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General Information
Symbol
Dmel\HC2.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0066052
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Internal deletion of a 588bp PstI fragment (between 837 and 1425, amino acids 192-389).

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of HC2.hs using heat shock only induces ectopic wing veins when it is overexpressed between day 5 and 6 after egg deposition. The phenocritical period is restricted to the prepupal and early pupal stage, starting approximately at the larval-prepupal transition. Bifurcation of wing vein L2 is sometimes seen. Overexpression of HC2.hs during the mid- to late-third instar does not result in ectopic vein formation. Co-expression of Hhs.PM and HC2.hs results in a synergistic phenotype with strong induction of ectopic wing veins.

Heat induced expression causes no or negligible bristle duplications or socket to shaft transformations. Expression does cause a specific net-like wing venation is observed on the wings.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

HC2.hs has visible | heat sensitive phenotype, enhanceable by CycB3L6540/CycB3[+]

HC2.hs has visible | heat sensitive phenotype, enhanceable by Df(3R)X10/+

HC2.hs has visible | heat sensitive phenotype, enhanceable by Egfr[+]/EgfrE1

HC2.hs has visible | heat sensitive phenotype, enhanceable by N[+]/NAx-E2

HC2.hs has visible | heat sensitive phenotype, enhanceable by bs03267/bs[+]

HC2.hs has visible | heat sensitive phenotype, enhanceable by emc04322/emc[+]

HC2.hs has visible | heat sensitive phenotype, enhanceable by groE48/gro[+]

HC2.hs has visible | heat sensitive phenotype, enhanceable by Dadj1E4/Dad[+]

HC2.hs has visible | heat sensitive phenotype, enhanceable by heixk11403/heix[+]

HC2.hs has visible | heat sensitive phenotype, enhanceable by lace[+]/lace2

HC2.hs has visible | heat sensitive phenotype, enhanceable by net1/net[+]

HC2.hs has visible | heat sensitive phenotype, enhanceable by px[+]/px1

HC2.hs has visible | heat sensitive phenotype, enhanceable by Df(3R)Dl-FX3/+

HC2.hs has visible | heat sensitive phenotype, enhanceable by Df(3R)P11/+

Suppressed by
Statement
Reference

HC2.hs has visible | heat sensitive phenotype, suppressible by Df(1)N-54l9

HC2.hs has visible | heat sensitive phenotype, suppressible by Nnd-3/N[+]

HC2.hs has visible | heat sensitive phenotype, suppressible by S54/S[+]

HC2.hs has visible | heat sensitive phenotype, suppressible by Sk09530/S[+]

HC2.hs has visible | heat sensitive phenotype, suppressible by ac1/sc1

HC2.hs has visible | heat sensitive phenotype, suppressible by aop[+]/aop1

HC2.hs has visible | heat sensitive phenotype, suppressible by boss44/boss[+]

HC2.hs has visible | heat sensitive phenotype, suppressible by Df(1)sc-B57/+

HC2.hs has visible | heat sensitive phenotype, suppressible by cno3/cno[+]

HC2.hs has visible | heat sensitive phenotype, suppressible by cv-d[+]/cv-d1

HC2.hs has visible | heat sensitive phenotype, suppressible by dpps4/dpp[+]

HC2.hs has visible | heat sensitive phenotype, suppressible by emc[+]/emcD

HC2.hs has visible | heat sensitive phenotype, suppressible by groE75/gro[+]

HC2.hs has visible | heat sensitive phenotype, suppressible by hv1/hv[+]

HC2.hs has visible | heat sensitive phenotype, suppressible by mam04615/mam[+]

HC2.hs has visible | heat sensitive phenotype, suppressible by neur[+]/neur11

HC2.hs has visible | heat sensitive phenotype, suppressible by rho5/rho[+]

HC2.hs has visible | heat sensitive phenotype, suppressible by rhove-1/rho[+]

HC2.hs has visible | heat sensitive phenotype, suppressible by N264-10

HC2.hs has visible | heat sensitive phenotype, suppressible by sax[+]/sax2

HC2.hs has visible | heat sensitive phenotype, suppressible by vn[+]/vn1

HC2.hs has visible | heat sensitive phenotype, suppressible by N55e11

HC2.hs has visible | heat sensitive phenotype, suppressible by N[+]/Nnd-1

Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

HC2.hs has wing vein | ectopic | heat sensitive phenotype, enhanceable by CycB3L6540/CycB3[+]

HC2.hs has wing vein | ectopic | heat sensitive phenotype, enhanceable by Df(3R)P11/+

HC2.hs has wing | heat sensitive phenotype, enhanceable by Df(3R)P11/+

HC2.hs has wing vein | ectopic | heat sensitive phenotype, enhanceable by Df(3R)X10/+

HC2.hs has wing | heat sensitive phenotype, enhanceable by Df(3R)X10/+

HC2.hs has wing vein | ectopic | heat sensitive phenotype, enhanceable by Egfr[+]/EgfrE1

HC2.hs has wing | heat sensitive phenotype, enhanceable by Egfr[+]/EgfrE1

HC2.hs has wing vein | ectopic | heat sensitive phenotype, enhanceable by N[+]/NAx-E2

HC2.hs has wing | heat sensitive phenotype, enhanceable by CycB3L6540/CycB3[+]

