Allele Dmel\dy^MR

General Information
Symbol	Dmel\dy^MR	Species	D. melanogaster
Name		FlyBase ID	FBal0065856
Feature type	allele	Associated gene	Dmel\dy

Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	CkIIβ^And (Roberts and Jackson, 1997)
Nature of the lesion	Statement Reference 19-25kb deletion in the m-dy interval removing part or all of both transcription units. (Roberts and Jackson, 1997)
Caused by aberration	Df(1)m-MR (Roberts and Jackson, 1997, Roch et al., 2003, Akten et al., 2002)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference Hemizygous viable. Resulting adults have wings that are smaller than normal although the wing veins are correctly patterned. Wing hairs are much closer together than normal. Mutant hairs are twisted and branched. Cuticular blobs bulge out of the main wing surface. The dorsal and ventral wing surfaces are separate in the mutants, instead of closely apposed as in wild type, with the space between them filled with cell debris and cuticle invaginations. (Roch et al., 2003)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference dy^MR, m^MR has body color defective phenotype (Akten et al., 2002, Akten et al., 2002) dy^MR, m^MR has decreased cell size phenotype (Roch et al., 2003, Roch et al., 2003) dy^MR, m^MR has viable phenotype (Roch et al., 2003, Roch et al., 2003)
Phenotype Manifest In
Other
Statement Reference dy^MR, m^MR has wing & epidermis & microvillus phenotype (Roch et al., 2003, Roch et al., 2003) dy^MR, m^MR has wing & epidermis & pupa phenotype (Roch et al., 2003) dy^MR, m^MR has wing & epidermis phenotype (Roch et al., 2003, Roch et al., 2003) dy^MR, m^MR has wing & pupal epidermis phenotype (Roch et al., 2003, Roch et al., 2003) dy^MR, m^MR has wing hair phenotype (Roch et al., 2003, Roch et al., 2003) dy^MR, m^MR has wing phenotype (Roch et al., 2003, Akten et al., 2002, Akten et al., 2002, Roch et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference Df(1)m-MR is hemizygous viable. Resulting adults have wings that are smaller than normal although the wing veins are correctly patterned. Wing hairs are much closer together than normal, suggesting that cell size is reduced. Mutant hairs are twisted and branched. Cuticular blobs bulge out of the main wing surface. The dorsal and ventral wing surfaces are separate in the mutants, instead of closely apposed as in wild type, with the space between them filled with cell debris and cuticle invaginations. Cuticle covering the epidermis of other parts of the body appears completely normal. Morphology of Df(1)m-MR mutant cells at 28-32 hours APF show no abnormalities. Between 42 and 48 hours APF mutant cells do not undergo the flattening characteristic of wild type cells, and the prominent actin-filled extensions - the hair pedestals - do not form. Actin accumulation is abnormal - the actin forms a ring in the apical part of the mutant cells. By 62-66 hours APF, when wild type apical cell membrane is secreting the chitinous cuticle, the Df(1)m-MR apical membrane folds deeply into the cleft between adjacent cells. Formation of the cuticulin envelope is not prevented in Df(1)m-MR wings, though the microvilli underlying the cuticulin layer are shorter and membrane invaginations beneath the cuticulin layer are more extensive and less well organised than in wild type. (Roch et al., 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	dy^MR
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Roch et al., 2003, J. Cell Sci. 116(7): 1199--1207 Drosophila miniature and dusky encode ZP proteins required for cytoskeletal reorganisation during wing morphogenesis. [FBrf0159036] Akten et al., 2002, genesis 34(1-2): 156--159 RNA interference from a CAX trinucleotide repeat. [FBrf0152369] Roberts and Jackson, 1997, D. I. S. 80: 104--105 A new miniature-dusky allele. [FBrf0098440]

Allele Dmel\dyMR

Allele Dmel\dy^MR