Allele Dmel\W^unspecified

General Information
Symbol	Dmel\W^unspecified	Species	D. melanogaster
Name		FlyBase ID	FBal0065920
Feature type	allele	Associated gene	Dmel\W

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	flightless \| dominant (Rancourt et al., 1991) increased cell death (Udan et al., 2003) viable (Rancourt et al., 1991)
Phenotype Manifest In
	dorsal closure embryo (Zhou et al., 1999) embryonic brain (Zhou et al., 1999) midline glial cell (Bergmann et al., 2002)
Detailed Description
	Statement Reference W^unspecified mutant embryos at stage 17 have an average of 5.8 midline glial cells per segment (n=182), compared to an average of 2.8 per segment in wild-type. (Bergmann et al., 2002) Embryos often show defects in head involution and the brain appears larger than normal. (Zhou et al., 1999)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference W^unspecified has increased cell death phenotype, suppressible by hpo^KC202 (Udan et al., 2003)
Suppressor of
Statement Reference W[+]/W^unspecified is a suppressor of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, ttm50^{Scer\UAS.T:Ivir\HA1} (Sugiyama et al., 2007)
Other
Statement Reference W[+]/W^unspecified, pie^EB3 has lethal \| dominant phenotype (Shi et al., 2003) W^unspecified, pie^EB3/pie[+] has lethal \| dominant phenotype (Shi et al., 2003)
Phenotype Manifest In
Enhancer of
Statement Reference W^unspecified/W^unspecified is an enhancer of midline glial cell phenotype of rl^Sem (Bergmann et al., 2002, Bergmann et al., 2002)
Suppressor of
Statement Reference W[+]/W^unspecified is a suppressor of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, ttm50^{Scer\UAS.T:Ivir\HA1} (Sugiyama et al., 2007) W^unspecified/W^unspecified is a suppressor of midline glial cell phenotype of rl^unspecified (Bergmann et al., 2002, Bergmann et al., 2002) W^unspecified is a suppressor of Malpighian tubule phenotype of Egfr^f24 (Sudarsan et al., 2002) W^unspecified is a suppressor of midline glial cell phenotype of comm^Δe39 (Bergmann et al., 2002)
Additional Comments
Genetic Interactions
Statement Reference The rough eye phenotype caused by expression of ttm50^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF is suppressed by W^unspecified/+. (Sugiyama et al., 2007) pie^EB3/+ is lethal in combination with W^unspecified/+. (Shi et al., 2003) hpo^KC202 mutant clones partially suppress the cell death observed in eye discs that ectopically express W^unspecified. (Udan et al., 2003) The reduction in midline glial cell numbers seen in comm^Δe39 mutant embryos is suppressed in double mutants with W^unspecified. These rescued midline glial cells are scattered throughout the midline, which lacks axons in these animals. The absence of midline glia (MG) in rl^unspecified embryos is suppressed by W^unspecified/W^unspecified, although the resulting cells are mislocated, lying directly below the cuticle, often in clusters of up to 20 cells. Approximately twice as many MG cells survive as in wild-type. (Bergmann et al., 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	hid (Sudarsan et al., 2002) W^unspecified
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	Sugiyama et al., 2007, Genetics 176(2): 927--936 Involvement of the mitochondrial protein translocator component Tim50 in growth, cell proliferation and the modulation of respiration in Drosophila. [FBrf0200675] Shi et al., 2003, Genetics 165(4): 1869--1879 The pineapple eye gene is required for survival of Drosophila imaginal disc cells. [FBrf0167647] Udan et al., 2003, Nat. Cell Biol. 5(10): 914--920 Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. [FBrf0167938] Bergmann et al., 2002, Dev. Cell 2(2): 159--170 Regulation of cell number by MAPK-dependent control of apoptosis: a mechanism for trophic survival signaling. [FBrf0144794] Sudarsan et al., 2002, Development 129(4): 935--944 A genetic hierarchy establishes mitogenic signalling and mitotic competence in the renal tubules of Drosophila. [FBrf0144843] Zhou et al., 1999, Mol. Cell 4(5): 745--755 HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosis. [FBrf0123261] Rancourt et al., 1991, D. I. S. 70: 185 A flightless host for biological containment of P-mediated transformants. [FBrf0053580]

Allele Dmel\Wunspecified

Allele Dmel\W^unspecified