HC2.hs has wing | heat sensitive phenotype, enhanceable by N[+]/NAx-E2

HC2.hs has wing vein | ectopic | heat sensitive phenotype, enhanceable by bs03267/bs[+]

HC2.hs has wing | heat sensitive phenotype, enhanceable by bs03267/bs[+]

HC2.hs has wing vein | ectopic | heat sensitive phenotype, enhanceable by emc04322/emc[+]

HC2.hs has wing | heat sensitive phenotype, enhanceable by emc04322/emc[+]

HC2.hs has wing vein | ectopic | heat sensitive phenotype, enhanceable by groE48/gro[+]

HC2.hs has wing | heat sensitive phenotype, enhanceable by groE48/gro[+]

HC2.hs has wing vein | ectopic | heat sensitive phenotype, enhanceable by heixk11403/heix[+]

HC2.hs has wing | heat sensitive phenotype, enhanceable by heixk11403/heix[+]

HC2.hs has wing vein | ectopic | heat sensitive phenotype, enhanceable by lace[+]/lace2

HC2.hs has wing | heat sensitive phenotype, enhanceable by lace[+]/lace2

HC2.hs has wing vein | ectopic | heat sensitive phenotype, enhanceable by net1/net[+]

HC2.hs has wing | heat sensitive phenotype, enhanceable by net1/net[+]

HC2.hs has wing vein | ectopic | heat sensitive phenotype, enhanceable by Dadj1E4/Dad[+]

HC2.hs has wing vein | ectopic | heat sensitive phenotype, enhanceable by px[+]/px1

HC2.hs has wing | heat sensitive phenotype, enhanceable by px[+]/px1

HC2.hs has wing | heat sensitive phenotype, enhanceable by Dadj1E4/Dad[+]

HC2.hs has wing vein | ectopic | heat sensitive phenotype, enhanceable by Df(3R)Dl-FX3/+

HC2.hs has wing | heat sensitive phenotype, enhanceable by Df(3R)Dl-FX3/+

Suppressed by
Statement
Reference

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by Df(1)N-54l9

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by N[+]/Nnd-1

HC2.hs has wing | heat sensitive phenotype, suppressible by N[+]/Nnd-1

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by Nnd-3/N[+]

HC2.hs has wing | heat sensitive phenotype, suppressible by Nnd-3/N[+]

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by S54/S[+]

HC2.hs has wing | heat sensitive phenotype, suppressible by S54/S[+]

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by Sk09530/S[+]

HC2.hs has wing | heat sensitive phenotype, suppressible by Df(1)N-54l9

HC2.hs has wing | heat sensitive phenotype, suppressible by Sk09530/S[+]

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by ac1/sc1

HC2.hs has wing | heat sensitive phenotype, suppressible by ac1/sc1

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by aop[+]/aop1

HC2.hs has wing | heat sensitive phenotype, suppressible by aop[+]/aop1

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by boss44/boss[+]

HC2.hs has wing | heat sensitive phenotype, suppressible by boss44/boss[+]

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by cno3/cno[+]

HC2.hs has wing | heat sensitive phenotype, suppressible by cno3/cno[+]

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by cv-d[+]/cv-d1

HC2.hs has wing | heat sensitive phenotype, suppressible by cv-d[+]/cv-d1

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by dpps4/dpp[+]

HC2.hs has wing | heat sensitive phenotype, suppressible by dpps4/dpp[+]

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by Df(1)sc-B57/+

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by emc[+]/emcD

HC2.hs has wing | heat sensitive phenotype, suppressible by emc[+]/emcD

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by groE75/gro[+]

HC2.hs has wing | heat sensitive phenotype, suppressible by groE75/gro[+]

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by hv1/hv[+]

HC2.hs has wing | heat sensitive phenotype, suppressible by hv1/hv[+]

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by mam04615/mam[+]

HC2.hs has wing | heat sensitive phenotype, suppressible by Df(1)sc-B57/+

HC2.hs has wing | heat sensitive phenotype, suppressible by mam04615/mam[+]

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by neur[+]/neur11

HC2.hs has wing | heat sensitive phenotype, suppressible by neur[+]/neur11

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by rho5/rho[+]

HC2.hs has wing | heat sensitive phenotype, suppressible by rho5/rho[+]

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by rhove-1/rho[+]

HC2.hs has wing | heat sensitive phenotype, suppressible by rhove-1/rho[+]

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by sax[+]/sax2

HC2.hs has wing | heat sensitive phenotype, suppressible by sax[+]/sax2

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by vn[+]/vn1

HC2.hs has wing | heat sensitive phenotype, suppressible by vn[+]/vn1

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by N55e11

HC2.hs has wing | heat sensitive phenotype, suppressible by N55e11

HC2.hs has wing vein | ectopic | heat sensitive phenotype, suppressible by N264-10

HC2.hs has wing | heat sensitive phenotype, suppressible by N264-10

Additional Comments
Genetic Interactions
Statement
Reference

net ; HC2.hs homozygotes are semi-lethal at 25oC (and viable at 18oC). The animals have massive patches of vein tissue and extensive blistering of the wing.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to rescue

HC2.hs fails to rescue HP41

Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Carried in plasmid "C2" and expressed in S2 cell culture to test for proper protein expression.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
HC2.hs
Name Synonyms
Secondary FlyBase IDs
    References (2)