR-dependent mechanism during the organogenesis of Drosophila proprioceptors. [FBrf0180120] Martin-Bermudo, 2000, Development 127(12): 2607--2615 Integrins modulate the Egfr signaling pathway to regulate tendon cell differentiation in the Drosophila embryo. [FBrf0128565] Golembo et al., 1999, Genes Dev. 13(2): 158--162 Vein expression is induced by the EGF receptor pathway to provide a positive feedback loop in patterning the Drosophila embryonic ventral ectoderm. [FBrf0106549] Nabel-Rosen et al., 1999, Mol. Cell 4(4): 573--584 The balance between two isoforms of the Drosophila RNA-binding protein how controls tendon cell differentiation. [FBrf0111987] Yarnitzky et al., 1998, Mech. Dev. 79(1,2): 73--82 An interplay between two EGF-receptor ligands, Vein and Spitz, is required for the formation of a subset of muscle precursors in Drosophila. [FBrf0106043] Yarnitzky et al., 1997, Genes Dev. 11(20): 2691--2700 The Drosophila neuregulin homolog vein mediates inductive interactions between myotubes and their epidermal attachment cells. [FBrf0098912]

Allele Dmel\vnScer\UAS.cYa

Allele Dmel\vn^Scer\UAS.cYa